Ofut1, neurotic, nti, O-fut, O-fucosyl transferase
modifies Notch by attaching fucose within EGF domains - positively required for Notch signaling, essential for the physical interaction of Notch with its ligand Delta and for the ability of Fringe to modulate this interaction
Gene model reviewed during 5.50
Interacts with N (via its EGF domains); the interaction is required for the endocyctic transport of N.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\O-fut1 using the Feature Mapper tool.
Transcript is detected uniformly throughout early embryos and gradually disappears by stage 11.
Transcript is highly expressed in the lymph gland and germ cells of the gonad in post Stage 12 embryos. The transcript is uniform in some larval tissues such as the wing, haltere, leg and antennal discs but shows an increased level of expression posterior to the morphogenetic furrow in eye discs and a complex expression pattern in the larval central nervous system.
GBrowse - Visual display of RNA-Seq signalsView Dmel\O-fut1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Embryos derived from homozygous germline clones show a strong neurogenic phenotype. Zygotic mutant embryos have a normal nervous system. Mutant clones in the wing result in loss of wing margin and vein thickening.