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Gene Dmel\Ctf4

General Information
Symbol	Dmel\Ctf4	Species	D. melanogaster
Name		Annotation symbol	CG13350
Feature type	protein_coding_gene	FlyBase ID	FBgn0033890
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50C23-50C23	Sequence location	2R:9,867,867..9,870,979 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Ctf4 (CG13350, FBgn0033890). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: preblastoderm mitotic cell cycle; mitotic cell cycle; DNA endoreduplication. 7 alleles are reported. The phenotypes of these alleles are annotated with: polytene chromosome; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein of unknown function DUF3639; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623830_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG13350. Gene sequence location is 2R:9867867..9870979.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA06380 BKN27329
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50C23-50C23   Limits computationally determined from genome sequence between P{lacW}Cp1k15819&P{EP}CG6701EP2054 and P{lacW}mamk05821
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ctf4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	<new comment> DGC clone SD03057 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ctf4-RA FBtr0087606  NM_137077   3113   895
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ctf4-PA   FBpp0086732   96.6   895   4.98     NP_610921   AAF58306
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) Protein of unknown function DUF3639 (IPR022100)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58306   AI531792   AI532556   AW944281   AX154831   AY061581 AAL29129   BE977299   BF486650   BF494459   BF495874   BF505242   BG633515   BI234774   BI241718   BI483474   BI635217   BP555558   BP559866   BT023774   CK604764   CK604765   CO154677   CO283475   CO320377   CO342445   CZ479710   CZ479711   DQ138854 ABA86460   EC073495   EC231798   EC257243   EC265603   GH748728   GH749043   GH754981   GH755166   GH755499   GH773262   GH773312   GH783169   GH785125   GH787369   GH795077   GH809550   GH810202   GH816514   GH821127   GH827552   GH829441   GH832126   GH838515   GH841268   GH846476   GH847771   GH851945   GH858464   GH859108   GH862082   GH862178   GH867389   GH874926   GH878775   GH880558   GH881573   GH883159   GH889495   GH896592   GH897633   GH903528   GH911284   GH921252   GH924956   GH929738   GH932056   GH935786   GH937071
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2XY08 Q95R77 Q494K2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033890    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033890 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033890 expression level Developmental Stage   Expression Level embryo 00-02hr    5721 embryo 02-04hr    1490 embryo 04-06hr    2156 embryo 06-08hr    1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day    2168 adult female 30day    2485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5721) embryo 02-04hr  (1490) embryo 04-06hr  (2156) embryo 06-08hr  (1451) embryo 08-10hr  (905) embryo 10-12hr  (625) embryo 12-14hr  (276) embryo 14-16hr  (541) embryo 16-18hr  (302) embryo 18-20hr  (151) embryo 20-22hr  (108) embryo 22-24hr  (110) larva L1  (666) larva L2  (528) larva L3 12hr old  (346) larva L3 puffstage 1-2  (259) larva L3 puffstage 3-6  (333) larva L3 puffstage 7-9  (289) white prepupae new  (258) white prepupae 12hr  (442) white prepupae 24hr  (392) pupae 2d postWPP  (136) pupae 3d postWPP    92 pupae 4d postWPP  (184) adult male 01day  (172) adult male 05day  (225) adult male 30day  (264) adult female 01day  (1300) adult female 05day  (2168) adult female 30day  (2485) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5721) embryo 02-04hr  1490 embryo 04-06hr  (2156) embryo 06-08hr  1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day  (2168) adult female 30day  (2485) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5721 embryo 02-04hr    1490 embryo 04-06hr    2156 embryo 06-08hr    1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day    2168 adult female 30day    2485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5721 embryo 02-04hr    1490 embryo 04-06hr    2156 embryo 06-08hr    1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day    2168 adult female 30day    2485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033890 expression level Developmental Stage   Expression Level embryo 00-02hr    5721 embryo 02-04hr    1490 embryo 04-06hr    2156 embryo 06-08hr    1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day    2168 adult female 30day    2485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5721) embryo 02-04hr  (1490) embryo 04-06hr  (2156) embryo 06-08hr  (1451) embryo 08-10hr  (905) embryo 10-12hr  (625) embryo 12-14hr  (276) embryo 14-16hr  (541) embryo 16-18hr  (302) embryo 18-20hr  (151) embryo 20-22hr  108 embryo 22-24hr  110 larva L1  (666) larva L2  (528) larva L3 12hr old  (346) larva L3 puffstage 1-2  (259) larva L3 puffstage 3-6  (333) larva L3 puffstage 7-9  (289) white prepupae new  (258) white prepupae 12hr  (442) white prepupae 24hr  (392) pupae 2d postWPP  136 pupae 3d postWPP    92 pupae 4d postWPP  (184) adult male 01day  (172) adult male 05day  (225) adult male 30day  (264) adult female 01day  (1300) adult female 05day  (2168) adult female 30day  (2485) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5721) embryo 02-04hr  1490 embryo 04-06hr  2156 embryo 06-08hr  1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day  2168 adult female 30day  (2485) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5721 embryo 02-04hr    1490 embryo 04-06hr    2156 embryo 06-08hr    1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day    2168 adult female 30day    2485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5721 embryo 02-04hr    1490 embryo 04-06hr    2156 embryo 06-08hr    1451 embryo 08-10hr    905 embryo 10-12hr    625 embryo 12-14hr    276 embryo 14-16hr    541 embryo 16-18hr    302 embryo 18-20hr    151 embryo 20-22hr    108 embryo 22-24hr    110 larva L1    666 larva L2    528 larva L3 12hr old    346 larva L3 puffstage 1-2    259 larva L3 puffstage 3-6    333 larva L3 puffstage 7-9    289 white prepupae new    258 white prepupae 12hr    442 white prepupae 24hr    392 pupae 2d postWPP    136 pupae 3d postWPP    92 pupae 4d postWPP    184 adult male 01day    172 adult male 05day    225 adult male 30day    264 adult female 01day    1300 adult female 05day    2168 adult female 30day    2485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033890    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033890 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033890 expression level Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033890 expression level Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    113.3 Larval Midgut    6.8 Larval Hindgut    37.3 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    94.5 Larval Trachea    53.55 Larval Carcass    49.625 Adult Head no informative data Adult Eye    9.05 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    332.2 Adult Testis    36.2 Adult Male Accessory Gland    38.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    9.05   NA  Brain    no informative data   113.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   6.8  Midgut    no informative data   37.3  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   94.5  Salivary Gland    no informative data   NA  Heart    no informative data   53.55  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    332.2   NA  Testis    36.2   NA  Male Accessory Gland    38.3   49.625  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033890 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13350-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | adult stage, with Scer\GAL4Act.PU Ctf4GD4433 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Ctf4GD4433 Other Phenotypes Allele chemical sensitive | larval stage, with Scer\GAL4Act.PU Ctf4GD4433 endomitotic cell cycle defective | larval stage, with Scer\GAL4Act.PU Ctf4GD4433 mitotic cell cycle defective | cleavage stage | maternal effect | heat sensitive Ctf4GD4433 mitotic cell cycle defective | larval stage, with Scer\GAL4Act.PU Ctf4GD4433 visible, with Scer\GAL4pnr-MD237 Ctf4GD4433 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Ctf4GD4433 polytene chromosome, with Scer\GAL4Act.PU Ctf4GD4433
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Ctf4 Class Mutagen Stocks Known lesion Ctf4CB-0870-3 1 -- Ctf4e01894 piggyBac transposase 1 -- Ctf4G3237 P-element activity 1 -- Ctf4GS2275 1 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ctf4 Class Mutagen Stocks Known lesion Ctf4GD4433 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ctf4HMS00764 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ctf4KK107329 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7129 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}Ctf4CB-0870-3 NA PBac{RB}Ctf4e01894 NA insertion of mobile activating element P{EP}Ctf4G3237 NA P{GSV1}CG6701GS2275 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
DNA endoreduplication inferred from mutant phenotype (Gosnell and Christensen, 2011) mitotic cell cycle inferred from mutant phenotype (Gosnell and Christensen, 2011) preblastoderm mitotic cell cycle inferred from mutant phenotype (Gosnell and Christensen, 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
DNA binding inferred from sequence or structural similarity with UniProtKB:O75717 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ctf4 allele Gene References unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033890 DroID - A comprehensive database of gene and protein interactions. • FBgn0033890 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36551
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11148 Dere\GG22452 Dgri\GH22947 Dmoj\GI18438 Dper\GL20084 Dpse\GA12225 Dsec\GM20238 Dsim\GD25724 Dvir\GJ21522 Dwil\GK19526 Dyak\GE13323
Curated drosophilid orthologs	Dere\GG22452 (Comeron and Guthrie, 2005.7.21) Dpse\GA12225   Dsim\GD25724 (Comeron and Guthrie, 2005.7.21) Dyak\GE13323 (Comeron and Guthrie, 2005.7.21)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001399-PA Aedes aegypti (mosquito) AGAP007423-PA Anopheles gambiae (mosquito) XP_393361.3 Apis mellifera (honey bee) XP_001944662.1 Acyrthosiphon pisum (pea aphid) At3g42660.1 Arabidopsis thaliana (wall cress) 84660 Batrachochytrium dendrobatidis (chytrid fungus) 122323 Branchiostoma floridae (lancelet) BGIBMGA003534-PA Bombyx mori (silk worm) ENSBTAP00000025453 Bos taurus (bovine) CAL0000499 Candida albicans (a form of yeast) CN14232 Caenorhabditis brenneri (small nematode) CBP20643 Caenorhabditis briggsae (nematode) CE05657 Caenorhabditis elegans (worm) ENSCAFP00000022083 Canis familiaris (dog) CAGL0D04862g Candida glabrata (haploid yeast) ENSCINP00000012393 Ciona intestinalis (sea squirt) JA14218 Caenorhabditis japonica (nematode) cn10253 Cryptococcus neoformans (yeast-like fungus) CPIJ013601 Culex pipens (mosquito) ENSCPOP00000003106 Cavia porcellus (guinea pig) RP28332 Caenorhabditis remanei (nematode) ENSCSAVP00000002573 Ciona savignyi (sedentary tunicate) 108416 Capitella spl (polychaete worm) DDB0189629 Dictyostelium discoideum (amoeba) DEHA2E08470g Debaryomyces Hansenii (yeast) 65744 Daphnia pulex (daphnia) ENSECAP00000013243 Equus caballus (horse) ENSGACP00000022875 Gymnopilus aculeatus (mushroom) ENSGALP00000019893 Gallus gallus (chicken) ENSP00000353793 Homo sapiens (human) ISCW019022-PA Ixodes scapularis (deer tick) 110682 Lottia gigantea (owl limpet) LmjF12.1220 Leishmania major (virus) 23531 Monocosta brevicollis (choanoflagellate) ENSMODP00000014659 Monodelphis domestica (gray opossum) ENSMMUP00000000409 Macaca mulatta (rhesus monkey) ENSMUSP00000107421 Mus musculus (house mouse) 20744 Nematostella vectensis (starlet anemone) XP_001607060.1 Nasonia vitripennis (wasp) ENSORLP00000024510 Oryzias latipes (japanese killifish) LOC_Os09g06560.1 Oryza sativa (asian rice) 37422 Ostreococcus tauri (green alga) PHUM002787-PA Pediculus humanus (human body louse) PP00664 Pristionchus pacificus (nematode) ENSPPYP00000006628 Pongo pygmaeus (orangutan) 75107 Phytophthora ramorum (sudden oak death pathogen) 133166 Phytophthora sojae (root rot pathogen) 661832 Populus trichocarpa (black cottonwood) ENSPTRP00000040950 Pan troglodytes (chimpanzee) ENSRNOP00000015100 Rattus norvegicus (norway rat) 4865014 Sorghum bicolor (sorghum) Smp_054610 Schistosoma mansoni (trematode parasite) SPAPB1E7.02c Schizosaccharomyces pombe (fission yeast) 32433 Trichoplax adhaerens (metazoa) XP_972092.1 Tribolium castaneum (red flour beetle) Tc00.1047053506529.130 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510885.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021986 Tetraodon nigroviridis (green spotted pufferfish) 269422 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039340 Takifugu rubripes (pufferfish Takifugu) 91714.m00082 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026675 Xenopus tropicalis (frog) YALI0A20636g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12374 LH17917 ISCW019022 FBgn0084708 FBgn0221524 FBgn0208642 FBgn0084111 FBgn0175121 JGI_V11_65744 FBgn0072271 FBgn0157679 FBgn0141177 FBgn0130404 FBgn0084742 FBgn0088188 CPIJ013601 BGIBMGA003534 ACYPI006805 GB15749 AGAP007423 AAEL001399 PB20666 PHUM375670 GLEAN_12023
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	28457 y1 w*; P{EP}Ctf4G3237 32968 y1 sc* v1; P{TRiP.HMS00764}attP2/TM3, Sb1
Harvard	- PBac{RB}Ctf4e01894
Kyoto	123350 w1118; P{RS3}Ctf4CB-0870-3 200381 y1 w67c23; P{GSV1}CG6701GS2275/SM1
VDRC	v108242 P{KK107329}VIE-260B v44474 w1118; P{GD4433}v44474 v44475 w1118; P{GD4433}v44475/CyO
Genomic Clones ( 1 )
	BACR06M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47422 SD03057
Other clones	DPiM_LD47422
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03066 AT07428 AT09559 AT21114 RE30530 RE38855 RE66376 SD04096 SD16503
Other clones	43954 214243.37 524004 bs62b02 CK01.128A.G5 EK163356 EK284509 EN04562 EP14928 FGM235H08 FGM323D03 GH28831 RP003002235 RP003011788 RP003036330 RP003044299 RP003065862 RP003079098 RP003087722 RP003093422 RP003106050 RP003118408 RP003123344 RP003148383 RP003163759 RP003175675 RP003180568 RP003207287 RP003211726 RP003226614 RP003228976 RP003242759 RP003310063 RP003316306 RP003322443 RP003342003 RP003345284 RP003360126 RP003398516 RP003427776 RP003431764 RP003439614 RP003448468 RP003475830 RP003480308 RP003493400 RP003542859 RP003551125 RP003557827 RP003558293 RP003563669 RP003578762 RP003620749 RP003633866 RP003671755 RP003677521 UT01434
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033890 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36551
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ctf4 CG13350 (Gosnell and Christensen, 2011)
Source for database merge of	Source for merge of: CG13350 anon-WO0140519.180 (FlyBase, 1996-)
Additional comments	Source for merge of CG13350 anon-WO0140519.180 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137077 RefSeq (Proteins) • NP_610921 DDBJ / EMBL / GenBank • AAF58306 AAL29129 ABA86460 AI531792 AW944281 AX154831 AY061581 CZ479710 CZ479711 DQ138854 Entrez Gene - A searchable database of RefSeq genes. • 36551 UniProtKB/TrEMBL • Q2XY08 Q95R77 Q494K2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) Protein of unknown function DUF3639 (IPR022100)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033890 DroID - A comprehensive database of gene and protein interactions. • FBgn0033890 DRSC - Results from RNAi screens. • FBgn0033890 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033890 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13350-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033890 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36551 InParanoid A subset of ortholog calls from InParanoid. • AAEL001399-PA Aedes aegypti (mosquito) AGAP007423-PA Anopheles gambiae (mosquito) XP_393361.3 Apis mellifera (honey bee) XP_001944662.1 Acyrthosiphon pisum (pea aphid) At3g42660.1 Arabidopsis thaliana (wall cress) 84660 Batrachochytrium dendrobatidis (chytrid fungus) 122323 Branchiostoma floridae (lancelet) BGIBMGA003534-PA Bombyx mori (silk worm) ENSBTAP00000025453 Bos taurus (bovine) CAL0000499 Candida albicans (a form of yeast) CN14232 Caenorhabditis brenneri (small nematode) CBP20643 Caenorhabditis briggsae (nematode) CE05657 Caenorhabditis elegans (worm) ENSCAFP00000022083 Canis familiaris (dog) CAGL0D04862g Candida glabrata (haploid yeast) ENSCINP00000012393 Ciona intestinalis (sea squirt) JA14218 Caenorhabditis japonica (nematode) cn10253 Cryptococcus neoformans (yeast-like fungus) CPIJ013601 Culex pipens (mosquito) ENSCPOP00000003106 Cavia porcellus (guinea pig) RP28332 Caenorhabditis remanei (nematode) ENSCSAVP00000002573 Ciona savignyi (sedentary tunicate) 108416 Capitella spl (polychaete worm) DDB0189629 Dictyostelium discoideum (amoeba) DEHA2E08470g Debaryomyces Hansenii (yeast) 65744 Daphnia pulex (daphnia) ENSECAP00000013243 Equus caballus (horse) ENSGACP00000022875 Gymnopilus aculeatus (mushroom) ENSGALP00000019893 Gallus gallus (chicken) ENSP00000353793 Homo sapiens (human) ISCW019022-PA Ixodes scapularis (deer tick) 110682 Lottia gigantea (owl limpet) LmjF12.1220 Leishmania major (virus) 23531 Monocosta brevicollis (choanoflagellate) ENSMODP00000014659 Monodelphis domestica (gray opossum) ENSMMUP00000000409 Macaca mulatta (rhesus monkey) ENSMUSP00000107421 Mus musculus (house mouse) 20744 Nematostella vectensis (starlet anemone) XP_001607060.1 Nasonia vitripennis (wasp) ENSORLP00000024510 Oryzias latipes (japanese killifish) LOC_Os09g06560.1 Oryza sativa (asian rice) 37422 Ostreococcus tauri (green alga) PHUM002787-PA Pediculus humanus (human body louse) PP00664 Pristionchus pacificus (nematode) ENSPPYP00000006628 Pongo pygmaeus (orangutan) 75107 Phytophthora ramorum (sudden oak death pathogen) 133166 Phytophthora sojae (root rot pathogen) 661832 Populus trichocarpa (black cottonwood) ENSPTRP00000040950 Pan troglodytes (chimpanzee) ENSRNOP00000015100 Rattus norvegicus (norway rat) 4865014 Sorghum bicolor (sorghum) Smp_054610 Schistosoma mansoni (trematode parasite) SPAPB1E7.02c Schizosaccharomyces pombe (fission yeast) 32433 Trichoplax adhaerens (metazoa) XP_972092.1 Tribolium castaneum (red flour beetle) Tc00.1047053506529.130 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510885.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021986 Tetraodon nigroviridis (green spotted pufferfish) 269422 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039340 Takifugu rubripes (pufferfish Takifugu) 91714.m00082 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026675 Xenopus tropicalis (frog) YALI0A20636g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36551 modMine - Data generated by the modENCODE project. • FBgn0033890 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12374 LH17917 ISCW019022 FBgn0084708 FBgn0221524 FBgn0208642 FBgn0084111 FBgn0175121 JGI_V11_65744 FBgn0072271 FBgn0157679 FBgn0141177 FBgn0130404 FBgn0084742 FBgn0088188 CPIJ013601 BGIBMGA003534 ACYPI006805 GB15749 AGAP007423 AAEL001399 PB20666 PHUM375670 GLEAN_12023
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	anon-WO0140519.180   CG13350 (Gregory et al., 2007, Gosnell and Christensen, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5) Ctf4
Name Synonym
Secondary FlyBase IDs
	FBgn0044696
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 3 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 3 ) Automatic genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 1 )
	Gosnell and Christensen, 2011, BMC Mol. Biol. 12: 13 Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression. [FBrf0213597] Show all research papers ...