FlyBase Gene Report: Dmel\Drl-2

General Information

Symbol

Dmel\Drl-2

Species

D. melanogaster

Name

Derailed 2

Annotation Symbol

CG3915

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033791

Gene Model Status

Stock Availability

14 publicly available

Gene Snapshot

Derailed 2 (Drl-2) is a member of the RYK gene family encoding a receptor tyrosine kinase that transduces Wnt5 signaling. It regulates salivary gland positioning, muscle attachment site selection and olfactory system development. The products of Drl-2 and drl can play both cooperative and opposing roles, depending on the cells where they are differentially expressed. [Date last reviewed: 2018-10-11]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

doughnut-like, dnl

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:13,055,246..13,079,539 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13055246..13079539

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

PUTATIVE PSEUDOKINASES

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

protein heterodimerization activity; Wnt-protein binding

Predictions / Assertions

ATP binding; NOT protein tyrosine kinase activity

Summaries

Gene Group (FlyBase)

PUTATIVE PSEUDOKINASES -: Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).
RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the GBrowse view of Dmel\Drl-2 or the JBrowse view of Dmel\Drl-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0087794

4688

648

FBtr0339747

6020

648

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0086907

71.1

648

6.66

FBpp0308795

71.1

648

6.66

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

648 aa isoforms: Drl-2-PB, Drl-2-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q7JQT0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drl-2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Drl-2_1

Linkouts

Gene Ontology (17 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

protein heterodimerization activity

inferred from physical interaction with FLYBASE:drl; FB:FBgn0015380

(Petrova et al., 2013)

inferred from physical interaction with FLYBASE:dnt; FB:FBgn0024245

(Petrova et al., 2013)

Wnt-protein binding

inferred from physical interaction with FLYBASE:Wnt5; FB:FBgn0010194

(Reynaud et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

inferred from electronic annotation with InterPro:IPR000719

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

NOT protein tyrosine kinase activity

inferred from sequence or structural similarity with FLYBASE:drl; FB:FBgn0015380

(FlyBase Curators, 2008--)

Biological Process (11 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

chemorepulsion of axon

inferred from mutant phenotype

(Reynaud et al., 2015)

motor neuron axon guidance

inferred from mutant phenotype

(Inaki et al., 2007)

salivary gland morphogenesis

inferred from mutant phenotype

(Harris and Beckendorf, 2007)

synaptic target inhibition

inferred from mutant phenotype

(Inaki et al., 2007)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

inferred from biological aspect of ancestor with PANTHER:PTN002521291

(assigned by GO_Central )

(Gaudet et al., 2011)

cell-cell signaling by wnt

traceable author statement

(assigned by ParkinsonsUK-UCL )

(Fradkin et al., 2010)

multicellular organism development

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

nervous system development

inferred from biological aspect of ancestor with PANTHER:PTN002521291

(assigned by GO_Central )

(Gaudet et al., 2011)

positive regulation of kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

transmembrane receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

receptor complex

inferred from direct assay

(Petrova et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN002356460

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

ventral longitudinal muscle 1 | restricted

(Inaki et al., 2007)

A1-7 ventral longitudinal muscle 2 | restricted

(Inaki et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6 -- P7

antennal lobe | restricted

(Sakurai et al., 2009)

olfactory receptor neuron | subset

• axon

(Sakurai et al., 2009)

antennal lobe glomerulus | subset

(Sakurai et al., 2009)

adult antennal lobe commissure | restricted

(Sakurai et al., 2009)

pharate adult stage P8

adult mushroom body beta-lobe

Comment: 48 APF

(Reynaud et al., 2015)

adult mushroom body alpha-lobe

Comment: 48 APF

(Reynaud et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

receptor complex

inferred from direct assay

(Petrova et al., 2013)

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.0}Drl-2^{MI08950-TG4.0}

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain | restricted

(Lee et al., 2018)

adult mushroom body

(Lee et al., 2018)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Drl-2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Drl-2

View exonic expression by tissue for Dmel\Drl-2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0033791

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

S.C2R001120;CG3915-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3915

Flygut - An atlas of the Drosophila adult midgut

FBgn0033791

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Drl-2

Transgenic constructs containing regulatory region of Drl-2

Deletions and Duplications ( 1 )

Disrupted in

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Drl-2^GD11105

viable, with Scer\GAL4^Mef2.PR

Drl-2^GD11105

viable, with Scer\GAL4^pnr-MD237

Drl-2^GD11105

viable, with Scer\GAL4^tin.CΔ4

Drl-2^GD11105

Other Phenotypes

Allele

neuroanatomy defective

Drl-2^E124

neuroanatomy defective (with Df(2R)Exel8057)

Drl-2^E124

neuroanatomy defective | embryonic stage, with Scer\GAL4^eg-Mz360

Drl-2^UAS.Tag:MYC

Phenotype manifest in

Allele

alpha/beta Kenyon cell (with Df(2R)Exel8057)

Drl-2^E124

Drl-2^E124

antennal lobe glomerulus VL1

Drl-2^E124

antennal lobe glomerulus VM7

Drl-2^E124

Drl-2^E124

mushroom body alpha-lobe (with Df(2R)Exel8057)

Drl-2^E124

posterior commissure | embryonic stage, with Scer\GAL4^eg-Mz360

Drl-2^UAS.Tag:MYC

presumptive embryonic salivary gland

Drl-2^E124

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

8 of 15

Yes

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

8 of 15

Yes

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (7)

6 of 13

Yes

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

Rnor\LOC102552659

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (5)

6 of 12

Yes

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (8)

9 of 15

Yes

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:ch73-383l1.1

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (3)

8 of 15

Yes

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

1 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904OU )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00002476

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509RE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY006565

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02290

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009521

Anopheles darlingi

American malaria mosquito

Adar\ADAC010329

Anopheles gambiae

Malaria mosquito

Agam\AGAP006405

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018309

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ020115

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03U7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002700

Bombyx mori

Silkmoth

Bmor\BGIBMGA002597

Danaus plexippus

Monarch butterfly

Dple\DPOGS201449-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS201439-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015985

Heliconius melpomene

Postman butterfly

Hmel\HMEL015485

Apis florea

Little honeybee

Aflo\4297090708

Apis florea

Little honeybee

Aflo\2583794580

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000307

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002d43

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007570

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007584

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM613930

Rhodnius prolixus

Kissing bug

Rpro\RPRC004208

Cimex lectularius

Bed bug

Clec\CLEC001964

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003507

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI28818

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05667

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08071

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03RF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW009358

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80785.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g02860

Tetranychus urticae

Two-spotted spider mite

Turt\tetur23g00580

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307904

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0353 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\LOC100177957

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (18)

Gene Symbol

Score

Source

Alignment

6 of 10

6 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RYK; receptor like tyrosine kinase

8 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, western blot

(Reynaud et al., 2015)

anti tag coimmunoprecipitation, anti tag western blot

(Petrova et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot

(Reynaud et al., 2015, Petrova et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Sakurai et al., 2009)

suppressible

(Reynaud et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Reynaud et al., 2015, Sakurai et al., 2009)

enhanceable

(Sakurai et al., 2009)

enhanceable

(Reynaud et al., 2015)

suppressible

(Sakurai et al., 2009)

enhanceable

(Reynaud et al., 2015)

suppressible

(Sakurai et al., 2009)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033791

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36436

MIST (genetic) - An integrated Molecular Interaction Database

Drl-2

MIST (protein-protein) - An integrated Molecular Interaction Database

Drl-2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-68

Cytogenetic map

Sequence location

2R:13,055,246..13,079,539 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F1-49F1

Limits computationally determined from genome sequence between P{lacW}Psc^k07834&P{lacW}Su(z)2^k06344 and P{EP}EP873^EP873

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

12655

w¹¹¹⁸; P{GT1}Drl-2^BG02105

25627

w¹¹¹⁸; Mi{ET1}Drl-2^MB06584

25961

y¹ v¹; P{TRiP.JF01981}attP2

64297

w^* P{UAS-Drl-2.S}1a P{UAS-Drl-2.S}1b

64341

w¹¹¹⁸; PBac{UAS-Drl-2.WT.MYC}VK00027

64339

w¹¹¹⁸; PBac{UAS-Drl-2.ΔWIF.MYC}VK00027

64340

w¹¹¹⁸; PBac{UAS-Drl-2.Δcyto.MYC}VK00027

44839

y¹ w^*; Mi{MIC}Drl-2^MI08950

21771

y¹ w^67c23; P{wHy}Drl-2^DG38805

64302

y¹ w^67c23; Drl-2^E124/CyO, P{ActGFP}JMR1

v102192

P{KK111058}VIE-260B

v40484

w¹¹¹⁸; P{GD11105}v40484

More stocks available...

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

DPiM_GH27039

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033791

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033791

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36436

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Amourda and Saunders, 2020, Sakurai et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG3915 CG12463

(Manning, 2002.2.8)

Source for merge of: CG12463 CG3915

(Santschi, 2002.3.6)

Additional comments

Other Comments

Drl-2 is required for mushroom body α branch axon guidance during brain development. It is expressed within mushroom body axons and functions as a repulsive Wnt5 signaling receptor. Biochemical data indicates that a cleaved and shed drl extracellular domain can form a ternary complex with Wnt5 and Drl-2, providing a mechanism by which mushroom body α axon guidance may occur, since drl protein is expressed in the dorsomedial lineages adjacent to the mushroom bodies and the cleaved drl extracellular domain is detected at the tip of the mushroom body α lobe in pupae.

(Reynaud et al., 2015)

Drl-2 is epistatic to Wnt5 and functions downstream of Wnt5.

(Sakurai et al., 2009)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36436

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7JQT0

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033791

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Drl-2_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3915

Flygut - An atlas of the Drosophila adult midgut

FBgn0033791

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36436

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3915

modMine - A data warehouse for the modENCODE project

FBgn0033791

Linkouts

DPiM - Drosophila Protein interaction map

FBgn0033791

DroID - A comprehensive database of gene and protein interactions.

FBgn0033791

DRSC - Results frm RNAi screens

FBgn0033791

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0033791

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

S.C2R001120;CG3915-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033791

FlyMine - An integrated database for Drosophila genomics

FBgn0033791

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36436

MIST (genetic) - An integrated Molecular Interaction Database

Drl-2

MIST (protein-protein) - An integrated Molecular Interaction Database

Drl-2

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG12463

CG3915

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15)

DNT-like

(Morrison et al., 2000)

DRL-2

(Petrova et al., 2013)

Drl-2

(Amourda and Saunders, 2020, Yasunaga et al., 2015, Zwarts et al., 2015, Ashwal-Fluss et al., 2014, Vernes, 2014, Sopko and Perrimon, 2013, Wang et al., 2013, Yin et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Lahaye et al., 2012, Morillo Prado et al., 2012, Nose, 2012, Park et al., 2012, Kong et al., 2010, Harris and Beckendorf, 2007, Jordan et al., 2005)

dnl

(Manning, 2002.2.8)

drl-2

(Mele and Johnson, 2019, Reynaud et al., 2015, Nose, 2012, Sakurai et al., 2009, Inaki et al., 2007)

drl2

(Zhu et al., 2019)

Name Synonyms

Derailed 2

(Mele and Johnson, 2019, Sopko and Perrimon, 2013, Harris and Beckendorf, 2007, Jordan et al., 2005, Santschi, 2002.3.6)

Derailed-2

(Petrova et al., 2013, Lahaye et al., 2012, Nose, 2012)

derailed-2

(Cridland et al., 2013, Inaki et al., 2007)

doughnut-like

(Manning, 2002.2.8)

Secondary FlyBase IDs

FBgn0033790

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (65)

Report Sections