Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drl-2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Drl-2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Drl-2 is required for mushroom body α branch axon guidance during brain development. It is expressed within mushroom body axons and functions as a repulsive Wnt5 signaling receptor. Biochemical data indicates that a cleaved and shed drl extracellular domain can form a ternary complex with Wnt5 and Drl-2, providing a mechanism by which mushroom body α axon guidance may occur, since drl protein is expressed in the dorsomedial lineages adjacent to the mushroom bodies and the cleaved drl extracellular domain is detected at the tip of the mushroom body α lobe in pupae.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.