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Gene Dmel\CG11807

General Information
Symbol	Dmel\CG11807	Species	D. melanogaster
Name		Annotation symbol	CG11807
Feature type	protein_coding_gene	FlyBase ID	FBgn0033996
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51E5-51E5	Sequence location	2R:11,088,758..11,091,971 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11807 (FBgn0033996). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: phosphatidylinositol binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cell communication. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Leucine rich repeat 4; Leucine-rich repeat; Phox homologous domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628627_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11807. Gene sequence location is 2R:11088758..11091971.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51E5-51E5   Limits computationally determined from genome sequence between P{PZ}chn02064 and P{PZ}scb01288
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11807 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11807-RA FBtr0087363  NM_137173   1945   491 CG11807-RB FBtr0310139  NM_001274061   2106   491 CG11807-RC FBtr0310140  NM_001274062   1993   491
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11807-PA   FBpp0086496   55.2   491   6.43     NP_611017   AAF58166 CG11807-PB   FBpp0301824   55.2   491   6.43     NP_001260990   AGB93522 CG11807-PC   FBpp0301825   55.2   491   6.43     NP_001260991   AGB93523
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine rich repeat 4 (IPR025875) Phox homologous domain (IPR001683) Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA978421   AE013599 AAF58166   AE013599 AGB93522   AE013599 AGB93523   AI296111   AI387072   AI403717   AI532450   AI534265   AW944336   AY052088 AAK93512   BG634934   BG635953   BG636036   BI170851   BI362297   BI636076   CO177208   CO181681   CO268754   CO280977   CO302583   CO307232   CO309991   CO310634   CO321301   CO325735   CO344693   EC058865   EC063476   EC082519   EC195224   EC201997   EC203708   EC209886   EC214885   EC218421   EC222010   EC236608   EC248512   EC248989   EC255134   EL885564   EV594548   GH739859   GH740344   GH740686   GH743618   GH743775   GH743784   GH744221   GH745116   GH745450   GH746159   GH746502   GH746631   GH746740   GH761505   GH762202   GH762538   GH764016   GH764115   GH764920   GH765011   GH765162   GH765565   GH765567   GH765594   GH765670   GH765848   GH766437   GH766688   GH766986   GH767639   GH767992   GH768031   GH768104   GH768666   GH769155   GO254500
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K490
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.35 Larval Midgut    85.8 Larval Hindgut    195.5 Larval Malpighian Tubules    205.3 Larval Fat Body    312.7 Larval Salivary Gland    143.8 Larval Trachea    119.025 Larval Carcass    221.425 Adult Head    196 Adult Eye    100.225 Adult Brain    300.6 Adult Thoracic-Abdominal Ganglion    259.1 Adult Crop    353.8 Adult Midgut    77.8 Adult Hindgut    197.5 Adult Malpighian Tubules    172.5 Adult Fat Body    225.7 Adult Salivary Gland    169 Adult Heart    161 Adult VirginFemale Spermatheca    122.4 Adult InseminatedFemale Spermatheca    145.3 Adult Ovary    448.3 Adult Testis    318.3 Adult Male Accessory Gland    142.4 Adult Carcass    169.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    196   NA  Eye    100.225   NA  Brain    300.6   190.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    259.1   NA  Crop    353.8   85.8  Midgut    77.8   195.5  Hindgut    197.5   205.3  Malpighian Tubules    172.5   312.7  Fat Body    225.7   143.8  Salivary Gland    169   NA  Heart    161   119.025  Trachea    NA   NA  VirginFemale Spermatheca    122.4   NA  InseminatedFemale Spermatheca    145.3   NA  Ovary    448.3   NA  Testis    318.3   NA  Male Accessory Gland    142.4   221.425  Carcass    169.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    51 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male  (27) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (51) testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    51 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    51 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    51 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male  27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (51) testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    51 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    18 central nervous system, pupae P8    21 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    27 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    7 fat body, larvae L3 wandering    8 fat body, white prepupae    16 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    51 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day  (27) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day    27 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day  27 adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    10 embryo 04-06hr    8 embryo 06-08hr    14 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    20 embryo 14-16hr    11 embryo 16-18hr    11 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    9 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    17 white prepupae 24hr    19 pupae 2d postWPP    22 pupae 3d postWPP    20 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    17 adult male 30day    17 adult female 01day    14 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2  26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2  26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    26 embryonic Kc167    25 embryonic S1    10 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    15 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    22 ovary fGS/OSS    14 ovary OSC    6 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (32) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • SD03973 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033996 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11807-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG11807GD7390 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11807 Class Mutagen Stocks Known lesion CG11807DP00617 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11807 Class Mutagen Stocks Known lesion CG11807GD7390 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11807KK102801 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7135 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7390} NA P{KK102801} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}CG11807DP00617 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
phosphatidylinositol binding inferred from electronic annotation with InterPro:IPR001683 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell communication inferred from electronic annotation with InterPro:IPR001683 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG11807 - Act5C experimental knowledge based (Guruharsha et al., 2011) CG11807 - CG16789 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG11807 - Ef1α48D experimental knowledge based (Guruharsha et al., 2011) CG11807 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11807 - Inos anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11807 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62423 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033996 DroID - A comprehensive database of gene and protein interactions. • FBgn0033996 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36683
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6640XG Dipteran inclusive ortholog search EOG612MDN Insect inclusive ortholog search EOG6G1KBQ Arthropod inclusive ortholog search EOG6GQNM8 Metazoa inclusive ortholog search EOG6TFCCJ
Orthologs in Drosophila Species (EOG6640XG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11807     Drosophila simulans   Dsim\GD11101 Y   Drosophila sechellia   Dsec\GM21593 Y   Drosophila erecta   Dere\GG20501 Y   Drosophila yakuba   Dyak\GE13634 Y   Drosophila ananassae   Dana\GF12314 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11211 Y   Drosophila persimilis   Dper\GL10613 Y   Drosophila willistoni   Dwil\GK19704 Y   Drosophila virilis   Dvir\GJ21737 Y   Drosophila mojavensis   Dmoj\GI18719 Y   Drosophila grimshawi   Dgri\GH21113 Y
Orthologs in non-Drosophila Dipterans (EOG612MDN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002819   Anopheles gambiae Malaria mosquito  Agam\AGAP011394   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003255
Orthologs in non-Dipteran Insects (EOG6G1KBQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC411145   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005424   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22606   Atta cephalotes Leafcutter ant  Acep\ACEP24201   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15012   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14428   Linepithema humile Argentine ant  Lhum\LH19963   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14319   Solenopsis invicta Red fire ant  Sinv\SINV16552   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006596   Bombyx mori Silkmoth  Bmor\BGIBMGA008614   Pediculus humanus Human body louse  Phum\PHUM261940   Tribolium castaneum Red flour beetle  Tcas\TC014222
Orthologs in non-Insect Arthropods (EOG6GQNM8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_304938   Ixodes scapularis Deer tick  Isca\ISCW017885
Orthologs in non-Arthropod Metazoa (EOG6TFCCJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F13E9.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015624gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016077gn   Danio rerio Zebrafish  Drer\si:ch1073-288d12.1   Danio rerio Zebrafish  Drer\ENSDARG00000043077   Xenopus tropicalis Western clawed frog  Xtro\nisch   Gallus gallus Domestic chicken  Ggal\NISCH   Mus musculus House mouse  Mmus\ENSMUSG00000021910   Rattus norvegicus Norway rat  Rnor\Nisch   Homo sapiens Human  Hsap\NISCH
Human Orthologs (1)
Gene OMIM HGNC Hsap\NISCH
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11101 Drosophila sechellia Dsec\GM21593 Drosophila erecta Dere\GG20501 Drosophila yakuba Dyak\GE13634 Drosophila ananassae Dana\GF12314 Drosophila pseudoobscura pseudoobscura Dpse\GA11211 Drosophila persimilis Dper\GL10613 Drosophila willistoni Dwil\GK19704 Drosophila virilis Dvir\GJ21737 Drosophila mojavensis Dmoj\GI18719 Drosophila grimshawi Dgri\GH21113
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	21820 y1 w67c23; P{Mae-UAS.6.11}CG11807DP00617
VDRC	v108222 P{KK102801}VIE-260B v38564 w1118; P{GD7390}v38564/CyO v38566 w1118; P{GD7390}v38566/TM3
Genomic Clones ( 2 )
	BACR30C07 BACR33K06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 76 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD03973
Other clones	DPiM_SD03973
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT31341 GH17502 GH23216 LD30537 LP09927 RE12451 RE46825 SD07032 SD13492 SD13617 SD17643
Other clones	15575 37288 69855 97397 99387 106880 121629 148387 153159 214447.69 CK01.41B.C6 CK01.67A.H2 CK01.94B.C4 CK01.121A.C5 Dmel_neb_011813_0668_3462 EC14831 EK052761 EK092611 EK155634 EK184505 EK197344 EK220214 EK222164 EK254031 EK290652 EP19734 IP16936 RP01303 RP01559 RP001006554 RP001011201 RP001012001 RP001012460 RP001013000 RP001013360 RP001013689 RP001016440 RP001016846 RP001017182 RP001018994 RP001020622 RP001022708 RP001023534 RP001023925 RP001025402 RP001025846 RP001034277 RP001034734 RP001035644 RP001040000 RP001040216 RP001045982 RP001046854 RP001046884 RP001047326 RP001048073 RP001048817 RP001049160 RP001051800 RP001052011 RP001052907 RP001053339 RP001055857
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033996 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36683
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137173 NM_001274061 NM_001274062 RefSeq (Proteins) • NP_611017 NP_001260990 NP_001260991 DDBJ / EMBL / GenBank • AAF58166 AAK93512 AGB93522 AGB93523 AI532450 AW944336 AY052088 Entrez Gene - A searchable database of RefSeq genes. • 36683 UniProtKB/TrEMBL • Q7K490
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine rich repeat 4 (IPR025875) Phox homologous domain (IPR001683) Leucine-rich repeat (IPR001611) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD03973
Linkouts
	BioGRID - A database of protein and genetic interactions • 62423 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033996 DroID - A comprehensive database of gene and protein interactions. • FBgn0033996 DRSC - Results from RNAi screens. • FBgn0033996 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033996 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11807-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033996 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36683 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36683 modMine - Data generated by the modENCODE project. • FBgn0033996
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG11807 (Keleman et al., 2009.8.5, Nawaz et al., 2012) CT14564 (Hynes and Zhao, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Nawaz et al., 2012, PLoS ONE 7(5): e35640 Differential evolutionary wiring of the tyrosine kinase btk. [FBrf0218278]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Hynes and Zhao, 2000, J. Cell Biol. 150(2): Table S7. LRR repeat-containing proteins. [FBrf0132111]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Matthews, 2008.4.15, DP and HP P-element insertions submitted to the Bloomington Drosophila Stock Center. DP and HP P-element insertions submitted to the Bloomington Drosophila Stock Center. [FBrf0204789] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	Heiman, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126693]