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Gene Dmel\Dg

General Information
Symbol	Dmel\Dg	Species	D. melanogaster
Name	Dystroglycan	Annotation symbol	CG18250
Feature type	protein_coding_gene	FlyBase ID	FBgn0034072
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	DmDG, atu
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52E2-52E4	Sequence location	2R:11,968,681..11,986,069 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dystroglycan is referred to in FlyBase by the symbol Dmel\Dg (CG18250, FBgn0034072). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 17 unique biological process terms, many of which group under: single-organism developmental process; cellular process; cellular component organization or biogenesis; biological regulation; multicellular organism reproduction; establishment or maintenance of cell polarity; establishment or maintenance of bipolar cell polarity; actin filament-based process; gamete generation; anterior/posterior axis specification; post-embryonic organ morphogenesis; growth; establishment or maintenance of polarity of follicular epithelium. 42 alleles are reported. The phenotypes of these alleles are annotated with: leg; posterior crossvein; eye; crossvein; oocyte; embryonic/larval neuromuscular junction; follicle cell; eye photoreceptor cell; wing. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cadherin-like; Dystroglycan; Dystroglycan-type cadherin-like; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1641448_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Dg. Gene sequence location is 2R:11968681..11986069.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52E2-52E4   Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52D2-52D15     (Greener, 2000.6.14)
Experimentally Determined Recombination Data
Location	2- (Takeuchi, 2001.12.19, Takeuchi, 2001.12.19, Takeuchi, 2001.12.19)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dg-RA FBtr0087256  NM_079032   5247   997 Dg-RB FBtr0087257  NM_166138   4998   914 Dg-RC FBtr0087258  NM_176184   5793   1179 Dg-RD FBtr0306238  NM_176183   6533   1262
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dg-PA   FBpp0086394   110.8   997   6.05     NP_523756   AAF58068 Dg-PB   FBpp0086395   102.6   914   6.32     NP_725523   AAM70943 Dg-PC   FBpp0086396   129.6   1179   4.93     NP_788364   AAO41377 Dg-PD   FBpp0297348   137.7   1262   4.86     NP_788363   AAO41376
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dystroglycan-type cadherin-like (IPR006644) Dystroglycan (IPR008465) Cadherin-like (IPR015919) Alpha-dystroglycan domain 2 (IPR027468) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201679   AA391686   AA978941   AE013599 AAF58068   AE013599 AAM70943   AE013599 AAO41376   AE013599 AAO41377   AC004248   AF277390 AAG17399   AF461099 AAL66367   AF461100 AAL66368   AF461101 AAL66369   AI109925   AI258332   AI402170   AI531345   AI534175   AI534934   AQ254841   AW941559   AY069076 AAL39221   AY069330 AAL39475   BI352148   BI632137   BP557566   BT025858   CK657103   CK660375   CO177970   CO178479   CO179044   CO189736   CO195297   CO271305   CO273554   CO274790   CO275431   CO275686   CO277304   CO282873   CO284930   CO285153   CO287885   CO291352   CO298721   CO299739   CO310639   CO310658   CO311840   CO314743   CO317578   CO317653   CO320699   CO321423   CO322947   CO330184   CO330324   CO330614   CO333164   CO341661   CZ479364   CZ480364   EC058329   EC060066   EC060513   EC062129   EC062901   EC068160   EC069281   EC069823   EC070472   EC073795   EC075447   EC078699   EC078915   EC078939   EC085194   EC090094   EC194544   EC195442   EC195621   EC198191   EC200630   EC216267   EC221350   EC222748   EC227037   EC227039   EC227877   EC230202   EC232257   EC232719   EC234876   EC240061   EC241985   EC244095   EC246755   EC248008   EC248284   EC254144   EL875226   EL875355   EL884080   ES693571   GH946330   GH948214   GH953314   GH958469   GH960562   GH962686   GH964364   GH965693   GH967016   GH967433   GH972281   GH973757   GH974528   GH979136   GH979925   GH980591   GH982474   GH983146
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8STB9 Q8WR08 A1ZA89 Q9GT67 Q8WR09 Q8T0G6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   mesectoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium organism | faint & ubiquitous   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   circular visceral muscle fiber   (Fisher et al., 2012) dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic dorsal apodeme   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic ventral apodeme   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval dorsal vessel   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basal plasma membrane inferred from direct assay (Yatsenko et al., 2007, Yatsenko et al., 2009) dystroglycan complex inferred from direct assay (Sciandra et al., 2001) dystrophin-associated glycoprotein complex inferred from physical interaction with Dys (Yatsenko et al., 2007) neuromuscular junction inferred from direct assay (Bogdanik et al., 2008) sarcolemma inferred from direct assay (Kucherenko et al., 2011) T-tubule inferred from direct assay (Haines et al., 2007) Z disc inferred from direct assay (Kucherenko et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (772.625) Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    772.625 Larval Midgut    27.1 Larval Hindgut    16.5 Larval Malpighian Tubules    17.5 Larval Fat Body    14.7 Larval Salivary Gland    47.1 Larval Trachea    39.7 Larval Carcass    13.65 Adult Head    35.6 Adult Eye    47.05 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    198.9 Adult Crop    18.2 Adult Midgut    14.3 Adult Hindgut    12.6 Adult Malpighian Tubules    8.2 Adult Fat Body    11.5 Adult Salivary Gland    23.4 Adult Heart    31.65 Adult VirginFemale Spermatheca    8.5 Adult InseminatedFemale Spermatheca    11.8 Adult Ovary    9.7 Adult Testis    11.2 Adult Male Accessory Gland    50.6 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    35.6   NA  Eye    47.05   NA  Brain    206.9   772.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    198.9   NA  Crop    18.2   27.1  Midgut    14.3   16.5  Hindgut    12.6   17.5  Malpighian Tubules    8.2   no informative data  Fat Body    11.5   47.1  Salivary Gland    no informative data   NA  Heart    31.65   39.7  Trachea    NA   NA  VirginFemale Spermatheca    8.5   NA  InseminatedFemale Spermatheca    11.8   NA  Ovary    9.7   NA  Testis    no informative data   NA  Male Accessory Gland    50.6   13.65  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    102 central nervous system, pupae P8    97 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8    39 carcass, larvae L3 wandering    43 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    27 ovary, mated 4-day female    31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (102) central nervous system, pupae P8  (97) head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering  (32) digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8  (39) carcass, larvae L3 wandering  (43) carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female  (27) ovary, mated 4-day female  (31) testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3  102 central nervous system, pupae P8    97 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8    39 carcass, larvae L3 wandering    43 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    27 ovary, mated 4-day female    31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    102 central nervous system, pupae P8    97 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8    39 carcass, larvae L3 wandering    43 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    27 ovary, mated 4-day female    31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    102 central nervous system, pupae P8    97 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8    39 carcass, larvae L3 wandering    43 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    27 ovary, mated 4-day female    31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (102) central nervous system, pupae P8  (97) head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering  32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8  (39) carcass, larvae L3 wandering  (43) carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female  27 ovary, mated 4-day female  31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3  102 central nervous system, pupae P8    97 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8    39 carcass, larvae L3 wandering    43 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    27 ovary, mated 4-day female    31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    102 central nervous system, pupae P8    97 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    22 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    15 fat body, pupae P8    39 carcass, larvae L3 wandering    43 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    27 ovary, mated 4-day female    31 testis, mated 4-day male    7 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    28 embryo 04-06hr    27 embryo 06-08hr    45 embryo 08-10hr    52 embryo 10-12hr    50 embryo 12-14hr    80 embryo 14-16hr    99 embryo 16-18hr    87 embryo 18-20hr    36 embryo 20-22hr    25 embryo 22-24hr    30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    37 white prepupae new    44 white prepupae 12hr    34 white prepupae 24hr    55 pupae 2d postWPP    63 pupae 3d postWPP    36 pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr  (28) embryo 04-06hr  (27) embryo 06-08hr  (45) embryo 08-10hr  (52) embryo 10-12hr  (50) embryo 12-14hr  (80) embryo 14-16hr  (99) embryo 16-18hr  (87) embryo 18-20hr  (36) embryo 20-22hr    25 embryo 22-24hr  (30) larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (37) white prepupae new  (44) white prepupae 12hr  (34) white prepupae 24hr  (55) pupae 2d postWPP  (63) pupae 3d postWPP  (36) pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    28 embryo 04-06hr    27 embryo 06-08hr    45 embryo 08-10hr    52 embryo 10-12hr    50 embryo 12-14hr    80 embryo 14-16hr    99 embryo 16-18hr    87 embryo 18-20hr    36 embryo 20-22hr    25 embryo 22-24hr    30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    37 white prepupae new    44 white prepupae 12hr    34 white prepupae 24hr    55 pupae 2d postWPP    63 pupae 3d postWPP    36 pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    28 embryo 04-06hr    27 embryo 06-08hr    45 embryo 08-10hr    52 embryo 10-12hr    50 embryo 12-14hr    80 embryo 14-16hr    99 embryo 16-18hr    87 embryo 18-20hr    36 embryo 20-22hr    25 embryo 22-24hr    30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    37 white prepupae new    44 white prepupae 12hr    34 white prepupae 24hr    55 pupae 2d postWPP    63 pupae 3d postWPP    36 pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    28 embryo 04-06hr    27 embryo 06-08hr    45 embryo 08-10hr    52 embryo 10-12hr    50 embryo 12-14hr    80 embryo 14-16hr    99 embryo 16-18hr    87 embryo 18-20hr    36 embryo 20-22hr    25 embryo 22-24hr    30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    37 white prepupae new    44 white prepupae 12hr    34 white prepupae 24hr    55 pupae 2d postWPP    63 pupae 3d postWPP    36 pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr  28 embryo 04-06hr  27 embryo 06-08hr  (45) embryo 08-10hr  (52) embryo 10-12hr  (50) embryo 12-14hr  (80) embryo 14-16hr  (99) embryo 16-18hr  (87) embryo 18-20hr  (36) embryo 20-22hr    25 embryo 22-24hr  30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (37) white prepupae new  (44) white prepupae 12hr  (34) white prepupae 24hr  (55) pupae 2d postWPP  (63) pupae 3d postWPP  (36) pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    28 embryo 04-06hr    27 embryo 06-08hr    45 embryo 08-10hr    52 embryo 10-12hr    50 embryo 12-14hr    80 embryo 14-16hr    99 embryo 16-18hr    87 embryo 18-20hr    36 embryo 20-22hr    25 embryo 22-24hr    30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    37 white prepupae new    44 white prepupae 12hr    34 white prepupae 24hr    55 pupae 2d postWPP    63 pupae 3d postWPP    36 pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    28 embryo 04-06hr    27 embryo 06-08hr    45 embryo 08-10hr    52 embryo 10-12hr    50 embryo 12-14hr    80 embryo 14-16hr    99 embryo 16-18hr    87 embryo 18-20hr    36 embryo 20-22hr    25 embryo 22-24hr    30 larva L1    20 larva L2    16 larva L3 12hr old    9 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    37 white prepupae new    44 white prepupae 12hr    34 white prepupae 24hr    55 pupae 2d postWPP    63 pupae 3d postWPP    36 pupae 4d postWPP    11 adult male 01day    12 adult male 05day    10 adult male 30day    9 adult female 01day    16 adult female 05day    19 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    43 embryonic 1182-4H    63 embryonic GM2    50 embryonic Kc167    23 embryonic S1    29 embryonic S3    137 leg disc CME L1    56 wing disc CME-W2    51 wing disc ML-DmD8    86 wing disc ML-DmD9    70 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    18 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    42 ovary fGS/OSS    80 ovary OSC    61 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (66) Schneider line 2 Sg4  (43) embryonic 1182-4H  (63) embryonic GM2  (50) embryonic Kc167    23 embryonic S1  (29) embryonic S3  (137) leg disc CME L1  (56) wing disc CME-W2  (51) wing disc ML-DmD8  (86) wing disc ML-DmD9  (70) wing disc ML-DmD16-c3  (33) wing disc ML-DmD21    18 wing disc ML-DmD32  (46) haltere disc ML-DmD17-c3  (90) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  (42) ovary fGS/OSS  (80) ovary OSC  (61) ovary OSS  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    43 embryonic 1182-4H    63 embryonic GM2    50 embryonic Kc167    23 embryonic S1    29 embryonic S3  (137) leg disc CME L1    56 wing disc CME-W2    51 wing disc ML-DmD8    86 wing disc ML-DmD9    70 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    18 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    42 ovary fGS/OSS    80 ovary OSC    61 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    43 embryonic 1182-4H    63 embryonic GM2    50 embryonic Kc167    23 embryonic S1    29 embryonic S3    137 leg disc CME L1    56 wing disc CME-W2    51 wing disc ML-DmD8    86 wing disc ML-DmD9    70 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    18 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    42 ovary fGS/OSS    80 ovary OSC    61 ovary OSS    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    43 embryonic 1182-4H    63 embryonic GM2    50 embryonic Kc167    23 embryonic S1    29 embryonic S3    137 leg disc CME L1    56 wing disc CME-W2    51 wing disc ML-DmD8    86 wing disc ML-DmD9    70 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    18 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    42 ovary fGS/OSS    80 ovary OSC    61 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (66) Schneider line 2 Sg4  (43) embryonic 1182-4H  (63) embryonic GM2  (50) embryonic Kc167    23 embryonic S1  29 embryonic S3  (137) leg disc CME L1  (56) wing disc CME-W2  (51) wing disc ML-DmD8  (86) wing disc ML-DmD9  (70) wing disc ML-DmD16-c3  (33) wing disc ML-DmD21    18 wing disc ML-DmD32  (46) haltere disc ML-DmD17-c3  (90) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  (42) ovary fGS/OSS  (80) ovary OSC  (61) ovary OSS  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    43 embryonic 1182-4H    63 embryonic GM2    50 embryonic Kc167    23 embryonic S1    29 embryonic S3  137 leg disc CME L1    56 wing disc CME-W2    51 wing disc ML-DmD8    86 wing disc ML-DmD9    70 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    18 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    42 ovary fGS/OSS    80 ovary OSC    61 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    43 embryonic 1182-4H    63 embryonic GM2    50 embryonic Kc167    23 embryonic S1    29 embryonic S3    137 leg disc CME L1    56 wing disc CME-W2    51 wing disc ML-DmD8    86 wing disc ML-DmD9    70 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    18 wing disc ML-DmD32    46 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    42 ovary fGS/OSS    80 ovary OSC    61 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (27) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    18 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • CG18250 GH09323 LD04782 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034072 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18250-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Dg Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | early third instar larval stage Dg248 Dg323 lethal | early third instar larval stage (with Dg248) Dg323 lethal | early third instar larval stage (with Dg323) Dg248 partially lethal - majority die, with Scer\GAL4tub.PU DgFL.Scer\UAS.P\T partially lethal - majority die | larval stage, with Scer\GAL469B DgdsRNA.Scer\UAS partially lethal - majority die | larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS partially lethal - majority live DgO38 DgO43 DgO55 DgO86 partially lethal - majority live (with Df(2R)ED2457) DgO38 DgO43 DgO55 DgO86 Dgunspecified partially lethal - majority live (with DgJ43) DgO38 DgO43 DgO55 DgO86 partially lethal - majority live (with DgO38) DgJ43 partially lethal - majority live (with DgO43) DgJ43 partially lethal - majority live (with DgO55) DgJ43 partially lethal - majority live (with DgO86) DgJ43 viable Dg248 Dg323 viable, with Scer\GAL4how-24B DgdsRNA.Scer\UAS viable (with Dg248) DgO38 DgO43 DgO55 DgO86 viable (with Dg323) DgO38 DgO43 DgO55 DgO86 viable (with DgO38) Dg248 Dg323 DgO43 DgO55 DgO86 viable (with DgO43) Dg248 Dg323 DgO38 DgO55 DgO86 viable (with DgO55) Dg248 Dg323 DgO38 DgO43 DgO86 viable (with DgO86) Dg248 Dg323 DgO38 DgO43 DgO55 Other Phenotypes Allele behavior defective Dgatu cell polarity defective, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 Dg2WW.Scer\UAS.P\T DgC1.Scer\UAS.P\T DgFL.Scer\UAS.P\T DgPPSG.Scer\UAS.P\T cell polarity defective | cell autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS cell polarity defective | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS cell polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS cell polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS cell polarity defective | germline clone Dg323 locomotor behavior defective | adult stage | conditional, with Scer\GAL4how-24B DgdsRNA.Scer\UAS locomotor behavior defective | adult stage | conditional, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS neuroanatomy defective | somatic clone | third instar larval stage Dg323 neuroanatomy defective | third instar larval stage, with Scer\GAL4GMR.PU DgdsRNA.Scer\UAS neuroanatomy defective | third instar larval stage, with Scer\GAL4repo.PU DgdsRNA.Scer\UAS neuroanatomy defective | third instar larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS neurophysiology defective (with Df(2R)ED2457) Dge01554 neurophysiology defective | larval stage Dge01554 neurophysiology defective | larval stage, with Scer\GAL4how-24B DgdsRNA.Scer\UAS thermotaxis behavior defective | third instar larval stage Dgatu DgEP2241 thermotaxis behavior defective | third instar larval stage, with Scer\GAL4Act5C.PI DgdsRNA.cTa.Scer\UAS thermotaxis behavior defective | third instar larval stage (with Dgatu) DgEP2241 thermotaxis behavior defective | third instar larval stage (with DgEP2241) Dgatu visible DgO86 visible, with Scer\GAL4[-]: DgEP2241 visible, with Scer\GAL4Act5C.PI DgEx.Scer\UAS.T:Zzzz\FLAG visible, with Scer\GAL4en-e16E DgdsRNA.Scer\UAS.cUa visible (with Dg248) DgO86 visible (with Dg323) DgO86 visible (with DgJ43) DgO38 DgO43 DgO55 DgO86 visible (with DgO38) DgJ43 visible (with DgO43) DgJ43 visible (with DgO55) DgJ43 visible (with DgO86) Dg248 Dg323 DgJ43 Phenotype manifest in Allele crossvein DgO86 crossvein, with Scer\GAL4Act5C.PI DgEx.Scer\UAS.T:Zzzz\FLAG crossvein (with Dg248) DgO86 crossvein (with Dg323) DgO86 crossvein (with DgJ43) DgO38 DgO43 DgO55 DgO86 crossvein (with DgO38) DgJ43 crossvein (with DgO43) DgJ43 crossvein (with DgO55) DgJ43 crossvein (with DgO86) Dg248 Dg323 DgJ43 egg | maternal effect DgO86 embryonic/larval muscle system | second instar larval stage Dg248 Dg323 embryonic/larval muscle system | second instar larval stage (with Dg248) Dg323 embryonic/larval muscle system | second instar larval stage (with Dg323) Dg248 embryonic/larval muscle system | third instar larval stage, with Scer\GAL4how-24B DgdsRNA.Scer\UAS embryonic/larval muscle system | third instar larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS embryonic/larval neuromuscular junction Dge01554 embryonic/larval neuromuscular junction, with Scer\GAL4how-24B DgdsRNA.Scer\UAS eye (with Df(2R)ED2457) Dgunspecified eye disc | cell autonomous | somatic clone | third instar larval stage Dg323 eye disc | cell non-autonomous | somatic clone | third instar larval stage Dg323 eye disc | third instar larval stage, with Scer\GAL4GMR.PU DgdsRNA.Scer\UAS eye disc | third instar larval stage, with Scer\GAL4repo.PU DgdsRNA.Scer\UAS eye disc | third instar larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS eye photoreceptor cell, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS eye photoreceptor cell | somatic clone Dg323 eye photoreceptor cell | somatic clone | third instar larval stage Dg323 eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PU DgdsRNA.Scer\UAS eye photoreceptor cell | third instar larval stage, with Scer\GAL4repo.PU DgdsRNA.Scer\UAS eye photoreceptor cell | third instar larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS follicle cell, with Scer\GAL4αTub84B.PL DgdsRNA.Scer\UAS follicle cell | somatic clone Dg248 Dg323 DgO43 DgO86 glial cell | somatic clone | third instar larval stage Dg323 hemocyte | pupal stage DgO86 indirect flight muscle | conditional, with Scer\GAL4how-24B DgdsRNA.Scer\UAS indirect flight muscle | conditional, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS lamina plexus | somatic clone | third instar larval stage Dg323 lamina plexus | third instar larval stage, with Scer\GAL4GMR.PU DgdsRNA.Scer\UAS lamina plexus | third instar larval stage, with Scer\GAL4repo.PU DgdsRNA.Scer\UAS lamina plexus | third instar larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS leg (with Df(2R)ED2457) Dgunspecified muscle attachment site | second instar larval stage Dg248 Dg323 muscle attachment site | second instar larval stage (with Dg248) Dg323 muscle attachment site | second instar larval stage (with Dg323) Dg248 oocyte, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 DgPPSG.Scer\UAS.P\T Dg2WW.Scer\UAS.P\T DgFL.Scer\UAS.P\T DgC1.Scer\UAS.P\T oocyte | cell non-autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS oocyte | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS oocyte | germline clone Dg323 oocyte associated follicle cell | cell autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS oocyte associated follicle cell | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS posterior crossvein, with Scer\GAL4[-]: DgEP2241 ring canal | germline clone Dg323 sarcomere | second instar larval stage (with Dg248) Dg323 sarcomere | second instar larval stage (with Dg323) Dg248 sarcomere | third instar larval stage, with Scer\GAL4how-24B DgdsRNA.Scer\UAS sarcomere | third instar larval stage, with Scer\GAL4tub.PU DgdsRNA.Scer\UAS stage S6 oocyte | germline clone Dg248 stress fiber & follicle cell (with DgO43) DgO86 stress fiber & follicle cell (with DgO86) DgO43 stress fiber & follicle cell | somatic clone | cell autonomous DgO86 wing, with Scer\GAL4en-e16E DgdsRNA.Scer\UAS.cUa wing (with Df(2R)ED2457) Dgunspecified
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of Dg Class Mutagen Stocks Known lesion DgB148 2 -- Dge01554 piggyBac transposase 1 -- Dge02580 piggyBac transposase 1 -- DgMI05230 1 -- DgMI06589 1 -- Dg248 hypomorphic allele - genetic evidence Delta2-3 0 Yes Dg323 hypomorphic allele - genetic evidence Delta2-3 0 Yes Dg62 Delta2-3 0 Yes Dgatu hypomorphic allele - genetic evidence P-element activity 0 Yes DgDG30704 P-element activity 0 -- DgEP2241 P-element activity 0 Yes DgJ43 P-element activity 0 Yes DgO38 ethyl methanesulfonate 0 Yes DgO43 ethyl methanesulfonate 0 Yes DgO55 ethyl methanesulfonate 0 Yes DgO86 ethyl methanesulfonate 0 Yes DgR1 P-element activity 0 Yes Dgunspecified 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dg Class Mutagen Stocks Known lesion DgHMS01240 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DgKK100828 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dg2WW.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Dg4P.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes DgAATA.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes DgALLP.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes DgB.Scer\UAS in vitro construct - regulatory fusion 0 Yes DgC.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DgC.Scer\UAS in vitro construct - regulatory fusion 0 Yes DgC1.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes DgC2.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes Dgcyto.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DgDC2.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes DgdsRNA.cTa.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DgdsRNA.Scer\UAS.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DgdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DgEx.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DgFL.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes DgGD3513 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DgPA.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes DgPPSG.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes DgScer\UAS.cDb in vitro construct - regulatory fusion 0 -- DgScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes Dgt1.3 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7139 (Ryder, 2004.4.26)
Partially disrupted in	Df(2R)Dg248 (Mirouse et al., 2009) Df(2R)Dg323 (Mirouse et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3513} NA P{KK100828} NA P{TRiP.HMS01240} NA P{UAS-Dg.cyto} NA P{UAS-Dg.Db} NA P{UAS-Dg.dsRNA.T} NA P{UAS-Dg.dsRNA} NA P{UAS-Dg.Ex} NA P{UAS-Dg.T} NA P{UAS-Dg-B} NA P{UAS-Dg-C.GFP} NA P{UAS-Dg-C} NA P{UAS-Dg-IR.U} NA P{UASp-Dg.2WW} NA P{UASp-Dg.PPSG} NA characterization construct P{mRpL34+t1.3} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DgEP2241 NA miscellaneous insertions Mi{MIC}DgMI05230 NA Mi{MIC}DgMI06589 NA P{?'EP}Dg248 NA P{wHy}DgDG30704 NA PBac{5HPw+}DgB148 NA PBac{RB}Dge01554 NA PBac{RB}Dge02580 NA insertion of enhancer trap P{lacW}l(2)SH1091SH1091 No P{lwB}Dgatu No
Gene Ontology: Function, Process & Cellular Component ( 28 unique terms )
Terms Based on Experimental Evidence ( 25 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Dys (Shcherbata et al., 2007)
Biological Process
CV term Evidence References
actin cytoskeleton reorganization inferred from mutant phenotype (Marrone et al., 2011) axon guidance inferred from genetic interaction with dock (Shcherbata et al., 2007) establishment of cell polarity inferred from mutant phenotype (Shcherbata et al., 2007, Yatsenko et al., 2009) establishment or maintenance of apical/basal cell polarity inferred from mutant phenotype (Poulton and Deng, 2006) establishment or maintenance of cell polarity inferred from mutant phenotype (Yatsenko et al., 2007) establishment or maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Deng et al., 2003, Yatsenko et al., 2007) establishment or maintenance of polarity of follicular epithelium inferred from mutant phenotype (Deng et al., 2003) germarium-derived egg chamber formation inferred from mutant phenotype (Yatsenko et al., 2009) growth of a germarium-derived egg chamber inferred from mutant phenotype (Yatsenko et al., 2007) imaginal disc-derived wing vein specification inferred from mutant phenotype (Christoforou et al., 2008) muscle attachment inferred from mutant phenotype (Haines et al., 2007) muscle cell homeostasis inferred from mutant phenotype (Shcherbata et al., 2007, Haines et al., 2007, Kucherenko et al., 2011) oocyte anterior/posterior axis specification inferred from mutant phenotype (Deng et al., 2003) oocyte axis specification inferred from mutant phenotype (Poulton and Deng, 2006) regulation of glycolysis inferred from genetic interaction with Pgk (Kucherenko et al., 2011) regulation of synaptic activity inferred from mutant phenotype (Wairkar et al., 2008) sarcomere organization inferred from mutant phenotype (Haines et al., 2007)
Cellular Component
CV term Evidence References
basal plasma membrane inferred from direct assay (Yatsenko et al., 2007, Yatsenko et al., 2009) dystroglycan complex inferred from direct assay (Sciandra et al., 2001) dystrophin-associated glycoprotein complex inferred from physical interaction with Dys (Yatsenko et al., 2007) neuromuscular junction inferred from direct assay (Bogdanik et al., 2008) sarcolemma inferred from direct assay (Kucherenko et al., 2011) T-tubule inferred from direct assay (Haines et al., 2007) Z disc inferred from direct assay (Kucherenko et al., 2011)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR006644, InterPro:IPR015919 (FlyBase Curators et al., 2004-) structural constituent of muscle inferred from sequence or structural similarity with human DAG1 (Greener and Roberts, 2000)
Biological Process
CV term Evidence References
cytoskeletal anchoring at plasma membrane inferred from electronic annotation with InterPro:IPR008465 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hynes and Zhao, 2000)
Cellular Component
CV term Evidence References
dystroglycan complex inferred from sequence or structural similarity (Hynes and Zhao, 2000) inferred from sequence or structural similarity with human DAG1 (Greener and Roberts, 2000) non-traceable author statement (Greener, 2000.6.14)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dg allele Gene References unspecified Ras85D (Poulton and Deng, 2006) sli (Qian et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62498 DroID - A comprehensive database of gene and protein interactions. • FBgn0034072 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36773
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6HHPMV Dipteran inclusive ortholog search EOG6H46C0 Insect inclusive ortholog search EOG69W199 Arthropod inclusive ortholog search EOG666T1V Metazoa inclusive ortholog search EOG6JQGQD
Orthologs in Drosophila Species (EOG6HHPMV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dg     Drosophila sechellia   Dsec\GM20094 Y   Drosophila erecta   Dere\GG22304 Y   Drosophila yakuba   Dyak\GE14101 Y   Drosophila ananassae   Dana\GF13572 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14855 Y   Drosophila persimilis   Dper\GL17285 Y   Drosophila willistoni   Dwil\GK23093 Y   Drosophila virilis   Dvir\GJ20081 Y   Drosophila mojavensis   Dmoj\GI20410 Y   Drosophila grimshawi   Dgri\GH19821 Y
Orthologs in non-Drosophila Dipterans (EOG6H46C0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013147   Anopheles gambiae Malaria mosquito  Agam\AGAP005162   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018999
Orthologs in non-Dipteran Insects (EOG69W199)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46966   Apis mellifera Western honey bee  Amel\GB46696   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003009   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11031   Atta cephalotes Leafcutter ant  Acep\ACEP20003   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20863   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22917   Linepithema humile Argentine ant  Lhum\LH16340   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18992   Solenopsis invicta Red fire ant  Sinv\SINV20220   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001164   Bombyx mori Silkmoth  Bmor\BGIBMGA001935   Pediculus humanus Human body louse  Phum\PHUM379620   Tribolium castaneum Red flour beetle  Tcas\TC009157
Orthologs in non-Insect Arthropods (EOG666T1V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Arcn1   Ixodes scapularis Deer tick  Isca\ISCW015049
Orthologs in non-Arthropod Metazoa (EOG6JQGQD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dgn-2   Caenorhabditis elegans Nematode  Cele\dgn-1   Caenorhabditis elegans Nematode  Cele\dgn-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010116gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028775gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007757gn   Danio rerio Zebrafish  Drer\dag1   Xenopus tropicalis Western clawed frog  Xtro\dag1   Gallus gallus Domestic chicken  Ggal\DAG1   Mus musculus House mouse  Mmus\Dag1   Rattus norvegicus Norway rat  Rnor\Dag1   Homo sapiens Human  Hsap\DAG1
Human Orthologs (1)
Gene OMIM HGNC Hsap\DAG1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25571 Drosophila sechellia Dsec\GM20094 Drosophila erecta Dere\GG22304 Drosophila yakuba Dyak\GE14101 Drosophila ananassae Dana\GF13572 Drosophila pseudoobscura pseudoobscura Dpse\GA14855 Drosophila persimilis Dper\GL17285 Drosophila willistoni Dwil\GK23093 Drosophila virilis Dvir\GJ20081 Drosophila mojavensis Dmoj\GI20410 Drosophila grimshawi Dgri\GH19821
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	42067 y1 w*; Mi{MIC}DgMI05230 42406 y1 w*; Mi{MIC}DgMI06589 34895 y1 sc* v1; P{TRiP.HMS01240}attP2 16156 y1 w1118; PBac{5HPw+}DgB148/CyO
Harvard	- PBac{RB}Dge01554 - PBac{RB}Dge02580
Kyoto	114427 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D PBac{5HPw+}DgB148 /CyO y+
VDRC	v107029 P{KK100828}VIE-260B
Genomic Clones ( 2 )
	BACR04O19 BACR29I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 102 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH09323 IP15543 LD04782
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD11619 LD33152 LP01490 LP18907 LP23124 SD01224 SD02341 SD06707 SD25742
Other clones	4840 11466 13541 14837 20825 31071 45575 50383 51498 60135 60681 63295 66302 77114 99419 103573 164214 164229 180262 181303 192091 192252 214283.76 CK01.7C.F5 CK01.49A.C10 CK01.55B.E11 CK01.63A.A8 CK01.68B.F10 CK01.71C.A8 CK01.74A.F4 CK01.84C.D2 CK01.101B.B8 CK01.111A.E1 CK01.111A.F1 CK01.168A.F6 EC39996 EK045020 EK054853 EK056833 EK058254 EK067034 EK077840 EK102942 EK111427 EK115513 EK117559 EK118306 EK123755 EK161530 EK167609 EK168353 EK173601 EK176437 EK185641 EK189261 EK222205 EK222229 EK226952 EK237704 EK268540 EK268712 EK287243 EK294660 EK294958 EK295730 EK306106 EP12916 FGM310A06 GM18073 IP15243 IP15343 IP15443 RP004033307 RP004131903 RP004199737 RP004213865 RP004220516 RP004221124 RP004239955 RP004246791 RP004253354 RP004362223 RP004376444 RP004399835 RP004467402 RP004473353 RP004489576 RP004504612 RP004523429 RP004544037
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034072 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36773
Antibody Information
	polyclonal (Bogdanik et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dg CG18250 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Dg CG18250 was sequence comparison (date:001003). (FlyBase, 1996-)
Other Comments
	Dg is not required for the apical-basal polarity of follicle cells under normal food conditions. It is required for the correct planar polarity of the basal actin stress fibres of the follicle cells under these conditions. (Mirouse et al., 2009) Dg is required for apical-basal polarity of follicle cells under energetic stress. (Mirouse et al., 2009) Dg is required cell autonomously for cellular polarity in the epithelial cells (apicobasal polarity) and the oocyte (anteroposterior polarity). Dg is also required non-cell-autonomously to organise the planar polarity of basal actin in follicle cells. (Deng et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079032 NM_166138 NM_176183 NM_176184 RefSeq (Proteins) • NP_523756 NP_725523 NP_788363 NP_788364 DDBJ / EMBL / GenBank • AA201679 AA391686 AA978941 AAF58068 AAF58068.2 AAG17399 AAL39221 AAL39475 AAL66367 AAL66368 AAL66369 AAM70943 AAM70943.2 AAM70943.3 AAO41376 AAO41377 AAO41377.1 AAO41377.2 AC004248 AF277390 AF461099 AF461100 AF461101 AI109925 AI402170 AI534175 AQ254841 AW941559 AY069076 AY069330 CZ479364 CZ480364 Entrez Gene - A searchable database of RefSeq genes. • 36773 UniProtKB/TrEMBL • A1ZA89 Q8STB9 Q8T0G6 Q8WR08 Q8WR09 Q9GT67
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dystroglycan-type cadherin-like (IPR006644) Dystroglycan (IPR008465) Cadherin-like (IPR015919) Alpha-dystroglycan domain 2 (IPR027468) Immunoglobulin-like fold (IPR013783) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • CG18250 GH09323 LD04782
Linkouts
	BioGRID - A database of protein and genetic interactions • 62498 DroID - A comprehensive database of gene and protein interactions. • FBgn0034072 DRSC - Results from RNAi screens. • FBgn0034072 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034072 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18250-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034072 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36773 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/dystrog1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36773 modMine - Data generated by the modENCODE project. • FBgn0034072
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	atu (Larschan et al., 2012, Takeuchi et al., 2009) CG18250 (Dekkers et al., 2004, Schneider, 2002.9.17, Schneider, 2002.6.17, Ponting et al., 2001, Sciandra et al., 2001, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CT41273 (Hynes and Zhao, 2000) Dg (Bogdanik et al., 2008, Shcherbata et al., 2007, Kucherenko et al., 2007, Nakamura et al., 2007, Christoforou et al., 2008, Kucherenko et al., 2007, Schneider et al., 2006, Vanderploeg et al., 2012, Kucherenko et al., 2008, Pantoja et al., 2008, Yatsenko et al., 2007, Urbano et al., 2011, Shcherbata et al., 2007, Mirouse et al., 2007, Medioni et al., 2008, Conder et al., 2007, Haines et al., 2007, Mirouse et al., 2009, Yatsenko et al., 2009, Dworkin et al., 2009, Woolworth et al., 2009, Wairkar et al., 2008, Mirouse et al., 2009, Denef et al., 2008, Greene et al., 2005, Dubruille et al., 2009, Ueyama et al., 2010, Kucherenko et al., 2011, Marrone et al., 2011, Syed et al., 2012) dg (Bogdanik et al., 2008, Qian et al., 2005, Deng et al., 2002, Wairkar et al., 2008) DG (Qian et al., 2005, Gray et al., 2005, Poulton and Deng, 2006, Breloy et al., 2008, Polesello and Tapon, 2007, Meignin et al., 2007, Genevet et al., 2009, Zhan et al., 2010, Nakamura et al., 2010) dgn (Schneider and Baumgartner, 2001) DmDG (Greener and Roberts, 2000, Takeuchi et al., 2009) dys (Deng et al., 2001)
Name Synonym	atsugari (Takeuchi et al., 2009) Dystroglycan (Bogdanik et al., 2008, Shcherbata et al., 2007, Ray et al., 2007, Kucherenko et al., 2007, Poulton and Deng, 2006, Nakamura et al., 2007, Tsuda et al., 2006, Christoforou et al., 2008, Vanderploeg et al., 2012, Kucherenko et al., 2008, Pantoja et al., 2008, Breloy et al., 2008, Urbano et al., 2011, Shcherbata et al., 2007, Denef et al., 2008, Mirouse et al., 2007, Conder et al., 2007, Polesello and Tapon, 2007, Meignin et al., 2007, Haines et al., 2007, Mirouse et al., 2009, Yatsenko et al., 2009, Genevet et al., 2009, Greene et al., 2005, Schneider and Baumgartner, 2008, Zhan et al., 2010, Nakamura et al., 2010, Marrone et al., 2011, Paré et al., 2012) dystroglycan (Medioni et al., 2008, Tanentzapf et al., 2007, Wairkar et al., 2008, Ueyama et al., 2010) dystroglycan-like (Mendez et al., 2002)
Secondary FlyBase IDs
References ( 99 )
Generate a list of	All references relating to this gene ( 99 )
List References by type	Research paper  ( 50 ) Supplementary material  ( 5 ) Review  ( 5 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 18 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 4 ) Website  ( 1 )
Recent research papers ( 11 )
	Koper et al., 2012, PLoS ONE 7(4): e36339 Analysis of Adhesion Molecules and Basement Membrane Contributions to Synaptic Adhesion at the Drosophila Embryonic NMJ. [FBrf0218212] Larschan et al., 2012, PLoS Genet. 8(7): e1002830 Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation. [FBrf0219020] Marrone et al., 2012, BMC Cell Biol. 13: 26 Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile. [FBrf0220581] Paré et al., 2012, PLoS ONE 7(5): e36254 The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. [FBrf0218280] Syed et al., 2012, PLoS Genet. 8(8): e1002850 A Luminal Glycoprotein Drives Dose-Dependent Diameter Expansion of the Drosophila melanogaster Hindgut Tube. [FBrf0219128] Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Marrone et al., 2011, BMC Neurosci. 12: 93 New Dystrophin/Dystroglycan interactors control neuron behavior in Drosophila eye. [FBrf0216731] Marrone et al., 2011, Sci. Rep. 1: 47 Hyperthermic seizures and aberrant cellular homeostasis in Drosophila dystrophic muscles. [FBrf0217412] Urbano et al., 2011, PLoS ONE 6(9): e23893 PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis. [FBrf0216260] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...