unc-5-like, CT20824, Unc5d
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Phosphorylated on different cytoplasmic tyrosine residues.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\unc-5 using the Feature Mapper tool.
At embryonic stage 15 before the cardiomyocytes from the bilateral primordia meet at the dorsal midline, unc-5 is localized to these cells in a polarized fashion. Strong signal is observed on the prospective lumen forming side and a slightly weaker signal is seen at the opposite membrane region. Essentially no proteinis detected on the lateral sides of cardiomyocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\unc-5 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Overexpression of unc-5 on all CNS axons prevents them from crossing the midline, resulting in a commissureless phenotype. This gain-of-function Unc5d phenotype requires Netrin function. Overexpression of unc-5 in specific interneurons is also sufficient to force them out of the CNS.
The growth cone response (repulsive) is determined by the cytoplasmic domain of unc-5.