FB2021_03, released June 15, 2021

Gene: Dmel\unc-5

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General Information
Symbol
Dmel\unc-5
Species
D. melanogaster
Name
unc-5
Annotation Symbol
CG8166
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034013
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
unc-5 (unc-5) encodes a netrin receptor involved in motor axon guidance and glial migration as well as netrin-mediated repulsion during salivary gland migration. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

unc-5-like, CT20824, Unc5d

Key Links
Genomic Location
Cytogenetic map
51F9-51F11
Sequence location
2R:15,340,472..15,368,300 [+]
Recombination map
2-74
RefSeq locus
NT_033778 REGION:15340472..15368300
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables netrin receptor activity involved in chemorepulsion
inferred from sequence or structural similarity
(Keleman and Dickson, 2001)
enables netrin receptor activity
inferred from electronic annotation with InterPro:IPR037936
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Brankatschk and Dickson, 2006, Keleman and Dickson, 2001)
inferred from genetic interaction with FLYBASE:NetA; FB:FBgn0015773
(Brankatschk and Dickson, 2006)
inferred from genetic interaction with FLYBASE:NetB; FB:FBgn0015774
(Brankatschk and Dickson, 2006, Keleman and Dickson, 2001)
involved_in glial cell migration
inferred from mutant phenotype
(von Hilchen et al., 2010, Freeman et al., 2003)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Zarin et al., 2014, Labrador et al., 2005)
involved_in positive regulation of cell migration
inferred from mutant phenotype
(Raza and Jacobs, 2016)
involved_in salivary gland boundary specification
inferred from mutant phenotype
(Kolesnikov and Beckendorf, 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in motor neuron axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN002650052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in netrin-activated signaling pathway
inferred from electronic annotation with InterPro:IPR037936
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR037936
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the unc-5 family. (Q95TU8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
unc-5 (unc-5) encodes a netrin receptor involved in motor axon guidance and glial migration as well as netrin-mediated repulsion during salivary gland migration. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.
(UniProt, Q95TU8)
Summary (Interactive Fly)

multiple domain protein that functions as a repulsive netrin receptor - essential for heart lumen formation

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\unc-5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
unc-5-RA
FBtr0087382
NM_137189
5033
1072
unc-5-RB
FBtr0339998
NM_001299521
5235
1072
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
unc-5-PA
FBpp0086514
116.4
1072
6.09
NP_611033
AAF58143
unc-5-PB
FBpp0309017
116.4
1072
6.09
NP_001286450
AHN56248
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1072 aa isoforms: unc-5-PA, unc-5-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification

Phosphorylated on different cytoplasmic tyrosine residues.

(UniProt, Q95TU8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\unc-5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14 -- 17
larval segmental nerve
(Keleman and Dickson, 2001)
embryonic stage 15 -- 16
embryonic/larval cardial cell
(Albrecht et al., 2011)
embryonic stage 16
embryonic/larval dorsal vessel
(Albrecht et al., 2011)
embryonic stage 16 -- 17
motor neuron of larval segmental nerve
• axon
(Keleman and Dickson, 2001)
larval segmental nerve branch SNa of A1-7
(Keleman and Dickson, 2001)
larval intersegmental nerve branch ISNb of A1-7
(Keleman and Dickson, 2001)
larval segmental nerve branch SNc of A1-7
(Keleman and Dickson, 2001)
exit glial cell of larval segmental nerve
(Keleman and Dickson, 2001)
peripheral glial cell of larval intersegmental nerve
(Keleman and Dickson, 2001)
exit glial cell of larval intersegmental nerve
(Keleman and Dickson, 2001)
Additional Descriptive Data

At embryonic stage 15 before the cardiomyocytes from the bilateral primordia meet at the dorsal midline, unc-5 is localized to these cells in a polarized fashion. Strong signal is observed on the prospective lumen forming side and a slightly weaker signal is seen at the opposite membrane region. Essentially no proteinis detected on the lateral sides of cardiomyocytes.

(Albrecht et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\unc-5 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of unc-5
Transgenic constructs containing regulatory region of unc-5
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4scrt-11-6
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell migration | dominant | embryonic stage
abnormal locomotor rhythm, with Scer\GAL45-40
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL45-40
abnormal neuroanatomy, with Scer\GAL4ap-md544
abnormal neuroanatomy, with Scer\GAL4eg-Mz360
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy, with Scer\GAL4NP6558
abnormal neuroanatomy (with Df(2R)XTE-18)
abnormal neuroanatomy (with unc-52)
abnormal neuroanatomy (with unc-58)
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage, with Scer\GAL4repo
some die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Phenotype manifest in
Allele
cell body & serotonin neuron, with Scer\GAL4eg-Mz360
embryonic/larval neuron, with Scer\GAL4ap-md544
embryonic heart cardioblast
embryonic peripheral glial cell 5 | embryonic stage
embryonic peripheral glial cell 6 | embryonic stage
embryonic peripheral glial cell 8 | embryonic stage
EW neuron, with Scer\GAL4eg-Mz360
filopodium | embryonic stage
heart primordium
interface glial cell
interface glial cell | embryonic stage, with Scer\GAL4repo
lamellipodium | embryonic stage
larval abdominal segmental nerve
larval abdominal segmental nerve (with Df(2R)XTE-18)
larval abdominal segmental nerve (with unc-52)
larval abdominal segmental nerve (with unc-58)
larval anterior commissure, with Scer\GAL4elav.PLu
larval intersegmental nerve
larval intersegmental nerve, with Scer\GAL4elav.PLu
larval longitudinal connective, with Scer\GAL4NP6558
larval posterior commissure, with Scer\GAL4elav.PLu
larval ventral nerve cord, with Scer\GAL4ap-md544
larval ventral nerve cord commissure
peripheral glial cell | embryonic stage
photoreceptor cell R7, with Scer\GAL4GMR.PF
presumptive embryonic salivary gland, with Scer\GAL4prd.RG1
serotonin neuron & ventral nerve cord, with Scer\GAL4eg-Mz360
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\UNC5C
15 of 15
Yes
Yes
Hsap\UNC5A
13 of 15
No
Yes
Hsap\UNC5B
13 of 15
No
Yes
Hsap\UNC5D
12 of 15
No
Yes
Hsap\UNC5CL
4 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Unc5c
14 of 15
Yes
Yes
Mmus\Unc5a
13 of 15
No
Yes
Mmus\Unc5b
13 of 15
No
Yes
Mmus\Unc5d
12 of 15
No
Yes
Mmus\Unc5cl
4 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Unc5b
12 of 13
Yes
Yes
Rnor\Unc5d
12 of 13
Yes
Yes
Rnor\Unc5c
11 of 13
No
Yes
Rnor\Unc5a
9 of 13
No
Yes
Rnor\Unc5cl
3 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\unc5c
9 of 12
Yes
Yes
Xtro\unc5b
8 of 12
No
Yes
Xtro\unc5d
8 of 12
No
Yes
Xtro\unc5a
2 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\unc5b
10 of 15
Yes
Yes
Drer\unc5da
10 of 15
Yes
Yes
Drer\unc5a
8 of 15
No
Yes
Drer\unc5db
8 of 15
No
Yes
Drer\si:ch73-72b7.1
7 of 15
No
Yes
Drer\unc5c
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\unc-5
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901XL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005505
Drosophila simulans
Dsim\GD11111
Drosophila sechellia
Dsec\GM21606
Drosophila erecta
Dere\GG20514
Drosophila yakuba
Dyak\GE11698
Drosophila ananassae
Dana\GF13032
Drosophila pseudoobscura pseudoobscura
Dpse\GA20860
Drosophila persimilis
Dper\GL16941
Drosophila willistoni
Dwil\GK10614
Drosophila virilis
Dvir\unc-5
Drosophila mojavensis
Dmoj\GI19611
Drosophila grimshawi
Dgri\GH20429
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500VC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021843
Glossina morsitans
Tsetse fly
Gmor\GMOY010867
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08685
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00UQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012668
Danaus plexippus
Monarch butterfly
Dple\DPOGS211421-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210087-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005676
Heliconius melpomene
Postman butterfly
Hmel\HMEL011789
Heliconius melpomene
Postman butterfly
Hmel\HMEL012726
Apis florea
Little honeybee
Aflo\4271915716
Apis florea
Little honeybee
Aflo\3926941380
Apis mellifera
Western honey bee
Amel\GB47918
Apis mellifera
Western honey bee
Amel\GB56032
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10631
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11974
Bombus terrestris
Buff-tailed bumblebee
Bter\15213544
Bombus terrestris
Buff-tailed bumblebee
Bter\15213545
Linepithema humile
Argentine ant
Lhum\LH22319
Linepithema humile
Argentine ant
Lhum\LH22317
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024c1
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024c6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020101
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04007
Tribolium castaneum
Red flour beetle
Tcas\TC033250
Pediculus humanus
Human body louse
Phum\PHUM590880
Rhodnius prolixus
Kissing bug
Rpro\RPRC015335
Rhodnius prolixus
Kissing bug
Rpro\RPRC009007
Cimex lectularius
Bed bug
Clec\CLEC009194
Cimex lectularius
Bed bug
Clec\CLEC009193
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI29381
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04593
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X019B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000410
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62729.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62730.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04680
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04730
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_46926
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_49901
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01JM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unc5
Ciona intestinalis
Vase tunicate
Cint\LOC100176438
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    UNC5C; unc-5 netrin receptor C
    15 of 15
    603610
        UNC5A; unc-5 netrin receptor A
        13 of 15
        607869
            UNC5B; unc-5 netrin receptor B
            13 of 15
            607870
                UNC5D; unc-5 netrin receptor D
                12 of 15
                616466
                    UNC5CL; unc-5 family C-terminal like
                    4 of 15
                    617464
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        esyN Network Diagram
                        Show neighbor-neighbor interactions:
                        Select Layout:
                        Legend:
                        Protein
                        RNA
                        Selected Interactor(s)
                        Interactions Browser
                        View in Interactions Browser
                        Please see the Physical Interaction reports below for full details
                        protein-protein
                        Physical Interaction
                        Assay
                        References
                        unc-5 - sns
                        enzyme linked immunosorbent assay, surface plasmon resonance
                        (Ozkan et al., 2013, Ozkan et al., 2013)
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        esyN Network Key:
                        Suppression
                        Enhancement
                        View in Interactions Browser
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        unc-5|Nrg
                        enhanceable
                        beat-Ia
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        beat-Ia
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        beat-Ia|eve
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        eve
                        (Zarin et al., 2014)
                        Nrg|beat-Ia|unc-5
                        enhanceable
                        Fas2
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        Fas2
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        Fas2|Nrg|beat-Ia
                        (Zarin et al., 2014)
                        unc-5
                        suppressible
                        fra
                        (Keleman and Dickson, 2001)
                        unc-5
                        suppressible
                        NetA|NetB
                        (Brankatschk and Dickson, 2006, Labrador et al., 2005)
                        unc-5
                        enhanceable
                        Nrg
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        Nrg|beat-Ia
                        (Zarin et al., 2014)
                        unc-5
                        enhanceable
                        robo1
                        (Raza and Jacobs, 2016)
                        unc-5
                        suppressible
                        robo1
                        (Raza and Jacobs, 2016)
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        beat-Ia
                        enhanceable
                        Fas2|unc-5
                        (Zarin et al., 2014)
                        beat-Ia
                        enhanceable
                        Nrg|unc-5
                        (Zarin et al., 2014)
                        beat-Ia
                        enhanceable
                        unc-5
                        (Zarin et al., 2014)
                        eve
                        suppressible
                        unc-5
                        (Zarin et al., 2014, Labrador et al., 2005)
                        eve
                        enhanceable
                        beat-Ia|unc-5
                        (Zarin et al., 2014)
                        eve
                        enhanceable
                        unc-5
                        (Zarin et al., 2014)
                        eve
                        suppressible
                        beat-Ia|unc-5
                        (Zarin et al., 2014)
                        fra
                        enhanceable
                        unc-5
                        (O'Donnell and Bashaw, 2013)
                        grn
                        suppressible
                        unc-5
                        (Zarin et al., 2012)
                        robo1
                        suppressible
                        unc-5
                        (Raza and Jacobs, 2016)
                        robo1
                        enhanceable
                        unc-5
                        (Raza and Jacobs, 2016)
                        External Data
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        External Data
                        Linkouts
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        2R
                        Recombination map
                        2-74
                        Cytogenetic map
                        51F9-51F11
                        Sequence location
                        2R:15,340,472..15,368,300 [+]
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        51F9-51F11
                        Limits computationally determined from genome sequence between P{PZ}scb01288 and P{lacW}dupk03308
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        51F-51F
                        (Grossberger, 2000.3.23)
                        Experimentally Determined Recombination Data
                        Location

                        2-74

                        (FlyBase, 2016)

                        2-78.2

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (10)
                        Genomic Clones (30)
                        cDNA Clones (42)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                          Drosophila Genomics Resource Center cDNA clones

                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                          cDNA Clones, End Sequenced (ESTs)
                          BDGP DGC clones
                          Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          Antibody Information
                          Laboratory Generated Antibodies
                           

                          polyclonal

                          (Albrecht et al., 2011, Keleman and Dickson, 2001)
                          Commercially Available Antibodies
                           
                          Other Information
                          Relationship to Other Genes
                          Source for database identify of

                          Source for identity of: unc-5 CG8166 CG8168

                          (FlyBase, 1996-)
                          Source for database merge of
                          Additional comments

                          Source for identity of unc-5 CG8166 CG8168 was sequence comparison ( date:000607 ).

                          (FlyBase, 1996-)
                          Other Comments

                          Overexpression of unc-5 on all CNS axons prevents them from crossing the midline, resulting in a commissureless phenotype. This gain-of-function Unc5d phenotype requires Netrin function. Overexpression of unc-5 in specific interneurons is also sufficient to force them out of the CNS.

                          (Keleman and Dickson, 2001)

                          The growth cone response (repulsive) is determined by the cytoplasmic domain of unc-5.

                          (Keleman and Dickson, 2001)

                          The unc-5 Netrin receptor mediates long range (with fra) and short range (either acting alone or with a co-receptor other than fra) repulsive responses to Netrin. Midline repulsion mediated by unc-5 operates independently of that mediated by sli and robo.

                          (Keleman and Dickson, 2001)
                          Origin and Etymology
                          Discoverer
                          Etymology
                          Identification
                          External Crossreferences and Linkouts ( 52 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DRscDB
                          EMBL-EBI Single Cell Expression Atlas
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL
                          modMine - A data warehouse for the modENCODE project
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyMine - An integrated database for Drosophila genomics
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                          MIST (genetic) - An integrated Molecular Interaction Database
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Synonyms and Secondary IDs (18)
                          Reported As
                          Symbol Synonym
                          AAF7419
                          (Vernooy et al., 2000)
                          CG8166
                          (Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Krejcí et al., 2009, Vogel et al., 2003)
                          CG8168
                          CT20824
                          (Hynes and Zhao, 2000, Hynes and Zhao, 2000, Hynes and Zhao, 2000)
                          Dunc5
                          (Grossberger, 2000.3.23)
                          UNC-5
                          (Losada-Perez, 2018, Chilton, 2006)
                          UNC5
                          (Bravo-Ambrosio and Kaprielian, 2011, Grunwald and Klein, 2002)
                          UNC5D
                          (Keleman and Dickson, 2001)
                          Unc-5
                          (Kang et al., 2019, Seyres et al., 2016, O'Donnell and Bashaw, 2013, Ozkan et al., 2013, Labrador, 2005, Labrador et al., 2005, Chotard and Salecker, 2004)
                          Unc5
                          (Koch et al., 2017, Ocorr et al., 2014, Zarin et al., 2014, Lee et al., 2013, Ozkan et al., 2013, Nose, 2012, Hakeda-Suzuki et al., 2011, Hakeda-Suzuki et al., 2011, Brankatschk and Dickson, 2006, Terman et al., 2002, Keleman and Dickson, 2001, McKinnon et al., 2001)
                          Unc5d
                          (Couch et al., 2004, Keleman and Dickson, 2001)
                          dUnc5
                          (Gupta et al., 2014)
                          unc-5
                          (Valdes-Aleman et al., 2021, Shih et al., 2019, Yildirim et al., 2019, Aw et al., 2017, Sarov et al., 2016, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Ghavi-Helm et al., 2014, Gupta et al., 2014, Wolfram et al., 2014, Berger-Müller et al., 2013, Jin et al., 2013, O'Donnell and Bashaw, 2013, Ozkan et al., 2013, Ozkan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, von Hilchen et al., 2010, Ayroles et al., 2009, Hazelett et al., 2009, Krejcí et al., 2009, Southall and Brand, 2009, Akdemir et al., 2007, Garbe et al., 2007, Lipatov et al., 2005)
                          unc5
                          (Suzuki et al., 2018, Altenhein et al., 2016, Gupta et al., 2016, Raza and Jacobs, 2016, Pézeron et al., 2014, Macabenta et al., 2013, Zarin et al., 2012, Albrecht et al., 2011, Meyer et al., 2011, von Hilchen et al., 2010, Zlatic et al., 2009, Garbe et al., 2007, Hughes and Thomas, 2007)
                          Name Synonyms
                          UNC5 protein
                          (Banyai and Patthy, 2004)
                          Unc-5
                          (Zarin et al., 2014)
                          Uncoordinated5
                          (Albrecht et al., 2011)
                          unc-5
                          (Lipatov et al., 2005)
                          unc-5-like
                          (Hynes and Zhao, 2000, Hynes and Zhao, 2000, Hynes and Zhao, 2000)
                          uncoordinated 5
                          (von Hilchen et al., 2010)
                          Secondary FlyBase IDs
                          • FBgn0034014
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          References (108)