Gene Dmel\Arc1

FlyGene Wiki Help Close All Open All

General Information

Symbol

Dmel\Arc1

Species

D. melanogaster

Name

Activity-regulated cytoskeleton associated protein 1

Annotation symbol

CG12505

Feature type

protein_coding_gene

FlyBase ID

FBgn0033926

Gene Model Status

Current

Stock availability

8 publicly available

Also Known As

dARC1

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

50F6-50F6

Sequence location

2R:10,245,432..10,247,802 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Activity-regulated cytoskeleton associated protein 1 is referred to in FlyBase by the symbol Dmel\Arc1 (CG12505, FBgn0033926). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: behavioral response to starvation; muscle system process. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger, CCHC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late larval stages, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult fat body, adult salivary gland, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639180_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Arc1. Gene sequence location is 2R:10245432..10247802.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50F6-50F6

Limits computationally determined from genome sequence between P{lacW}l(2)s3475^s3475&P{lacW}Hsc70-5^k04907 and P{PZ}Tfb1⁰⁶⁹⁴⁹&P{PZ}l(2)03563⁰³⁵⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Arc1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Arc1-RA

FBtr0087560

NM_137111

2371

254

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Arc1-PA

FBpp0086687

28.9

254

6.44

NP_610955

AAF58256

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, CCHC-type (IPR001878)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q7K1U0

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

ring gland | restricted

(Mattaliano et al., 2007)

neuron | subset

(Mattaliano et al., 2007)

ventral nerve cord | restricted

(Mattaliano et al., 2007)

adult stage

ventral nerve cord | restricted

(Mattaliano et al., 2007)

adult pars intercerebralis | restricted

(Mattaliano et al., 2007)

adult brain | lateral & restricted

(Mattaliano et al., 2007)

adult antennal lobe | restricted

(Mattaliano et al., 2007)

adult subesophageal ganglion | restricted

(Mattaliano et al., 2007)

neurosecretory neuron | subset

(Mattaliano et al., 2007)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Arc1 is expressed in a number of large neurons that innervate the larval ring gland. It is expressed in all dilp+ median cells and in several other pars neurosecretory cells.

(Mattaliano et al., 2007)

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

sarcomere

inferred from direct assay

(Montana and Littleton, 2006)

synapse

inferred from direct assay

(Montana and Littleton, 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult fat body, adult salivary gland, adult ovary, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		830.325
Larval Midgut		6265.3
Larval Hindgut		3934.1
Larval Malpighian Tubules		1676.4
Larval Fat Body		413.4
Larval Salivary Gland		5732.1
Larval Trachea		3444.75
Larval Carcass		4403.375
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		1426.1
Adult Crop		1674.1
Adult Midgut		4680
Adult Hindgut		1358.3
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		1940.775
Adult VirginFemale Spermatheca		1138
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		7016.9
Adult Carcass		1154.7
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		(830.325)
Larval Midgut		(6265.3)
Larval Hindgut		(3934.1)
Larval Malpighian Tubules		(1676.4)
Larval Fat Body		413.4
Larval Salivary Gland		(5732.1)
Larval Trachea		(3444.75)
Larval Carcass		(4403.375)
Adult Head		(669.1)
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		(1426.1)
Adult Crop		(1674.1)
Adult Midgut		(4680)
Adult Hindgut		(1358.3)
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		(1940.775)
Adult VirginFemale Spermatheca		(1138)
Adult InseminatedFemale Spermatheca		(782)
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		(7016.9)
Adult Carcass		(1154.7)
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		830.325
Larval Midgut		(6265.3)
Larval Hindgut		(3934.1)
Larval Malpighian Tubules		(1676.4)
Larval Fat Body		413.4
Larval Salivary Gland		(5732.1)
Larval Trachea		(3444.75)
Larval Carcass		(4403.375)
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		(1426.1)
Adult Crop		(1674.1)
Adult Midgut		(4680)
Adult Hindgut		(1358.3)
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		(1940.775)
Adult VirginFemale Spermatheca		(1138)
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		(7016.9)
Adult Carcass		(1154.7)
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		830.325
Larval Midgut		6265.3
Larval Hindgut		3934.1
Larval Malpighian Tubules		1676.4
Larval Fat Body		413.4
Larval Salivary Gland		5732.1
Larval Trachea		3444.75
Larval Carcass		4403.375
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		1426.1
Adult Crop		1674.1
Adult Midgut		4680
Adult Hindgut		1358.3
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		1940.775
Adult VirginFemale Spermatheca		1138
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		7016.9
Adult Carcass		1154.7
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		830.325
Larval Midgut		6265.3
Larval Hindgut		3934.1
Larval Malpighian Tubules		1676.4
Larval Fat Body		413.4
Larval Salivary Gland		5732.1
Larval Trachea		3444.75
Larval Carcass		4403.375
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		1426.1
Adult Crop		1674.1
Adult Midgut		4680
Adult Hindgut		1358.3
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		1940.775
Adult VirginFemale Spermatheca		1138
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		7016.9
Adult Carcass		1154.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		(830.325)
Larval Midgut		(6265.3)
Larval Hindgut		(3934.1)
Larval Malpighian Tubules		(1676.4)
Larval Fat Body		413.4
Larval Salivary Gland		(5732.1)
Larval Trachea		(3444.75)
Larval Carcass		(4403.375)
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		(1426.1)
Adult Crop		(1674.1)
Adult Midgut		(4680)
Adult Hindgut		(1358.3)
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		(1940.775)
Adult VirginFemale Spermatheca		(1138)
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		(7016.9)
Adult Carcass		(1154.7)
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		830.325
Larval Midgut		(6265.3)
Larval Hindgut		(3934.1)
Larval Malpighian Tubules		1676.4
Larval Fat Body		413.4
Larval Salivary Gland		(5732.1)
Larval Trachea		(3444.75)
Larval Carcass		(4403.375)
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		1426.1
Adult Crop		1674.1
Adult Midgut		(4680)
Adult Hindgut		1358.3
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		(1940.775)
Adult VirginFemale Spermatheca		1138
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		(7016.9)
Adult Carcass		1154.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		830.325
Larval Midgut		6265.3
Larval Hindgut		3934.1
Larval Malpighian Tubules		1676.4
Larval Fat Body		413.4
Larval Salivary Gland		5732.1
Larval Trachea		3444.75
Larval Carcass		4403.375
Adult Head		669.1
Adult Eye		136.575
Adult Brain		512.3
Adult Thoracic-Abdominal Ganglion		1426.1
Adult Crop		1674.1
Adult Midgut		4680
Adult Hindgut		1358.3
Adult Malpighian Tubules		90.8
Adult Fat Body		136.8
Adult Salivary Gland		185.6
Adult Heart		1940.775
Adult VirginFemale Spermatheca		1138
Adult InseminatedFemale Spermatheca		782
Adult Ovary		476
Adult Testis		267.1
Adult Male Accessory Gland		7016.9
Adult Carcass		1154.7
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	669.1
NA	Eye	136.575
NA	Brain	512.3
830.325	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	1426.1
NA	Crop	1674.1
6265.3	Midgut	4680
3934.1	Hindgut	1358.3
1676.4	Malpighian Tubules	no informative data
413.4	Fat Body	136.8
5732.1	Salivary Gland	185.6
NA	Heart	1940.775
3444.75	Trachea	NA
NA	VirginFemale Spermatheca	1138
NA	InseminatedFemale Spermatheca	782
NA	Ovary	476
NA	Testis	267.1
NA	Male Accessory Gland	7016.9
4403.375	Carcass	1154.7

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		485
central nervous system, larvae L3		216
central nervous system, pupae P8		51
head, virgin 1-day female		56
head, virgin 4-day female		48
head, virgin 20-day female		96
head, mated 1-day female		43
head, mated 4-day female		32
head, mated 20-day female		71
head, mated 1-day male		53
head, mated 4-day male		46
head, mated 20-day male		119
salivary gland, larvae L3 wandering		583
salivary gland, white prepupae		2258
digestive system, larvae L3 wandering		2811
digestive system, 1-day adult		935
digestive system, 4-day adult		595
digestive system, 20-day adult		1142
fat body, larvae L3 wandering		103
fat body, white prepupae		119
fat body, pupae P8		347
carcass, larvae L3 wandering		458
carcass, 1-day adult		251
carcass, 4-day adult		240
carcass, 20-day adult		689
ovary, virgin 4-day female		118
ovary, mated 4-day female		103
testis, mated 4-day male		283
accessory gland, mated 4-day male		1611
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(485)
central nervous system, larvae L3		(216)
central nervous system, pupae P8		(51)
head, virgin 1-day female		(56)
head, virgin 4-day female		(48)
head, virgin 20-day female		(96)
head, mated 1-day female		(43)
head, mated 4-day female		(32)
head, mated 20-day female		(71)
head, mated 1-day male		(53)
head, mated 4-day male		(46)
head, mated 20-day male		(119)
salivary gland, larvae L3 wandering		(583)
salivary gland, white prepupae		(2258)
digestive system, larvae L3 wandering		(2811)
digestive system, 1-day adult		(935)
digestive system, 4-day adult		(595)
digestive system, 20-day adult		(1142)
fat body, larvae L3 wandering		(103)
fat body, white prepupae		(119)
fat body, pupae P8		(347)
carcass, larvae L3 wandering		(458)
carcass, 1-day adult		(251)
carcass, 4-day adult		(240)
carcass, 20-day adult		(689)
ovary, virgin 4-day female		(118)
ovary, mated 4-day female		(103)
testis, mated 4-day male		(283)
accessory gland, mated 4-day male		(1611)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(485)
central nervous system, larvae L3		(216)
central nervous system, pupae P8		51
head, virgin 1-day female		56
head, virgin 4-day female		48
head, virgin 20-day female		96
head, mated 1-day female		43
head, mated 4-day female		32
head, mated 20-day female		71
head, mated 1-day male		53
head, mated 4-day male		46
head, mated 20-day male		(119)
salivary gland, larvae L3 wandering		(583)
salivary gland, white prepupae		(2258)
digestive system, larvae L3 wandering		(2811)
digestive system, 1-day adult		(935)
digestive system, 4-day adult		(595)
digestive system, 20-day adult		(1142)
fat body, larvae L3 wandering		103
fat body, white prepupae		(119)
fat body, pupae P8		(347)
carcass, larvae L3 wandering		(458)
carcass, 1-day adult		(251)
carcass, 4-day adult		(240)
carcass, 20-day adult		(689)
ovary, virgin 4-day female		(118)
ovary, mated 4-day female		103
testis, mated 4-day male		(283)
accessory gland, mated 4-day male		(1611)
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		485
central nervous system, larvae L3		216
central nervous system, pupae P8		51
head, virgin 1-day female		56
head, virgin 4-day female		48
head, virgin 20-day female		96
head, mated 1-day female		43
head, mated 4-day female		32
head, mated 20-day female		71
head, mated 1-day male		53
head, mated 4-day male		46
head, mated 20-day male		119
salivary gland, larvae L3 wandering		583
salivary gland, white prepupae		2258
digestive system, larvae L3 wandering		2811
digestive system, 1-day adult		935
digestive system, 4-day adult		595
digestive system, 20-day adult		1142
fat body, larvae L3 wandering		103
fat body, white prepupae		119
fat body, pupae P8		347
carcass, larvae L3 wandering		458
carcass, 1-day adult		251
carcass, 4-day adult		240
carcass, 20-day adult		689
ovary, virgin 4-day female		118
ovary, mated 4-day female		103
testis, mated 4-day male		283
accessory gland, mated 4-day male		1611
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		485
central nervous system, larvae L3		216
central nervous system, pupae P8		51
head, virgin 1-day female		56
head, virgin 4-day female		48
head, virgin 20-day female		96
head, mated 1-day female		43
head, mated 4-day female		32
head, mated 20-day female		71
head, mated 1-day male		53
head, mated 4-day male		46
head, mated 20-day male		119
salivary gland, larvae L3 wandering		583
salivary gland, white prepupae		2258
digestive system, larvae L3 wandering		2811
digestive system, 1-day adult		935
digestive system, 4-day adult		595
digestive system, 20-day adult		1142
fat body, larvae L3 wandering		103
fat body, white prepupae		119
fat body, pupae P8		347
carcass, larvae L3 wandering		458
carcass, 1-day adult		251
carcass, 4-day adult		240
carcass, 20-day adult		689
ovary, virgin 4-day female		118
ovary, mated 4-day female		103
testis, mated 4-day male		283
accessory gland, mated 4-day male		1611
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(485)
central nervous system, larvae L3		(216)
central nervous system, pupae P8		(51)
head, virgin 1-day female		(56)
head, virgin 4-day female		(48)
head, virgin 20-day female		(96)
head, mated 1-day female		(43)
head, mated 4-day female		32
head, mated 20-day female		(71)
head, mated 1-day male		(53)
head, mated 4-day male		(46)
head, mated 20-day male		(119)
salivary gland, larvae L3 wandering		(583)
salivary gland, white prepupae		(2258)
digestive system, larvae L3 wandering		(2811)
digestive system, 1-day adult		(935)
digestive system, 4-day adult		(595)
digestive system, 20-day adult		(1142)
fat body, larvae L3 wandering		(103)
fat body, white prepupae		(119)
fat body, pupae P8		(347)
carcass, larvae L3 wandering		(458)
carcass, 1-day adult		(251)
carcass, 4-day adult		(240)
carcass, 20-day adult		(689)
ovary, virgin 4-day female		(118)
ovary, mated 4-day female		(103)
testis, mated 4-day male		(283)
accessory gland, mated 4-day male		(1611)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(485)
central nervous system, larvae L3		(216)
central nervous system, pupae P8		51
head, virgin 1-day female		56
head, virgin 4-day female		48
head, virgin 20-day female		96
head, mated 1-day female		43
head, mated 4-day female		32
head, mated 20-day female		71
head, mated 1-day male		53
head, mated 4-day male		46
head, mated 20-day male		119
salivary gland, larvae L3 wandering		(583)
salivary gland, white prepupae		(2258)
digestive system, larvae L3 wandering		(2811)
digestive system, 1-day adult		(935)
digestive system, 4-day adult		(595)
digestive system, 20-day adult		(1142)
fat body, larvae L3 wandering		103
fat body, white prepupae		119
fat body, pupae P8		(347)
carcass, larvae L3 wandering		(458)
carcass, 1-day adult		(251)
carcass, 4-day adult		(240)
carcass, 20-day adult		(689)
ovary, virgin 4-day female		118
ovary, mated 4-day female		103
testis, mated 4-day male		(283)
accessory gland, mated 4-day male		(1611)
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		485
central nervous system, larvae L3		216
central nervous system, pupae P8		51
head, virgin 1-day female		56
head, virgin 4-day female		48
head, virgin 20-day female		96
head, mated 1-day female		43
head, mated 4-day female		32
head, mated 20-day female		71
head, mated 1-day male		53
head, mated 4-day male		46
head, mated 20-day male		119
salivary gland, larvae L3 wandering		583
salivary gland, white prepupae		2258
digestive system, larvae L3 wandering		2811
digestive system, 1-day adult		935
digestive system, 4-day adult		595
digestive system, 20-day adult		1142
fat body, larvae L3 wandering		103
fat body, white prepupae		119
fat body, pupae P8		347
carcass, larvae L3 wandering		458
carcass, 1-day adult		251
carcass, 4-day adult		240
carcass, 20-day adult		689
ovary, virgin 4-day female		118
ovary, mated 4-day female		103
testis, mated 4-day male		283
accessory gland, mated 4-day male		1611
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late larval stages, during early pupal stages, in adult male stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		34
embryo 02-04hr		36
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		39
larva L3 puffstage 1-2		44
larva L3 puffstage 3-6		60
larva L3 puffstage 7-9		61
white prepupae new		68
white prepupae 12hr		76
white prepupae 24hr		40
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		47
adult male 30day		56
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(34)
embryo 02-04hr		(36)
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		(31)
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		(39)
larva L3 puffstage 1-2		(44)
larva L3 puffstage 3-6		(60)
larva L3 puffstage 7-9		(61)
white prepupae new		(68)
white prepupae 12hr		(76)
white prepupae 24hr		(40)
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		(28)
adult male 05day		(47)
adult male 30day		(56)
adult female 01day		19
adult female 05day		(28)
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		34
embryo 02-04hr		36
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		39
larva L3 puffstage 1-2		44
larva L3 puffstage 3-6		60
larva L3 puffstage 7-9		61
white prepupae new		68
white prepupae 12hr		76
white prepupae 24hr		40
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		47
adult male 30day		56
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		34
embryo 02-04hr		36
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		39
larva L3 puffstage 1-2		44
larva L3 puffstage 3-6		60
larva L3 puffstage 7-9		61
white prepupae new		68
white prepupae 12hr		76
white prepupae 24hr		40
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		47
adult male 30day		56
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		34
embryo 02-04hr		36
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		39
larva L3 puffstage 1-2		44
larva L3 puffstage 3-6		60
larva L3 puffstage 7-9		61
white prepupae new		68
white prepupae 12hr		76
white prepupae 24hr		40
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		47
adult male 30day		56
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(34)
embryo 02-04hr		(36)
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		(39)
larva L3 puffstage 1-2		(44)
larva L3 puffstage 3-6		(60)
larva L3 puffstage 7-9		(61)
white prepupae new		(68)
white prepupae 12hr		(76)
white prepupae 24hr		(40)
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		(47)
adult male 30day		(56)
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		34
embryo 02-04hr		36
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		39
larva L3 puffstage 1-2		44
larva L3 puffstage 3-6		60
larva L3 puffstage 7-9		61
white prepupae new		68
white prepupae 12hr		76
white prepupae 24hr		40
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		47
adult male 30day		56
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		34
embryo 02-04hr		36
embryo 04-06hr		24
embryo 06-08hr		20
embryo 08-10hr		31
embryo 10-12hr		25
embryo 12-14hr		18
embryo 14-16hr		20
embryo 16-18hr		17
embryo 18-20hr		19
embryo 20-22hr		24
embryo 22-24hr		20
larva L1		13
larva L2		9
larva L3 12hr old		39
larva L3 puffstage 1-2		44
larva L3 puffstage 3-6		60
larva L3 puffstage 7-9		61
white prepupae new		68
white prepupae 12hr		76
white prepupae 24hr		40
pupae 2d postWPP		21
pupae 3d postWPP		5
pupae 4d postWPP		14
adult male 01day		28
adult male 05day		47
adult male 30day		56
adult female 01day		19
adult female 05day		28
adult female 30day		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		150
Schneider line 2 Sg4		671
embryonic 1182-4H		831
embryonic GM2		1
embryonic Kc167		551
embryonic S1		549
embryonic S3		276
leg disc CME L1		713
wing disc CME-W2		963
wing disc ML-DmD8		652
wing disc ML-DmD9		2085
wing disc ML-DmD16-c3		1244
wing disc ML-DmD21		712
wing disc ML-DmD32		1342
haltere disc ML-DmD17-c3		252
eye-antennal disc ML-DmD11		2751
antennal disc ML-DmD20-c5		1551
mixed discs ML-DmD4-c1		946
CNS ML-DmBG1-c1		353
CNS ML-DmBG2-c2		380
tumorous blood cells mbn2		220
ovary fGS/OSS		100
ovary OSC		908
ovary OSS		80
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(150)
Schneider line 2 Sg4		(671)
embryonic 1182-4H		(831)
embryonic GM2		1
embryonic Kc167		(551)
embryonic S1		(549)
embryonic S3		(276)
leg disc CME L1		(713)
wing disc CME-W2		(963)
wing disc ML-DmD8		(652)
wing disc ML-DmD9		(2085)
wing disc ML-DmD16-c3		(1244)
wing disc ML-DmD21		(712)
wing disc ML-DmD32		(1342)
haltere disc ML-DmD17-c3		(252)
eye-antennal disc ML-DmD11		(2751)
antennal disc ML-DmD20-c5		(1551)
mixed discs ML-DmD4-c1		(946)
CNS ML-DmBG1-c1		(353)
CNS ML-DmBG2-c2		(380)
tumorous blood cells mbn2		(220)
ovary fGS/OSS		(100)
ovary OSC		(908)
ovary OSS		(80)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		(150)
Schneider line 2 Sg4		(671)
embryonic 1182-4H		(831)
embryonic GM2		1
embryonic Kc167		(551)
embryonic S1		(549)
embryonic S3		(276)
leg disc CME L1		(713)
wing disc CME-W2		(963)
wing disc ML-DmD8		(652)
wing disc ML-DmD9		(2085)
wing disc ML-DmD16-c3		(1244)
wing disc ML-DmD21		(712)
wing disc ML-DmD32		(1342)
haltere disc ML-DmD17-c3		(252)
eye-antennal disc ML-DmD11		(2751)
antennal disc ML-DmD20-c5		(1551)
mixed discs ML-DmD4-c1		(946)
CNS ML-DmBG1-c1		(353)
CNS ML-DmBG2-c2		(380)
tumorous blood cells mbn2		(220)
ovary fGS/OSS		100
ovary OSC		(908)
ovary OSS		80
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		150
Schneider line 2 Sg4		671
embryonic 1182-4H		831
embryonic GM2		1
embryonic Kc167		551
embryonic S1		549
embryonic S3		276
leg disc CME L1		713
wing disc CME-W2		963
wing disc ML-DmD8		652
wing disc ML-DmD9		2085
wing disc ML-DmD16-c3		1244
wing disc ML-DmD21		712
wing disc ML-DmD32		1342
haltere disc ML-DmD17-c3		252
eye-antennal disc ML-DmD11		2751
antennal disc ML-DmD20-c5		1551
mixed discs ML-DmD4-c1		946
CNS ML-DmBG1-c1		353
CNS ML-DmBG2-c2		380
tumorous blood cells mbn2		220
ovary fGS/OSS		100
ovary OSC		908
ovary OSS		80
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		150
Schneider line 2 Sg4		671
embryonic 1182-4H		831
embryonic GM2		1
embryonic Kc167		551
embryonic S1		549
embryonic S3		276
leg disc CME L1		713
wing disc CME-W2		963
wing disc ML-DmD8		652
wing disc ML-DmD9		2085
wing disc ML-DmD16-c3		1244
wing disc ML-DmD21		712
wing disc ML-DmD32		1342
haltere disc ML-DmD17-c3		252
eye-antennal disc ML-DmD11		2751
antennal disc ML-DmD20-c5		1551
mixed discs ML-DmD4-c1		946
CNS ML-DmBG1-c1		353
CNS ML-DmBG2-c2		380
tumorous blood cells mbn2		220
ovary fGS/OSS		100
ovary OSC		908
ovary OSS		80
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(150)
Schneider line 2 Sg4		(671)
embryonic 1182-4H		(831)
embryonic GM2		1
embryonic Kc167		(551)
embryonic S1		(549)
embryonic S3		(276)
leg disc CME L1		(713)
wing disc CME-W2		(963)
wing disc ML-DmD8		(652)
wing disc ML-DmD9		(2085)
wing disc ML-DmD16-c3		(1244)
wing disc ML-DmD21		(712)
wing disc ML-DmD32		(1342)
haltere disc ML-DmD17-c3		(252)
eye-antennal disc ML-DmD11		(2751)
antennal disc ML-DmD20-c5		(1551)
mixed discs ML-DmD4-c1		(946)
CNS ML-DmBG1-c1		(353)
CNS ML-DmBG2-c2		(380)
tumorous blood cells mbn2		(220)
ovary fGS/OSS		(100)
ovary OSC		(908)
ovary OSS		(80)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		(150)
Schneider line 2 Sg4		(671)
embryonic 1182-4H		(831)
embryonic GM2		1
embryonic Kc167		(551)
embryonic S1		(549)
embryonic S3		(276)
leg disc CME L1		(713)
wing disc CME-W2		(963)
wing disc ML-DmD8		(652)
wing disc ML-DmD9		(2085)
wing disc ML-DmD16-c3		(1244)
wing disc ML-DmD21		(712)
wing disc ML-DmD32		(1342)
haltere disc ML-DmD17-c3		(252)
eye-antennal disc ML-DmD11		(2751)
antennal disc ML-DmD20-c5		(1551)
mixed discs ML-DmD4-c1		(946)
CNS ML-DmBG1-c1		(353)
CNS ML-DmBG2-c2		(380)
tumorous blood cells mbn2		(220)
ovary fGS/OSS		100
ovary OSC		(908)
ovary OSS		80
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		150
Schneider line 2 Sg4		671
embryonic 1182-4H		831
embryonic GM2		1
embryonic Kc167		551
embryonic S1		549
embryonic S3		276
leg disc CME L1		713
wing disc CME-W2		963
wing disc ML-DmD8		652
wing disc ML-DmD9		2085
wing disc ML-DmD16-c3		1244
wing disc ML-DmD21		712
wing disc ML-DmD32		1342
haltere disc ML-DmD17-c3		252
eye-antennal disc ML-DmD11		2751
antennal disc ML-DmD20-c5		1551
mixed discs ML-DmD4-c1		946
CNS ML-DmBG1-c1		353
CNS ML-DmBG2-c2		380
tumorous blood cells mbn2		220
ovary fGS/OSS		100
ovary OSC		908
ovary OSS		80
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		679
cold shock, 4-day adult		726
heat shock, 4-day adult		532
Cadmium 50 mM 6 hrs, larvae L3		1058
Cadmium 50 mM 12 hrs, larvae L3		1055
Cadmium 50 mM 48 hrs, 4-day adult		695
Cadmium 100 mM 48 hrs, 4-day adult		393
Copper 0.5 mM 12 hrs, larvae L3		2841
Copper 15 mM 48 hrs, 4-day adult		148
Zinc 5 mM 12 hrs, larvae L3		1014
Zinc 4.5 mM 48 hrs, 4-day adult		236
Ethanol 2.5% 3 hrs, larvae L3		276
Ethanol 5% 3 hrs, larvae L3		1354
Ethanol 10% 3 hrs, larvae L3		1180
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1494
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		197
Caffeine 25 mg/ml 48 hrs, 4-day adult		408
Paraquat 5 mM 48 hrs, 4-day adult		117
Paraquat 10 mM 48 hrs, 4-day adult		431
Rotenone 2 μg 12 hrs, larvae L3		1397
Rotenone 8 μg 12 hrs, larvae L3		1391
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(679)
cold shock, 4-day adult		(726)
heat shock, 4-day adult		(532)
Cadmium 50 mM 6 hrs, larvae L3		(1058)
Cadmium 50 mM 12 hrs, larvae L3		(1055)
Cadmium 50 mM 48 hrs, 4-day adult		(695)
Cadmium 100 mM 48 hrs, 4-day adult		(393)
Copper 0.5 mM 12 hrs, larvae L3		(2841)
Copper 15 mM 48 hrs, 4-day adult		(148)
Zinc 5 mM 12 hrs, larvae L3		(1014)
Zinc 4.5 mM 48 hrs, 4-day adult		(236)
Ethanol 2.5% 3 hrs, larvae L3		(276)
Ethanol 5% 3 hrs, larvae L3		(1354)
Ethanol 10% 3 hrs, larvae L3		(1180)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(1494)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(197)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(408)
Paraquat 5 mM 48 hrs, 4-day adult		(117)
Paraquat 10 mM 48 hrs, 4-day adult		(431)
Rotenone 2 μg 12 hrs, larvae L3		(1397)
Rotenone 8 μg 12 hrs, larvae L3		(1391)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		(679)
cold shock, 4-day adult		(726)
heat shock, 4-day adult		(532)
Cadmium 50 mM 6 hrs, larvae L3		(1058)
Cadmium 50 mM 12 hrs, larvae L3		(1055)
Cadmium 50 mM 48 hrs, 4-day adult		(695)
Cadmium 100 mM 48 hrs, 4-day adult		(393)
Copper 0.5 mM 12 hrs, larvae L3		(2841)
Copper 15 mM 48 hrs, 4-day adult		(148)
Zinc 5 mM 12 hrs, larvae L3		(1014)
Zinc 4.5 mM 48 hrs, 4-day adult		(236)
Ethanol 2.5% 3 hrs, larvae L3		(276)
Ethanol 5% 3 hrs, larvae L3		(1354)
Ethanol 10% 3 hrs, larvae L3		(1180)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(1494)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(197)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(408)
Paraquat 5 mM 48 hrs, 4-day adult		(117)
Paraquat 10 mM 48 hrs, 4-day adult		(431)
Rotenone 2 μg 12 hrs, larvae L3		(1397)
Rotenone 8 μg 12 hrs, larvae L3		(1391)
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		679
cold shock, 4-day adult		726
heat shock, 4-day adult		532
Cadmium 50 mM 6 hrs, larvae L3		1058
Cadmium 50 mM 12 hrs, larvae L3		1055
Cadmium 50 mM 48 hrs, 4-day adult		695
Cadmium 100 mM 48 hrs, 4-day adult		393
Copper 0.5 mM 12 hrs, larvae L3		2841
Copper 15 mM 48 hrs, 4-day adult		148
Zinc 5 mM 12 hrs, larvae L3		1014
Zinc 4.5 mM 48 hrs, 4-day adult		236
Ethanol 2.5% 3 hrs, larvae L3		276
Ethanol 5% 3 hrs, larvae L3		1354
Ethanol 10% 3 hrs, larvae L3		1180
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1494
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		197
Caffeine 25 mg/ml 48 hrs, 4-day adult		408
Paraquat 5 mM 48 hrs, 4-day adult		117
Paraquat 10 mM 48 hrs, 4-day adult		431
Rotenone 2 μg 12 hrs, larvae L3		1397
Rotenone 8 μg 12 hrs, larvae L3		1391
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		679
cold shock, 4-day adult		726
heat shock, 4-day adult		532
Cadmium 50 mM 6 hrs, larvae L3		1058
Cadmium 50 mM 12 hrs, larvae L3		1055
Cadmium 50 mM 48 hrs, 4-day adult		695
Cadmium 100 mM 48 hrs, 4-day adult		393
Copper 0.5 mM 12 hrs, larvae L3		2841
Copper 15 mM 48 hrs, 4-day adult		148
Zinc 5 mM 12 hrs, larvae L3		1014
Zinc 4.5 mM 48 hrs, 4-day adult		236
Ethanol 2.5% 3 hrs, larvae L3		276
Ethanol 5% 3 hrs, larvae L3		1354
Ethanol 10% 3 hrs, larvae L3		1180
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1494
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		197
Caffeine 25 mg/ml 48 hrs, 4-day adult		408
Paraquat 5 mM 48 hrs, 4-day adult		117
Paraquat 10 mM 48 hrs, 4-day adult		431
Rotenone 2 μg 12 hrs, larvae L3		1397
Rotenone 8 μg 12 hrs, larvae L3		1391
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(679)
cold shock, 4-day adult		(726)
heat shock, 4-day adult		(532)
Cadmium 50 mM 6 hrs, larvae L3		(1058)
Cadmium 50 mM 12 hrs, larvae L3		(1055)
Cadmium 50 mM 48 hrs, 4-day adult		(695)
Cadmium 100 mM 48 hrs, 4-day adult		(393)
Copper 0.5 mM 12 hrs, larvae L3		(2841)
Copper 15 mM 48 hrs, 4-day adult		(148)
Zinc 5 mM 12 hrs, larvae L3		(1014)
Zinc 4.5 mM 48 hrs, 4-day adult		(236)
Ethanol 2.5% 3 hrs, larvae L3		(276)
Ethanol 5% 3 hrs, larvae L3		(1354)
Ethanol 10% 3 hrs, larvae L3		(1180)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(1494)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(197)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(408)
Paraquat 5 mM 48 hrs, 4-day adult		(117)
Paraquat 10 mM 48 hrs, 4-day adult		(431)
Rotenone 2 μg 12 hrs, larvae L3		(1397)
Rotenone 8 μg 12 hrs, larvae L3		(1391)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		(679)
cold shock, 4-day adult		(726)
heat shock, 4-day adult		(532)
Cadmium 50 mM 6 hrs, larvae L3		(1058)
Cadmium 50 mM 12 hrs, larvae L3		(1055)
Cadmium 50 mM 48 hrs, 4-day adult		(695)
Cadmium 100 mM 48 hrs, 4-day adult		(393)
Copper 0.5 mM 12 hrs, larvae L3		(2841)
Copper 15 mM 48 hrs, 4-day adult		(148)
Zinc 5 mM 12 hrs, larvae L3		(1014)
Zinc 4.5 mM 48 hrs, 4-day adult		(236)
Ethanol 2.5% 3 hrs, larvae L3		(276)
Ethanol 5% 3 hrs, larvae L3		(1354)
Ethanol 10% 3 hrs, larvae L3		(1180)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(1494)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(197)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(408)
Paraquat 5 mM 48 hrs, 4-day adult		117
Paraquat 10 mM 48 hrs, 4-day adult		(431)
Rotenone 2 μg 12 hrs, larvae L3		(1397)
Rotenone 8 μg 12 hrs, larvae L3		(1391)
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		679
cold shock, 4-day adult		726
heat shock, 4-day adult		532
Cadmium 50 mM 6 hrs, larvae L3		1058
Cadmium 50 mM 12 hrs, larvae L3		1055
Cadmium 50 mM 48 hrs, 4-day adult		695
Cadmium 100 mM 48 hrs, 4-day adult		393
Copper 0.5 mM 12 hrs, larvae L3		2841
Copper 15 mM 48 hrs, 4-day adult		148
Zinc 5 mM 12 hrs, larvae L3		1014
Zinc 4.5 mM 48 hrs, 4-day adult		236
Ethanol 2.5% 3 hrs, larvae L3		276
Ethanol 5% 3 hrs, larvae L3		1354
Ethanol 10% 3 hrs, larvae L3		1180
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1494
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		197
Caffeine 25 mg/ml 48 hrs, 4-day adult		408
Paraquat 5 mM 48 hrs, 4-day adult		117
Paraquat 10 mM 48 hrs, 4-day adult		431
Rotenone 2 μg 12 hrs, larvae L3		1397
Rotenone 8 μg 12 hrs, larvae L3		1391
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033926

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG12505-RA;CG10102-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

locomotor behavior defective

Arc1^esm18

stress response defective

Arc1^esm18

Phenotype manifest in

Allele

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of Arc1	Class	Mutagen	Stocks	Known lesion
Arc1^esm113		P-element activity	1	Yes
Arc1^esm18		P-element activity	1	Yes

Alleles Carried on Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Arc1	Mutagen	Stocks	Known lesion
Arc1^GD16710	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Arc1^GD6751	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Arc1^JF01974	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Arc1^Scer\UAS.cMb	in vitro construct - regulatory fusion	1	Yes
Arc1^KK115868	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Arc1^Scer\UAS.cMa	in vitro construct - regulatory fusion	0	Yes
Arc1^{Scer\UAS.T:Avic\GFP}	in vitro construct - regulatory fusion	0	Yes