FB2021_03, released June 15, 2021

Gene: Dmel\CG12374

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General Information
Symbol
Dmel\CG12374
Species
D. melanogaster
Name
Annotation Symbol
CG12374
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033774
Gene Model Status
Current
Stock Availability
2 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
49C3-49C3
Sequence location
2R:12,762,113..12,763,825 [+]
Recombination map
2-67
RefSeq locus
NT_033778 REGION:12762113..12763825
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables metallocarboxypeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000194073
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR000834
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proteolysis
inferred from biological aspect of ancestor with PANTHER:PTN000194073
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000194073
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
M14 METALLOCARBOXYPEPTIDASES -
M14 metallopeptidases belong to MEROPS family M14. They hydrolyse single, C-terminal amino acids from polypeptide chains and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Their functions are numerous and diverse, and include digestion of food and processing of bioactive peptides. (Adapted from FBrf0239469.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG12374 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG12374-RA
FBtr0087854
NM_136975
1464
422
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG12374-PA
FBpp0086967
48.1
422
4.68
NP_610819
AAF58456
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG12374 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
dorsal sensory complex primordium
(Fisher et al., 2012)
posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG12374 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG12374
Transgenic constructs containing regulatory region of CG12374
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CPA2
8 of 15
Yes
No
Hsap\CPA1
7 of 15
No
No
Hsap\CPA4
7 of 15
No
No
1  
Hsap\CPA5
7 of 15
No
No
Hsap\CPB1
7 of 15
No
No
Hsap\CPA6
6 of 15
No
No
Hsap\CPB2
6 of 15
No
No
Hsap\CPO
6 of 15
No
No
Hsap\CPA3
5 of 15
No
No
Hsap\AGBL1
1 of 15
No
No
Hsap\AGBL2
1 of 15
No
No
Hsap\AGBL3
1 of 15
No
No
Hsap\AGBL4
1 of 15
No
No
Hsap\AGBL5
1 of 15
No
No
Hsap\AGTPBP1
1 of 15
No
No
Hsap\PRKAR1A
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cpa2
8 of 15
Yes
No
Mmus\Cpa1
7 of 15
No
No
Mmus\Cpa3
7 of 15
No
No
Mmus\Cpa4
7 of 15
No
No
Mmus\Cpa5
7 of 15
No
No
Mmus\Cpb1
7 of 15
No
No
Mmus\Cpb2
7 of 15
No
No
Mmus\Cpa6
6 of 15
No
No
Mmus\Agbl2
1 of 15
No
No
Mmus\Agbl3
1 of 15
No
No
Mmus\Agbl4
1 of 15
No
No
Mmus\Agbl5
1 of 15
No
No
Mmus\Agtpbp1
1 of 15
No
No
Mmus\Gm13754
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (12)
Rnor\Cpa2
8 of 13
Yes
No
Rnor\Cpa1
7 of 13
No
No
Rnor\Cpa3
7 of 13
No
No
Rnor\Cpa4
7 of 13
No
No
Rnor\Cpa5
7 of 13
No
No
Rnor\Cpb1
7 of 13
No
No
Rnor\Cpb2
7 of 13
No
No
Rnor\Cpa6
5 of 13
No
No
Rnor\Cpo
2 of 13
No
Yes
Rnor\Agbl2
1 of 13
No
No
Rnor\Agbl5
1 of 13
No
No
Rnor\Agtpbp1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\cpb2
6 of 12
Yes
No
Xtro\cpa1
5 of 12
No
No
Xtro\cpa3
5 of 12
No
No
Xtro\cpb1
5 of 12
No
Yes
Xtro\cpo
5 of 12
No
No
Xtro\LOC100487462
5 of 12
No
No
Xtro\cpa6
2 of 12
No
No
Xtro\LOC100489361
2 of 12
No
No
Xtro\LOC100490370
2 of 12
No
No
Xtro\LOC105947369
2 of 12
No
Yes
Xtro\agbl1
1 of 12
No
No
Xtro\agbl2
1 of 12
No
No
Xtro\agbl5
1 of 12
No
No
Xtro\agtpbp1
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\cpa2
7 of 15
Yes
No
Drer\cpa4
6 of 15
No
Yes
Drer\cpa5
6 of 15
No
No
Drer\cpa6
6 of 15
No
No
Drer\cpb1
6 of 15
No
No
Drer\cpb2
6 of 15
No
No
Drer\cpo
6 of 15
No
No
Drer\cpa1
5 of 15
No
No
Drer\agbl2
1 of 15
No
No
Drer\agbl5
1 of 15
No
No
Drer\agtpbp1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\T06A4.1
6 of 15
Yes
No
Cele\ZC434.9
6 of 15
Yes
No
Cele\suro-1
5 of 15
No
No
Cele\T06A4.3
4 of 15
No
No
Cele\Y18H1A.9
4 of 15
No
No
Cele\Y47G6A.19
4 of 15
No
No
Cele\Y59C2A.1
4 of 15
No
No
Cele\F02D8.4
3 of 15
No
No
Cele\W01A8.6
3 of 15
No
No
Cele\ccpp-1
1 of 15
No
No
Cele\ccpp-6
1 of 15
No
No
Cele\oxy-5
1 of 15
No
Yes
Cele\sdc-3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT5G42320
2 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ECM14
7 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC337.07c
5 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909K6 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006637
Drosophila simulans
Dsim\GD10919
Drosophila sechellia
Dsec\GM21424
Drosophila erecta
Dere\GG20336
Drosophila yakuba
Dyak\GE12495
Drosophila ananassae
Dana\GF12918
Drosophila pseudoobscura pseudoobscura
Dpse\GA11590
Drosophila persimilis
Dper\GL17014
Drosophila willistoni
Dwil\GK23345
Drosophila virilis
Dvir\GJ22186
Drosophila mojavensis
Dmoj\GI19308
Drosophila mojavensis
Dmoj\GI26563
Drosophila grimshawi
Dgri\GH21762
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915066W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020835
Musca domestica
House fly
Mdoa\17016042
Musca domestica
House fly
Mdoa\17016044
Glossina morsitans
Tsetse fly
Gmor\GMOY011027
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0551 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006715
Bombyx mori
Silkmoth
Bmor\BGIBMGA004830
Bombyx mori
Silkmoth
Bmor\BGIBMGA013275
Bombyx mori
Silkmoth
Bmor\BGIBMGA009478
Bombyx mori
Silkmoth
Bmor\BGIBMGA006871
Bombyx mori
Silkmoth
Bmor\Bmo.8601
Bombyx mori
Silkmoth
Bmor\BGIBMGA004800
Bombyx mori
Silkmoth
Bmor\BGIBMGA013276
Bombyx mori
Silkmoth
Bmor\BGIBMGA004797
Bombyx mori
Silkmoth
Bmor\BGIBMGA004798
Bombyx mori
Silkmoth
Bmor\BGIBMGA009486
Bombyx mori
Silkmoth
Bmor\BGIBMGA004801
Bombyx mori
Silkmoth
Bmor\BGIBMGA009477
Danaus plexippus
Monarch butterfly
Dple\DPOGS204785-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204049-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205075-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202239-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204048-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204786-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204787-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212730-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211663-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212083-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204790-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004841
Heliconius melpomene
Postman butterfly
Hmel\HMEL011614
Heliconius melpomene
Postman butterfly
Hmel\HMEL013952
Heliconius melpomene
Postman butterfly
Hmel\HMEL009976
Heliconius melpomene
Postman butterfly
Hmel\HMEL004862
Heliconius melpomene
Postman butterfly
Hmel\HMEL002108
Heliconius melpomene
Postman butterfly
Hmel\HMEL017679
Heliconius melpomene
Postman butterfly
Hmel\HMEL012576
Heliconius melpomene
Postman butterfly
Hmel\HMEL014741
Heliconius melpomene
Postman butterfly
Hmel\HMEL012120
Heliconius melpomene
Postman butterfly
Hmel\HMEL017681
Heliconius melpomene
Postman butterfly
Hmel\HMEL017680
Apis florea
Little honeybee
Aflo\3610281764
Apis florea
Little honeybee
Aflo\4974457284
Apis florea
Little honeybee
Aflo\2147667987
Apis florea
Little honeybee
Aflo\3544226612
Apis florea
Little honeybee
Aflo\5302654100
Apis mellifera
Western honey bee
Amel\GB40134
Apis mellifera
Western honey bee
Amel\GB46286
Apis mellifera
Western honey bee
Amel\GB43739
Apis mellifera
Western honey bee
Amel\GB50662
Apis mellifera
Western honey bee
Amel\GB40135
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12756
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23443
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14807
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22088
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14806
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22087
Bombus terrestris
Buff-tailed bumblebee
Bter\15209848
Bombus terrestris
Buff-tailed bumblebee
Bter\15205165
Bombus terrestris
Buff-tailed bumblebee
Bter\15206725
Bombus terrestris
Buff-tailed bumblebee
Bter\15211704
Bombus terrestris
Buff-tailed bumblebee
Bter\15205161
Bombus terrestris
Buff-tailed bumblebee
Bter\15202803
Linepithema humile
Argentine ant
Lhum\LH25974
Linepithema humile
Argentine ant
Lhum\LH18993
Linepithema humile
Argentine ant
Lhum\LH11092
Linepithema humile
Argentine ant
Lhum\LH22078
Linepithema humile
Argentine ant
Lhum\LH16561
Linepithema humile
Argentine ant
Lhum\LH22075
Linepithema humile
Argentine ant
Lhum\LH11091
Linepithema humile
Argentine ant
Lhum\LH12924
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0012b2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002d46
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0012b4
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001a5c
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002f6e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022171
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001597
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021408
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000977
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017536
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016078
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022170
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006326
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001598
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006330
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022173
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008702
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021404
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003361
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021405
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022172
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016077
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02060
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11691
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04953
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08687
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11689
Tribolium castaneum
Red flour beetle
Tcas\TC006463
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15782
Tribolium castaneum
Red flour beetle
Tcas\TC033238
Tribolium castaneum
Red flour beetle
Tcas\TC004027
Tribolium castaneum
Red flour beetle
Tcas\TC004026
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15783
Tribolium castaneum
Red flour beetle
Tcas\TC013741
Pediculus humanus
Human body louse
Phum\PHUM019640
Pediculus humanus
Human body louse
Phum\PHUM564730
Pediculus humanus
Human body louse
Phum\PHUM145570
Rhodnius prolixus
Kissing bug
Rpro\RPRC009112
Rhodnius prolixus
Kissing bug
Rpro\RPRC014410
Rhodnius prolixus
Kissing bug
Rpro\RPRC002982
Rhodnius prolixus
Kissing bug
Rpro\RPRC013427
Rhodnius prolixus
Kissing bug
Rpro\RPRC012807
Cimex lectularius
Bed bug
Clec\CLEC000038
Cimex lectularius
Bed bug
Clec\CLEC006357
Cimex lectularius
Bed bug
Clec\CLEC006413
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005191
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05071
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16807
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06170
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04904
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16796
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00819
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00821
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X051D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008672
Strigamia maritima
European centipede
Smar\SMAR010187
Strigamia maritima
European centipede
Smar\SMAR012591
Strigamia maritima
European centipede
Smar\SMAR008712
Strigamia maritima
European centipede
Smar\SMAR005859
Strigamia maritima
European centipede
Smar\SMAR013019
Ixodes scapularis
Black-legged tick
Isca\ISCW011208
Ixodes scapularis
Black-legged tick
Isca\ISCW023731
Ixodes scapularis
Black-legged tick
Isca\ISCW007749
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63515.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73828.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81219.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59821.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74955.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g08650
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g04310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03150
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g00280
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g09490
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307810
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303899
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_315693
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_199303
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_93775
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306706
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305032
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_239963
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304390
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_129309
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_223347
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_224487
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_130340
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_117945
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304918
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312745
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_50545
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_265595
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303121
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306729
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_35749
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_214336
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_2528
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_194294
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312746
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_128385
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_195011
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59834
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HUI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CpBL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa2L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016427gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa2L_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa2L_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa4L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_013550gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CpaL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa3L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa2L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022101gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003176gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-PcbpdB1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa1L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-PcbpdA1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CpoL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa1L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpa3L_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007908
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000010660
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000437
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002468
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004085
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005496
Gallus gallus
Domestic chicken
Ggal\CPA2
Gallus gallus
Domestic chicken
Ggal\CPB1
Gallus gallus
Domestic chicken
Ggal\CPA6
Gallus gallus
Domestic chicken
Ggal\CPO
Gallus gallus
Domestic chicken
Ggal\CPA1
Gallus gallus
Domestic chicken
Ggal\CPB2
Gallus gallus
Domestic chicken
Ggal\CPA5
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG3097
7 of 10
CG2915
6 of 10
CG3108
6 of 10
CG4017
6 of 10
CG4408
6 of 10
CG7025
6 of 10
CG8539
6 of 10
CG8560
6 of 10
CG8562
6 of 10
CG8563
6 of 10
CG14820
6 of 10
CG17633
6 of 10
CG18417
6 of 10
CG18585
6 of 10
CG32379
6 of 10
CG42264
5 of 10
CG8564
4 of 10
CG8945
3 of 10
CG31019
1 of 10
CG43235
1 of 10
Nna1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CPA2; carboxypeptidase A2
    8 of 15
    600688
        CPA1; carboxypeptidase A1
        7 of 15
        114850
            CPA4; carboxypeptidase A4
            7 of 15
            607635
                 
                CPA5; carboxypeptidase A5
                7 of 15
                609561
                    CPB1; carboxypeptidase B1
                    7 of 15
                    114852
                        CPA6; carboxypeptidase A6
                        6 of 15
                        609562
                        CPB2; carboxypeptidase B2
                        6 of 15
                        603101
                            CPO; carboxypeptidase O
                            6 of 15
                            609563
                                CPA3; carboxypeptidase A3
                                5 of 15
                                114851
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Interactions Browser
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    External Data
                                    Linkouts
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    2R
                                    Recombination map
                                    2-67
                                    Cytogenetic map
                                    49C3-49C3
                                    Sequence location
                                    2R:12,762,113..12,763,825 [+]
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    49C3-49C3
                                    Limits computationally determined from genome sequence between P{PZ}Nacα04329 and P{lacW}bick10712
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    Experimentally Determined Recombination Data
                                    Location

                                    2-67

                                    (FlyBase, 2016)

                                    2-70.5

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (2)
                                    Genomic Clones (14)
                                     

                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                    cDNA Clones (66)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       
                                      Commercially Available Antibodies
                                       
                                      Other Information
                                      Relationship to Other Genes
                                      Source for database identify of
                                      Source for database merge of

                                      Source for merge of: CG12374 anon-WO0140519.63

                                      (FlyBase, 1996-)
                                      Additional comments

                                      Source for merge of CG12374 anon-WO0140519.63 was sequence comparison ( date:051113 ).

                                      (FlyBase, 1996-)
                                      Other Comments
                                      Origin and Etymology
                                      Discoverer
                                      Etymology
                                      Identification
                                      External Crossreferences and Linkouts ( 37 )
                                      Sequence Crossreferences
                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                      Other crossreferences
                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                      DRscDB
                                      EMBL-EBI Single Cell Expression Atlas
                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                      Flygut - An atlas of the Drosophila adult midgut
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                      InterPro - A database of protein families, domains and functional sites
                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                      MARRVEL_MODEL
                                      modMine - A data warehouse for the modENCODE project
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      DroID - A comprehensive database of gene and protein interactions.
                                      DRSC - Results frm RNAi screens
                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                      FlyMine - An integrated database for Drosophila genomics
                                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                      Synonyms and Secondary IDs (2)
                                      Datasets (0)
                                      Study focus (0)
                                      Experimental Role
                                      Project
                                      Project Type
                                      Title
                                      References (43)