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Gene Dmel\AQP

General Information
Symbol	Dmel\AQP	Species	D. melanogaster
Name	aquaporin	Annotation symbol	CG12251
Feature type	protein_coding_gene	FlyBase ID	FBgn0033807
Gene Model Status	Current	Stock availability	None publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49F9-49F10	Sequence location	2R:9,099,837..9,102,005 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene aquaporin is referred to in FlyBase by the symbol Dmel\AQP (CG12251, FBgn0033807). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: water transmembrane transporter activity. It is reported to be involved in the biological process: water transport. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Aquaporin 11/12; Aquaporin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult hindgut, adult heart, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626560_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of AQP. Gene sequence location is 2R:9099837..9102005.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN22833 HFA06122
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49F9-49F10
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AQP for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone HL08087 appears problematic: incomplete CDS DGC clone GH06377 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AQP-RA FBtr0087766  NM_079004   1308   276 AQP-RB FBtr0300286  NM_001169669   1278   266
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AQP-PA   FBpp0086879   30.2   276   7.26     NP_523728   AAF58409 AQP-PB   FBpp0289514   29.0   266   7.26     NP_001163140   ACZ94413
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aquaporin 11/12 (IPR016697) Aquaporin-like (IPR023271)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58409   AB036345 BAB03660   AE013599 ACZ94413   AI106755   AI107085   BT003592   CO317104   CO326396   DN154000   EC051983   EC204112   EC207589   EC222085   EC256827   GH776312   GH790499
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KY01 E1JH55
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033807    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033807 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033807 expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP    2400 pupae 4d postWPP    16238 adult male 01day    7766 adult male 05day    5138 adult male 30day    3463 adult female 01day    5596 adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr  (114) embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr  (139) embryo 12-14hr  (143) embryo 14-16hr  (307) embryo 16-18hr  (306) embryo 18-20hr  (350) embryo 20-22hr  (248) embryo 22-24hr  (176) larva L1  (480) larva L2  (517) larva L3 12hr old  (1082) larva L3 puffstage 1-2  (770) larva L3 puffstage 3-6  (495) larva L3 puffstage 7-9  (194) white prepupae new  (158) white prepupae 12hr  (195) white prepupae 24hr  (276) pupae 2d postWPP  (701) pupae 3d postWPP  (2400) pupae 4d postWPP  (16238) adult male 01day  (7766) adult male 05day  (5138) adult male 30day  (3463) adult female 01day  (5596) adult female 05day  (688) adult female 30day  (549) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP  (2400) pupae 4d postWPP  (16238) adult male 01day  (7766) adult male 05day  (5138) adult male 30day  (3463) adult female 01day  (5596) adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP    2400 pupae 4d postWPP  (16238) adult male 01day    7766 adult male 05day    5138 adult male 30day    3463 adult female 01day    5596 adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP    2400 pupae 4d postWPP    16238 adult male 01day    7766 adult male 05day    5138 adult male 30day    3463 adult female 01day    5596 adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033807 expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP    2400 pupae 4d postWPP    16238 adult male 01day    7766 adult male 05day    5138 adult male 30day    3463 adult female 01day    5596 adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr  114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr  139 embryo 12-14hr  143 embryo 14-16hr  (307) embryo 16-18hr  (306) embryo 18-20hr  (350) embryo 20-22hr  (248) embryo 22-24hr  (176) larva L1  (480) larva L2  (517) larva L3 12hr old  (1082) larva L3 puffstage 1-2  (770) larva L3 puffstage 3-6  (495) larva L3 puffstage 7-9  (194) white prepupae new  (158) white prepupae 12hr  (195) white prepupae 24hr  (276) pupae 2d postWPP  (701) pupae 3d postWPP  (2400) pupae 4d postWPP  (16238) adult male 01day  (7766) adult male 05day  (5138) adult male 30day  (3463) adult female 01day  (5596) adult female 05day  (688) adult female 30day  (549) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP  2400 pupae 4d postWPP  (16238) adult male 01day  (7766) adult male 05day  (5138) adult male 30day  (3463) adult female 01day  (5596) adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP    2400 pupae 4d postWPP  16238 adult male 01day    7766 adult male 05day    5138 adult male 30day    3463 adult female 01day    5596 adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    114 embryo 04-06hr    63 embryo 06-08hr    42 embryo 08-10hr    20 embryo 10-12hr    139 embryo 12-14hr    143 embryo 14-16hr    307 embryo 16-18hr    306 embryo 18-20hr    350 embryo 20-22hr    248 embryo 22-24hr    176 larva L1    480 larva L2    517 larva L3 12hr old    1082 larva L3 puffstage 1-2    770 larva L3 puffstage 3-6    495 larva L3 puffstage 7-9    194 white prepupae new    158 white prepupae 12hr    195 white prepupae 24hr    276 pupae 2d postWPP    701 pupae 3d postWPP    2400 pupae 4d postWPP    16238 adult male 01day    7766 adult male 05day    5138 adult male 30day    3463 adult female 01day    5596 adult female 05day    688 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033807    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033807 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult hindgut, adult heart, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033807 expression level Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop    632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass    1008.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop  (632.2) Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass  (1008.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop    632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass  1008.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop    632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass    1008.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033807 expression level Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop    632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass    1008.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop  632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass  (1008.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop    632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass  1008.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.625 Larval Midgut    9.6 Larval Hindgut    73.8 Larval Malpighian Tubules    4.1 Larval Fat Body    34.7 Larval Salivary Gland    3.3 Larval Trachea no informative data Larval Carcass    338.375 Adult Head    206.2 Adult Eye    29.875 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    41.1 Adult Crop    632.2 Adult Midgut    44.8 Adult Hindgut    233.1 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    338.5 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    41.4 Adult Ovary    2.9 Adult Testis    141.9 Adult Male Accessory Gland    129.6 Adult Carcass    1008.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    206.2   NA  Eye    29.875   NA  Brain    6.7   5.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    41.1   NA  Crop    632.2   9.6  Midgut    44.8   73.8  Hindgut    233.1   4.1  Malpighian Tubules    no informative data   34.7  Fat Body    no informative data   3.3  Salivary Gland    no informative data   NA  Heart    338.5   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    26.4   NA  InseminatedFemale Spermatheca    41.4   NA  Ovary    2.9   NA  Testis    141.9   NA  Male Accessory Gland    129.6   338.375  Carcass    1008.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033807 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12251-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for AQP Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of AQP Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AQP Class Mutagen Stocks Known lesion AQPGD1974 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AQPKK102737 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8057 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1974} NA P{KK102737} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
water transmembrane transporter activity non-traceable author statement (Ishibashi, 1999.12.23)
Biological Process
CV term Evidence References
water transport non-traceable author statement (Ishibashi, 1999.12.23)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AQP allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0033807
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12963 Dere\GG22514 Dgri\GH24920 Dmoj\GI18394 Dper\GL10509 Dpse\GA11509 Dsec\GM20300 Dsim\GD25912 Dvir\GJ21471 Dwil\GK17891 Dyak\GE13386
Curated drosophilid orthologs	Dpse\GA11509
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014108-PA Aedes aegypti (mosquito) AAEL014255-PA Aedes aegypti (mosquito) AGAP010878-PA Anopheles gambiae (mosquito) XP_001119893.1 Apis mellifera (honey bee) 122402 Branchiostoma floridae (lancelet) 130953 Branchiostoma floridae (lancelet) ENSBTAP00000026547 Bos taurus (bovine) CN10727 Caenorhabditis brenneri (small nematode) CN24643 Caenorhabditis brenneri (small nematode) CBP14899 Caenorhabditis briggsae (nematode) CE41143 Caenorhabditis elegans (worm) ENSCAFP00000007308 Canis familiaris (dog) JA13552 Caenorhabditis japonica (nematode) CPIJ004456 Culex pipens (mosquito) ENSCPOP00000005935 Cavia porcellus (guinea pig) RP27113 Caenorhabditis remanei (nematode) 65598 Capitella spl (polychaete worm) 203591 Daphnia pulex (daphnia) ENSDARP00000063532 Danio rerio (zebra fish) ENSECAP00000011522 Equus caballus (horse) ENSGACP00000014661 Gymnopilus aculeatus (mushroom) ENSGALP00000010373 Gallus gallus (chicken) ENSP00000384894 Homo sapiens (human) ISCW015444-PA Ixodes scapularis (deer tick) 137826 Lottia gigantea (owl limpet) ENSMODP00000023015 Monodelphis domestica (gray opossum) ENSMMUP00000024926 Macaca mulatta (rhesus monkey) ENSMMUP00000037298 Macaca mulatta (rhesus monkey) ENSMUSP00000060622 Mus musculus (house mouse) 213742 Nematostella vectensis (starlet anemone) ENSOANP00000015652 Ornithorynchus anatinus (platypus) ENSORLP00000018866 Oryzias latipes (japanese killifish) PHUM006908-PA Pediculus humanus (human body louse) PP15036 Pristionchus pacificus (nematode) ENSPPYP00000014971 Pongo pygmaeus (orangutan) ENSPTRP00000007062 Pan troglodytes (chimpanzee) ENSRNOP00000005935 Rattus norvegicus (norway rat) 4998192 Sorghum bicolor (sorghum) XP_001188771.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000020773 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000025165 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14680 PB14681 LH16387 ISCW015444 FBgn0231065 FBgn0219890 FBgn0208597 FBgn0197190 FBgn0175183 JGI_V11_203591 FBgn0071560 FBgn0148119 FBgn0141133 FBgn0132375 FBgn0114685 FBgn0089997 CPIJ004456 BGIBMGA007339 BGIBMGA007338 GB10223 AGAP010878 AAEL014255 AAEL014108 PHUM127940 GLEAN_06172
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR05M17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL08087
Other clones	DPiM_HL08087
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06377 GH07690
Other clones	38212 163049 214441.34 CK01.86A.C5 EC051983 EK150427 EK267131 EP03836 RP003185408 RP003486803
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033807 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36456
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: AQP CG12251 (FlyBase, 1996-)
Additional comments	Source for merge of AQP CG12251 was sequence comparison (date:000815). (FlyBase, 1996-)
Other Comments
	Identified with: HL08087 (BDGP-DGC) <up>FlyBase curator comment: EST subsequently found to be chimeric</up>. (BDGP Project Members, 2000-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079004 NM_001169669 RefSeq (Proteins) • NP_523728 NP_001163140 DDBJ / EMBL / GenBank • AAF58409 AAF58409.2 AB036345 ACZ94413 BAB03660 Entrez Gene - A searchable database of RefSeq genes. • 36456 UniProtKB/TrEMBL • E1JH55 Q7KY01
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aquaporin 11/12 (IPR016697) Aquaporin-like (IPR023271)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0033807 DRSC - Results from RNAi screens. • FBgn0033807 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033807 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12251-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033807 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36456 InParanoid A subset of ortholog calls from InParanoid. • AAEL014108-PA Aedes aegypti (mosquito) AAEL014255-PA Aedes aegypti (mosquito) AGAP010878-PA Anopheles gambiae (mosquito) XP_001119893.1 Apis mellifera (honey bee) 122402 Branchiostoma floridae (lancelet) 130953 Branchiostoma floridae (lancelet) ENSBTAP00000026547 Bos taurus (bovine) CN10727 Caenorhabditis brenneri (small nematode) CN24643 Caenorhabditis brenneri (small nematode) CBP14899 Caenorhabditis briggsae (nematode) CE41143 Caenorhabditis elegans (worm) ENSCAFP00000007308 Canis familiaris (dog) JA13552 Caenorhabditis japonica (nematode) CPIJ004456 Culex pipens (mosquito) ENSCPOP00000005935 Cavia porcellus (guinea pig) RP27113 Caenorhabditis remanei (nematode) 65598 Capitella spl (polychaete worm) 203591 Daphnia pulex (daphnia) ENSDARP00000063532 Danio rerio (zebra fish) ENSECAP00000011522 Equus caballus (horse) ENSGACP00000014661 Gymnopilus aculeatus (mushroom) ENSGALP00000010373 Gallus gallus (chicken) ENSP00000384894 Homo sapiens (human) ISCW015444-PA Ixodes scapularis (deer tick) 137826 Lottia gigantea (owl limpet) ENSMODP00000023015 Monodelphis domestica (gray opossum) ENSMMUP00000024926 Macaca mulatta (rhesus monkey) ENSMMUP00000037298 Macaca mulatta (rhesus monkey) ENSMUSP00000060622 Mus musculus (house mouse) 213742 Nematostella vectensis (starlet anemone) ENSOANP00000015652 Ornithorynchus anatinus (platypus) ENSORLP00000018866 Oryzias latipes (japanese killifish) PHUM006908-PA Pediculus humanus (human body louse) PP15036 Pristionchus pacificus (nematode) ENSPPYP00000014971 Pongo pygmaeus (orangutan) ENSPTRP00000007062 Pan troglodytes (chimpanzee) ENSRNOP00000005935 Rattus norvegicus (norway rat) 4998192 Sorghum bicolor (sorghum) XP_001188771.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000020773 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000025165 Takifugu rubripes (pufferfish Takifugu) modMine - Data generated by the modENCODE project. • FBgn0033807 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14680 PB14681 LH16387 ISCW015444 FBgn0231065 FBgn0219890 FBgn0208597 FBgn0197190 FBgn0175183 JGI_V11_203591 FBgn0071560 FBgn0148119 FBgn0141133 FBgn0132375 FBgn0114685 FBgn0089997 CPIJ004456 BGIBMGA007339 BGIBMGA007338 GB10223 AGAP010878 AAEL014255 AAEL014108 PHUM127940 GLEAN_06172
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	AQP (Apel et al., 2008, Wang et al., 2004) AQP-dr (Ishibashi, 1999.12.23) CG12251 (Wang et al., 2004, Keleman et al., 2009.8.5)
Name Synonym	aquaporin (Ishibashi, 1999.12.23, Apel et al., 2008)
Secondary FlyBase IDs
References ( 9 )
Research paper	Wang et al., 2004, GenomeBiol. 5(9): R69 Function-informed transcriptome analysis of Drosophila renal tubule. [FBrf0180324]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Abstract	Apel et al., 2008, A. Dros. Res. Conf. 49: 264C Water channels, oviduct osmolarity and egg activation in Drosophila. [FBrf0204098]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Ishibashi, 1999.12.23, GenBank/EMBL/DDBJ: AB036345 Drosophila melanogaster AQP-dr mRNA for aquaporin, complete cds. [FBrf0130717]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]