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Gene Dmel\Cyp4aa1

General Information
Symbol	Dmel\Cyp4aa1	Species	D. melanogaster
Name	Cyp4aa1	Annotation symbol	CG8302
Feature type	protein_coding_gene	FlyBase ID	FBgn0034053
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52D3-52D4	Sequence location	2R:11,830,386..11,834,772 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyp4aa1 is referred to in FlyBase by the symbol Dmel\Cyp4aa1 (CG8302, FBgn0034053). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: electron carrier activity. It is reported to be involved in the biological process: insecticide catabolic process; hormone metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome P450; Cytochrome P450, E-class, group IV; Cytochrome P450, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627068_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cyp4aa1. Gene sequence location is 2R:11830386..11834772.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543 Sequence features BKN27191 HFA07368
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52D3-52D4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52D2-52D2     (Dunkov, 2000.6.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyp4aa1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyp4aa1-RB FBtr0114558  NM_137223   2092   510
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyp4aa1-PB   FBpp0113050   58.5   510   8.34     NP_611067   AAF58091
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group IV (IPR002403) Cytochrome P450, conserved site (IPR017972)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58091   BT025154   CA805943   CO296235   EL875880   EL876006   EL876133
UniProtKB/Swiss-Prot	Q9V7G5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034053    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034053 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034053 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr  (238) embryo 10-12hr  (319) embryo 12-14hr  (170) embryo 14-16hr  (226) embryo 16-18hr  (1357) embryo 18-20hr  (1351) embryo 20-22hr  (832) embryo 22-24hr  (1000) larva L1  (834) larva L2  (287) larva L3 12hr old  (629) larva L3 puffstage 1-2  (254) larva L3 puffstage 3-6    94 larva L3 puffstage 7-9  (122) white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP  (300) pupae 4d postWPP  (284) adult male 01day  (579) adult male 05day  (772) adult male 30day  (436) adult female 01day  (432) adult female 05day  (399) adult female 30day  (214) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034053 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr  (238) embryo 10-12hr  (319) embryo 12-14hr  (170) embryo 14-16hr  (226) embryo 16-18hr  (1357) embryo 18-20hr  (1351) embryo 20-22hr  (832) embryo 22-24hr  (1000) larva L1  (834) larva L2  (287) larva L3 12hr old  (629) larva L3 puffstage 1-2  (254) larva L3 puffstage 3-6    94 larva L3 puffstage 7-9  122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP  (300) pupae 4d postWPP  (284) adult male 01day  (579) adult male 05day  (772) adult male 30day  (436) adult female 01day  (432) adult female 05day  (399) adult female 30day  (214) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    4 embryo 04-06hr    9 embryo 06-08hr    72 embryo 08-10hr    238 embryo 10-12hr    319 embryo 12-14hr    170 embryo 14-16hr    226 embryo 16-18hr    1357 embryo 18-20hr    1351 embryo 20-22hr    832 embryo 22-24hr    1000 larva L1    834 larva L2    287 larva L3 12hr old    629 larva L3 puffstage 1-2    254 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    122 white prepupae new    49 white prepupae 12hr    95 white prepupae 24hr    39 pupae 2d postWPP    32 pupae 3d postWPP    300 pupae 4d postWPP    284 adult male 01day    579 adult male 05day    772 adult male 30day    436 adult female 01day    432 adult female 05day    399 adult female 30day    214 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034053    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034053 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034053 expression level Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034053 expression level Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.65 Larval Midgut    1.6 Larval Hindgut    228.7 Larval Malpighian Tubules    1.5 Larval Fat Body    1.7 Larval Salivary Gland    5.2 Larval Trachea    0.975 Larval Carcass    2.95 Adult Head no informative data Adult Eye    0.85 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    3.5 Adult Crop    399.5 Adult Midgut no informative data Adult Hindgut    232.2 Adult Malpighian Tubules    1.3 Adult Fat Body    7.5 Adult Salivary Gland    4.7 Adult Heart    1.175 Adult VirginFemale Spermatheca    0.7 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.4 Adult Testis    0.7 Adult Male Accessory Gland    1.6 Adult Carcass    279.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    0.85   NA  Brain    0.8   1.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.5   NA  Crop    399.5   1.6  Midgut    no informative data   228.7  Hindgut    232.2   1.5  Malpighian Tubules    1.3   1.7  Fat Body    7.5   5.2  Salivary Gland    4.7   NA  Heart    1.175   0.975  Trachea    NA   NA  VirginFemale Spermatheca    0.7   NA  InseminatedFemale Spermatheca    0.9   NA  Ovary    1.4   NA  Testis    0.7   NA  Male Accessory Gland    1.6   2.95  Carcass    279.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8302-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Cyp4aa1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyp4aa1 Class Mutagen Stocks Known lesion Cyp4aa1GD2021 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cyp4aa1KK107191 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7138 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2021} NA P{KK107191} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from electronic annotation with InterPro:IPR001128 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Dunkov, 1999.11) non-traceable author statement (Dunkov, 2000.6.29, Swiss-Prot Project Members, 2000.10.1) heme binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403 (FlyBase Curators et al., 2004-) monooxygenase activity inferred from electronic annotation with InterPro:IPR002403 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
hormone metabolic process non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) insecticide catabolic process non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) oxidation-reduction process inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) microsome non-traceable author statement (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyp4aa1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034053
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11549 Dere\GG20554 Dgri\GH22055 Dmoj\GI19140 Dper\GL20655 Dpse\GA20970 Dsec\GM21646 Dsim\GD11146 Dvir\GJ22273 Dwil\GK22193 Dyak\GE11739
Curated drosophilid orthologs	Dpse\GA20970
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP003608-PA Anopheles gambiae (mosquito) At1g31800.1 Arabidopsis thaliana (wall cress) XP_001602111.1 Nasonia vitripennis (wasp) LOC_Os02g57810.1 Oryza sativa (asian rice) LOC_Os07g23570.1 Oryza sativa (asian rice) LOC_Os07g44140.1 Oryza sativa (asian rice) 110612 Physcomitrella patens (moss) 188189 Physcomitrella patens (moss) 197852 Physcomitrella patens (moss) XP_973810.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15526 LH24569 FBgn0229533 FBgn0224178 FBgn0209386 FBgn0182901 FBgn0176526 FBgn0080959 FBgn0158250 FBgn0141879 FBgn0129516 FBgn0112744 FBgn0088589 GB17784 AGAP003608 GLEAN_03478
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v104458 P{KK107191}VIE-260B v51942 w1118; P{GD2021}v51942 v51943 w1118; P{GD2021}v51943
Genomic Clones ( 1 )
	BACR07M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03146
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EK213202 ESG0120b.B21_F11 IP05786 IP05886 IP05986
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36752
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137223 RefSeq (Proteins) • NP_611067 DDBJ / EMBL / GenBank • AAF58091 AAF58091.1 Entrez Gene - A searchable database of RefSeq genes. • 36752 UniProtKB/Swiss-Prot • Q9V7G5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group IV (IPR002403) Cytochrome P450, conserved site (IPR017972)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034053 DRSC - Results from RNAi screens. • FBgn0034053 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8302-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36752 InParanoid A subset of ortholog calls from InParanoid. • AGAP003608-PA Anopheles gambiae (mosquito) At1g31800.1 Arabidopsis thaliana (wall cress) XP_001602111.1 Nasonia vitripennis (wasp) LOC_Os02g57810.1 Oryza sativa (asian rice) LOC_Os07g23570.1 Oryza sativa (asian rice) LOC_Os07g44140.1 Oryza sativa (asian rice) 110612 Physcomitrella patens (moss) 188189 Physcomitrella patens (moss) 197852 Physcomitrella patens (moss) XP_973810.2 Tribolium castaneum (red flour beetle) modMine - Data generated by the modENCODE project. • FBgn0034053 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15526 LH24569 FBgn0229533 FBgn0224178 FBgn0209386 FBgn0182901 FBgn0176526 FBgn0080959 FBgn0158250 FBgn0141879 FBgn0129516 FBgn0112744 FBgn0088589 GB17784 AGAP003608 GLEAN_03478
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	4aa1 (Nelson, 2001.2.5) CG8302 (Keleman et al., 2009.8.5) Cyp4aa1 (Niwa et al., 2011)
Name Synonym	Cyp4aa1   cytochrome P450 (Chung et al., 2009)
Secondary FlyBase IDs
References ( 15 )
Research paper	Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543 Expressions of the cytochrome P450 monooxygenase gene Cyp4g1 and its homolog in the prothoracic glands of the fruit fly Drosophila melanogaster (Diptera: Drosophilidae) and the silkworm Bombyx mori (Lepidoptera: Bombycidae). [FBrf0216541] Chung et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(14): 5731--5736 Characterization of Drosophila melanogaster cytochrome P450 genes. [FBrf0207683] Daborn et al., 2001, Molec. Genet. Genomics 266(4): 556--563 DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. [FBrf0145128] Tijet et al., 2001, Gene 262(1-2): 189--198 The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogeny. [FBrf0134628] Champagne et al., 2000, J. molec. Biol. 300(4): 759--777 Drosophila Stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. [FBrf0129758]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Nelson, 2001.2.5, Drosophila melanogaster P450 protein sequences. Drosophila melanogaster P450 protein sequences. [FBrf0136021] Dunkov, 2000.6.29, Table of the D. melanogaster cytochrome P450 genes, locations and transcripts. Table of the D. melanogaster cytochrome P450 genes, locations and transcripts. [FBrf0126925]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Curated genome annotation	Dunkov, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126661]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9V7G5 PROBABLE CYTOCHROME P450 4AA1 (EC 1.14.-.-) (CYPIVAA1). [FBrf0131879]