FB2021_05, released October 15, 2021

Gene: Dmel\CG6145

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General Information
Symbol
Dmel\CG6145
Species
D. melanogaster
Name
Annotation Symbol
CG6145
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033853
Gene Model Status
Current
Stock Availability
12 publicly available
Enzyme Name (EC)
NAD(+) kinase (2.7.1.23)
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
50B1-50B1
Sequence location
Recombination map
2-68
RefSeq locus
NT_033778 REGION:13537371..13547577
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables NAD+ kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000463643
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000003810
(FlyBase Curators, 2008--)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in NAD metabolic process
inferred from electronic annotation with InterPro:IPR017437
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in NADP biosynthetic process
inferred from sequence or structural similarity with SGD:S000003810
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000463643
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with SGD:S000003810
(FlyBase Curators, 2008--)
located_in nucleus
inferred from sequence or structural similarity with SGD:S000003810
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + NAD(+) = ADP + NADP(+) (2.7.1.23)
Summaries
Gene Group (FlyBase)
OTHER KINASES -
Other kinases are a collection of kinases that do not fit into any other major kinases.
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\CG6145 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG6145-RA
FBtr0087685
NM_137040
2213
520
CG6145-RB
FBtr0087687
NM_166004
1826
420
CG6145-RC
FBtr0087686
NM_166003
2260
548
CG6145-RE
FBtr0300192
NM_001169674
1843
483
CG6145-RF
FBtr0300193
NM_001169675
1989
484
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG6145-PA
FBpp0086805
57.5
520
6.57
NP_610884
AAF58358
CG6145-PB
FBpp0086807
46.8
420
6.19
NP_725315
AAM68590
CG6145-PC
FBpp0086806
61.3
548
6.95
NP_725314
AAM68589
CG6145-PE
FBpp0289429
53.8
483
7.09
NP_001163145
ACZ94417
CG6145-PF
FBpp0289430
54.1
484
7.33
NP_001163146
ACZ94418
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG6145 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.2}CG6145MI03574-TG4.2
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG6145 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG6145
Transgenic constructs containing regulatory region of CG6145
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NADK
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nadk
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Nadk
12 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\nadk
12 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\nadkb
11 of 15
Yes
Yes
Drer\nadka
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y77E11A.2
2 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (2)
Atha\NADK1
7 of 9
Yes
Yes
Atha\NADK2
4 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\UTR1
11 of 15
Yes
Yes
Scer\YEF1
11 of 15
Yes
Yes
Scer\POS5
5 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPAC3H5.11
8 of 12
Yes
No
Spom\SPAC1B1.02c
6 of 12
No
Yes
Spom\SPCC24B10.02c
6 of 12
No
Yes
Spom\pos5
3 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907U8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006564
Drosophila simulans
Dsim\GD25753
Drosophila sechellia
Dsec\GM20270
Drosophila erecta
Dere\GG22483
Drosophila yakuba
Dyak\GE13354
Drosophila ananassae
Dana\GF11178
Drosophila pseudoobscura pseudoobscura
Dpse\GA24350
Drosophila persimilis
Dper\GL17067
Drosophila willistoni
Dwil\GK15610
Drosophila virilis
Dvir\GJ19674
Drosophila mojavensis
Dmoj\GI21329
Drosophila grimshawi
Dgri\GH22633
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915057I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014019
Glossina morsitans
Tsetse fly
Gmor\GMOY010621
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13147
Mayetiola destructor
Hessian fly
Mdes\Mdes006596
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000278
Anopheles darlingi
American malaria mosquito
Adar\ADAC002517
Anopheles gambiae
Malaria mosquito
Agam\AGAP011122
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018515
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06JN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007449
Danaus plexippus
Monarch butterfly
Dple\DPOGS215492-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008354
Apis florea
Little honeybee
Aflo\2322783796
Apis mellifera
Western honey bee
Amel\GB52716
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18207
Bombus terrestris
Buff-tailed bumblebee
Bter\15206177
Linepithema humile
Argentine ant
Lhum\LH15307
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001188
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001254
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12134
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00464
Tribolium castaneum
Red flour beetle
Tcas\TC006614
Pediculus humanus
Human body louse
Phum\PHUM127760
Rhodnius prolixus
Kissing bug
Rpro\RPRC005309
Cimex lectularius
Bed bug
Clec\CLEC009713
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006649
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17206
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06FE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001689
Ixodes scapularis
Black-legged tick
Isca\ISCW019567
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72467.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur222g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g00260
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_187852
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09US )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nadk
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005331
Gallus gallus
Domestic chicken
Ggal\NADK
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG33156
9 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NADK; NAD kinase
    14 of 15
    611616
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        CG6145
        two hybrid
        (Hu et al., 2017.6.13)
        CG6145 - CG14402
        two hybrid
        (Hu et al., 2017.6.13)
        CG6145 - CG14407
        two hybrid
        (Hu et al., 2017.6.13)
        CG6145 - CG14615
        two hybrid
        (Hu et al., 2017.6.13)
        CG6145 - CG18371
        two hybrid
        (Hu et al., 2017.6.13)
        CG6145 - CG33156
        experimental knowledge based
        (Guruharsha et al., 2011)
        CG6145 - CG5111
        two hybrid
        (Hu et al., 2017.6.13)
        CG6145 - Vta1
        two hybrid
        (Hu et al., 2017.6.13)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Duox
        suppressible
        CG6145
        (Hurd et al., 2015)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-68
        Cytogenetic map
        50B1-50B1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        50B1-50B1
        Limits computationally determined from genome sequence between P{lacW}drkk13809&P{EP}mip120EP606 and P{lacW}l(2)03105k16702&P{lacW}fl(2)dk16105
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-68

        (FlyBase, 2016)

        2-72.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (12)
        Genomic Clones (19)
        cDNA Clones (60)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

        (Claridge-Chang et al., 2001)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 68 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (2)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (35)