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Gene Dmel\vis

General Information
Symbol	Dmel\vis	Species	D. melanogaster
Name	vismay	Annotation symbol	CG8821
Feature type	protein_coding_gene	FlyBase ID	FBgn0033748
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	zaa
Genomic Location
Chromosome (arm)	2R	Recombination map	2-65.5 +/- 3.3
Cytogenetic map	49A10-49A10	Sequence location	2R:8,395,401..8,398,120 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene vismay is referred to in FlyBase by the symbol Dmel\vis (CG8821, FBgn0033748). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. There is experimental evidence that it is involved in the biological process: positive regulation of transcription, DNA-dependent; spermatogenesis. 7 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox KN domain; Homeodomain; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1624663_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of vis. Gene sequence location is 2R:8395401..8398120.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles vis[MI07740]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49A10-49A10   Limits computationally determined from genome sequence between P{lacW}fdlk17040 and P{EP}CG8569EP1182
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-65.5 +/- 3.3 (White-Cooper, 1999.3.3)
Left of (cM)	c (White-Cooper, 1999.3.3)
Right of (cM)	cn (White-Cooper, 1999.3.3)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\vis for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) vis-RA FBtr0087944  NM_078990   1824   424 vis-RB FBtr0087945  NM_176157   2124   524
Additional Transcript Data & Comments
Reported size (kB)	1.6, 1.2 (northern blot) (Ayyar et al., 2003)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein vis-PA   FBpp0087055   47.2   424   4.47     NP_523714   AAG22280 vis-PB   FBpp0087056   58.3   524   4.83     NP_788337   AAO41402
Additional Polypeptide Data & Comments
Reported size (kDa)	80, 60 (kD) (Wang and Mann, 2003)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain (IPR001356) Homeodomain-like (IPR009057) Homeobox KN domain (IPR008422)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAG22280   AE013599 AAO41402   AI534944   AI542528   AW944170   AY058750 AAL13979   BE977222   BT003510
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K380 A1Z913
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   testis   (Ayyar et al., 2003) Comment:RA and RB transcripts adult stage | female   organism   (Ayyar et al., 2003) Comment:RA transcript only adult stage | male   organism   (Ayyar et al., 2003) Comment:gonadectomized bodies; RA transcript only RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Ayyar et al., 2003) adult stage   testis | restricted   (Ayyar et al., 2003) testis   (Ayyar et al., 2003) Comment:RA and RB transcripts adult stage | female   organism   (Ayyar et al., 2003) Comment:RA transcript only adult stage | male   organism   (Ayyar et al., 2003) Comment:gonadectomized bodies; RA transcript only
Additional Descriptive Data
	Developmental RT PCR analysis using a probe that detects all isoforms of both achi and vis indicate roughly equal expression through all stages of development. In situ analysis of adult testes detect high achi and/or vis expression in the primary spermatocyte stage, persisting into the meiotic divisions. No expression is detect in the apex. (Ayyar et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   • nucleus (Wang and Mann, 2003) larval stage   wing disc   • nucleus (Wang and Mann, 2003) adult stage | male   spermatocyte   • cytoplasm (Wang and Mann, 2003) Comment:meiotic metaphase spermatocyte   • nucleus (Wang and Mann, 2003) Comment:NOT meiotic metaphase adult stage   spermatid   • cytoplasm & nucleus (Wang and Mann, 2003) Comment:NOT mitochondrion egg chamber   • nucleus (Wang and Mann, 2003) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   ovary   (Wang and Mann, 2003) organism   (Wang and Mann, 2003) testis   (Wang and Mann, 2003)
Additional Descriptive Data
	The long isoform ofboth achi and vis is testis specific. (Wang and Mann, 2003) The smaller isoformof both achi and vis is found in both males and females and in males is expressed in both the testis and somatic tissue. (Wang and Mann, 2003)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Hyman et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis    506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis  506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis    506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis    506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis    506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis  506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis    506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.5 Larval Midgut    3.2 Larval Hindgut    2.9 Larval Malpighian Tubules    1.9 Larval Fat Body    46.7 Larval Salivary Gland    4.2 Larval Trachea    3.425 Larval Carcass    4 Adult Head    4.4 Adult Eye    4.35 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    3.1 Adult Midgut    5.7 Adult Hindgut    2.2 Adult Malpighian Tubules    2.1 Adult Fat Body    1.2 Adult Salivary Gland    4.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    2.7 Adult Testis    506.5 Adult Male Accessory Gland    21.2 Adult Carcass    1.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.4   NA  Eye    4.35   NA  Brain    3.5   2.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.6   NA  Crop    3.1   3.2  Midgut    5.7   2.9  Hindgut    2.2   1.9  Malpighian Tubules    2.1   46.7  Fat Body    1.2   4.2  Salivary Gland    4.2   NA  Heart    1.725   3.425  Trachea    NA   NA  VirginFemale Spermatheca    1.3   NA  InseminatedFemale Spermatheca    2.6   NA  Ovary    2.7   NA  Testis    506.5   NA  Male Accessory Gland    21.2   4  Carcass    1.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    35 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (35) accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    35 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    35 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    35 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (35) accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    35 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    6 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    35 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    7 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    10 adult male 30day    5 adult female 01day    0 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    6 embryonic Kc167    8 embryonic S1    5 embryonic S3    1 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    3 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_33 mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	BDGP expression data • SD01238 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033748 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8821-RA;CG8821-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 visGD17540 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 visGD17540 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 visGD17540 trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 visGD17540
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of vis Class Mutagen Stocks Known lesion visG2720 P-element activity 1 -- visMI07740 1 -- visachi-1 P-element activity 0 Yes visZ3922 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of vis Class Mutagen Stocks Known lesion visGD17540 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes vis+t4.7 in vitro construct - genomic fragment 1 Yes visHMS01480 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes visJF02406 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)achi1 (Ayyar et al., 2003) Df(2R)achi2 (Ayyar et al., 2003) Df(2R)achi3 (Ayyar et al., 2003) Df(2R)achi4 (Ayyar et al., 2003) Df(2R)CX1 (White-Cooper, 1999.3.3) Df(2R)pingpong (Wang and Mann, 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD17540} NA P{TRiP.HMS01480} NA P{TRiP.JF02406} NA characterization construct P{vis} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}visG2720 NA miscellaneous insertions Mi{MIC}visMI07740 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Mad (Hyman et al., 2003) inferred from physical interaction with Smox (Hyman et al., 2003) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Hyman et al., 2003)
Biological Process
CV term Evidence References
positive regulation of transcription, DNA-dependent inferred from direct assay (Hyman et al., 2003) spermatogenesis inferred from expression pattern AND inferred from mutant phenotype (Ayyar et al., 2003) inferred from expression pattern AND inferred from mutant phenotype AND inferred from physical interaction with aly AND inferred from physical interaction with comr (Wang and Mann, 2003)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Hyman et al., 2003)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
histone deacetylase binding non-traceable author statement (White-Cooper et al., 2003) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with NCBI:NP_777480 (FlyBase, 1992-) transcription corepressor activity inferred from sequence or structural similarity (Ayyar and White, 2001)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Ayyar and White, 2001) inferred from sequence or structural similarity with NCBI:NP_777480 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
vis - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) vis - CG15445 experimental knowledge based (Guruharsha et al., 2011) vis - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) vis - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) vis - achi anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions vis allele Gene References visachi-1 achi (Ayyar et al., 2003) visZ3922 achi (Ayyar et al., 2003)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033748 DroID - A comprehensive database of gene and protein interactions. • FBgn0033748 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36372
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65QJ03 Dipteran inclusive ortholog search EOG6W0XNN Insect inclusive ortholog search EOG69ZWKB Arthropod inclusive ortholog search EOG6WM39P Metazoa inclusive ortholog search EOG69D336
Orthologs in Drosophila Species (EOG65QJ03)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\achi     Drosophila melanogaster fruit fly  Dmel\vis     Drosophila simulans   Dsim\GD25834   Y Drosophila sechellia   Dsec\GM20354   Y Drosophila sechellia   Dsec\GM20355   Y Drosophila erecta   Dere\GG22573   Y Drosophila yakuba   Dyak\GE13442   Y Drosophila ananassae   Dana\GF12447   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA21345   Y Drosophila persimilis   Dper\GL10213   Y Drosophila willistoni   Dwil\GK17831   Y Drosophila virilis   Dvir\GJ18217   Y Drosophila mojavensis   Dmoj\GI19763   Y Drosophila grimshawi   Dgri\GH20569   Y
Orthologs in non-Drosophila Dipterans (EOG6W0XNN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009047 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007018 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008448 Y
Orthologs in non-Dipteran Insects (EOG69ZWKB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45632 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG025836 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16656 Y Atta cephalotes Leafcutter ant  Acep\ACEP15882 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16412 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16697 Y Linepithema humile Argentine ant  Lhum\LH20640 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13369 Y Solenopsis invicta Red fire ant  Sinv\SINV21833 Y Bombyx mori Silkmoth  Bmor\BGIBMGA004158 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006116 Y Pediculus humanus Human body louse  Phum\PHUM225040 Y Tribolium castaneum Red flour beetle  Tcas\TC013909 Y Tribolium castaneum Red flour beetle  Tcas\TC009623 Y
Orthologs in non-Insect Arthropods (EOG6WM39P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_310984 Y Ixodes scapularis Deer tick  Isca\ISCW017749 Y
Orthologs in non-Arthropod Metazoa (EOG69D336)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018126gn Y Xenopus tropicalis Western clawed frog  Xtro\tgif2 Y Mus musculus House mouse  Mmus\Tgif1 Y Mus musculus House mouse  Mmus\Tgif2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042146 Y Rattus norvegicus Norway rat  Rnor\RGD1564927 Y Homo sapiens Human  Hsap\TGIF2 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\TGIF2
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	29544 y1 v1; P{TRiP.JF02406}attP2 28451 y1 w*; P{EP}visG2720 43914 y1 w*; Mi{MIC}visMI07740 35738 y1 sc* v1; P{TRiP.HMS01480}attP2 8509 w*; Df(2R)pingpong, achipingpong/CyO; P{vis}3/MKRS
VDRC	v49639 w1118; P{GD17540}v49639 v49640 w1118; P{GD17540}v49640 v52633 w1118; P{GD17540}v52633
Genomic Clones ( 1 )
	BACR24H09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE30881 SD01238
Other clones	DPiM_RE30881 DPiM_SD01238
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD08875
Other clones	bs61b11
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033748 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36372
Antibody Information
	polyclonal (Wang and Mann, 2003)
Other Information
Discoverer
Etymology
	'vismay' is a Hindi word meaning 'surprise'. (Ayyar et al., 2003) "vismay" is Hindi for "surprise" - reflecting the surprise of the investigators upon discovering a tandem duplication in the genome which was the basis of the confusion surrounding the molecular analysis of achi. (Ayyar, 2001.3.5)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: vismay CG8821 (Ayyar, 2001.3.5)
Source for database merge of
Additional comments	The zaa line is found to be a combination of two alleles visZ3922 and visZ3922. (Ayyar et al., 2003)
Other Comments
	achi and vis are essential for developmentally regulated transcription during spermatogenesis. (Ayyar et al., 2003) achi, vis, aly and comr proteins may exist in a complex. (Wang and Mann, 2003) achi is required during spermatogenesis. (Wang and Mann, 2003) aly-like meiotic arrest gene. (White-Cooper and Fuller, 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078990 NM_176157 RefSeq (Proteins) • NP_523714 NP_788337 DDBJ / EMBL / GenBank • AAG22280 AAL13979 AAO41402 AI534944 AW944170 AY058750 Entrez Gene - A searchable database of RefSeq genes. • 36372 UniProtKB/TrEMBL • A1Z913 Q7K380
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain (IPR001356) Homeodomain-like (IPR009057) Homeobox KN domain (IPR008422) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD01238
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033748 DroID - A comprehensive database of gene and protein interactions. • FBgn0033748 DRSC - Results from RNAi screens. • FBgn0033748 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033748 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8821-RA;CG8821-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033748 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36372 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/achinta1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36372 modMine - Data generated by the modENCODE project. • FBgn0033748
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	achi/vis (Benson et al., 2007) CG8821 (Hyman et al., 2003, Fedorka et al., 2011, Perkins et al., 2009, Zhan et al., 2011, Ni et al., 2011.7.19) dTGIFa (Hyman et al., 2003) TGIFa (Hyman et al., 2003) vis (Mikhaylova et al., 2006, Jiang et al., 2007, Liu et al., 2005, Jiang et al., 2007, Georlette et al., 2007, Doggett et al., 2011, White-Cooper, 2010, Zhao et al., 2010) zaa (White-Cooper, 1999.3.3, White-Cooper et al., 2003, White-Cooper and Fuller, 1999, Jiang et al., 2001)
Name Synonym	achi/vis (Boutanaev et al., 2007) vismay (Ayyar, 2001.3.5, Ayyar and White, 2001, Fedorka et al., 2011, Zhao et al., 2010) Vismay (Hyman et al., 2003) zuker-aly-like a (White-Cooper, 1999.3.3)
Secondary FlyBase IDs
	FBgn0026155
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Chen et al., 2011, Development 138(12): 2441--2450 Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. [FBrf0213772] Doggett et al., 2011, Dev. Biol. 355(2): 381--393 Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. [FBrf0213964] Fedorka et al., 2011, Evolution 65(2): 584--590 Perceived sperm competition intensity influences seminal fluid protein production prior to courtship and mating. [FBrf0212865] Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Show all research papers ...