FlyBase Gene Report: Dmel\sug

General Information

Symbol

Dmel\sug

Species

D. melanogaster

Name

sugarbabe

Annotation Symbol

CG3850

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033782

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

sugarbabe (sug) encodes a transcription factor that regulates the expression of insulin-like peptides and genes involved in lipid and carbohydrate metabolism. It is a direct target of the sugar sensor encoded by Mondo and its expression is also promoted by the product of daw. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

49E1-49E1

Sequence location

2R:12,924,567..12,930,644 [+]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12924567..12930644

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN001803442

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN001803442

(GO Reference Genome Project, 2011-)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR043359

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cellular response to nutrient

inferred from direct assay

(Zinke et al., 2002)

involved_in negative regulation of transcription by RNA polymerase II

inferred from direct assay

(Zinke et al., 2002)

involved_in response to starvation

inferred from mutant phenotype

(Varghese et al., 2010)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in central nervous system development

inferred from biological aspect of ancestor with PANTHER:PTN001067772

(GO Reference Genome Project, 2011-)

involved_in negative regulation of DNA-templated transcription

inferred from sequence or structural similarity with UniProtKB:Q8VDL9

(Gene Ontology Curators, 2002-)

involved_in negative regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN008571319

(GO Reference Genome Project, 2011-)

involved_in positive regulation of DNA-templated transcription

inferred from sequence or structural similarity with UniProtKB:Q8VDL9

(Gene Ontology Curators, 2002-)

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN008571319

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from electronic annotation with InterPro:IPR043359

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in nuclear speck

inferred from sequence or structural similarity with UniProtKB:Q8VDL9

(Gene Ontology Curators, 2002-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001803442

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from electronic annotation with InterPro:IPR043359

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the GLI C2H2-type zinc-finger protein family. (Q7K0S9)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Protein Function (UniProtKB)

Transcription factor which represses a set of lipase genes involved in fat catabolism.

(UniProt, Q7K0S9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sug for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K0S9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sug-RA

FBtr0087789

NM_136982

1343

384

sug-RB

FBtr0331985

NM_001274003

1468

322

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

sug-PA

FBpp0086902

44.0

384

8.38

FBpp0304310

36.8

322

8.57

A0A0B4KEP0

NP_001260932

AGB93465

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sug using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sug_1
sug_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.04

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

embryonic stage 12

mesoderm

(Cunha et al., 2010)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

adult stage

adult insulin secreting cell of pars intercerebralis

(Varghese et al., 2010)

adult stage | male

adult fat body

(Ellis and Carney, 2011)

adult abdominal fat mass

(Ellis and Carney, 2011)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

sug expression is detected in the IPC cells in the adult brain by fluorescent in situ hybridization. Little or no expression is observed in other parts of the brain.

(Varghese et al., 2010)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sug in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sug

View exonic expression by tissue for Dmel\sug

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033782

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36424/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033782

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033782

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033782

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3850

Flygut - An atlas of the Drosophila adult midgut

FBgn0033782

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\sug

Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sug

Transgenic constructs containing regulatory region of sug

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7123

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | male | heat sensitive, with Scer\GAL4^hs.PB

sug^UAS.cZa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sug^GD11090

viable, with Scer\GAL4^Mef2.PR

sug^GD11090

viable, with Scer\GAL4^pnr-MD237

sug^GD11090

viable, with Scer\GAL4^tin.CΔ4

sug^GD11090

Other Phenotypes

Allele

abnormal developmental rate | heat sensitive, with Scer\GAL4^hs.PB

sug^UAS.cZa

abnormal starvation stress response | adult stage, with Scer\GAL4^Ilp2.215-3

sug^UAS.cZa

visible, with Scer\GAL4^Bx-MS1096

Phenotype manifest in

Allele

wing, with Scer\GAL4^Bx-MS1096

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (147)

Hsap\GLIS2

8 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Hsap\CTCFL

1 of 14

Hsap\ERV3-1-ZNF117

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZBTB24

1 of 14

Hsap\ZBTB34

1 of 14

Yes

Hsap\ZBTB37

1 of 14

Hsap\ZBTB40

1 of 14

Yes

Hsap\ZFAT

1 of 14

Hsap\ZFP1

1 of 14

Yes

Hsap\ZFP28

1 of 14

Hsap\ZFP69B

1 of 14

Hsap\ZFP91

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF146

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF416

1 of 14

Yes

Hsap\ZNF417

1 of 14

Hsap\ZNF426

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (51)

Rnor\Glis2

8 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zbtb34

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp180

1 of 14

Rnor\Zfp236

1 of 14

Yes

Rnor\Zfp251

1 of 14

Yes

Rnor\Zfp266

1 of 14

Yes

Rnor\Zfp287

1 of 14

Rnor\Zfp316

1 of 14

Rnor\Zfp410

1 of 14

Yes

Rnor\Zfp420

1 of 14

Rnor\Zfp426

1 of 14

Yes

Rnor\Zfp467

1 of 14

Yes

Rnor\Zfp523

1 of 14

Yes

Rnor\Zfp668

1 of 14

Rnor\Zfp697

1 of 14

Yes

Rnor\Zfp771

1 of 14

Rnor\Zfp787

1 of 14

Rnor\Zfp846

1 of 14

Yes

Rnor\Zfp867

1 of 14

Yes

Rnor\Zfp868

1 of 14

Yes

Rnor\Zkscan2

1 of 14

Rnor\Zscan2

1 of 14

Rnor\Zscan10

1 of 14

Yes

Rnor\Zscan22

1 of 14

Yes

Rnor\Zxdc

1 of 14

Mus musculus (laboratory mouse) (69)

Mmus\Glis2

8 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zbtb34

1 of 14

Yes

Mmus\Zbtb40

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp251

1 of 14

Yes

Mmus\Zfp266

1 of 14

Mmus\Zfp287

1 of 14

Yes

Mmus\Zfp316

1 of 14

Mmus\Zfp354a

1 of 14

Yes

Mmus\Zfp386

1 of 14

Yes

Mmus\Zfp410

1 of 14

Yes

Mmus\Zfp422

1 of 14

Yes

Mmus\Zfp426

1 of 14

Yes

Mmus\Zfp433

1 of 14

Mmus\Zfp523

1 of 14

Yes

Mmus\Zfp534

1 of 14

Mmus\Zfp551

1 of 14

Mmus\Zfp560

1 of 14

Yes

Mmus\Zfp617

1 of 14

Mmus\Zfp629

1 of 14

Mmus\Zfp668

1 of 14

Yes

Mmus\Zfp697

1 of 14

Yes

Mmus\Zfp709

1 of 14

Mmus\Zfp771

1 of 14

Mmus\Zfp787

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp941

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (53)

Xtro\glis2

5 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\cxcl9

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100494812

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\zic1

1 of 13

Xtro\zic4

1 of 13

Xtro\znf143

1 of 13

Yes

Xtro\znf276

1 of 13

Yes

Xtro\znf292

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (71)

Drer\glis2a

7 of 14

Yes

Drer\glis2b

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100329258

1 of 14

Drer\LOC100329723

1 of 14

Yes

Drer\LOC100333406

1 of 14

Drer\LOC100537936

1 of 14

Yes

Drer\LOC101882607

1 of 14

Yes

Drer\LOC103909533

1 of 14

Yes

Drer\LOC108179178

1 of 14

Yes

Drer\LOC108183927

1 of 14

Yes

Drer\LOC108184006

1 of 14

Drer\LOC108190743

1 of 14

Yes

Drer\LOC110437813

1 of 14

Yes

Drer\LOC110438163

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:cabz01032454.3

1 of 14

Drer\si:ch73-221f6.1

1 of 14

Drer\si:ch211-162i8.2

1 of 14

Yes

Drer\si:ch211-223a21.4

1 of 14

Yes

Drer\si:ch1073-127d16.1

1 of 14

Drer\si:dkey-156n14.3

1 of 14

Yes

Drer\si:dkey-208k4.2

1 of 14

Drer\si:dkeyp-104f11.6

1 of 14

Yes

Drer\zbtb7b

1 of 14

Yes

Drer\zbtb16b

1 of 14

Yes

Drer\zbtb24

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:173702

1 of 14

Yes

Drer\zgc:173716

1 of 14

Yes

Drer\zgc:174314

1 of 14

Drer\zgc:174624

1 of 14

Drer\zgc:174703

1 of 14

Yes

Drer\znf76

1 of 14

Yes

Drer\znf143a

1 of 14

Yes

Drer\znf143b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\ref-2

2 of 14

Yes

Cele\tra-1

2 of 14

Yes

Cele\ztf-14

2 of 14

Yes

Cele\F47E1.20

1 of 14

Yes

Cele\klf-1

1 of 14

Cele\znf-782

1 of 14

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP006736

9 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010979

1 of 12

Yes

Agam\AgaP_AGAP011655

1 of 12

Agam\AgaP_AGAP011674

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\YY1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ZAP1

2 of 13

Yes

Scer\CMR3

1 of 13

Scer\YPR015C

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\iec1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:sug. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (26)

lmd

5 of 13

4 of 13

opa

4 of 13

Cf2

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

hkb

1 of 13

jim

1 of 13

jing

1 of 13

MTF-1

1 of 13

odd

1 of 13

peb

1 of 13

Phs

1 of 13

sna

1 of 13

topi

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

acute myeloid leukemia, CBFA2T3-GLIS2 fusion

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GLIS2; GLIS family zinc finger 2

model of nephronophthisis 7

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GLIS2; GLIS family zinc finger 2

8 of 14

608539

NEPHRONOPHTHISIS 7; NPHP7

nephronophthisis 7

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

sug - mir-14

luminiscence technology, necessary binding region, quantitative reverse transcription pcr, fluorescence technology

(Varghese et al., 2010)

protein-protein

Physical Interaction

Assay

References

sug - Ada2b

two hybrid array

(Shokri et al., 2019)

sug - CG3815

two hybrid array

(Shokri et al., 2019)

sug - Cenp-C

two hybrid array

(Shokri et al., 2019)

sug - E(spl)mδ-HLH

two hybrid array

(Shokri et al., 2019)

sug - croc

two hybrid array

(Shokri et al., 2019)

sug - drm

two hybrid array

(Shokri et al., 2019)

sug - ems

two hybrid array

(Shokri et al., 2019)

sug - foxo

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Erk7

suppressible

sug

(Hasygar et al., 2021)

mir-14

suppressible

sug

(Varghese et al., 2010)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62194

DroID - A comprehensive database of gene and protein interactions.

FBgn0033782

MIST (protein-protein) - An integrated Molecular Interaction Database

36424

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-67

Cytogenetic map

49E1-49E1

Sequence location

2R:12,924,567..12,930,644 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49E1-49E1

Limits computationally determined from genome sequence between P{PZ}l(2)01424⁰¹⁴²⁴ and P{lacW}Psc^k07834&P{lacW}Su(z)2^k06344

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-67

(FlyBase, 2016)

2-71.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27026

y¹ v¹; P{TRiP.JF02347}attP2

604720

y¹ v¹; P{TOE.GS02950}attP40

24803

w¹¹¹⁸; Mi{ET1}sug^MB03297/SM6a

81267

y¹ w^*; PBac{sug-GFP.FPTB}VK00031

55419

y¹ w^*; Mi{MIC}sug^MI04011

98518

y¹ w^*; TI{CRIMIC.TG4.2}sug^{CR70776-TG4.2}/SM6a

FlyORF

F000721

M{UAS-sug.ORF.3xHA.GW}ZH-86Fb

F004883

M{UAS-sug.ORF-VNshort}ZH-86Fb

3850R-1

v109584

v21719

w¹¹¹⁸; P{GD11090}v21719

v341546

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00622}attP40/CyO-GFP

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (135)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD36528

Other clones

DPiM_LD36528

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033782

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033782

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: sug CG3850

(Zinke et al., 2002)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG3850

(National Institute of Genetics Fly Stocks, 2022-, Ellis and Carney, 2011, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Mohammad et al., 2009, Perkins et al., 2009.3.31, Kadener et al., 2007, Aruga, 2004, Roxstrom-Lindquist et al., 2004, Stanyon et al., 2004, Giot et al., 2003, Zinke et al., 2002)

Sug

(Hasygar et al., 2021, Parra-Peralbo et al., 2021)

sug

(Drewell et al., 2024, Jang et al., 2024, Zhang et al., 2024, Örkenby et al., 2023, Yamada et al., 2023, Zhang et al., 2023, Deshpande et al., 2022, Eickelberg et al., 2022, Pegoraro et al., 2022, Sebastian et al., 2022, Girard et al., 2021, Wang et al., 2021, Vásquez-Procopio et al., 2020, Hall et al., 2019, Lammers et al., 2019, Shokri et al., 2019, Xu et al., 2019, Bischof et al., 2018, Gene Disruption Project members, 2018-, Joos et al., 2018, Chng et al., 2017, Transgenic RNAi Project members, 2017-, Mattila et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Nadimpalli et al., 2015, Schertel et al., 2015, Ciglar et al., 2014, Awofala et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Vamos and Boros, 2012, Zhou et al., 2012, Ellis and Carney, 2011, Napoletano et al., 2011, Xu et al., 2011, Cunha et al., 2010, Fujikawa et al., 2009, Stergiopoulos et al., 2009, Zsindely et al., 2009)

sugarbabe

(Mattila and Hietakangas, 2017)

Name Synonyms

Sugarbabe

(Yun et al., 2024, Havula and Hietakangas, 2018, Chng et al., 2017, Castillo et al., 2015, Nässel et al., 2015)

sugarbabe

(Chatterjee and Perrimon, 2021, Signor, 2020, Signor and Nuzhdin, 2018, Harrop et al., 2014, Farhadian et al., 2012, Dalton et al., 2010, Varghese et al., 2010, Stergiopoulos et al., 2009, Zsindely et al., 2009, King-Jones et al., 2006, Teleman et al., 2005, Walther et al., 2004)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36424

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K0S9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7K0S9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KEP0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K0S9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033782

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36424/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033782

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033782

FlyMine - An integrated database for Drosophila genomics

FBgn0033782

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3850

MARRVEL_MODEL - MARRVEL (model organism gene)

36424

Linkouts

BioGRID - A database of protein and genetic interactions.

62194

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033782

DroID - A comprehensive database of gene and protein interactions.

FBgn0033782

DRSC - Results frm RNAi screens

FBgn0033782

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sug_1
sug_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033782

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033782

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3850

Flygut - An atlas of the Drosophila adult midgut

FBgn0033782

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000326

MIST (protein-protein) - An integrated Molecular Interaction Database

36424

References (106)

The following external sites may use different assemblies or annotations than FlyBase.

-1.04

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