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Gene Dmel\EndoG

General Information
Symbol	Dmel\EndoG	Species	D. melanogaster
Name	Endonuclease G	Annotation symbol	CG8862
Feature type	protein_coding_gene	FlyBase ID	FBgn0033690
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48E4-48E4	Sequence location	2R:8,064,935..8,066,058 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Endonuclease G is referred to in FlyBase by the symbol Dmel\EndoG (CG8862, FBgn0033690). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endoribonuclease activity; endodeoxyribonuclease activity. There is experimental evidence that it is involved in the biological process: mitochondrion inheritance; spermatid development. 5 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; mitochondrial nucleoid. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA/RNA non-specific endonuclease; DNA/RNA non-specific endonuclease, active site; Extracellular Endonuclease, subunit A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, larval/adult midgut, larval hindgut, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632094_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of EndoG. Gene sequence location is 2R:8064935..8066058.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48E4-48E4   Limits computationally determined from genome sequence between P{PZ}SmD302833 and P{PZ}Cam03909
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\EndoG for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) EndoG-RA FBtr0088012  NM_136893   1124   310
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein EndoG-PA   FBpp0087120   34.6   310   8.96     NP_610737   AAF58564
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA/RNA non-specific endonuclease (IPR001604) DNA/RNA non-specific endonuclease, active site (IPR018524) Extracellular Endonuclease, subunit A (IPR020821) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08862
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58564   AI515790   AI518881   AW943293   AY094821 AAM11174   CL868619   EV591197
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JXB9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic midgut chamber   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, larval/adult midgut, larval hindgut, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.35 Larval Midgut    104 Larval Hindgut    104.2 Larval Malpighian Tubules    98.3 Larval Fat Body    59.6 Larval Salivary Gland    77.9 Larval Trachea    117.275 Larval Carcass    66.475 Adult Head    76.4 Adult Eye    58.4 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    89 Adult Crop    81.4 Adult Midgut    148.8 Adult Hindgut    96.6 Adult Malpighian Tubules    84.4 Adult Fat Body    88.7 Adult Salivary Gland    74.2 Adult Heart    91.55 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    61.6 Adult Ovary    261.7 Adult Testis    40.7 Adult Male Accessory Gland    64 Adult Carcass    78.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    76.4   NA  Eye    58.4   NA  Brain    107   98.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    89   NA  Crop    81.4   104  Midgut    148.8   104.2  Hindgut    96.6   98.3  Malpighian Tubules    84.4   59.6  Fat Body    88.7   77.9  Salivary Gland    74.2   NA  Heart    91.55   117.275  Trachea    NA   NA  VirginFemale Spermatheca    47.8   NA  InseminatedFemale Spermatheca    61.6   NA  Ovary    261.7   NA  Testis    40.7   NA  Male Accessory Gland    64   66.475  Carcass    78.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    5 carcass, larvae L3 wandering    4 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    19 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    32 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    30 embryo 22-24hr    21 larva L1    35 larva L2    29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP    33 pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr  (27) embryo 12-14hr    17 embryo 14-16hr  (32) embryo 16-18hr  (27) embryo 18-20hr  (27) embryo 20-22hr  (30) embryo 22-24hr    21 larva L1  (35) larva L2  (29) larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP  (33) pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    32 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    30 embryo 22-24hr    21 larva L1    35 larva L2    29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP    33 pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    32 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    30 embryo 22-24hr    21 larva L1    35 larva L2    29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP    33 pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    32 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    30 embryo 22-24hr    21 larva L1    35 larva L2    29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP    33 pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr  27 embryo 12-14hr    17 embryo 14-16hr  32 embryo 16-18hr  27 embryo 18-20hr  27 embryo 20-22hr  30 embryo 22-24hr    21 larva L1  (35) larva L2  29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP  (33) pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    32 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    30 embryo 22-24hr    21 larva L1    35 larva L2    29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP    33 pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    9 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    17 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    32 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    30 embryo 22-24hr    21 larva L1    35 larva L2    29 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    8 pupae 2d postWPP    19 pupae 3d postWPP    33 pupae 4d postWPP    14 adult male 01day    10 adult male 05day    8 adult male 30day    10 adult female 01day    20 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (30) Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2  (27) tumorous blood cells mbn2  (27) ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2  27 tumorous blood cells mbn2  27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    21 embryonic 1182-4H    21 embryonic GM2    23 embryonic Kc167    10 embryonic S1    18 embryonic S3    23 leg disc CME L1    23 wing disc CME-W2    10 wing disc ML-DmD8    19 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    22 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    27 ovary fGS/OSS    11 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD35517 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033690 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8862-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable EndoGEY14272 EndoGMB07150 viable, with Scer\GAL4pnr-MD237 EndoGGD5747 viable (with Df(2R)BSC699) EndoGMB07150 Sterility Allele fertile EndoGEY14272 EndoGMB07150 fertile (with Df(2R)BSC699) EndoGMB07150 Phenotype manifest in Allele mitochondrial nucleoid EndoGMB07150 mitochondrial nucleoid (with Df(2R)BSC699) EndoGMB07150 spermatid EndoGMB07150 spermatid (with Df(2R)BSC699) EndoGMB07150
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of EndoG Class Mutagen Stocks Known lesion EndoGEY14272 P-element activity 1 -- EndoGMB07150 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of EndoG Class Mutagen Stocks Known lesion EndoGGD5747 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes EndoGKK109029 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EndoGScer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK109029} NA P{UASp-EndoG.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}EndoGEY14272 NA insertion of enhancer trap binary system Mi{ET1}EndoGMB07150 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
endodeoxyribonuclease activity inferred from direct assay (Temme et al., 2009) endoribonuclease activity inferred from direct assay (Temme et al., 2009)
Biological Process
CV term Evidence References
mitochondrion inheritance inferred from mutant phenotype (Deluca and O'Farrell, 2012) spermatid development inferred from mutant phenotype (Deluca and O'Farrell, 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
endodeoxyribonuclease activity inferred from sequence or structural similarity with UniProtKB:P38447 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q14249 (Sardiello et al., 2003.6.11) metal ion binding inferred from electronic annotation with InterPro:IPR001604, InterPro:IPR018524, InterPro:IPR020821 (FlyBase Curators et al., 2004-) nucleic acid binding inferred from electronic annotation with InterPro:IPR001604, InterPro:IPR018524, InterPro:IPR020821 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
DNA-dependent DNA replication inferred from sequence or structural similarity with UniProtKB:Q14249 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial inner membrane inferred from sequence or structural similarity with Saccharomyces NUC1 (FlyBase, 1992-) mitochondrion inferred from sequence or structural similarity with UniProtKB:Q14249 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
EndoG - CG10418 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG11337 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG13126 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG14786 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG31769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - CG8021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Cbp80 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - EndoGI experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) EndoG - Fmr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) EndoG - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - RpL37a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Su(P) experimental knowledge based (Guruharsha et al., 2011) EndoG - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - bsf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - btz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - eIF4AIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - exu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - how anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - me31B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - miple2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - mod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - mtDNA-helicase experimental knowledge based (Guruharsha et al., 2011) EndoG - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) EndoG - th anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions EndoG allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62090 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033690 DroID - A comprehensive database of gene and protein interactions. • FBgn0033690 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36309
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6F7P55 Dipteran inclusive ortholog search EOG6JHCQH Insect inclusive ortholog search EOG6VX11Z Arthropod inclusive ortholog search EOG6QRFKS Metazoa inclusive ortholog search EOG6QZMFB
Orthologs in Drosophila Species (EOG6F7P55)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\EndoG     Drosophila sechellia   Dsec\GM20380 Y   Drosophila erecta   Dere\GG22601 Y   Drosophila yakuba   Dyak\GE13469 Y   Drosophila ananassae   Dana\GF12638 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24605 Y   Drosophila persimilis   Dper\GL24726     Drosophila persimilis   Dper\GL11082 Y   Drosophila persimilis   Dper\GL13439     Drosophila willistoni   Dwil\GK23216 Y   Drosophila virilis   Dvir\GJ19936 Y   Drosophila mojavensis   Dmoj\GI19378 Y   Drosophila grimshawi   Dgri\GH22148 Y
Orthologs in non-Drosophila Dipterans (EOG6JHCQH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009589   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002064   Anopheles gambiae Malaria mosquito  Agam\AGAP007845   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015538
Orthologs in non-Dipteran Insects (EOG6VX11Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC551715   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005267   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20603   Atta cephalotes Leafcutter ant  Acep\ACEP12871   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17436   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21416   Linepithema humile Argentine ant  Lhum\LH10728   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25657   Solenopsis invicta Red fire ant  Sinv\SINV17407   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004054   Bombyx mori Silkmoth  Bmor\BGIBMGA004328   Pediculus humanus Human body louse  Phum\PHUM180000   Tribolium castaneum Red flour beetle  Tcas\TC011076
Orthologs in non-Insect Arthropods (EOG6QRFKS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Jph2 Y Ixodes scapularis Deer tick  Isca\ISCW023434 Y
Orthologs in non-Arthropod Metazoa (EOG6QZMFB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cps-6 Y Danio rerio Zebrafish  Drer\DKEY-34G4.1 Y Xenopus tropicalis Western clawed frog  Xtro\endog Y Gallus gallus Domestic chicken  Ggal\ENDOG Y Mus musculus House mouse  Mmus\Endog Y Rattus norvegicus Norway rat  Rnor\Endog Y Homo sapiens Human  Hsap\ENDOG Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENDOG
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM20380 Drosophila erecta Dere\GG22601 Drosophila yakuba Dyak\GE13469 Drosophila ananassae Dana\GF12638 Drosophila pseudoobscura pseudoobscura Dpse\GA24605 Drosophila persimilis Dper\GL11082 Drosophila willistoni Dwil\GK23216 Drosophila virilis Dvir\GJ19936 Drosophila mojavensis Dmoj\GI19378 Drosophila grimshawi Dgri\GH22148
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26072 w1118; Mi{ET1}EndoGMB07150 20796 y1 w67c23; P{EPgy2}EndoGEY14272
VDRC	v105749 P{KK109029}VIE-260B v38084 w1118; P{GD5747}v38084 v38085 w1118; P{GD5747}v38085
Genomic Clones ( 2 )
	BACR04E21 BACR37I09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35517
Other clones	DPiM_LD35517
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD41461
Other clones	Dmel_neb_001965_0354_0329
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033690 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36309
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: EndoG CG8862 (Temme et al., 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136893 RefSeq (Proteins) • NP_610737 DDBJ / EMBL / GenBank • AAF58564 AAM11174 AI518881 AW943293 AY094821 CL868619 Entrez Gene - A searchable database of RefSeq genes. • 36309 UniProtKB/TrEMBL • Q7JXB9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA/RNA non-specific endonuclease (IPR001604) DNA/RNA non-specific endonuclease, active site (IPR018524) Extracellular Endonuclease, subunit A (IPR020821) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08862 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD35517
Linkouts
	BioGRID - A database of protein and genetic interactions • 62090 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033690 DroID - A comprehensive database of gene and protein interactions. • FBgn0033690 DRSC - Results from RNAi screens. • FBgn0033690 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033690 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8862-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033690 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36309 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36309 modMine - Data generated by the modENCODE project. • FBgn0033690
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG8862 (Temme et al., 2009, Keleman et al., 2009.8.5) EndoG (Loll et al., 2009, Temme et al., 2009, Deluca and O'Farrell, 2012)
Name Synonym	CG8862   Endonuclease G (Temme et al., 2009)
Secondary FlyBase IDs
References ( 19 )
Research paper	Deluca and O'Farrell, 2012, Dev. Cell 22(3): 660--668 Barriers to male transmission of mitochondrial DNA in sperm development. [FBrf0217815] Loll et al., 2009, Nucleic Acids Res. 37(21): 7312--7320 Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. [FBrf0209495] Temme et al., 2009, J. Biol. Chem. 284(13): 8337--8348 The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. [FBrf0207466] Orian et al., 2003, Genes Dev. 17(9): 1101--1114 Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. [FBrf0158942]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Bellen, 2008.11.7, set816.xml set816.xml [FBrf0206132] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]