FB2021_06, released December 14, 2021

Gene: Dmel\achi

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General Information
Symbol
Dmel\achi
Species
D. melanogaster
Name
achintya
Annotation Symbol
CG8819
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033749
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
achintya (achi) encodes a homeodomain transcription factor (TGIF subclass) that is required along with homeodomain protein encoded by vis for meiotic division in spermatogenesis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

zaa

Key Links
Genomic Location
Cytogenetic map
49A10-49A10
Sequence location
Recombination map
2-67
RefSeq locus
NT_033778 REGION:12511534..12515062
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Hyman et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000219731
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000219731
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in positive regulation of transcription, DNA-templated
inferred from direct assay
(Hyman et al., 2003)
inferred from mutant phenotype
(Wang et al., 2008)
involved_in spermatogenesis
inferred from expression pattern
(Ayyar et al., 2003, Wang and Mann, 2003)
inferred from mutant phenotype
(Ayyar et al., 2003, Wang and Mann, 2003)
inferred from physical interaction with FLYBASE:aly; FB:FBgn0004372
(Wang and Mann, 2003)
inferred from physical interaction with FLYBASE:comr; FB:FBgn0034667
(Wang and Mann, 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000219731
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Hyman et al., 2003)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
achintya (achi) encodes a homeodomain transcription factor (TGIF subclass) that is required along with homeodomain protein encoded by vis for meiotic division in spermatogenesis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
TALE HOMEOBOX TRANSCRIPTION FACTORS -
TALE homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. These proteins are characterized by an atypical homeodomain that possesses a three amino acid insertion in the first loop. (Adapted from FBrf0232555 and PMID:18797923).
Summary (Interactive Fly)

homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Achintya, for meiotic division in spermatogenesis

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\achi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
achi-RA
FBtr0087943
NM_165911
2122
426
achi-RC
FBtr0087942
NM_165912
2509
555
achi-RD
FBtr0339635
NM_001299423
2277
555
Additional Transcript Data and Comments
Reported size (kB)

1.6, 1.2 (northern blot)

(Ayyar et al., 2003)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
achi-PA
FBpp0087054
47.7
426
4.45
NP_725182
AAF58497
achi-PC
FBpp0087053
61.5
555
4.85
NP_725183
AAM68695
achi-PD
FBpp0308697
61.5
555
4.85
NP_001286352
AHN56150
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

555 aa isoforms: achi-PC, achi-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

80, 60 (kD)

(Wang and Mann, 2003)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\achi using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
testis

Comment: RA and RC transcripts

(Ayyar et al., 2003)
adult stage | female
organism

Comment: RA transcript only

(Ayyar et al., 2003)
adult stage | male
organism

Comment: gonadectomized bodies; RA transcript only

(Ayyar et al., 2003)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Ayyar et al., 2003)
adult stage
testis | restricted
(Ayyar et al., 2003)
testis

Comment: RA and RC transcripts

(Ayyar et al., 2003)
adult stage | female
organism

Comment: RA transcript only

(Ayyar et al., 2003)
adult stage | male
organism

Comment: gonadectomized bodies; RA transcript only

(Ayyar et al., 2003)
Additional Descriptive Data

Developmental RT PCR analysis using a probe that detects all isoforms of both achi and vis indicate roughly equal expression through all stages of development. In situ analysis of adult testes detect high achi and/or vis expression in the primary spermatocyte stage, persisting into the meiotic divisions. No expression is detect in the apex.

(Ayyar et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
• nucleus
(Wang and Mann, 2003)
larval stage
wing disc
• nucleus
(Wang and Mann, 2003)
adult stage | male
spermatocyte

Comment: meiotic metaphase

(Wang and Mann, 2003)
spermatocyte
• nucleus

Comment: NOT meiotic metaphase

(Wang and Mann, 2003)
adult stage
spermatid

Comment: NOT mitochondrion

(Wang and Mann, 2003)
egg chamber
• nucleus
(Wang and Mann, 2003)
adult stage | male & spermatogenesis
male germline stem cell | faint
• nucleus
(Zhao et al., 2013)
spermatogonium | faint
• nucleus
(Zhao et al., 2013)
spermatocyte | intense
• nucleus
(Zhao et al., 2013)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ovary
(Wang and Mann, 2003)
testis
(Wang and Mann, 2003)
organism
(Wang and Mann, 2003)
Additional Descriptive Data

achi protein is expressed at high levels in the nuclei of spermatocytes, and at low levels at earlier stages. It can thus be used as a marker to identify cells that have advanced from spermatogonial stages into spermatocytes.

(Zhao et al., 2013)

The smaller isoformof both achi and vis is found in both males and females and in males is expressed in both the testis and somatic tissue.

(Wang and Mann, 2003)

The long isoform ofboth achi and vis is testis specific.

(Wang and Mann, 2003)
Marker for
 
spermatocyte
(Zhao et al., 2013)
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Hyman et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\achi in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of achi
Transgenic constructs containing regulatory region of achi
Aberrations (Deficiencies and Duplications) ( 5 )
Inferred from experimentation ( 5 )
Gene disrupted in
Df(2R)achi1
(Ayyar et al., 2003)
Df(2R)achi2
(Ayyar et al., 2003)
Df(2R)achi3
(Ayyar et al., 2003)
Df(2R)achi4
(Ayyar et al., 2003)
Df(2R)pingpong
(Wang and Mann, 2003)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TGIF1
9 of 15
Yes
Yes
Hsap\TGIF2
5 of 15
No
Yes
2  
Hsap\TGIF2LX
5 of 15
No
Yes
1  
Hsap\TGIF2LY
5 of 15
No
Yes
1  
Hsap\TGIF2-RAB5IF
3 of 15
No
No
Hsap\MEIS1
2 of 15
No
No
Hsap\MEIS2
2 of 15
No
No
1  
Hsap\MEIS3
2 of 15
No
No
Hsap\MKX
2 of 15
No
No
Hsap\PKNOX1
2 of 15
No
Yes
1  
Hsap\PKNOX2
2 of 15
No
No
0  
Hsap\IRX1
1 of 15
No
No
Hsap\IRX2
1 of 15
No
No
Hsap\IRX3
1 of 15
No
No
Hsap\IRX4
1 of 15
No
No
Hsap\IRX5
1 of 15
No
No
Hsap\IRX6
1 of 15
No
No
Hsap\PBX1
1 of 15
No
No
0  
Hsap\PBX2
1 of 15
No
No
Hsap\PBX3
1 of 15
No
No
Hsap\PBX4
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tgif1
8 of 15
Yes
Yes
Mmus\Tgif2lx1
6 of 15
No
Yes
Mmus\Tgif2
6 of 15
No
No
Mmus\Tgif2lx2
4 of 15
No
Yes
Mmus\Meis1
2 of 15
No
No
Mmus\Meis2
2 of 15
No
No
Mmus\Meis3
2 of 15
No
No
Mmus\Mkx
2 of 15
No
No
Mmus\Pknox1
2 of 15
No
Yes
Mmus\Pknox2
2 of 15
No
No
Mmus\Irx1
1 of 15
No
No
Mmus\Irx2
1 of 15
No
No
Mmus\Irx3
1 of 15
No
No
Mmus\Irx4
1 of 15
No
No
Mmus\Irx5
1 of 15
No
No
Mmus\Irx6
1 of 15
No
No
Mmus\Pbx1
1 of 15
No
No
Mmus\Pbx2
1 of 15
No
No
Mmus\Pbx3
1 of 15
No
No
Mmus\Pbx4
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Tgif1
7 of 13
Yes
Yes
Rnor\Tgif2
7 of 13
Yes
Yes
Rnor\Meis1
2 of 13
No
No
Rnor\Meis2
2 of 13
No
No
Rnor\Meis3
2 of 13
No
No
Rnor\Mkx
2 of 13
No
No
Rnor\Pknox1
2 of 13
No
Yes
Rnor\Pknox2
2 of 13
No
Yes
Rnor\Tgif2lx2
2 of 13
No
Yes
Rnor\Irx1
1 of 13
No
No
Rnor\Irx2
1 of 13
No
No
Rnor\Irx3
1 of 13
No
No
Rnor\Irx4
1 of 13
No
No
Rnor\Irx5
1 of 13
No
No
Rnor\Irx6
1 of 13
No
No
Rnor\Pbx2
1 of 13
No
No
Rnor\Pbx3
1 of 13
No
No
Rnor\Pbx4
1 of 13
No
No
Rnor\Tgif2-ps1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (15)
Xtro\tgif1
7 of 12
Yes
No
Xtro\tgif2
6 of 12
No
Yes
Xtro\meis1
2 of 12
No
No
Xtro\meis2
2 of 12
No
No
Xtro\meis3
2 of 12
No
No
Xtro\mkx
2 of 12
No
No
Xtro\pknox2
2 of 12
No
Yes
Xtro\irx1
1 of 12
No
No
Xtro\irx2
1 of 12
No
No
Xtro\irx3
1 of 12
No
No
Xtro\irx4
1 of 12
No
No
Xtro\irx5
1 of 12
No
No
Xtro\pbx1
1 of 12
No
No
Xtro\pbx2
1 of 12
No
No
Xtro\pbx3
1 of 12
No
No
Danio rerio (Zebrafish) (29)
Drer\tgif1
7 of 15
Yes
Yes
Drer\LOC100535338
3 of 15
No
Yes
Drer\meis1a
2 of 15
No
No
Drer\meis1b
2 of 15
No
No
Drer\meis2a
2 of 15
No
No
Drer\meis2b
2 of 15
No
No
Drer\meis3
2 of 15
No
No
Drer\pknox1.1
2 of 15
No
Yes
Drer\pknox1.2
2 of 15
No
Yes
Drer\pknox2
2 of 15
No
No
Drer\irx1a
1 of 15
No
No
Drer\irx1b
1 of 15
No
No
Drer\irx2a
1 of 15
No
No
Drer\irx3a
1 of 15
No
No
Drer\irx3b
1 of 15
No
No
Drer\irx4a
1 of 15
No
No
Drer\irx4b
1 of 15
No
No
Drer\irx5a
1 of 15
No
No
Drer\irx5b
1 of 15
No
No
Drer\irx6a
1 of 15
No
No
Drer\irx7
1 of 15
No
No
Drer\mkxa
1 of 15
No
No
Drer\mkxb
1 of 15
No
No
Drer\pbx1a
1 of 15
No
No
Drer\pbx1b
1 of 15
No
No
Drer\pbx2
1 of 15
No
No
Drer\pbx3a
1 of 15
No
No
Drer\pbx3b
1 of 15
No
No
Drer\pbx4
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\ceh-60
2 of 15
Yes
No
Cele\irx-1
1 of 15
No
No
Cele\psa-3
1 of 15
No
Yes
Cele\unc-62
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (21)
Atha\ATH1
1 of 9
Yes
No
Atha\BEL1
1 of 9
Yes
No
Atha\BEL10
1 of 9
Yes
No
Atha\BLH1
1 of 9
Yes
No
Atha\BLH2
1 of 9
Yes
No
Atha\BLH3
1 of 9
Yes
No
Atha\BLH4
1 of 9
Yes
Yes
Atha\BLH5
1 of 9
Yes
No
Atha\BLH6
1 of 9
Yes
No
Atha\BLH7
1 of 9
Yes
No
Atha\BLH8
1 of 9
Yes
No
Atha\BLH11
1 of 9
Yes
No
Atha\KNAT1
1 of 9
Yes
No
Atha\KNAT2
1 of 9
Yes
No
Atha\KNAT3
1 of 9
Yes
No
Atha\KNAT4
1 of 9
Yes
No
Atha\KNAT5
1 of 9
Yes
No
Atha\KNAT6
1 of 9
Yes
No
Atha\KNAT7
1 of 9
Yes
No
Atha\RPL
1 of 9
Yes
No
Atha\STM
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\CUP9
4 of 15
Yes
No
Scer\TOS8
4 of 15
Yes
No
Scer\HMLALPHA2
2 of 15
No
Yes
Scer\HMRA2
2 of 15
No
Yes
Scer\MATALPHA2
2 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919068R )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002635
Drosophila simulans
Dsim\GD25834
Drosophila sechellia
Dsec\GM20354
Drosophila sechellia
Dsec\GM20355
Drosophila erecta
Dere\GG22573
Drosophila yakuba
Dyak\GE13442
Drosophila ananassae
Dana\GF12447
Drosophila pseudoobscura pseudoobscura
Dpse\GA21345
Drosophila persimilis
Dper\GL10213
Drosophila willistoni
Dwil\GK17831
Drosophila virilis
Dvir\GJ18217
Drosophila mojavensis
Dmoj\GI19763
Drosophila grimshawi
Dgri\GH20569
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C7A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020935
Glossina morsitans
Tsetse fly
Gmor\GMOY000856
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08454
Mayetiola destructor
Hessian fly
Mdes\Mdes009392
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009047
Anopheles darlingi
American malaria mosquito
Adar\ADAC006185
Anopheles gambiae
Malaria mosquito
Agam\AGAP007018
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008448
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EFK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004158
Bombyx mori
Silkmoth
Bmor\BGIBMGA006116
Danaus plexippus
Monarch butterfly
Dple\DPOGS202882-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209060-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004871
Heliconius melpomene
Postman butterfly
Hmel\HMEL014586
Apis florea
Little honeybee
Aflo\2677091572
Apis mellifera
Western honey bee
Amel\GB45632
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12435
Bombus terrestris
Buff-tailed bumblebee
Bter\15216729
Linepithema humile
Argentine ant
Lhum\LH20640
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001032
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG025836
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03907
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11283
Tribolium castaneum
Red flour beetle
Tcas\TC009623
Tribolium castaneum
Red flour beetle
Tcas\TC013909
Pediculus humanus
Human body louse
Phum\PHUM225040
Rhodnius prolixus
Kissing bug
Rpro\RPRC005484
Cimex lectularius
Bed bug
Clec\CLEC008329
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI27465
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02386
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EEG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005809
Ixodes scapularis
Black-legged tick
Isca\ISCW017749
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59026.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58906.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g03690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310984
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N1F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tgif
Gallus gallus
Domestic chicken
Ggal\TGIF2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
vis
5 of 10
hth
3 of 10
exd
2 of 10
ara
1 of 10
caup
1 of 10
CG11617
1 of 10
mirr
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TGIF1; TGFB induced factor homeobox 1
    model of  holoprosencephaly 4
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TGIF1; TGFB induced factor homeobox 1
    9 of 15
    602630
    TGIF2; TGFB induced factor homeobox 2
    5 of 15
    607294
         
        TGIF2LX; TGFB induced factor homeobox 2 like X-linked
        5 of 15
        300411
             
            TGIF2LY; TGFB induced factor homeobox 2 like Y-linked
            5 of 15
            400025
                 
                TGIF2-RAB5IF; TGIF2-RAB5IF readthrough
                3 of 15
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    achi - CG13775
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - CG15445
                    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, two hybrid
                    (Hu et al., 2017.6.13, Rhee et al., 2014, Guruharsha et al., 2011)
                    achi - CG31955
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - CG42726
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - Camp
                    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                    (Rhee et al., 2014)
                    achi - Doc3
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - RpL38
                    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                    (Rhee et al., 2014)
                    achi - Ubx
                    bimolecular fluorescence complementation, fluorescence microscopy
                    (Bischof et al., 2018)
                    achi - Zif
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - abd-A
                    bimolecular fluorescence complementation, fluorescence microscopy
                    (Bischof et al., 2018)
                    achi - cad
                    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                    (Rhee et al., 2014)
                    achi - drm
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - org-1
                    two hybrid array
                    (Shokri et al., 2019)
                    achi - vis
                    experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Rhee et al., 2014, Guruharsha et al., 2011)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    External Data
                    Linkouts
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2R
                    Recombination map
                    2-67
                    Cytogenetic map
                    49A10-49A10
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    49A10-49A10
                    Limits computationally determined from genome sequence between P{lacW}fdlk17040 and P{EP}CG8569EP1182
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    2-67

                    (FlyBase, 2016)

                    2-68.8

                    (Comeron et al., 2012)

                    2-65.5 +/- 3.3

                    (White-Cooper, 1999.3.3)
                    Left of (cM)
                    (White-Cooper, 1999.3.3)
                    Right of (cM)
                    (White-Cooper, 1999.3.3)
                    Notes
                    Stocks and Reagents
                    Stocks (13)
                    Genomic Clones (26)
                    cDNA Clones (49)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (Wang and Mann, 2003)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: achintya CG8819

                    (Ayyar, 2001.3.5)
                    Source for database merge of
                    Additional comments

                    The zaa line is found to be a combination of two alleles visZ3922 and visZ3922.

                    (Ayyar et al., 2003)
                    Other Comments

                    achi and vis are essential for developmentally regulated transcription during spermatogenesis.

                    (Ayyar et al., 2003)

                    achi, vis, achi and comr proteins may exist in a complex.

                    (Wang and Mann, 2003)

                    achi is required during spermatogenesis.

                    (Wang and Mann, 2003)

                    aly-like meiotic arrest gene.

                    (White-Cooper and Fuller, 1999)
                    Origin and Etymology
                    Discoverer
                    Etymology

                    'achintya' is a Sanskrit word meaning 'that which is beyond thought and contemplation'.

                    (Ayyar et al., 2003)

                    "achintya" is a Sanskrit word meaning "inconceivable" or "beyond thought", reflecting the initial complexity of the molecular analysis of the locus.

                    (Ayyar, 2001.3.5)
                    Identification
                    External Crossreferences and Linkouts ( 51 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (14)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (79)