Gene Dmel\CG8485

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General Information

Symbol

Dmel\CG8485

Species

D. melanogaster

Name

Annotation symbol

CG8485

Feature type

protein_coding_gene

FlyBase ID

FBgn0033915

Gene Model Status

Current

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

50E4-50E4

Sequence location

2R:10,123,292..10,127,208 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG8485 (FBgn0033915). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: SAP kinase activity. It is reported to be involved in the biological process: protein phosphorylation. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult hindgut, adult heart, adult fat body, adult female reproductive system, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628969_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of CG8485. Gene sequence location is 2R:10123292..10127208.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

Controlled Vocabulary Terms

cellular_component

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50E4-50E4

Limits computationally determined from genome sequence between P{lacW}l(2)s3475^s3475&P{lacW}Hsc70-5^k04907 and P{PZ}Tfb1⁰⁶⁹⁴⁹&P{PZ}l(2)03563⁰³⁵⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG8485 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG8485-RA

FBtr0087569

NM_137098

3198

860

CG8485-RB

FBtr0087571

NM_166041

2990

860

CG8485-RC

FBtr0087572

NM_166042

3175

860

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG8485-PA

FBpp0086695

96.3

860

8.33

NP_610942

AAF58274

CG8485-PB

FBpp0086697

96.3

860

8.33

NP_725370

AAM70994

CG8485-PC

FBpp0086698

96.3

860

8.33

NP_725371

AAM70995

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290)

Serine/threonine-protein kinase, active site (IPR008271)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult hindgut, adult heart, adult fat body, adult female reproductive system, adult testis, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		284.6
Larval Midgut		60.2
Larval Hindgut		90.3
Larval Malpighian Tubules		50.5
Larval Fat Body		54.5
Larval Salivary Gland		81
Larval Trachea		59.25
Larval Carcass		71.7
Adult Head		174.5
Adult Eye		80.35
Adult Brain		367.8
Adult Thoracic-Abdominal Ganglion		229.4
Adult Crop		94.1
Adult Midgut		73.3
Adult Hindgut		101.1
Adult Malpighian Tubules		69.2
Adult Fat Body		480.3
Adult Salivary Gland		73
Adult Heart		180.925
Adult VirginFemale Spermatheca		435.1
Adult InseminatedFemale Spermatheca		343.4
Adult Ovary		351.3
Adult Testis		118.8
Adult Male Accessory Gland		84.1
Adult Carcass		146.7
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	174.5
NA	Eye	80.35
NA	Brain	367.8
284.6	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	229.4
NA	Crop	94.1
60.2	Midgut	73.3
90.3	Hindgut	101.1
50.5	Malpighian Tubules	69.2
54.5	Fat Body	480.3
81	Salivary Gland	73
NA	Heart	180.925
59.25	Trachea	NA
NA	VirginFemale Spermatheca	435.1
NA	InseminatedFemale Spermatheca	343.4
NA	Ovary	351.3
NA	Testis	118.8
NA	Male Accessory Gland	84.1
71.7	Carcass	146.7

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		51
ovary, mated 4-day female		43
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		(32)
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		(27)
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		(51)
ovary, mated 4-day female		(43)
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		51
ovary, mated 4-day female		43
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		51
ovary, mated 4-day female		43
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		51
ovary, mated 4-day female		43
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		(51)
ovary, mated 4-day female		(43)
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		51
ovary, mated 4-day female		43
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		24
central nervous system, larvae L3		26
central nervous system, pupae P8		32
head, virgin 1-day female		17
head, virgin 4-day female		23
head, virgin 20-day female		14
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		13
head, mated 1-day male		27
head, mated 4-day male		26
head, mated 20-day male		26
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		6
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		16
carcass, larvae L3 wandering		14
carcass, 1-day adult		10
carcass, 4-day adult		12
carcass, 20-day adult		12
ovary, virgin 4-day female		51
ovary, mated 4-day female		43
testis, mated 4-day male		21
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		47
embryo 02-04hr		35
embryo 04-06hr		39
embryo 06-08hr		46
embryo 08-10hr		46
embryo 10-12hr		41
embryo 12-14hr		33
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(47)
embryo 02-04hr		(35)
embryo 04-06hr		(39)
embryo 06-08hr		(46)
embryo 08-10hr		(46)
embryo 10-12hr		(41)
embryo 12-14hr		(33)
embryo 14-16hr		(27)
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		(28)
adult female 30day		(30)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		47
embryo 02-04hr		35
embryo 04-06hr		39
embryo 06-08hr		46
embryo 08-10hr		46
embryo 10-12hr		41
embryo 12-14hr		33
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		47
embryo 02-04hr		35
embryo 04-06hr		39
embryo 06-08hr		46
embryo 08-10hr		46
embryo 10-12hr		41
embryo 12-14hr		33
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		47
embryo 02-04hr		35
embryo 04-06hr		39
embryo 06-08hr		46
embryo 08-10hr		46
embryo 10-12hr		41
embryo 12-14hr		33
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(47)
embryo 02-04hr		(35)
embryo 04-06hr		(39)
embryo 06-08hr		(46)
embryo 08-10hr		(46)
embryo 10-12hr		(41)
embryo 12-14hr		(33)
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		47
embryo 02-04hr		35
embryo 04-06hr		39
embryo 06-08hr		46
embryo 08-10hr		46
embryo 10-12hr		41
embryo 12-14hr		33
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		47
embryo 02-04hr		35
embryo 04-06hr		39
embryo 06-08hr		46
embryo 08-10hr		46
embryo 10-12hr		41
embryo 12-14hr		33
embryo 14-16hr		27
embryo 16-18hr		22
embryo 18-20hr		16
embryo 20-22hr		18
embryo 22-24hr		21
larva L1		14
larva L2		12
larva L3 12hr old		8
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		12
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		22
pupae 2d postWPP		19
pupae 3d postWPP		13
pupae 4d postWPP		7
adult male 01day		14
adult male 05day		15
adult male 30day		15
adult female 01day		18
adult female 05day		28
adult female 30day		30
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		38
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		45
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		(38)
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		(45)
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		(27)
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		38
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		45
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		38
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		45
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		38
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		45
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		(38)
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		(45)
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		38
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		45
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		26
Schneider line 2 Sg4		14
embryonic 1182-4H		15
embryonic GM2		22
embryonic Kc167		17
embryonic S1		17
embryonic S3		19
leg disc CME L1		17
wing disc CME-W2		14
wing disc ML-DmD8		12
wing disc ML-DmD9		12
wing disc ML-DmD16-c3		38
wing disc ML-DmD21		15
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		16
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		45
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		24
ovary fGS/OSS		27
ovary OSC		20
ovary OSS		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		(35)
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		(31)
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(34)
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		(30)
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		(35)
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(34)
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		21
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		5
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		11
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		22
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033915

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG8485-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | adult stage, with Scer\GAL4^pnr-MD237

CG8485^GD13939

Other Phenotypes

Allele

body color defective, with Scer\GAL4^pnr-MD237

CG8485^GD13939

visible, with Scer\GAL4^pnr-MD237

CG8485^GD13939

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CG8485^GD13939

trichogen cell, with Scer\GAL4^pnr-MD237

CG8485^GD13939

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG8485	Class	Mutagen	Stocks	Known lesion
CG8485^c00431		piggyBac transposase	1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG8485	Class	Mutagen	Stocks	Known lesion
CG8485^GD13939		in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG8485^GL00097		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Disrupted in

Df(2R)Exel7131

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD13939}

P{TRiP.GL00097}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}CG8485^c00431

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

There is no information supporting a cellular component term for this gene.

(Based on a review of available data on: 2013-03-14)

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(FlyBase Curators et al., 2004-)

protein serine/threonine kinase activity

non-traceable author statement

(Morrison et al., 2000)

SAP kinase activity

inferred from sequence or structural similarity with EMBL:AF074714

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271

(FlyBase Curators et al., 2004-)

non-traceable author statement

(Morrison et al., 2000)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG8485 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0033915

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

36579

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

Q0E981

Orthologs

OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6QC1QV

Dipteran inclusive ortholog search

EOG6614C3

Insect inclusive ortholog search

EOG6PZH2N

Arthropod inclusive ortholog search

EOG61G1K6

Metazoa inclusive ortholog search

EOG6GBM07

Orthologs in Drosophila Species (EOG6QC1QV)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21109

Drosophila persimilis

Dper\GL10204

Drosophila willistoni

Dwil\GK20862

Drosophila virilis

Dvir\GJ22300

Drosophila mojavensis

Dmoj\GI20450

Drosophila grimshawi

Dgri\GH20041

Orthologs in non-Drosophila Dipterans (EOG6614C3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003896

Anopheles gambiae

Malaria mosquito

Agam\AGAP001752

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003599

Orthologs in non-Dipteran Insects (EOG6PZH2N)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC413510

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG018486

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH14022

Atta cephalotes

Leafcutter ant

Acep\ACEP13267

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO17852

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL17488

Linepithema humile

Argentine ant

Lhum\LH22278

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB12422

Solenopsis invicta

Red fire ant

Sinv\SINV19412

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003493

Bombyx mori

Silkmoth

Bmor\BGIBMGA011673

Pediculus humanus

Human body louse

Phum\PHUM188260

Tribolium castaneum

Red flour beetle

Tcas\TC010386

Orthologs in non-Insect Arthropods (EOG61G1K6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\CELA3B

Ixodes scapularis

Deer tick

Isca\ISCW022262

Orthologs in non-Arthropod Metazoa (EOG6GBM07)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\ZK524.4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020786gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028687gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000102gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004413gn

Danio rerio

Zebrafish

Drer\snrk1

Danio rerio

Zebrafish

Drer\snrk

Xenopus tropicalis

Western clawed frog

Xtro\snrk

Gallus gallus

Domestic chicken

Ggal\SNRK

Mus musculus

House mouse

Mmus\Snrk

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000037772

Rattus norvegicus

Norway rat

Rnor\Snrk

Homo sapiens

Human

Hsap\SNRK

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\SNRK

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21109

Drosophila persimilis

Dper\GL10204

Drosophila willistoni

Dwil\GK20862

Drosophila virilis

Dvir\GJ22300

Drosophila mojavensis

Dmoj\GI20450

Drosophila grimshawi

Dgri\GH20041

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

35217

y¹ sc^* v¹; P{TRiP.GL00097}attP2

Harvard

PBac{PB}CG8485^c00431

VDRC

v35940

w¹¹¹⁸; P{GD13939}v35940

v35939

w¹¹¹⁸; P{GD13939}v35939/TM3

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 70 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

FI07852

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0033915

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

36579

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

FlyBase curator comment: the insertion in the "e04168" Exelixis line (PBac{RB}CG8494^e04168) was originally assigned to the CG8485 gene in FBrf0179797, resulting in the "CG8485^e04168" (FBal0160915) allele. However, FBrf0184340 shows that the insertion is actually within CG8494.

(Bloomington Drosophila Stock Center, 2004.11.6)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

36579

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290)

Serine/threonine-protein kinase, active site (IPR008271)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0033915

DRSC - Results from RNAi screens.

•

FBgn0033915

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033915

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG8485-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0033915

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

36579

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

36579

modMine - Data generated by the modENCODE project.

•

FBgn0033915

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

Q0E981

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

152964_at

(Kristensen et al., 2005)

CG8485

(Ni et al., 2011.7.19)

SNRK

(Morrison et al., 2000)

Name Synonym

Secondary FlyBase IDs

References ( 24 )

Generate a list of

All references relating to this gene ( 24 )

List References by type

Recent research papers ( 2 )

Shaukat et al., 2012, PLoS ONE 7(10): e47447: A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. [FBrf0219770]
Dottorini et al., 2011, BMC Bioinformatics 12: 34: Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379]

Show all research papers ...