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Gene Dmel\CG6145

General Information
Symbol	Dmel\CG6145	Species	D. melanogaster
Name		Annotation symbol	CG6145
Feature type	protein_coding_gene	FlyBase ID	FBgn0033853
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50B1-50B1	Sequence location	2R:9,424,876..9,435,082 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6145 (FBgn0033853). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: NAD+ kinase activity. There is experimental evidence that it is involved in the biological process: neuron projection morphogenesis. 19 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: ATP-NAD kinase, PpnK-type, all-beta; ATP-NAD kinase-like domain; Inorganic polyphosphate/ATP-NAD kinase, domain 1; Inorganic polyphosphate/ATP-NAD kinase, predicted. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart, larval/adult fat body, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. Gene sequence location is 2R:9424876..9435082.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50B1-50B1   Limits computationally determined from genome sequence between P{lacW}drkk13809&P{EP}mip120EP606 and P{lacW}l(2)03105k16702&P{lacW}fl(2)dk16105
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6145 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6145-RA FBtr0087685  NM_137040   2213   520 CG6145-RB FBtr0087687  NM_166004   1826   420 CG6145-RC FBtr0087686  NM_166003   2260   548 CG6145-RE FBtr0300192  NM_001169674   1843   483 CG6145-RF FBtr0300193  NM_001169675   1989   484
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6145-PA   FBpp0086805   57.5   520   6.57     NP_610884   AAF58358 CG6145-PB   FBpp0086807   46.8   420   6.19     NP_725315   AAM68590 CG6145-PC   FBpp0086806   61.3   548   6.95     NP_725314   AAM68589 CG6145-PE   FBpp0289429   53.8   483   7.09     NP_001163145   ACZ94417 CG6145-PF   FBpp0289430   54.1   484   7.33     NP_001163146   ACZ94418
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Inorganic polyphosphate/ATP-NAD kinase, predicted (IPR002504) ATP-NAD kinase-like domain (IPR016064) ATP-NAD kinase, PpnK-type, all-beta (IPR017437) Inorganic polyphosphate/ATP-NAD kinase, domain 1 (IPR017438)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440120   AE013599 AAF58358   AE013599 AAM68589   AE013599 AAM68590   AE013599 ACZ94417   AE013599 ACZ94418   AI259779   AQ072935   AQ073416   AW944017   AY069729 AAL39874   BG638071   BH214596   BI357739   BI362525   BI593192   BI629177   BI637726   BT001677   BT014633   BT122070   CA806337   CO266691   CO282294   CO309387   CO314516   CO329450   CO329791   CZ473016   CZ473017   CZ475854   CZ487061   CZ488061   CZ488062   DU708677   EC061591   EC076794   EC089243   EC090192   EC199579   EC213590   EC224942   EC240425   EC247802   EC250733   EL883219   EL883452   EV585873   GH751144   GH752346   GH758795   GH758953   GH772407   GH774962   GH778570   GH780387   GH780885   GH782707   GH783282   GH790931   GH795147   GH811353   GH821342   GH823885   GH824876   GH827430   GH827844   GH834412   GH842491   GH851188   GH855733   GH856462   GH861138   GH862215   GH864260   GH868470   GH868615   GH873121   GH873611   GH881130   GH887358   GH894536   GH895278   GH895861   GH905501   GH913716   GH916665   GH929845   GH939239
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SZX5 Q6IDH2 A1Z9F0 E1JH60 E1JH61
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart, larval/adult fat body, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female    35 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult    28 carcass, 4-day adult    33 carcass, 20-day adult    38 ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female  (35) head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female  (28) head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male  (32) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering  (28) digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult  (28) carcass, 4-day adult  (33) carcass, 20-day adult  (38) ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female    35 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult    28 carcass, 4-day adult    33 carcass, 20-day adult    38 ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female    35 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult    28 carcass, 4-day adult    33 carcass, 20-day adult    38 ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female    35 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult    28 carcass, 4-day adult    33 carcass, 20-day adult    38 ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female  (35) head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female  28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male  32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering  28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult  28 carcass, 4-day adult  (33) carcass, 20-day adult  (38) ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female    35 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult    28 carcass, 4-day adult    33 carcass, 20-day adult    38 ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    17 head, virgin 4-day female    20 head, virgin 20-day female    35 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    28 head, mated 1-day male    20 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    14 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    21 carcass, 1-day adult    28 carcass, 4-day adult    33 carcass, 20-day adult    38 ovary, virgin 4-day female    14 ovary, mated 4-day female    13 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    30 embryo 04-06hr    32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    31 embryo 18-20hr    36 embryo 20-22hr    42 embryo 22-24hr    41 larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    32 white prepupae new    49 white prepupae 12hr    53 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day    35 adult male 05day    32 adult male 30day    31 adult female 01day    34 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (29) embryo 02-04hr  (30) embryo 04-06hr  (32) embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr  (30) embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr  (31) embryo 18-20hr  (36) embryo 20-22hr  (42) embryo 22-24hr  (41) larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  (32) white prepupae new  (49) white prepupae 12hr  (53) white prepupae 24hr  26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day  (35) adult male 05day  (32) adult male 30day  (31) adult female 01day  (34) adult female 05day  (30) adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    30 embryo 04-06hr    32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    31 embryo 18-20hr    36 embryo 20-22hr    42 embryo 22-24hr    41 larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    32 white prepupae new    49 white prepupae 12hr    53 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day    35 adult male 05day    32 adult male 30day    31 adult female 01day    34 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    30 embryo 04-06hr    32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    31 embryo 18-20hr    36 embryo 20-22hr    42 embryo 22-24hr    41 larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    32 white prepupae new    49 white prepupae 12hr    53 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day    35 adult male 05day    32 adult male 30day    31 adult female 01day    34 adult female 05day    30 adult female 30day    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    30 embryo 04-06hr    32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    31 embryo 18-20hr    36 embryo 20-22hr    42 embryo 22-24hr    41 larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    32 white prepupae new    49 white prepupae 12hr    53 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day    35 adult male 05day    32 adult male 30day    31 adult female 01day    34 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  29 embryo 02-04hr  30 embryo 04-06hr  32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr  30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr  31 embryo 18-20hr  (36) embryo 20-22hr  (42) embryo 22-24hr  (41) larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  32 white prepupae new  (49) white prepupae 12hr  (53) white prepupae 24hr  26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day  (35) adult male 05day  32 adult male 30day  31 adult female 01day  (34) adult female 05day  30 adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    30 embryo 04-06hr    32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    31 embryo 18-20hr    36 embryo 20-22hr    42 embryo 22-24hr    41 larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    32 white prepupae new    49 white prepupae 12hr    53 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day    35 adult male 05day    32 adult male 30day    31 adult female 01day    34 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    30 embryo 04-06hr    32 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    30 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    31 embryo 18-20hr    36 embryo 20-22hr    42 embryo 22-24hr    41 larva L1    14 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    32 white prepupae new    49 white prepupae 12hr    53 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    24 adult male 01day    35 adult male 05day    32 adult male 30day    31 adult female 01day    34 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    6 embryonic 1182-4H    7 embryonic GM2    9 embryonic Kc167    12 embryonic S1    4 embryonic S3    6 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    10 ovary fGS/OSS    5 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033853 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6145-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG614590-3 CG6145LA00952 Phenotype manifest in Allele
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of CG6145 Class Mutagen Stocks Known lesion CG6145LA00952 P-element activity 2 -- CG6145CB-6864-3 1 -- CG6145d02819 P-element activity 1 -- CG6145f04526 piggyBac transposase 1 -- CG6145f05477 piggyBac transposase 1 -- CG6145KG02707 P-element activity 1 -- CG6145MI03574 1 -- CG6145MI06601 1 -- CG6145NP3008 1 -- CG61455-HA-2065 0 -- CG614590-3 Delta2-3 0 Yes CG6145d07644 P-element activity 0 -- CG6145EP2144 P-element activity 0 -- CG6145EP2229 P-element activity 0 -- CG6145rev1 Delta2-3 0 Yes CG6145rev2 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6145 Class Mutagen Stocks Known lesion CG6145GD16376 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG6145KK106577 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6145NIG.6145R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16376} NA P{KK106577} NA P{NIG.6145R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG6145EP2144 NA P{EP}CG6145EP2229 NA P{Mae-UAS.6.11}CG6145LA00952 NA P{XP}CG6145d02819 NA P{XP}CG6145d07644 NA miscellaneous insertions Mi{MIC}CG6145MI03574 NA Mi{MIC}CG6145MI06601 NA P{RS3}CG6145CB-6864-3 NA P{RS5}CG61455-HA-2065 NA P{SUPor-P}CG6145KG02707 NA PBac{WH}CG6145f04526 NA PBac{WH}CG6145f05477 NA insertion of enhancer trap binary system P{GawB}CG6145NP3008 No insertion of enhancer trap P{luc-sniffer}CG614590-3 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neuron projection morphogenesis inferred from mutant phenotype (Sepp et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
NAD+ kinase activity inferred from electronic annotation with InterPro:IPR002504, InterPro:IPR016064, InterPro:IPR017437, InterPro:IPR017438 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
NAD metabolic process inferred from electronic annotation with InterPro:IPR017437 (FlyBase Curators et al., 2004-) NADP biosynthetic process inferred from electronic annotation with InterPro:IPR002504 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG6145 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - CG17776 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - CG33156 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6145 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Prosα6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6145 - slmb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6145 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62262 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033853 DroID - A comprehensive database of gene and protein interactions. • FBgn0033853 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36506
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67M2HJ Dipteran inclusive ortholog search EOG6JDHG3 Insect inclusive ortholog search EOG6K6F0D Arthropod inclusive ortholog search EOG6NGF2V Metazoa inclusive ortholog search EOG60SC89
Orthologs in Drosophila Species (EOG67M2HJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6145     Drosophila simulans   Dsim\GD25753     Drosophila sechellia   Dsec\GM20270     Drosophila erecta   Dere\GG22483 Y   Drosophila yakuba   Dyak\GE13354 Y   Drosophila ananassae   Dana\GF11178     Drosophila pseudoobscura pseudoobscura   Dpse\GA24350     Drosophila persimilis   Dper\GL17067     Drosophila willistoni   Dwil\GK15610 Y   Drosophila virilis   Dvir\GJ19674     Drosophila mojavensis   Dmoj\GI21329     Drosophila grimshawi   Dgri\GH22633
Orthologs in non-Drosophila Dipterans (EOG6JDHG3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000278 Y Anopheles gambiae Malaria mosquito  Agam\AGAP011122 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018515 Y
Orthologs in non-Dipteran Insects (EOG6K6F0D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52716 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001254 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\ppnK Y Atta cephalotes Leafcutter ant  Acep\ACEP16393 Y Atta cephalotes Leafcutter ant  Acep\ACEP16390 Y Camponotus floridanus Florida carpenter ant  Cflo\ppnK Y Harpegnathos saltator Jerdons jumping ant  Hsal\ppnK Y Linepithema humile Argentine ant  Lhum\LH15307 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16667 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16666 Y Solenopsis invicta Red fire ant  Sinv\SINV13307 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006649 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007449 Y Pediculus humanus Human body louse  Phum\PHUM127760 Y Tribolium castaneum Red flour beetle  Tcas\TC006614 Y
Orthologs in non-Insect Arthropods (EOG6NGF2V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI Y Ixodes scapularis Deer tick  Isca\ISCW019567 Y
Orthologs in non-Arthropod Metazoa (EOG60SC89)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026156gn Y Danio rerio Zebrafish  Drer\nadka Y Danio rerio Zebrafish  Drer\ENSDARG00000076525 Y Danio rerio Zebrafish  Drer\nadkb Y Xenopus tropicalis Western clawed frog  Xtro\nadk Y Gallus gallus Domestic chicken  Ggal\NADK Y Mus musculus House mouse  Mmus\Nadk Y Rattus norvegicus Norway rat  Rnor\Nadk Y Homo sapiens Human  Hsap\NADK Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\NADK
AAA Orthologs (3) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG22483 Drosophila yakuba Dyak\GE13354 Drosophila willistoni Dwil\GK15610
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	42409 y1 w*; Mi{MIC}CG6145MI06601 37057 y1 w*; Mi{MIC}CG6145MI03574/SM6a 12917 y1 w67c23; P{SUPor-P}CG6145KG02707 22257 y1 w*; P{Mae-UAS.6.11}CG6145LA00952
Harvard	- P{XP}CG6145d02819 - PBac{WH}CG6145f04526 - PBac{WH}CG6145f05477
Kyoto	124243 w1118; P{RS3}CG6145CB-6864-3 104338 w1118; P{GawB}CG6145NP3008 / CyO
VDRC	v104271 P{KK106577}VIE-260B v48698 w1118; P{GD16376}v48698 v48699 w1118; P{GD16376}v48699
	More stocks available...
Genomic Clones ( 1 )
	BACR36J03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP03268 RE54276 RH58004
Other clones	DPiM_RH58004 MIP19477
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE44288 RE47108 RH11153 SD19788
Other clones	36458 44719 83232 83490 101858 117306 158236 190447 191460 CK01.7B.D8 Dmel_dig_018839_0677_0769 EK147237 EK160148 EK217464 EK236745 EK292852 EK293852 ESG012d.E21_E08 IP12927 IP13127 LD14711 RP003069358 RP003075055 RP003075057 RP003090262 RP003099144 RP003104929 RP003110686 RP003136983 RP003148243 RP003163421 RP003186564 RP003214719 RP003242484 RP003243213 RP003243407 RP003249624 RP003250678 RP003271093 RP003280568 RP003286208 RP003288121 RP003300165 RP003304279 RP003306824 RP003310610 RP003317002 RP003330077 RP003330819 RP003339332 RP003418785 RP003419113 RP003436368 RP003448043 RP003488150 RP003523141 RP003549488 RP003571447 RP003601503 RP003637822 RP003644183 RP003650943
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033853 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36506
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137040 NM_166003 NM_166004 NM_001169674 NM_001169675 RefSeq (Proteins) • NP_610884 NP_725314 NP_725315 NP_001163145 NP_001163146 DDBJ / EMBL / GenBank • AAF58358 AAL39874 AAM68589 AAM68590 ACZ94417 ACZ94418 AI259779 AQ072935 AQ073416 AW944017 AY069729 BH214596 BI629177 CZ473016 CZ473017 CZ475854 CZ487061 CZ488061 CZ488062 DU708677 Entrez Gene - A searchable database of RefSeq genes. • 36506 UniProtKB/TrEMBL • A1Z9F0 E1JH60 E1JH61 Q6IDH2 Q8SZX5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Inorganic polyphosphate/ATP-NAD kinase, predicted (IPR002504) ATP-NAD kinase-like domain (IPR016064) ATP-NAD kinase, PpnK-type, all-beta (IPR017437) Inorganic polyphosphate/ATP-NAD kinase, domain 1 (IPR017438)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62262 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033853 DroID - A comprehensive database of gene and protein interactions. • FBgn0033853 DRSC - Results from RNAi screens. • FBgn0033853 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033853 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6145-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033853 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36506 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36506 modMine - Data generated by the modENCODE project. • FBgn0033853
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG6145 (Keleman et al., 2009.8.5, Beckstead et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Sepp et al., 2008) CT19307 (Ceriani et al., 2002)
Name Synonym
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Stock list  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...