FB2021_01, released Feb 18, 2021

Gene: Dmel\Tfb1

Open Close
General Information
Symbol
Dmel\Tfb1
Species
D. melanogaster
Name
Transcription factor B1
Annotation Symbol
CG8151
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033929
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Transcription factor B1 (Tfb1) encodes a subunit of the Transcription factor II H complex (TFIIH). TFIIH operates in RNA polymerase I and II-mediated transcription, DNA repair and cell cycle regulation. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

l(2)06949, p62, TfBl

Key Links
Genomic Location
Cytogenetic map
50F6-50F6
Sequence location
2R:14,363,048..14,365,473 [+]
Recombination map

2-70

RefSeq locus
NT_033778 REGION:14363048..14365473
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (9 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in response to UV
inferred from mutant phenotype
(Castro et al., 2002)
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
involved_in DNA repair
inferred from biological aspect of ancestor with PANTHER:PTN000304482
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in nucleotide-excision repair
inferred from sequence or structural similarity with HGNC:4655
(Castro et al., 2002)
involved_in phosphorylation of RNA polymerase II C-terminal domain
inferred from biological aspect of ancestor with PANTHER:PTN000304482
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in promoter clearance from RNA polymerase II promoter
inferred from sequence or structural similarity with HGNC:4655
(Castro et al., 2002)
involved_in transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000304482
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in transcription by RNA polymerase I
inferred from biological aspect of ancestor with PANTHER:PTN000304482
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in transcription initiation from RNA polymerase II promoter
inferred from sequence or structural similarity with HGNC:4655
(Aoyagi and Wassarman, 2000)
inferred from sequence or structural similarity with SGD:S000002719
(Aoyagi and Wassarman, 2000)
involved_in transcription open complex formation at RNA polymerase II promoter
inferred from sequence or structural similarity with HGNC:4655
(Castro et al., 2002)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of transcription factor TFIIH holo complex
inferred from direct assay
(Aguilar-Fuentes et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in nucleus
inferred from sequence or structural similarity with HGNC:4655
(Castro et al., 2002)
inferred from sequence or structural similarity with SGD:S000002719
(Castro et al., 2002)
part_of transcription factor TFIIH core complex
inferred from biological aspect of ancestor with PANTHER:PTN000304482
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:4655
(Castro et al., 2002)
inferred from sequence or structural similarity with SGD:S000002719
(Castro et al., 2002)
part_of transcription factor TFIIH holo complex
inferred from biological aspect of ancestor with PANTHER:PTN000304482
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:4655
(Aoyagi and Wassarman, 2000)
inferred from sequence or structural similarity with SGD:S000002719
(Aoyagi and Wassarman, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TFB1 family. (Q960E8)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TRANSCRIPTION FACTOR II H - CORE COMPLEX -
The general transcription factor complex Transcription factor II H (TFIIH) is required in RNA pol II transcription at initiation, promoter escape, early elongation steps and transcription re-initiation after polymerase pausing. TFIIH can be divided into two subcomplexes: core and cyclin-dependent protein kinase-activating kinase (CAK). The core complex contains an ATP-dependent DNA helicase activity required for promoter DNA opening and nucleotide excision repair (NER). (Adapted from PMID:25693126 and PMID:21592869).
Protein Function (UniProtKB)
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
(UniProt, Q960E8)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Tfb1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tfb1-RA
FBtr0087550
NM_166048
2145
585
Tfb1-RB
FBtr0087548
NM_137113
2025
585
Tfb1-RC
FBtr0087549
NM_166049
2022
585
Tfb1-RD
FBtr0305616
NM_001259392
2018
585
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Tfb1-PA
FBpp0086678
66.3
585
9.27
NP_725382
AAF58253
Tfb1-PB
FBpp0086676
66.3
585
9.27
NP_610957
AAM71000
Tfb1-PC
FBpp0086677
66.3
585
9.27
NP_725383
AAM71001
Tfb1-PD
FBpp0294063
66.3
585
9.27
NP_001246321
AFH08075
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

585 aa isoforms: Tfb1-PA, Tfb1-PB, Tfb1-PC, Tfb1-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.

(UniProt, Q960E8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tfb1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Castro et al., 2002)
Additional Descriptive Data

RT-PCR analysis indicates that transcript is present in all stages of development. Expression is higher in gastrulating embryos and transcript is expressed preferentially in adult males.

(Castro et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of transcription factor TFIIH holo complex
inferred from direct assay
(Aguilar-Fuentes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tfb1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tfb1
Transgenic constructs containing regulatory region of Tfb1
Aberrations (Deficiencies and Duplications) ( 4 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GTF2H1
15 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gtf2h1
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Gtf2h1
11 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\gtf2h1
13 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\gtf2h1
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\gtf-2H1
14 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G61420
9 of 9
Yes
Yes
Atha\AT1G55750
8 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\TFB1
11 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\tfb1
7 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904R2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002514
Drosophila simulans
Dsim\GD11042
Drosophila sechellia
Dsec\GM21534
Drosophila erecta
Dere\GG20446
Drosophila yakuba
Dyak\GE13578
Drosophila ananassae
Dana\GF13498
Drosophila pseudoobscura pseudoobscura
Dpse\GA20852
Drosophila persimilis
Dper\GL10686
Drosophila willistoni
Dwil\GK21470
Drosophila virilis
Dvir\GJ22005
Drosophila mojavensis
Dmoj\GI20277
Drosophila grimshawi
Dgri\GH19743
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503Q8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024717
Glossina morsitans
Tsetse fly
Gmor\GMOY008151
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12401
Mayetiola destructor
Hessian fly
Mdes\Mdes007818
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012750
Anopheles darlingi
American malaria mosquito
Adar\ADAC006129
Anopheles gambiae
Malaria mosquito
Agam\AGAP011110
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015824
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04I2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010089
Danaus plexippus
Monarch butterfly
Dple\DPOGS212040-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL018066
Apis florea
Little honeybee
Aflo\2417177782
Apis mellifera
Western honey bee
Amel\Tfb1
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20460
Bombus terrestris
Buff-tailed bumblebee
Bter\15203425
Linepithema humile
Argentine ant
Lhum\LH12481
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002e23
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014417
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04802
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07976
Pediculus humanus
Human body louse
Phum\PHUM086680
Rhodnius prolixus
Kissing bug
Rpro\RPRC005856
Cimex lectularius
Bed bug
Clec\CLEC005889
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010246
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02865
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04EN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014461
Ixodes scapularis
Black-legged tick
Isca\ISCW021770
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77565.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g01100
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301632
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_328341
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06OP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_002228gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004652
Gallus gallus
Domestic chicken
Ggal\GTF2H1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GTF2H1; general transcription factor IIH subunit 1
    15 of 15
    189972
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Tfb1 - Ssl1
        anti bait coimmunoprecipitation, western blot
        (Aguilar-Fuentes et al., 2008)
        Tfb1 - hay
        anti bait coimmunoprecipitation, western blot
        (Villicaña et al., 2013)
        Tfb1 - p53
        anti bait coimmunoprecipitation, western blot
        (Villicaña et al., 2013)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
        (UniProt, Q960E8 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-70

        Cytogenetic map
        50F6-50F6
        Sequence location
        2R:14,363,048..14,365,473 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        50F6-50F6
        Limits computationally determined from genome sequence between P{lacW}l(2)s3475s3475&P{lacW}Hsc70-5k04907 and P{PZ}Tfb106949&P{PZ}l(2)0356303563
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        51A1-51A2
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        51A1-51A2
        51A1--5
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-70

        (FlyBase, 2016)

        2-75.4

        (Comeron et al., 2012)

        2-

        (Dickson et al., 1995)
        Left of (cM)
        Right of (cM)
        (Dickson et al., 1995)
        Notes

        17 recombinants in 29,738 progeny.

        (Dickson et al., 1995)
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (42)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Tfb1 CG8151

          (Aoyagi and Wassarman, 2000)
          Source for database merge of

          Source for merge of: Tfb1 l(2)06949

          (Castro et al., 2002)
          Additional comments

          "Tfb1" may correspond to "Scim25". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim25" near/in "Tfb1" or "CG13941".

          (Dobie and Karpen, 2001.4.18)

          "l(2)06949" probably corresponds to "CG8151"; the P{PZ} insertion in the "l(2)0694906949" allele maps 35bp upstream of the 5' end of the CT24236 transcript of "CG8151".

          (Misra, 2000.11.18)
          Other Comments

          Tfb1 heterozygotes are more sensitive to UV light irradiation than normal.

          (Castro et al., 2002)
          Origin and Etymology
          Discoverer
          Etymology

          Named "Tfb1" after the S. cerevisiae ortholog.

          (FlyBase, 2009-)
          Identification
          External Crossreferences and Linkouts ( 65 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (10)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (56)