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Gene Dmel\CG6543

General Information
Symbol	Dmel\CG6543	Species	D. melanogaster
Name		Annotation symbol	CG6543
Feature type	protein_coding_gene	FlyBase ID	FBgn0033879
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50C6-50C6	Sequence location	2R:9,740,452..9,741,836 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6543 (FBgn0033879). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: enoyl-CoA hydratase activity. Based on sequence similarity, it is predicted to be involved in the biological process: fatty acid beta-oxidation. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Crontonase, C-terminal; Crotonase superfamily; Enoyl-CoA hydratase/isomerase, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1640466_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG6543. Gene sequence location is 2R:9740452..9741836.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50C6-50C6   Limits computationally determined from genome sequence between P{lacW}l(2)03105k16702&P{lacW}fl(2)dk16105 and P{lacW}shotk03010
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6543 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency junction(s) not annotated. Gene model reviewed during 5.44 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6543-RA FBtr0087643  NM_137066   1051   295 CG6543-RB FBtr0087644  NM_166014   1124   295
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6543-PA   FBpp0086769   31.6   295   8.85     NP_610910   AAF58326 CG6543-PB   FBpp0086770   31.6   295   8.85     NP_725332   AAF58327
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Crotonase superfamily (IPR001753) Enoyl-CoA hydratase/isomerase, conserved site (IPR018376) Crontonase, C-terminal (IPR014748) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06543
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202990   AA820505   AA979188   AE013599 AAF58326   AE013599 AAF58327   AI063277   AI110092   AI114166   AI295521   AI387660   AI389748   AI456434   AI515245   AY232242   AY440918   BE976331   BF491934   BG640667   BI169511   BI170984   BI227602   BI237141   BI242331   BI242879   BI243777   BI351723   BI352442   BI352886   BI354757   BI362974   BI367798   BI565438   BI567110   BI570572   BI572308   BI572479   BI573144   BI575397   BI575815   BI577461   BI588042   BI591301   BI591342   BI593024   BI608386   BI616743   BI616760   BI623218   BI625341   BI626238   BI626469   BI627289   BI628332   BI629358   BI631295   BI631677   BI632987   BI633360   BI634427   BI636279   BI636369   BI639258   BQ103372   BQ103556   BT003259 AAO25016   BX008085   BX010288   BX024044   BX030650   BX045571   BX056124   BX058914   CK660078   CL610214   CO154326   CO182051   CO194479   CO195222   CO281826   CO283156   CO283618   CO288100   CO323043   CO335981   EC053186   EC063161   EC089937   EC207572   EC222200   EC250400   EC260962   EV578206   EV584916   GH747920   GH748217   GH748355   GH748433   GH749715   GH750114   GH750427   GH750978   GH752450   GH753073   GH753096   GH753644   GH753706   GH753759   GH754131   GH754577   GH756766   GH757037   GH757553   GH757850   GH757924   GH758142   GH759566   GH759586   GH760411   GH770681   GH774090   GH774145   GH774249   GH774612   GH775082   GH775808   GH776226   GH776389   GH777672   GH778223   GH781063   GH781618   GH781815   GH782138   GH782887   GH782968   GH783017   GH783166   GH783382   GH783688   GH784455   GH785360   GH785844   GH786096   GH787620   GH787884   GH788637   GH789507   GH791714   GH791998   GH792722   GH793618   GH794825   GH795662   GH796216   GH796518   GH796544   GH796688   GH797204   GH799012   GH800452   GH800893   GH801088   GH801220   GH802635   GH802968   GH804963   GH805525   GH805543   GH805802   GH806991   GH807186   GH807702   GH808342   GH808855   GH808889   GH809284   GH809709   GH809830   GH810124   GH811184   GH811994   GH812206   GH812441   GH812870   GH812949   GH813222   GH813233   GH813569   GH813772   GH815697   GH817554   GH817962   GH818528   GH818617   GH819524   GH819619   GH819668   GH820237   GH820892   GH822251   GH822626   GH823412   GH826497   GH827359   GH827462   GH828727   GH830048   GH830982   GH831867   GH833439   GH833452   GH833495   GH834668   GH834791   GH834960   GH835920   GH836169   GH836222   GH836514   GH838053   GH838145   GH840011   GH840018   GH840157   GH840216   GH840920   GH841233   GH841798   GH841886   GH843172   GH844236   GH845503   GH845756   GH846050   GH847436   GH847597   GH847640   GH850512   GH850530   GH850740   GH851670   GH852452   GH852838   GH854004   GH854356   GH857265   GH857287   GH857434   GH859297   GH859448   GH860574   GH860754   GH860978   GH861582   GH862245   GH862271   GH862385   GH862576   GH863708   GH863792   GH866916   GH867236   GH868091   GH868235   GH868426   GH868972   GH869502   GH870247   GH871018   GH871352   GH872326   GH873905   GH874586   GH874955   GH875531   GH875926   GH876176   GH877529   GH877945   GH878119   GH878469   GH879196   GH883272   GH883533   GH883906   GH884644   GH884753   GH885000   GH885660   GH885700   GH885971   GH886104   GH886228   GH886461   GH886480   GH887400   GH888237   GH890275   GH891529   GH891995   GH892561   GH892568   GH892608   GH893112   GH894570   GH895113   GH895774   GH896057   GH897194   GH897794   GH898239   GH898364   GH899715   GH899815   GH899918   GH900518   GH900656   GH902205   GH903207   GH904803   GH905117   GH906496   GH906868   GH908608   GH909281   GH909365   GH909520   GH909590   GH909785   GH910338   GH912723   GH913252   GH914480   GH914972   GH917066   GH918788   GH919931   GH920249   GH921334   GH922542   GH923773   GH926269   GH927252   GH930590   GH931291   GH931468   GH931560   GH932229   GH932335   GH932912   GH933939   GH935096   GH935758   GH936246   GH936870   GH937178   GH937796   GH938529   GH938680
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JR58
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   germline cell   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    668.425 Larval Midgut    1024.6 Larval Hindgut    1793.8 Larval Malpighian Tubules    1163.8 Larval Fat Body    828.6 Larval Salivary Gland    2047.9 Larval Trachea    1838.025 Larval Carcass    1799.45 Adult Head    997.7 Adult Eye    852.475 Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop    940.1 Adult Midgut    937.4 Adult Hindgut    757.4 Adult Malpighian Tubules    1281.4 Adult Fat Body    2016.2 Adult Salivary Gland    547.1 Adult Heart    1517.05 Adult VirginFemale Spermatheca    1279.3 Adult InseminatedFemale Spermatheca    702.5 Adult Ovary    879.3 Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass    1453.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (668.425) Larval Midgut  (1024.6) Larval Hindgut  (1793.8) Larval Malpighian Tubules  (1163.8) Larval Fat Body  (828.6) Larval Salivary Gland  (2047.9) Larval Trachea  (1838.025) Larval Carcass  (1799.45) Adult Head  (997.7) Adult Eye  (852.475) Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop  (940.1) Adult Midgut  (937.4) Adult Hindgut  (757.4) Adult Malpighian Tubules  (1281.4) Adult Fat Body  (2016.2) Adult Salivary Gland  (547.1) Adult Heart  (1517.05) Adult VirginFemale Spermatheca  (1279.3) Adult InseminatedFemale Spermatheca  (702.5) Adult Ovary  (879.3) Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass  (1453.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    668.425 Larval Midgut  1024.6 Larval Hindgut  (1793.8) Larval Malpighian Tubules  (1163.8) Larval Fat Body    828.6 Larval Salivary Gland  (2047.9) Larval Trachea  (1838.025) Larval Carcass  (1799.45) Adult Head    997.7 Adult Eye    852.475 Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop    940.1 Adult Midgut    937.4 Adult Hindgut    757.4 Adult Malpighian Tubules  (1281.4) Adult Fat Body  (2016.2) Adult Salivary Gland    547.1 Adult Heart  (1517.05) Adult VirginFemale Spermatheca  (1279.3) Adult InseminatedFemale Spermatheca    702.5 Adult Ovary    879.3 Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass  (1453.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    668.425 Larval Midgut    1024.6 Larval Hindgut    1793.8 Larval Malpighian Tubules    1163.8 Larval Fat Body    828.6 Larval Salivary Gland    2047.9 Larval Trachea    1838.025 Larval Carcass    1799.45 Adult Head    997.7 Adult Eye    852.475 Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop    940.1 Adult Midgut    937.4 Adult Hindgut    757.4 Adult Malpighian Tubules    1281.4 Adult Fat Body    2016.2 Adult Salivary Gland    547.1 Adult Heart    1517.05 Adult VirginFemale Spermatheca    1279.3 Adult InseminatedFemale Spermatheca    702.5 Adult Ovary    879.3 Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass    1453.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    668.425 Larval Midgut    1024.6 Larval Hindgut    1793.8 Larval Malpighian Tubules    1163.8 Larval Fat Body    828.6 Larval Salivary Gland    2047.9 Larval Trachea    1838.025 Larval Carcass    1799.45 Adult Head    997.7 Adult Eye    852.475 Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop    940.1 Adult Midgut    937.4 Adult Hindgut    757.4 Adult Malpighian Tubules    1281.4 Adult Fat Body    2016.2 Adult Salivary Gland    547.1 Adult Heart    1517.05 Adult VirginFemale Spermatheca    1279.3 Adult InseminatedFemale Spermatheca    702.5 Adult Ovary    879.3 Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass    1453.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  668.425 Larval Midgut  (1024.6) Larval Hindgut  (1793.8) Larval Malpighian Tubules  (1163.8) Larval Fat Body  (828.6) Larval Salivary Gland  (2047.9) Larval Trachea  (1838.025) Larval Carcass  (1799.45) Adult Head  (997.7) Adult Eye  (852.475) Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop  (940.1) Adult Midgut  (937.4) Adult Hindgut  757.4 Adult Malpighian Tubules  (1281.4) Adult Fat Body  (2016.2) Adult Salivary Gland  547.1 Adult Heart  (1517.05) Adult VirginFemale Spermatheca  (1279.3) Adult InseminatedFemale Spermatheca  702.5 Adult Ovary  (879.3) Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass  (1453.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    668.425 Larval Midgut  1024.6 Larval Hindgut  (1793.8) Larval Malpighian Tubules  1163.8 Larval Fat Body    828.6 Larval Salivary Gland  (2047.9) Larval Trachea  (1838.025) Larval Carcass  (1799.45) Adult Head    997.7 Adult Eye    852.475 Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop    940.1 Adult Midgut    937.4 Adult Hindgut    757.4 Adult Malpighian Tubules  1281.4 Adult Fat Body  (2016.2) Adult Salivary Gland    547.1 Adult Heart  1517.05 Adult VirginFemale Spermatheca  1279.3 Adult InseminatedFemale Spermatheca    702.5 Adult Ovary    879.3 Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass  1453.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    668.425 Larval Midgut    1024.6 Larval Hindgut    1793.8 Larval Malpighian Tubules    1163.8 Larval Fat Body    828.6 Larval Salivary Gland    2047.9 Larval Trachea    1838.025 Larval Carcass    1799.45 Adult Head    997.7 Adult Eye    852.475 Adult Brain    210.6 Adult Thoracic-Abdominal Ganglion    234.4 Adult Crop    940.1 Adult Midgut    937.4 Adult Hindgut    757.4 Adult Malpighian Tubules    1281.4 Adult Fat Body    2016.2 Adult Salivary Gland    547.1 Adult Heart    1517.05 Adult VirginFemale Spermatheca    1279.3 Adult InseminatedFemale Spermatheca    702.5 Adult Ovary    879.3 Adult Testis    167.3 Adult Male Accessory Gland    352.6 Adult Carcass    1453.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    997.7   NA  Eye    852.475   NA  Brain    210.6   668.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    234.4   NA  Crop    940.1   1024.6  Midgut    937.4   1793.8  Hindgut    757.4   1163.8  Malpighian Tubules    1281.4   828.6  Fat Body    2016.2   2047.9  Salivary Gland    547.1   NA  Heart    1517.05   1838.025  Trachea    NA   NA  VirginFemale Spermatheca    1279.3   NA  InseminatedFemale Spermatheca    702.5   NA  Ovary    879.3   NA  Testis    167.3   NA  Male Accessory Gland    352.6   1799.45  Carcass    1453.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female    62 head, virgin 4-day female    42 head, virgin 20-day female    76 head, mated 1-day female    32 head, mated 4-day female    30 head, mated 20-day female    57 head, mated 1-day male    54 head, mated 4-day male    41 head, mated 20-day male    52 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    90 digestive system, 4-day adult    43 digestive system, 20-day adult    62 fat body, larvae L3 wandering    73 fat body, white prepupae    19 fat body, pupae P8    49 carcass, larvae L3 wandering    38 carcass, 1-day adult    44 carcass, 4-day adult    35 carcass, 20-day adult    57 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    50 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (75) central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female  (62) head, virgin 4-day female  (42) head, virgin 20-day female  (76) head, mated 1-day female  (32) head, mated 4-day female  (30) head, mated 20-day female  (57) head, mated 1-day male  (54) head, mated 4-day male  (41) head, mated 20-day male  (52) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  (90) digestive system, 4-day adult  (43) digestive system, 20-day adult  (62) fat body, larvae L3 wandering  (73) fat body, white prepupae    19 fat body, pupae P8  (49) carcass, larvae L3 wandering  (38) carcass, 1-day adult  (44) carcass, 4-day adult  (35) carcass, 20-day adult  (57) ovary, virgin 4-day female  (100) ovary, mated 4-day female  (79) testis, mated 4-day male  (50) accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female    62 head, virgin 4-day female    42 head, virgin 20-day female    76 head, mated 1-day female    32 head, mated 4-day female    30 head, mated 20-day female    57 head, mated 1-day male    54 head, mated 4-day male    41 head, mated 20-day male    52 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    90 digestive system, 4-day adult    43 digestive system, 20-day adult    62 fat body, larvae L3 wandering    73 fat body, white prepupae    19 fat body, pupae P8    49 carcass, larvae L3 wandering    38 carcass, 1-day adult    44 carcass, 4-day adult    35 carcass, 20-day adult    57 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    50 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female    62 head, virgin 4-day female    42 head, virgin 20-day female    76 head, mated 1-day female    32 head, mated 4-day female    30 head, mated 20-day female    57 head, mated 1-day male    54 head, mated 4-day male    41 head, mated 20-day male    52 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    90 digestive system, 4-day adult    43 digestive system, 20-day adult    62 fat body, larvae L3 wandering    73 fat body, white prepupae    19 fat body, pupae P8    49 carcass, larvae L3 wandering    38 carcass, 1-day adult    44 carcass, 4-day adult    35 carcass, 20-day adult    57 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    50 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female    62 head, virgin 4-day female    42 head, virgin 20-day female    76 head, mated 1-day female    32 head, mated 4-day female    30 head, mated 20-day female    57 head, mated 1-day male    54 head, mated 4-day male    41 head, mated 20-day male    52 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    90 digestive system, 4-day adult    43 digestive system, 20-day adult    62 fat body, larvae L3 wandering    73 fat body, white prepupae    19 fat body, pupae P8    49 carcass, larvae L3 wandering    38 carcass, 1-day adult    44 carcass, 4-day adult    35 carcass, 20-day adult    57 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    50 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (75) central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female  (62) head, virgin 4-day female  (42) head, virgin 20-day female  (76) head, mated 1-day female  32 head, mated 4-day female  30 head, mated 20-day female  (57) head, mated 1-day male  (54) head, mated 4-day male  (41) head, mated 20-day male  (52) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  (90) digestive system, 4-day adult  (43) digestive system, 20-day adult  (62) fat body, larvae L3 wandering  (73) fat body, white prepupae    19 fat body, pupae P8  (49) carcass, larvae L3 wandering  (38) carcass, 1-day adult  (44) carcass, 4-day adult  (35) carcass, 20-day adult  (57) ovary, virgin 4-day female  (100) ovary, mated 4-day female  (79) testis, mated 4-day male  (50) accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female    62 head, virgin 4-day female    42 head, virgin 20-day female    76 head, mated 1-day female    32 head, mated 4-day female    30 head, mated 20-day female    57 head, mated 1-day male    54 head, mated 4-day male    41 head, mated 20-day male    52 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    90 digestive system, 4-day adult    43 digestive system, 20-day adult    62 fat body, larvae L3 wandering    73 fat body, white prepupae    19 fat body, pupae P8    49 carcass, larvae L3 wandering    38 carcass, 1-day adult    44 carcass, 4-day adult    35 carcass, 20-day adult    57 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    50 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    22 central nervous system, pupae P8    13 head, virgin 1-day female    62 head, virgin 4-day female    42 head, virgin 20-day female    76 head, mated 1-day female    32 head, mated 4-day female    30 head, mated 20-day female    57 head, mated 1-day male    54 head, mated 4-day male    41 head, mated 20-day male    52 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    90 digestive system, 4-day adult    43 digestive system, 20-day adult    62 fat body, larvae L3 wandering    73 fat body, white prepupae    19 fat body, pupae P8    49 carcass, larvae L3 wandering    38 carcass, 1-day adult    44 carcass, 4-day adult    35 carcass, 20-day adult    57 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    50 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    201 embryo 02-04hr    140 embryo 04-06hr    30 embryo 06-08hr    24 embryo 08-10hr    34 embryo 10-12hr    46 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    38 embryo 18-20hr    43 embryo 20-22hr    77 embryo 22-24hr    70 larva L1    284 larva L2    362 larva L3 12hr old    530 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    74 white prepupae new    74 white prepupae 12hr    60 white prepupae 24hr    75 pupae 2d postWPP    72 pupae 3d postWPP    64 pupae 4d postWPP    72 adult male 01day    115 adult male 05day    105 adult male 30day    89 adult female 01day    167 adult female 05day    171 adult female 30day    178 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (201) embryo 02-04hr  (140) embryo 04-06hr  (30) embryo 06-08hr    24 embryo 08-10hr  (34) embryo 10-12hr  (46) embryo 12-14hr  (36) embryo 14-16hr  (54) embryo 16-18hr  (38) embryo 18-20hr  (43) embryo 20-22hr  (77) embryo 22-24hr  (70) larva L1  (284) larva L2  (362) larva L3 12hr old  (530) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6  (112) larva L3 puffstage 7-9  (74) white prepupae new  (74) white prepupae 12hr  (60) white prepupae 24hr  (75) pupae 2d postWPP  (72) pupae 3d postWPP  (64) pupae 4d postWPP  (72) adult male 01day  (115) adult male 05day  (105) adult male 30day  (89) adult female 01day  (167) adult female 05day  (171) adult female 30day  (178) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (201) embryo 02-04hr  (140) embryo 04-06hr    30 embryo 06-08hr    24 embryo 08-10hr    34 embryo 10-12hr    46 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    38 embryo 18-20hr    43 embryo 20-22hr    77 embryo 22-24hr    70 larva L1  (284) larva L2  (362) larva L3 12hr old  (530) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6  (112) larva L3 puffstage 7-9    74 white prepupae new    74 white prepupae 12hr    60 white prepupae 24hr    75 pupae 2d postWPP    72 pupae 3d postWPP    64 pupae 4d postWPP    72 adult male 01day  (115) adult male 05day  105 adult male 30day    89 adult female 01day  (167) adult female 05day  (171) adult female 30day  (178) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    201 embryo 02-04hr    140 embryo 04-06hr    30 embryo 06-08hr    24 embryo 08-10hr    34 embryo 10-12hr    46 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    38 embryo 18-20hr    43 embryo 20-22hr    77 embryo 22-24hr    70 larva L1    284 larva L2    362 larva L3 12hr old    530 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    74 white prepupae new    74 white prepupae 12hr    60 white prepupae 24hr    75 pupae 2d postWPP    72 pupae 3d postWPP    64 pupae 4d postWPP    72 adult male 01day    115 adult male 05day    105 adult male 30day    89 adult female 01day    167 adult female 05day    171 adult female 30day    178 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    201 embryo 02-04hr    140 embryo 04-06hr    30 embryo 06-08hr    24 embryo 08-10hr    34 embryo 10-12hr    46 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    38 embryo 18-20hr    43 embryo 20-22hr    77 embryo 22-24hr    70 larva L1    284 larva L2    362 larva L3 12hr old    530 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    74 white prepupae new    74 white prepupae 12hr    60 white prepupae 24hr    75 pupae 2d postWPP    72 pupae 3d postWPP    64 pupae 4d postWPP    72 adult male 01day    115 adult male 05day    105 adult male 30day    89 adult female 01day    167 adult female 05day    171 adult female 30day    178 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (201) embryo 02-04hr  (140) embryo 04-06hr  30 embryo 06-08hr    24 embryo 08-10hr  (34) embryo 10-12hr  (46) embryo 12-14hr  (36) embryo 14-16hr  (54) embryo 16-18hr  (38) embryo 18-20hr  (43) embryo 20-22hr  (77) embryo 22-24hr  (70) larva L1  (284) larva L2  (362) larva L3 12hr old  (530) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6  (112) larva L3 puffstage 7-9  (74) white prepupae new  (74) white prepupae 12hr  (60) white prepupae 24hr  (75) pupae 2d postWPP  (72) pupae 3d postWPP  (64) pupae 4d postWPP  (72) adult male 01day  (115) adult male 05day  (105) adult male 30day  (89) adult female 01day  (167) adult female 05day  (171) adult female 30day  (178) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (201) embryo 02-04hr  140 embryo 04-06hr    30 embryo 06-08hr    24 embryo 08-10hr    34 embryo 10-12hr    46 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    38 embryo 18-20hr    43 embryo 20-22hr    77 embryo 22-24hr    70 larva L1  (284) larva L2  (362) larva L3 12hr old  (530) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6  112 larva L3 puffstage 7-9    74 white prepupae new    74 white prepupae 12hr    60 white prepupae 24hr    75 pupae 2d postWPP    72 pupae 3d postWPP    64 pupae 4d postWPP    72 adult male 01day  115 adult male 05day  105 adult male 30day    89 adult female 01day  (167) adult female 05day  (171) adult female 30day  (178) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    201 embryo 02-04hr    140 embryo 04-06hr    30 embryo 06-08hr    24 embryo 08-10hr    34 embryo 10-12hr    46 embryo 12-14hr    36 embryo 14-16hr    54 embryo 16-18hr    38 embryo 18-20hr    43 embryo 20-22hr    77 embryo 22-24hr    70 larva L1    284 larva L2    362 larva L3 12hr old    530 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    74 white prepupae new    74 white prepupae 12hr    60 white prepupae 24hr    75 pupae 2d postWPP    72 pupae 3d postWPP    64 pupae 4d postWPP    72 adult male 01day    115 adult male 05day    105 adult male 30day    89 adult female 01day    167 adult female 05day    171 adult female 30day    178 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    118 embryonic 1182-4H    102 embryonic GM2    44 embryonic Kc167    25 embryonic S1    106 embryonic S3    248 leg disc CME L1    68 wing disc CME-W2    67 wing disc ML-DmD8    97 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    208 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    117 eye-antennal disc ML-DmD11    174 antennal disc ML-DmD20-c5    164 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    25 ovary fGS/OSS    40 ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (75) Schneider line 2 Sg4  (118) embryonic 1182-4H  (102) embryonic GM2  (44) embryonic Kc167    25 embryonic S1  (106) embryonic S3  (248) leg disc CME L1  (68) wing disc CME-W2  (67) wing disc ML-DmD8  (97) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (208) wing disc ML-DmD32  (70) haltere disc ML-DmD17-c3  (117) eye-antennal disc ML-DmD11  (174) antennal disc ML-DmD20-c5  (164) mixed discs ML-DmD4-c1  (56) CNS ML-DmBG1-c1  (54) CNS ML-DmBG2-c2  (68) tumorous blood cells mbn2    25 ovary fGS/OSS  (40) ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4  (118) embryonic 1182-4H  102 embryonic GM2    44 embryonic Kc167    25 embryonic S1  106 embryonic S3  (248) leg disc CME L1    68 wing disc CME-W2    67 wing disc ML-DmD8    97 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    48 wing disc ML-DmD21  (208) wing disc ML-DmD32    70 haltere disc ML-DmD17-c3  (117) eye-antennal disc ML-DmD11  (174) antennal disc ML-DmD20-c5  (164) mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    25 ovary fGS/OSS    40 ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    118 embryonic 1182-4H    102 embryonic GM2    44 embryonic Kc167    25 embryonic S1    106 embryonic S3    248 leg disc CME L1    68 wing disc CME-W2    67 wing disc ML-DmD8    97 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    208 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    117 eye-antennal disc ML-DmD11    174 antennal disc ML-DmD20-c5    164 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    25 ovary fGS/OSS    40 ovary OSC    21 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    118 embryonic 1182-4H    102 embryonic GM2    44 embryonic Kc167    25 embryonic S1    106 embryonic S3    248 leg disc CME L1    68 wing disc CME-W2    67 wing disc ML-DmD8    97 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    208 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    117 eye-antennal disc ML-DmD11    174 antennal disc ML-DmD20-c5    164 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    25 ovary fGS/OSS    40 ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (75) Schneider line 2 Sg4  (118) embryonic 1182-4H  (102) embryonic GM2  (44) embryonic Kc167    25 embryonic S1  (106) embryonic S3  (248) leg disc CME L1  (68) wing disc CME-W2  (67) wing disc ML-DmD8  (97) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (208) wing disc ML-DmD32  (70) haltere disc ML-DmD17-c3  (117) eye-antennal disc ML-DmD11  (174) antennal disc ML-DmD20-c5  (164) mixed discs ML-DmD4-c1  (56) CNS ML-DmBG1-c1  (54) CNS ML-DmBG2-c2  (68) tumorous blood cells mbn2    25 ovary fGS/OSS  (40) ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4  118 embryonic 1182-4H  102 embryonic GM2    44 embryonic Kc167    25 embryonic S1  106 embryonic S3  (248) leg disc CME L1    68 wing disc CME-W2    67 wing disc ML-DmD8    97 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    48 wing disc ML-DmD21  (208) wing disc ML-DmD32    70 haltere disc ML-DmD17-c3  117 eye-antennal disc ML-DmD11  (174) antennal disc ML-DmD20-c5  (164) mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    25 ovary fGS/OSS    40 ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    118 embryonic 1182-4H    102 embryonic GM2    44 embryonic Kc167    25 embryonic S1    106 embryonic S3    248 leg disc CME L1    68 wing disc CME-W2    67 wing disc ML-DmD8    97 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    208 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    117 eye-antennal disc ML-DmD11    174 antennal disc ML-DmD20-c5    164 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    25 ovary fGS/OSS    40 ovary OSC    21 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    23 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    201 Cadmium 50 mM 12 hrs, larvae L3    101 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    65 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    74 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    238 Ethanol 10% 3 hrs, larvae L3    255 Caffeine 1.5 mg/ml 4 hrs, larvae L3    166 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    270 Rotenone 8 μg 12 hrs, larvae L3    380 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (27) cold shock, 4-day adult    23 heat shock, 4-day adult  (119) Cadmium 50 mM 6 hrs, larvae L3  (201) Cadmium 50 mM 12 hrs, larvae L3  (101) Cadmium 50 mM 48 hrs, 4-day adult  (131) Cadmium 100 mM 48 hrs, 4-day adult  (65) Copper 0.5 mM 12 hrs, larvae L3  (92) Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3  (74) Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (92) Ethanol 5% 3 hrs, larvae L3  (238) Ethanol 10% 3 hrs, larvae L3  (255) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (166) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (69) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (61) Paraquat 10 mM 48 hrs, 4-day adult  (75) Rotenone 2 μg 12 hrs, larvae L3  (270) Rotenone 8 μg 12 hrs, larvae L3  (380) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    23 heat shock, 4-day adult  (119) Cadmium 50 mM 6 hrs, larvae L3  (201) Cadmium 50 mM 12 hrs, larvae L3  101 Cadmium 50 mM 48 hrs, 4-day adult  (131) Cadmium 100 mM 48 hrs, 4-day adult    65 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    74 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3  (238) Ethanol 10% 3 hrs, larvae L3  (255) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (166) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3  (270) Rotenone 8 μg 12 hrs, larvae L3  (380) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    23 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    201 Cadmium 50 mM 12 hrs, larvae L3    101 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    65 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    74 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    238 Ethanol 10% 3 hrs, larvae L3    255 Caffeine 1.5 mg/ml 4 hrs, larvae L3    166 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    270 Rotenone 8 μg 12 hrs, larvae L3    380 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    23 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    201 Cadmium 50 mM 12 hrs, larvae L3    101 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    65 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    74 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    238 Ethanol 10% 3 hrs, larvae L3    255 Caffeine 1.5 mg/ml 4 hrs, larvae L3    166 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    270 Rotenone 8 μg 12 hrs, larvae L3    380 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  27 cold shock, 4-day adult    23 heat shock, 4-day adult  (119) Cadmium 50 mM 6 hrs, larvae L3  (201) Cadmium 50 mM 12 hrs, larvae L3  (101) Cadmium 50 mM 48 hrs, 4-day adult  (131) Cadmium 100 mM 48 hrs, 4-day adult  (65) Copper 0.5 mM 12 hrs, larvae L3  (92) Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3  (74) Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (92) Ethanol 5% 3 hrs, larvae L3  (238) Ethanol 10% 3 hrs, larvae L3  (255) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (166) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (69) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (61) Paraquat 10 mM 48 hrs, 4-day adult  (75) Rotenone 2 μg 12 hrs, larvae L3  (270) Rotenone 8 μg 12 hrs, larvae L3  (380) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    23 heat shock, 4-day adult  119 Cadmium 50 mM 6 hrs, larvae L3  (201) Cadmium 50 mM 12 hrs, larvae L3  101 Cadmium 50 mM 48 hrs, 4-day adult  131 Cadmium 100 mM 48 hrs, 4-day adult    65 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    74 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3  (238) Ethanol 10% 3 hrs, larvae L3  (255) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (166) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3  (270) Rotenone 8 μg 12 hrs, larvae L3  (380) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    23 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    201 Cadmium 50 mM 12 hrs, larvae L3    101 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    65 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    74 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    238 Ethanol 10% 3 hrs, larvae L3    255 Caffeine 1.5 mg/ml 4 hrs, larvae L3    166 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    270 Rotenone 8 μg 12 hrs, larvae L3    380 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD24265 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033879 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6543-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG6543 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG6543EY08499 viable, with Scer\GAL4pnr-MD237 CG6543GD11954 Sterility Allele fertile CG6543EY08499 Other Phenotypes Allele immune response defective | adult stage CG6543EY08499 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG6543 Class Mutagen Stocks Known lesion CG6543EY08499 P-element activity 1 -- CG6543NP1180 1 -- CG6543SH1959 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6543 Class Mutagen Stocks Known lesion CG6543GD11954 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG6543GL01031 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7128 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11954} NA P{TRiP.GL01031} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG6543EY08499 NA insertion of enhancer trap P{lacW}CG6543SH1959 No P{lacW}l(2)SH0882SH0882 No insertion of enhancer trap binary system P{GawB}CG6543NP1180 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
enoyl-CoA hydratase activity inferred from sequence or structural similarity with UniProtKB:P14604 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P30084 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
fatty acid beta-oxidation inferred from sequence or structural similarity with UniProtKB:P30084 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from sequence or structural similarity with UniProtKB:P30084 (Sardiello et al., 2003.6.11) mitochondrion inferred from sequence or structural similarity with UniProtKB:P14604 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG6543 - 5-HT7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Adam anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG10133 experimental knowledge based (Guruharsha et al., 2011) CG6543 - CG10750 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG11407 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG11534 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG12519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG12768 experimental knowledge based (Guruharsha et al., 2011) CG6543 - CG13385 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG13865 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG15484 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG16817 experimental knowledge based (Guruharsha et al., 2011) CG6543 - CG17323 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - CG18004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG2064 experimental knowledge based (Guruharsha et al., 2011) CG6543 - CG3088 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG31229 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - CG31712 experimental knowledge based (Guruharsha et al., 2011) CG6543 - CG32450 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG32549 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - CG3303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG3815 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG4004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG43755 experimental knowledge based (Guruharsha et al., 2011) CG6543 - CG4455 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG4962 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG5045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG5541 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG5565 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG6218 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CG8195 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - CG8891 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6543 - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Csat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - CtBP experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - Dip1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Drep-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Drip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Esp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Fer1HCH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Inos experimental knowledge based (Guruharsha et al., 2011) CG6543 - Jon65Ai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Kr-h2 experimental knowledge based (Guruharsha et al., 2011) CG6543 - Mes2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6543 - Nacα experimental knowledge based (Guruharsha et al., 2011) CG6543 - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - PGRP-LE anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6543 - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Pp2B-14D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Spindly experimental knowledge based (Guruharsha et al., 2011) CG6543 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - TER94 experimental knowledge based (Guruharsha et al., 2011) CG6543 - Tgt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - VhaM8.9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - capt experimental knowledge based (Guruharsha et al., 2011) CG6543 - dpr5 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - eEF1δ experimental knowledge based (Guruharsha et al., 2011) CG6543 - imd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - l(2)37Bb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - papi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - pio anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - ref(2)P experimental knowledge based (Guruharsha et al., 2011) CG6543 - roq anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6543 - ssp experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6543 - tub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6543 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62290 DroID - A comprehensive database of gene and protein interactions. • FBgn0033879 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36536
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZKK6G Dipteran inclusive ortholog search EOG67D9R0 Insect inclusive ortholog search EOG6J3VD9 Arthropod inclusive ortholog search EOG61ZCT4 Metazoa inclusive ortholog search EOG6Q8HS4
Orthologs in Drosophila Species (EOG6ZKK6G)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6543     Drosophila simulans   Dsim\GD25738 Y   Drosophila sechellia   Dsec\GM20252 Y   Drosophila erecta   Dere\GG22466 Y   Drosophila yakuba   Dyak\GE13337 Y   Drosophila ananassae   Dana\GF11161 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19673 Y   Drosophila persimilis   Dper\GL16995 Y   Drosophila willistoni   Dwil\GK17937 Y   Drosophila virilis   Dvir\GJ20693 Y   Drosophila mojavensis   Dmoj\GI20973 Y   Drosophila grimshawi   Dgri\GH20865 Y
Orthologs in non-Drosophila Dipterans (EOG67D9R0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003993   Anopheles gambiae Malaria mosquito  Agam\AGAP011833   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006455   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014621
Orthologs in non-Dipteran Insects (EOG6J3VD9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40460   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020640   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15982   Atta cephalotes Leafcutter ant  Acep\ACEP14694   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14306   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15223   Linepithema humile Argentine ant  Lhum\LH12182   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16390   Solenopsis invicta Red fire ant  Sinv\SINV18212   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001292   Bombyx mori Silkmoth  Bmor\BGIBMGA005656   Pediculus humanus Human body louse  Phum\PHUM328140   Tribolium castaneum Red flour beetle  Tcas\TC005928
Orthologs in non-Insect Arthropods (EOG61ZCT4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_322268   Ixodes scapularis Deer tick  Isca\ISCW012475
Orthologs in non-Arthropod Metazoa (EOG6Q8HS4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ech-7   Caenorhabditis elegans Nematode  Cele\ech-6   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022370gn   Danio rerio Zebrafish  Drer\echs1   Xenopus tropicalis Western clawed frog  Xtro\echs1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030329   Mus musculus House mouse  Mmus\Echs1   Rattus norvegicus Norway rat  Rnor\Echs1   Homo sapiens Human  Hsap\ECHS1
Human Orthologs (1)
Gene OMIM HGNC Hsap\ECHS1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25738 Drosophila sechellia Dsec\GM20252 Drosophila erecta Dere\GG22466 Drosophila yakuba Dyak\GE13337 Drosophila ananassae Dana\GF11161 Drosophila pseudoobscura pseudoobscura Dpse\GA19673 Drosophila persimilis Dper\GL16995 Drosophila willistoni Dwil\GK17937 Drosophila virilis Dvir\GJ20693 Drosophila mojavensis Dmoj\GI20973 Drosophila grimshawi Dgri\GH20865
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	36813 y1 sc* v1; P{TRiP.GL01031}attP2 20026 y1 w67c23; P{EPgy2}CG6543EY08499
Kyoto	103918 y* w*; P{GawB}CG6543NP1180 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v27658 w1118; P{GD11954}v27658 v27659 w1118; P{GD11954}v27659
Genomic Clones ( 2 )
	BACR06M19 BACR16G12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 346 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24265
Other clones	yak-ad_CG6543
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT28782 GH09552 GH10867 GH18243 GH20993 GM15851 GM19285 GM21175 GM28159 LD03412 LD33482 LD33716 LD36455 LD46984 LP09181 LP18330 RE10703 RE12624 RE24701 RE33311 RE39631 RE40353 RE41508 RE47671 RE53643 RE71142 RH05047 RH05096 RH05328 RH07789 RH08006 RH08860 RH10886 RH12822 RH29047 RH31020 RH32134 RH36963 RH38478 RH46806 RH46830 RH55318 RH56702 RH58209 RH60843 RH61304 RH63213 RH65685 RH66804 RH67422 RH68555 SD11805 SD17913 SD18022 SD21802 SD26904 SD27430
Other clones	39591 63897 175777 523441 bs49d12 CK01.85C.A6 Dmel_dig_009789_0660_1783 Dmel_dig_015099_0618_3421 EC22035 EC38644 EC39883 EC053186 EK067735 EK158903 EK162404 EK163762 EK189546 EN03927 EN11608 RP003004224 RP003014188 RP003016383 RP003017007 RP003017423 RP003018565 RP003018786 RP003019035 RP003019550 RP003021013 RP003024056 RP003025384 RP003026268 RP003026693 RP003027016 RP003032254 RP003035319 RP003039459 RP003051012 RP003052344 RP003059692 RP003060470 RP003060518 RP003065083 RP003070934 RP003071691 RP003072556 RP003072830 RP003081926 RP003082335 RP003082903 RP003083005 RP003085624 RP003089279 RP003093144 RP003096112 RP003099424 RP003101405 RP003101600 RP003110067 RP003112189 RP003119500 RP003120339 RP003120733 RP003121100 RP003122357 RP003123930 RP003126082 RP003127731 RP003127780 RP003127917 RP003133458 RP003134444 RP003136058 RP003137842 RP003138902 RP003138906 RP003139329 RP003139958 RP003141085 RP003142091 RP003149104 RP003150336 RP003151839 RP003152152 RP003152651 RP003153156 RP003153390 RP003154358 RP003154878 RP003156514 RP003157105 RP003161242 RP003162765 RP003165598 RP003166196 RP003166350 RP003170993 RP003171551 RP003172897 RP003173308 RP003175664 RP003177181 RP003183505 RP003183601 RP003186700 RP003197684 RP003199167 RP003199533 RP003200111 RP003204454 RP003205342 RP003207004 RP003213754 RP003216919 RP003217047 RP003217810 RP003220282 RP003222341 RP003223981 RP003225046 RP003227321 RP003229068 RP003232728 RP003235488 RP003240130 RP003241918 RP003244315 RP003250275 RP003250516 RP003250727 RP003254191 RP003255707 RP003255730 RP003256261 RP003268732 RP003269707 RP003274836 RP003275736 RP003281457 RP003284016 RP003284217 RP003284542 RP003288617 RP003289050 RP003291472 RP003294300 RP003295823 RP003302701 RP003306349 RP003308071 RP003310287 RP003312855 RP003314758 RP003317920 RP003318741 RP003319704 RP003326413 RP003326527 RP003326667 RP003327486 RP003330239 RP003332980 RP003333060 RP003336130 RP003336643 RP003336994 RP003337050 RP003340634 RP003341164 RP003345138 RP003347888 RP003350916 RP003355456 RP003356282 RP003359118 RP003368428 RP003370420 RP003381754 RP003382779 RP003385387 RP003386684 RP003387215 RP003400676 RP003401413 RP003403398 RP003405160 RP003405783 RP003410280 RP003413604 RP003416099 RP003427714 RP003432242 RP003435535 RP003437203 RP003439392 RP003440529 RP003451452 RP003451991 RP003452131 RP003459795 RP003460549 RP003460653 RP003461707 RP003461769 RP003462021 RP003465688 RP003473059 RP003474391 RP003481119 RP003481157 RP003484212 RP003485412 RP003489193 RP003489796 RP003489839 RP003499137 RP003501403 RP003501848 RP003502365 RP003503144 RP003504520 RP003506134 RP003508989 RP003511244 RP003512775 RP003514603 RP003516316 RP003519799 RP003520833 RP003521363 RP003522228 RP003523509 RP003526660 RP003527499 RP003528471 RP003539684 RP003542162 RP003542506 RP003544336 RP003545667 RP003546104 RP003548455 RP003549624 RP003556310 RP003560913 RP003565262 RP003565846 RP003566843 RP003567693 RP003568887 RP003570400 RP003572359 RP003574379 RP003577545 RP003579484 RP003580294 RP003581239 RP003587688 RP003592523 RP003597751 RP003602117 RP003604897 RP003607370 RP003607475 RP003609489 RP003612862 RP003618318 RP003619706 RP003622989 RP003633382 RP003633470 RP003634264 RP003640504 RP003642552 RP003645122 RP003647907 RP003651941 RP003655378 RP003656762 RP003666398 RP003668402 RP003669995 RP003678982 RP003680830 RP003682663 UUGC0776 UUGC0963
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033879 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36536
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6543 CG18645 (FlyBase, 1996-)
Additional comments	Source for merge of CG6543 CG18645 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137066 NM_166014 RefSeq (Proteins) • NP_610910 NP_725332 DDBJ / EMBL / GenBank • AA820505 AAF58326 AAF58327 AAO25016 BT003259 CL610214 Entrez Gene - A searchable database of RefSeq genes. • 36536 UniProtKB/TrEMBL • Q7JR58
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Crotonase superfamily (IPR001753) Enoyl-CoA hydratase/isomerase, conserved site (IPR018376) Crontonase, C-terminal (IPR014748) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06543 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24265
Linkouts
	BioGRID - A database of protein and genetic interactions • 62290 DroID - A comprehensive database of gene and protein interactions. • FBgn0033879 DRSC - Results from RNAi screens. • FBgn0033879 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033879 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6543-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033879 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36536 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36536 modMine - Data generated by the modENCODE project. • FBgn0033879
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG6543 (Beller et al., 2006, Cermelli et al., 2006, Terhzaz et al., 2006, Mosallanejad et al., 2010, Ni et al., 2011.7.19, Palanker et al., 2009, Fujikawa et al., 2009, Hughes et al., 2008, Cammarato et al., 2011, Fisher et al., 2008) CG18645   Echs1 (Von Ohlen et al., 2012)
Name Synonym
Secondary FlyBase IDs
	FBgn0033878
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Von Ohlen et al., 2012, Infect. Immun. 80(10): 3576--3586 Identification of Critical Host Mitochondrion-Associated Genes during Ehrlichia chaffeensis Infections. [FBrf0219421] Show all research papers ...