FlyBase Gene Report: Dmel\unc-5

General Information

Symbol

Dmel\unc-5

Species

D. melanogaster

Name

unc-5

Annotation Symbol

CG8166

Feature Type

protein_coding_gene

FlyBase ID

FBgn0034013

Gene Model Status

Stock Availability

10 publicly available

Gene Summary

unc-5 (unc-5) encodes a netrin receptor involved in motor axon guidance and glial migration as well as netrin-mediated repulsion during salivary gland migration. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

unc-5-like, CT20824, Unc5d

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:15,340,472..15,368,300 [+]

Recombination map

2-74

RefSeq locus

NT_033778 REGION:15340472..15368300

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables netrin receptor activity involved in chemorepulsion

inferred from sequence or structural similarity

(Keleman and Dickson, 2001)

enables netrin receptor activity

inferred from electronic annotation with InterPro:IPR037936

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Brankatschk and Dickson, 2006, Keleman and Dickson, 2001)

inferred from genetic interaction with FLYBASE:NetA; FB:FBgn0015773

(Brankatschk and Dickson, 2006)

inferred from genetic interaction with FLYBASE:NetB; FB:FBgn0015774

(Brankatschk and Dickson, 2006, Keleman and Dickson, 2001)

involved_in glial cell migration

inferred from mutant phenotype

(von Hilchen et al., 2010, Freeman et al., 2003)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Zarin et al., 2014, Labrador et al., 2005)

involved_in positive regulation of cell migration

inferred from mutant phenotype

(Raza and Jacobs, 2016)

involved_in salivary gland boundary specification

inferred from mutant phenotype

(Kolesnikov and Beckendorf, 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in motor neuron axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN002650052

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in netrin-activated signaling pathway

inferred from electronic annotation with InterPro:IPR037936

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from electronic annotation with InterPro:IPR037936

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the unc-5 family. (Q95TU8)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

unc-5 (unc-5) encodes a netrin receptor involved in motor axon guidance and glial migration as well as netrin-mediated repulsion during salivary gland migration. [Date last reviewed: 2019-03-21]

Protein Function (UniProtKB)

Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.

(UniProt, Q95TU8)

Summary (Interactive Fly)

multiple domain protein that functions as a repulsive netrin receptor - essential for heart lumen formation

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\unc-5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q95TU8)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0087382

5033

1072

FBtr0339998

5235

1072

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0086514

116.4

1072

6.09

FBpp0309017

116.4

1072

6.09

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1072 aa isoforms: unc-5-PA, unc-5-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

Phosphorylated on different cytoplasmic tyrosine residues.

(UniProt, Q95TU8)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\unc-5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

mesoderm anlage

(Keleman and Dickson, 2001)

embryonic stage 6 -- 14

(Keleman and Dickson, 2001)

embryonic stage 13 -- 14

dorsal vessel primordium

(Keleman and Dickson, 2001)

embryonic stage 13 -- 16

(von Hilchen et al., 2010)

embryonic stage 13 -- 17

presumptive embryonic/larval central nervous system | restricted

(Keleman and Dickson, 2001)

embryonic stage 14

embryonic/larval cardial cell

(Albrecht et al., 2011)

embryonic/larval pericardial cell

(Albrecht et al., 2011)

embryonic/larval dorsal vessel

(Albrecht et al., 2011)

embryonic stage 14 -- 17

exit glial cell

(Keleman and Dickson, 2001)

(Keleman and Dickson, 2001)

embryonic stage 15

(Zarin et al., 2014)

RP2 motor neuron

(Zarin et al., 2014)

Additional Descriptive Data

unc-5 trancripts are first detecteabel in the heart primordium at embryonic stage 14. They become more prominent by the end of embryogenesis. unc-5 ia expressed in all 104 cardiomyocytes of the heart. It is also expressed in pericardial cells.

(Albrecht et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14 -- 17

larval segmental nerve

(Keleman and Dickson, 2001)

embryonic stage 15 -- 16

embryonic/larval cardial cell

(Albrecht et al., 2011)

embryonic stage 16

embryonic/larval dorsal vessel

(Albrecht et al., 2011)

Additional Descriptive Data

At embryonic stage 15 before the cardiomyocytes from the bilateral primordia meet at the dorsal midline, unc-5 is localized to these cells in a polarized fashion. Strong signal is observed on the prospective lumen forming side and a slightly weaker signal is seen at the opposite membrane region. Essentially no proteinis detected on the lateral sides of cardiomyocytes.

(Albrecht et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\unc-5 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\unc-5

View exonic expression by tissue for Dmel\unc-5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36703/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034013

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034013

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034013

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8166

Flygut - An atlas of the Drosophila adult midgut

FBgn0034013

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of unc-5

Transgenic constructs containing regulatory region of unc-5

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^scrt-11-6

unc-5^GS15081

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

unc-5^GD3510

unc-5^MI05371

viable, with Scer\GAL4^Mef2.PR

unc-5^GD3510

viable, with Scer\GAL4^pnr-MD237

unc-5^GD3510

viable, with Scer\GAL4^tin.CΔ4

unc-5^GD3510

Other Phenotypes

Allele

abnormal cell migration | dominant | embryonic stage

unc-5⁸

abnormal locomotor rhythm, with Scer\GAL4^5-40

unc-5^UAS.cKa

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^5-40

unc-5^UAS.cKa

abnormal neuroanatomy, with Scer\GAL4^ap-md544

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

abnormal neuroanatomy, with Scer\GAL4^eg-Mz360

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

unc-5^UAS.cKa

abnormal neuroanatomy, with Scer\GAL4^NP6558

unc-5^UAS.cKa

abnormal neuroanatomy (with Df(2R)XTE-18)

unc-5⁸

abnormal neuroanatomy (with unc-5²)

unc-5⁸

abnormal neuroanatomy (with unc-5⁸)

unc-5²

abnormal neuroanatomy | embryonic stage

unc-5⁸

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^repo

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

unc-5^GD3510

Phenotype manifest in

Allele

cell body & serotonin neuron, with Scer\GAL4^eg-Mz360

unc-5^UAS.cKa

embryonic/larval neuron, with Scer\GAL4^ap-md544

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

embryonic heart cardioblast

unc-5⁸

embryonic peripheral glial cell 5 | embryonic stage

unc-5⁸

embryonic peripheral glial cell 6 | embryonic stage

unc-5⁸

embryonic peripheral glial cell 8 | embryonic stage

unc-5⁸

EW neuron, with Scer\GAL4^eg-Mz360

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

filopodium | embryonic stage

unc-5⁸

heart primordium

unc-5⁸

interface glial cell

unc-5^UAS.cKa

interface glial cell | embryonic stage, with Scer\GAL4^repo

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

lamellipodium | embryonic stage

unc-5⁸

larval abdominal segmental nerve

larval abdominal segmental nerve (with Df(2R)XTE-18)

unc-5⁸

larval abdominal segmental nerve (with unc-5²)

unc-5⁸

larval abdominal segmental nerve (with unc-5⁸)

unc-5²

larval anterior commissure, with Scer\GAL4^elav.PLu

larval intersegmental nerve

larval intersegmental nerve, with Scer\GAL4^elav.PLu

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

larval longitudinal connective, with Scer\GAL4^NP6558

unc-5^UAS.cKa

larval posterior commissure, with Scer\GAL4^elav.PLu

larval ventral nerve cord, with Scer\GAL4^ap-md544

unc-5^{UAS.Tag:HA,Tag:SS(wg)}

larval ventral nerve cord commissure

unc-5^UAS.cKa

photoreceptor cell R7, with Scer\GAL4^GMR.PF

unc-5^UAS.cKa

PNS glial cell | embryonic stage

unc-5⁸

presumptive embryonic salivary gland, with Scer\GAL4^prd.RG1

unc-5^UAS.cKa

serotonin neuron & ventral nerve cord, with Scer\GAL4^eg-Mz360

unc-5^UAS.cKa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

15 of 15

Yes

Yes

13 of 15

No

Yes

13 of 15

No

Yes

12 of 15

No

Yes

4 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

13 of 15

No

Yes

13 of 15

No

Yes

12 of 15

No

Yes

4 of 15

No

Yes

Rattus norvegicus (Norway rat) (5)

12 of 13

Yes

Yes

12 of 13

Yes

Yes

11 of 13

No

Yes

9 of 13

No

Yes

3 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (4)

9 of 12

Yes

Yes

8 of 12

No

Yes

8 of 12

No

Yes

2 of 12

No

Yes

Danio rerio (Zebrafish) (6)

10 of 15

Yes

Yes

10 of 15

Yes

Yes

8 of 15

No

Yes

8 of 15

No

Yes

Drer\si:ch73-72b7.1

7 of 15

No

Yes

5 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

13 of 15

Yes

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

UNC5C; unc-5 netrin receptor C

15 of 15

UNC5A; unc-5 netrin receptor A

13 of 15

UNC5B; unc-5 netrin receptor B

13 of 15

UNC5D; unc-5 netrin receptor D

12 of 15

UNC5CL; unc-5 family C-terminal like

4 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

enzyme linked immunosorbent assay, surface plasmon resonance

(Ozkan et al., 2013, Ozkan et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

Nrg|beat-Ia|unc-5

enhanceable

(Zarin et al., 2014)

enhanceable

Fas2|Nrg|beat-Ia

(Zarin et al., 2014)

suppressible

(Keleman and Dickson, 2001)

suppressible

(Brankatschk and Dickson, 2006, Labrador et al., 2005)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

suppressible

(Raza and Jacobs, 2016)

enhanceable

(Raza and Jacobs, 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

suppressible

(Zarin et al., 2014, Labrador et al., 2005)

suppressible

(Zarin et al., 2014)

enhanceable

(O'Donnell and Bashaw, 2013)

suppressible

(Zarin et al., 2012)

suppressible

(Raza and Jacobs, 2016)

enhanceable

(Raza and Jacobs, 2016)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62440

DroID - A comprehensive database of gene and protein interactions.

FBgn0034013

MIST (genetic) - An integrated Molecular Interaction Database

unc-5

MIST (protein-protein) - An integrated Molecular Interaction Database

unc-5

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0034013

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-74

Cytogenetic map

Sequence location

2R:15,340,472..15,368,300 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

51F9-51F11

Limits computationally determined from genome sequence between P{PZ}scb⁰¹²⁸⁸ and P{lacW}dup^k03308

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

51F-51F

(Grossberger, 2000.3.23)

Experimentally Determined Recombination Data

Location

2-74

(FlyBase, 2016)

2-78.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

37426

y¹ w^*; Mi{MIC}unc-5^MI04273

42316

y¹ w^*; Mi{MIC}unc-5^MI05371

22946

y¹ w^67c23; Mi{ET1}unc-5^MB00969

60547

y¹ w^67c23; Mi{PT-GFSTF.1}unc-5^{MI05371-GFSTF.1}

33756

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01099}attP2

v110155

P{KK102074}VIE-260B

v8138

w¹¹¹⁸; P{GD3510}v8138

v8137

w¹¹¹⁸; P{GD3510}v8137/TM3

v318261

PBac{fTRG00906.sfGFP-TVPTBF}VK00033

v342254

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01938}attP40/CyO-GFP

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (42)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0034013

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0034013

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36703

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Albrecht et al., 2011, Keleman and Dickson, 2001)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: unc-5 CG8166 CG8168

(FlyBase, 1996-)

Source for database merge of

Additional comments

Source for identity of unc-5 CG8166 CG8168 was sequence comparison ( date:000607 ).

(FlyBase, 1996-)

Other Comments

Overexpression of unc-5 on all CNS axons prevents them from crossing the midline, resulting in a commissureless phenotype. This gain-of-function Unc5d phenotype requires Netrin function. Overexpression of unc-5 in specific interneurons is also sufficient to force them out of the CNS.

(Keleman and Dickson, 2001)

The growth cone response (repulsive) is determined by the cytoplasmic domain of unc-5.

(Keleman and Dickson, 2001)

The unc-5 Netrin receptor mediates long range (with fra) and short range (either acting alone or with a co-receptor other than fra) repulsive responses to Netrin. Midline repulsion mediated by unc-5 operates independently of that mediated by sli and robo.

(Keleman and Dickson, 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36703

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q95TU8

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q95TU8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LFH9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q95TU8

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0034013

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36703/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034013

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034013

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034013

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8166

Flygut - An atlas of the Drosophila adult midgut

FBgn0034013

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0034013

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36703

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8166

MARRVEL_MODEL - MARRVEL (model organism gene)

36703

modMine - A data warehouse for the modENCODE project

FBgn0034013

Linkouts

BioGRID - A database of protein and genetic interactions.

62440

DroID - A comprehensive database of gene and protein interactions.

FBgn0034013

DRSC - Results frm RNAi screens

FBgn0034013

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0034013

FlyMine - An integrated database for Drosophila genomics

FBgn0034013

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

unc-5

MIST (protein-protein) - An integrated Molecular Interaction Database

unc-5

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

AAF7419

(Vernooy et al., 2000)

CG8166

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Krejcí et al., 2009, Vogel et al., 2003)

CG8168

CT20824

(Hynes and Zhao, 2000, Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Dunc5

(Grossberger, 2000.3.23)

UNC-5

(Losada-Perez, 2018, Chilton, 2006)

UNC5

(Bravo-Ambrosio and Kaprielian, 2011, Grunwald and Klein, 2002)

UNC5D

(Keleman and Dickson, 2001)

Unc-5

(Kang et al., 2019, Seyres et al., 2016, O'Donnell and Bashaw, 2013, Ozkan et al., 2013, Labrador, 2005, Labrador et al., 2005, Chotard and Salecker, 2004)

Unc5

(Koch et al., 2017, Ocorr et al., 2014, Zarin et al., 2014, Lee et al., 2013, Ozkan et al., 2013, Nose, 2012, Hakeda-Suzuki et al., 2011, Hakeda-Suzuki et al., 2011, Brankatschk and Dickson, 2006, Terman et al., 2002, Keleman and Dickson, 2001, McKinnon et al., 2001)

Unc5d

(Couch et al., 2004, Keleman and Dickson, 2001)

dUnc5

(Gupta et al., 2014)

unc5

(Suzuki et al., 2018, Altenhein et al., 2016, Gupta et al., 2016, Raza and Jacobs, 2016, Pézeron et al., 2014, Macabenta et al., 2013, Zarin et al., 2012, Albrecht et al., 2011, Meyer et al., 2011, von Hilchen et al., 2010, Zlatic et al., 2009, Garbe et al., 2007, Hughes and Thomas, 2007)

Name Synonyms

UNC5 protein

(Banyai and Patthy, 2004)

Unc-5

(Zarin et al., 2014)

Uncoordinated5

(Albrecht et al., 2011)

unc-5

(Lipatov et al., 2005)

unc-5-like

(Hynes and Zhao, 2000, Hynes and Zhao, 2000, Hynes and Zhao, 2000)

uncoordinated 5

(von Hilchen et al., 2010)

Secondary FlyBase IDs

FBgn0034014

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (108)