FlyBase Gene Report: Dmel\Dh44-R2

General Information

Symbol

Dmel\Dh44-R2

Species

D. melanogaster

Name

Diuretic hormone 44 receptor 2

Annotation Symbol

CG12370

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033744

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Snapshot

Diuretic hormone 44 receptor 2 (Dh44-R2) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathways, hormone-mediated signaling pathways, and response to salt stress. [Date last reviewed: 2019-07-11]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dh44R2

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:12,474,424..12,487,986 [+]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12474424..12487986

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

diuretic hormone receptor activity

inferred from physical interaction with FLYBASE:Dh44; FB:FBgn0012344

(Hector et al., 2009)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

calcitonin receptor activity

inferred from sequence or structural similarity

(Radford et al., 2002)

diuretic hormone receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

G protein-coupled peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001737881

(assigned by GO_Central )

(Gaudet et al., 2011)

neuropeptide receptor activity

inferred from sequence model

(Hewes and Taghert, 2001)

peptide hormone binding

inferred from biological aspect of ancestor with PANTHER:PTN001738162

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

G protein-coupled receptor signaling pathway

inferred from direct assay

(Hector et al., 2009)

hormone-mediated signaling pathway

inferred from direct assay

(Hector et al., 2009)

response to salt stress

inferred from mutant phenotype

(Hector et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001737881

(assigned by GO_Central )

(Gaudet et al., 2011)

cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR017981

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

G protein-coupled receptor signaling pathway

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

integral component of plasma membrane

inferred from direct assay

(Hector et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence model

(Hewes and Taghert, 2001)

plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001737881

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CLASS B GPCRs, SUBFAMILY B1

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CLASS B GPCRs, SUBFAMILY B1 -: The B1 subfamily of Class B GPCRs are largely classical hormone receptors. (Adapted from FBrf0147071 and FBrf0221117).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Dh44-R2 or the JBrowse view of Dmel\Dh44-R2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dh44-R2-RA

FBtr0087936

NM_165907

2100

475

Dh44-R2-RB

FBtr0113075

NM_136945

3069

476

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Dh44-R2-PA

FBpp0087047

54.0

475

7.09

NP_725175

AAF58501

Dh44-R2-PB

FBpp0111988

54.1

476

6.50

NP_610789

AAM68690

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dh44-R2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dh44-R2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

epitope tag

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult Malpighian tubule

(Cannell et al., 2016)

Additional Descriptive Data

Dh44-R2 is bound by fluorescently labelled Dh44 in the Mapighian tubules.

(Cannell et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

integral component of plasma membrane

inferred from direct assay

(Hector et al., 2009)

Expression Deduced from Reporters

Reporter: P{Dh44-R2-GAL4.D}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult enteroendocrine cell

(Dus et al., 2015)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dh44-R2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dh44-R2

View exonic expression by tissue for Dmel\Dh44-R2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0033744

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG12370-RA;CG12370-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0033744

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dh44-R2

Transgenic constructs containing regulatory region of Dh44-R2

Deletions and Duplications ( 4 )

Disrupted in

Df(2R)achi²

(Ayyar et al., 2003)

Df(2R)achi³

(Ayyar et al., 2003)

Df(2R)achi⁴

(Ayyar et al., 2003)

Df(2R)pingpong

(Wang and Mann, 2003)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dh44-R2^GD15731

viable, with Scer\GAL4^Mef2.PR

Dh44-R2^GD15731

viable, with Scer\GAL4^pnr-MD237

Dh44-R2^GD15731

viable, with Scer\GAL4^tin.CΔ4

Dh44-R2^GD15731

Other Phenotypes

Allele

circadian behavior defective | adult stage

Dh44-R2¹⁷⁴

circadian behavior defective | adult stage, with Scer\GAL4^elav-C155

circadian behavior defective | adult stage (with Df(2R)BSC305)

Dh44-R2¹⁷⁴

feeding behavior defective | adult stage | recessive | nutrition conditional

Dh44-R2^KO

osmotic stress response defective, with Scer\GAL4^Act5C.PI

Dh44-R2^GD15731

starvation stress response defective | adult stage, with Scer\GAL4^CapaR.1.5

Dh44-R2^KK111461

stress response defective | adult stage | conditional, with Scer\GAL4^CapaR.1.5

Dh44-R2^KK111461

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CRHR2

12 of 15

Yes

Hsap\CRHR1

9 of 15

Yes

7 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Crhr1

14 of 15

Yes

11 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Nnmt

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (15)

Rnor\Crhr1

12 of 13

Yes

11 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Nnmt

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (20)

Xtro\crhr1.2

7 of 12

Yes

4 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\gcgr

1 of 12

Xtro\gipr

1 of 12

Xtro\inmt

1 of 12

Yes

Xtro\LOC548368

1 of 12

Yes

Xtro\LOC594886

1 of 12

Yes

Xtro\LOC100127789

1 of 12

Yes

Xtro\LOC100145174

1 of 12

Yes

Xtro\MGC88898

1 of 12

Yes

Xtro\MGC107884

1 of 12

Yes

Xtro\nnmt

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (21)

Drer\crhr1

11 of 15

Yes

7 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\si:dkey-114g7.4

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\seb-3

8 of 15

Yes

Cele\pdfr-1

2 of 15

Cele\seb-2

2 of 15

Cele\anmt-2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919075M )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11587

Drosophila willistoni

Dwil\GK17974

Drosophila virilis

Dvir\GJ18092

Drosophila mojavensis

Dmoj\GI19749

Drosophila grimshawi

Dgri\GH21316

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150953 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17024720

Musca domestica

House fly

Mdoa\17007272

Glossina morsitans

Tsetse fly

Gmor\GMOY012160

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11389

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09717

Mayetiola destructor

Hessian fly

Mdes\Mdes002924

Mayetiola destructor

Hessian fly

Mdes\Mdes002928

Aedes aegypti

Yellow fever mosquito

Aaeg\GPRDIH1

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005894

Aedes aegypti

Yellow fever mosquito

Aaeg\GPRDIH2_1

Anopheles darlingi

American malaria mosquito

Adar\ADAC001348

Anopheles darlingi

American malaria mosquito

Adar\ADAC003604

Anopheles gambiae

Malaria mosquito

Agam\GPRDIH2

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008821

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008822

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07HG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001910

Danaus plexippus

Monarch butterfly

Dple\DPOGS214005-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014214

Heliconius melpomene

Postman butterfly

Hmel\HMEL002706

Apis florea

Little honeybee

Aflo\2183456996

Apis florea

Little honeybee

Aflo\2147541043

Apis florea

Little honeybee

Aflo\2147494673

Apis mellifera

Western honey bee

Amel\GB53839

Apis mellifera

Western honey bee

Amel\GB49166

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25049

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25051

Bombus terrestris

Buff-tailed bumblebee

Bter\15204997

Linepithema humile

Argentine ant

Lhum\LH16221

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001673

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001674

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002890

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05491

Tribolium castaneum

Red flour beetle

Tcas\TC034462

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07104

Pediculus humanus

Human body louse

Phum\PHUM132710

Rhodnius prolixus

Kissing bug

Rpro\RPRC015285

Rhodnius prolixus

Kissing bug

Rpro\RPRC000578

Cimex lectularius

Bed bug

Clec\CLEC025139

Cimex lectularius

Bed bug

Clec\CLEC000652

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI54924

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007338

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00345

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07CL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007370

Ixodes scapularis

Black-legged tick

Isca\ISCW007612

Ixodes scapularis

Black-legged tick

Isca\ISCW019312

Ixodes scapularis

Black-legged tick

Isca\ISCW019068

Ixodes scapularis

Black-legged tick

Isca\ISCW007036

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65479.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67079.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74893.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65480.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g00270

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g03970

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_62157

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_290680

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BBY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CtrhLr

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027048gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Crhr2L_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012294

Ciona intestinalis

Vase tunicate

Cint\LOC100179423

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000371

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000005657

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (18)

Gene Symbol

Score

Source

Alignment

9 of 10

4 of 10

3 of 10

hec

3 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CRHR2; corticotropin releasing hormone receptor 2

12 of 15

602034

CRHR1; corticotropin releasing hormone receptor 1

9 of 15

122561

LINC02210-CRHR1; LINC02210-CRHR1 readthrough

7 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dh44-R2 - Dh44

luminiscence technology, inferred by author

(Hector et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033744

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36368

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-67

Cytogenetic map

49A7-49A9

Sequence location

2R:12,474,424..12,487,986 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49A7-49A9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-67

(FlyBase, 2016)

2-68.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Bloomington

80701

w^*; Dh44-R2¹⁷⁴

29610

y¹ v¹; P{TRiP.JF03289}attP2

29129

w¹¹¹⁸; Mi{ET1}Dh44-R2^MB10503

33086

y¹ w^*; Mi{MIC}Dh44-R2^MI00778

67862

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05682}attP40

66865

y¹ w^*; Mi{Trojan-GAL4.2}Dh44-R2^{MI09411-TG4.2}/SM6a

VDRC

v102292

P{KK111461}VIE-260B

v109558

P{KK115681}VIE-260B

v43313

w¹¹¹⁸; P{GD15731}v43313

v43314

w¹¹¹⁸; P{GD15731}v43314

v318607

PBac{fTRG00561.sfGFP-TVPTBF}VK00033

v342175

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01715}attP40/CyO-GFP

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (37)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_IP10431

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033744

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033744

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36368

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG12370 anon-WO0170980.103 anon-WO0170980.104

(FlyBase Genome Annotators, 2006, FlyBase, 1996-)

Additional comments

Source for merge of CG12370 anon-WO0170980.103 anon-WO0170980.104 was sequence comparison ( date:051113 ).

(FlyBase Genome Annotators, 2006, FlyBase, 1996-)

Other Comments

Annotation CG13156 was eliminated in release 3 of the genome annotation, January 2003.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36368

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033744

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dh44-R2_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0033744

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36368

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG12370

modMine - A data warehouse for the modENCODE project

FBgn0033744

Linkouts

DPiM - Drosophila Protein interaction map

FBgn0033744

DroID - A comprehensive database of gene and protein interactions.

FBgn0033744

DRSC - Results frm RNAi screens

FBgn0033744

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0033744

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG12370-RA;CG12370-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033744

FlyMine - An integrated database for Drosophila genomics

FBgn0033744

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36368

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG12370

(Kondo et al., 2020, Sarov et al., 2016, Dus et al., 2015, Ashwal-Fluss et al., 2014, Li et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Hector et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Veenstra, 2009, Veenstra et al., 2008, Hauser et al., 2006, Hauser et al., 2006, Metpally and Sowdhamini, 2005, Wang et al., 2004, Harmar, 2001)

CG13156

(Luschnig, 2003.12.17)

DH-R

(Bowser and Tobe, 2006)

DH44-R2

(Mahishi and Huetteroth, 2019, Yang et al., 2018, Hector et al., 2009)

DH44R2

(Cardoso et al., 2014, Davies et al., 2014)

DH₄₄-R2

(Cannell et al., 2016)

Dh44-R2

(Kondo et al., 2020, Li et al., 2020, Hajji et al., 2019, Al-Ramahi et al., 2018, Lee et al., 2018, Crocker et al., 2016, Gene Disruption Project members, 2016-, Marianes and Spradling, 2013, Caers et al., 2012)

Dh44R2

(Dus et al., 2015, Lee et al., 2015)

anon-WO0170980.103

anon-WO0170980.104

Name Synonyms

CRF-like diuretic hormonereceptor 2

(Caers et al., 2012)

Dh44 receptor 2

(Lowenstein and Velazquez-Ulloa, 2018)

Diuretic hormone 44 receptor 2

Secondary FlyBase IDs

FBgn0033743
FBgn0046620
FBgn0046621

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (71)

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