• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\clu

General Information
Symbol	Dmel\clu	Species	D. melanogaster
Name	clueless	Annotation symbol	CG8443
Feature type	protein_coding_gene	FlyBase ID	FBgn0034087
Gene Model Status	Current	Stock availability	15 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52F5-52F7	Sequence location	2R:12,074,089..12,081,782 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene clueless is referred to in FlyBase by the symbol Dmel\clu (CG8443, FBgn0034087). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: mitochondrion localization. 19 alleles are reported. The phenotypes of these alleles are annotated with: mitochondrial crista; flight muscle; ovary; female germline cell; mitochondrial inner membrane; Nebenkern derivative; mesothoracic tergum; wing; female germline stem cell; mitochondrion. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: CLU domain; GSKIP/TIF31 domain; Protein of unknown function DUF727; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult fat body, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627927_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8443. Gene sequence location is 2R:12074089..12081782.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms intracellular distribution of mitochondria
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52F5-52F7   Limits computationally determined from genome sequence between P{lacW}Lis-1k11702&P{EP}CG8443EP969 and P{lacW}l(2)k07824k07824&P{lacW}vegk03402
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\clu for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) clu-RA FBtr0087242  NM_137251   5896   1448 clu-RB FBtr0333169  NM_001274092   5609   1289
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein clu-PA   FBpp0086380   160.9   1448   6.58     NP_611095   AAF58047 clu-PB   FBpp0305372   144.7   1289   6.85     NP_001261021   AGB93553
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CLU domain (IPR025697) Clustered mitochondria protein (IPR027523) Protein of unknown function DUF727 (IPR007967) Tetratricopeptide-like helical (IPR011990) GSKIP/TIF31 domain (IPR023231)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201736   AA390699   AA539996   AA694976   AA696101   AA802791   AA803322   AA938842   AE013599 AAF58047   AE013599 AGB93553   AI238582   AI257427   AI946036   AQ025006   AQ072904   AW942527   AX094019   AY061265 AAL28813   AY128431 AAM75024   BE977122   BF490316   BF493141   BF493924   BF495389   BF504373   BG633558   BH740770   BI241343   BI620723   BI621943   BT011344   CK661884   CO190648   CO196544   CO263354   CO269591   CO269606   CO271821   CO271857   CO279130   CO283405   CO290917   CO299545   CO303974   CO307681   CO311929   CO321868   CO324548   CO325209   CO327391   CO327937   CO330513   CO339555   CO341769   CZ471760   CZ487094   EC059865   EC062218   EC062912   EC067551   EC203588   EC204228   EC208235   EC208803   EC210841   EC212160   EC213811   EC217920   EC220479   EC221052   EC223888   EC225417   EC225418   EC241363   EC242337   EC249893   EC250787   EC251477   EC260038   EV582477   EV585481   EV596927
UniProtKB/Swiss-Prot	A1ZAB5
UniProtKB/TrEMBL	Q8MQR3 Q95RN1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   hindgut anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) gastric caecum   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference oogenesis stage S5 -- S9   egg chamber   • cytoplasm (Cox and Spradling, 2009) oogenesis stage S9   egg chamber   • cytoplasm (Cox and Spradling, 2009) Comment:in particles associated with mitochondria mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   organism   (Cox and Spradling, 2009)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Cox and Spradling, 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult fat body, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut    525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body    500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary    610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut  525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body  500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary  (610) Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut    525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body    500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary    610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut    525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body    500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary    610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut    525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body    500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary    610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut  525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body  500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary  610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut    525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body    500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary    610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    401.275 Larval Midgut    340.7 Larval Hindgut    525.3 Larval Malpighian Tubules    137.4 Larval Fat Body    235.9 Larval Salivary Gland    279.4 Larval Trachea    256.3 Larval Carcass    437.425 Adult Head    180 Adult Eye    142.975 Adult Brain    210 Adult Thoracic-Abdominal Ganglion    258.7 Adult Crop    297.1 Adult Midgut    293.8 Adult Hindgut    305.6 Adult Malpighian Tubules    326.7 Adult Fat Body    500.1 Adult Salivary Gland    277.4 Adult Heart    350.75 Adult VirginFemale Spermatheca    438.9 Adult InseminatedFemale Spermatheca    414.4 Adult Ovary    610 Adult Testis    58.6 Adult Male Accessory Gland    137.2 Adult Carcass    320 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    180   NA  Eye    142.975   NA  Brain    210   401.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    258.7   NA  Crop    297.1   340.7  Midgut    293.8   525.3  Hindgut    305.6   137.4  Malpighian Tubules    326.7   235.9  Fat Body    500.1   279.4  Salivary Gland    277.4   NA  Heart    350.75   256.3  Trachea    NA   NA  VirginFemale Spermatheca    438.9   NA  InseminatedFemale Spermatheca    414.4   NA  Ovary    610   NA  Testis    58.6   NA  Male Accessory Gland    137.2   437.425  Carcass    320 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    21 central nervous system, pupae P8    34 head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female    51 ovary, mated 4-day female    43 testis, mated 4-day male    31 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (32) central nervous system, larvae L3    21 central nervous system, pupae P8  (34) head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female  (51) ovary, mated 4-day female  (43) testis, mated 4-day male  (31) accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    21 central nervous system, pupae P8    34 head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female    51 ovary, mated 4-day female    43 testis, mated 4-day male    31 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    21 central nervous system, pupae P8    34 head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female    51 ovary, mated 4-day female    43 testis, mated 4-day male    31 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    21 central nervous system, pupae P8    34 head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female    51 ovary, mated 4-day female    43 testis, mated 4-day male    31 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  32 central nervous system, larvae L3    21 central nervous system, pupae P8  (34) head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female  (51) ovary, mated 4-day female  (43) testis, mated 4-day male  31 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    21 central nervous system, pupae P8    34 head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female    51 ovary, mated 4-day female    43 testis, mated 4-day male    31 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    21 central nervous system, pupae P8    34 head, virgin 1-day female    17 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    10 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    11 ovary, virgin 4-day female    51 ovary, mated 4-day female    43 testis, mated 4-day male    31 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    24 embryo 04-06hr    35 embryo 06-08hr    54 embryo 08-10hr    75 embryo 10-12hr    78 embryo 12-14hr    78 embryo 14-16hr    68 embryo 16-18hr    47 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    35 larva L1    69 larva L2    50 larva L3 12hr old    36 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    29 pupae 2d postWPP    46 pupae 3d postWPP    35 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    30 adult male 30day    26 adult female 01day    49 adult female 05day    54 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (39) embryo 02-04hr    24 embryo 04-06hr  (35) embryo 06-08hr  (54) embryo 08-10hr  (75) embryo 10-12hr  (78) embryo 12-14hr  (78) embryo 14-16hr  (68) embryo 16-18hr  (47) embryo 18-20hr  (31) embryo 20-22hr  (35) embryo 22-24hr  (35) larva L1  (69) larva L2  (50) larva L3 12hr old  (36) larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr  (29) pupae 2d postWPP  (46) pupae 3d postWPP  (35) pupae 4d postWPP  (28) adult male 01day  (30) adult male 05day  (30) adult male 30day  26 adult female 01day  (49) adult female 05day  (54) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    24 embryo 04-06hr    35 embryo 06-08hr    54 embryo 08-10hr    75 embryo 10-12hr    78 embryo 12-14hr    78 embryo 14-16hr    68 embryo 16-18hr    47 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    35 larva L1    69 larva L2    50 larva L3 12hr old    36 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    29 pupae 2d postWPP    46 pupae 3d postWPP    35 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    30 adult male 30day    26 adult female 01day    49 adult female 05day    54 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    24 embryo 04-06hr    35 embryo 06-08hr    54 embryo 08-10hr    75 embryo 10-12hr    78 embryo 12-14hr    78 embryo 14-16hr    68 embryo 16-18hr    47 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    35 larva L1    69 larva L2    50 larva L3 12hr old    36 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    29 pupae 2d postWPP    46 pupae 3d postWPP    35 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    30 adult male 30day    26 adult female 01day    49 adult female 05day    54 adult female 30day    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    24 embryo 04-06hr    35 embryo 06-08hr    54 embryo 08-10hr    75 embryo 10-12hr    78 embryo 12-14hr    78 embryo 14-16hr    68 embryo 16-18hr    47 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    35 larva L1    69 larva L2    50 larva L3 12hr old    36 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    29 pupae 2d postWPP    46 pupae 3d postWPP    35 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    30 adult male 30day    26 adult female 01day    49 adult female 05day    54 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (39) embryo 02-04hr    24 embryo 04-06hr  (35) embryo 06-08hr  (54) embryo 08-10hr  (75) embryo 10-12hr  (78) embryo 12-14hr  (78) embryo 14-16hr  (68) embryo 16-18hr  (47) embryo 18-20hr  31 embryo 20-22hr  (35) embryo 22-24hr  (35) larva L1  (69) larva L2  (50) larva L3 12hr old  (36) larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr  29 pupae 2d postWPP  (46) pupae 3d postWPP  (35) pupae 4d postWPP  28 adult male 01day  30 adult male 05day  30 adult male 30day  26 adult female 01day  (49) adult female 05day  (54) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    24 embryo 04-06hr    35 embryo 06-08hr    54 embryo 08-10hr    75 embryo 10-12hr    78 embryo 12-14hr    78 embryo 14-16hr    68 embryo 16-18hr    47 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    35 larva L1    69 larva L2    50 larva L3 12hr old    36 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    29 pupae 2d postWPP    46 pupae 3d postWPP    35 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    30 adult male 30day    26 adult female 01day    49 adult female 05day    54 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    24 embryo 04-06hr    35 embryo 06-08hr    54 embryo 08-10hr    75 embryo 10-12hr    78 embryo 12-14hr    78 embryo 14-16hr    68 embryo 16-18hr    47 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    35 larva L1    69 larva L2    50 larva L3 12hr old    36 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    29 pupae 2d postWPP    46 pupae 3d postWPP    35 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    30 adult male 30day    26 adult female 01day    49 adult female 05day    54 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    22 embryonic 1182-4H    28 embryonic GM2    46 embryonic Kc167    29 embryonic S1    36 embryonic S3    39 leg disc CME L1    26 wing disc CME-W2    28 wing disc ML-DmD8    28 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    66 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    53 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    29 ovary fGS/OSS    21 ovary OSC    45 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    22 embryonic 1182-4H  (28) embryonic GM2  (46) embryonic Kc167  (29) embryonic S1  (36) embryonic S3  (39) leg disc CME L1  26 wing disc CME-W2  (28) wing disc ML-DmD8  (28) wing disc ML-DmD9  (31) wing disc ML-DmD16-c3  (40) wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (66) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1  (53) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (31) tumorous blood cells mbn2  (29) ovary fGS/OSS    21 ovary OSC  (45) ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    22 embryonic 1182-4H    28 embryonic GM2    46 embryonic Kc167    29 embryonic S1    36 embryonic S3    39 leg disc CME L1    26 wing disc CME-W2    28 wing disc ML-DmD8    28 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    66 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    53 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    29 ovary fGS/OSS    21 ovary OSC    45 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    22 embryonic 1182-4H    28 embryonic GM2    46 embryonic Kc167    29 embryonic S1    36 embryonic S3    39 leg disc CME L1    26 wing disc CME-W2    28 wing disc ML-DmD8    28 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    66 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    53 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    29 ovary fGS/OSS    21 ovary OSC    45 ovary OSS    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    22 embryonic 1182-4H    28 embryonic GM2    46 embryonic Kc167    29 embryonic S1    36 embryonic S3    39 leg disc CME L1    26 wing disc CME-W2    28 wing disc ML-DmD8    28 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    66 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    53 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    29 ovary fGS/OSS    21 ovary OSC    45 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    22 embryonic 1182-4H  28 embryonic GM2  (46) embryonic Kc167  29 embryonic S1  (36) embryonic S3  (39) leg disc CME L1  26 wing disc CME-W2  28 wing disc ML-DmD8  28 wing disc ML-DmD9  31 wing disc ML-DmD16-c3  (40) wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (66) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1  (53) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  31 tumorous blood cells mbn2  29 ovary fGS/OSS    21 ovary OSC  (45) ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    22 embryonic 1182-4H    28 embryonic GM2    46 embryonic Kc167    29 embryonic S1    36 embryonic S3    39 leg disc CME L1    26 wing disc CME-W2    28 wing disc ML-DmD8    28 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    66 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    53 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    29 ovary fGS/OSS    21 ovary OSC    45 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    22 embryonic 1182-4H    28 embryonic GM2    46 embryonic Kc167    29 embryonic S1    36 embryonic S3    39 leg disc CME L1    26 wing disc CME-W2    28 wing disc ML-DmD8    28 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    21 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    66 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    53 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    29 ovary fGS/OSS    21 ovary OSC    45 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GM10569 LD19312 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034087 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8443-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for clu Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive clud08713 partially lethal - majority die clud00713 cluEP969 viable cluCA06604 cluG00271 viable, with Scer\GAL4pnr-MD237 cluGD13926 Sterility Allele fertile cluCA06604 cluG00271 male semi-sterile clud00713 male sterile cluEP969 sterile clud08713 cluf04554 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 cluGD13926 flightless clud08713 short lived clud08713 cluf04554 small body clud08713 cluf04554 uncoordinated | adult stage clud08713 cluf04554 Phenotype manifest in Allele embryonic/larval fat body | adult stage clud08713 female germline cell cluEP969 female germline stem cell clud08713 flight muscle clud08713 mesothoracic tergum, with Scer\GAL4pnr-MD237 cluGD13926 mitochondrial crista clud08713 mitochondrial inner membrane clud08713 mitochondrion cluEP969 clud08713 Nebenkern derivative cluEP969 ovary clud08713 wing clud08713
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of clu Class Mutagen Stocks Known lesion cluG00271 P-element activity 2 Yes cluNP6219 2 -- clud08713 amorphic allele - molecular evidence 1 -- cluf04554 amorphic allele - molecular evidence piggyBac transposase 1 -- clu5-SZ-3983 1 -- cluCB-5222-3 1 -- cluCB-6294-3 1 -- clud00713 hypomorphic allele - molecular evidence P-element activity 1 -- cluKG02346 P-element activity 1 -- cluNP0284 1 -- cluCA06604 P-element activity 0 Yes clud06837 0 -- clue04287 0 -- cluEP2101 P-element activity 0 -- cluEP969 hypomorphic allele - molecular evidence P-element activity 0 -- cluF3.28.03 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of clu Class Mutagen Stocks Known lesion cluGD13926 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cluKK108024 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cluNIG.8443R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.8443R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cluEP969 NA P{EP}cluEP2101 NA P{Mae-UAS.6.11}cluF3.28.03 NA P{XP}clud00713 NA P{XP}clud06837 NA P{XP}clud08713 NA miscellaneous insertions P{PTT-GA}cluCA06604 NA P{PTT-GA}cluG00271 NA P{RS3}cluCB-5222-3 NA P{RS3}cluCB-6294-3 NA P{RS5}clu5-SZ-3983 NA P{SUPor-P}cluKG02346 NA PBac{RB}clue04287 NA PBac{WH}cluf04554 NA insertion of enhancer trap P{lacW}l(2)SH0389SH0389 No insertion of enhancer trap binary system P{GawB}cluNP0284 No P{GawB}cluNP6219 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitochondrion localization inferred from mutant phenotype (Cox and Spradling, 2009)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Cox and Spradling, 2009)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
translation initiation factor activity inferred from sequence or structural similarity with Saccharomyces CLU1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
intracellular distribution of mitochondria inferred from electronic annotation with InterPro:IPR027523 (FlyBase Curators et al., 2004-) translational initiation inferred from sequence or structural similarity with Saccharomyces CLU1 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
eukaryotic translation initiation factor 3 complex inferred from sequence or structural similarity with Saccharomyces CLU1 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
clu - 312 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Aats-phe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Aats-tyr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Ald anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG10444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG10625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG10887 experimental knowledge based (Guruharsha et al., 2011) clu - CG11007 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG11109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG11455 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG11523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG1354 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG14342 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG1607 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG18004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG2493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG31278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG3568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG3795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG5516 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG7379 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG7675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG7739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG8830 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG9288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CG9960 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Cchl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Dlic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Hmgs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Hsc70-1 experimental knowledge based (Guruharsha et al., 2011) clu - Hsc70-2 experimental knowledge based (Guruharsha et al., 2011) clu - Ipk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Mfap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Mul1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - PCID2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Scox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Takr86C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Timp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Trap1 experimental knowledge based (Guruharsha et al., 2011) clu - Zpr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - Zyx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - bun anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - dlg1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - qua anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - rpr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) clu - sick experimental knowledge based (Guruharsha et al., 2011) clu - tobi experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions clu allele Gene References unspecified os (Mukherjee et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034087 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36793
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69S6RR Dipteran inclusive ortholog search EOG6PG67V Insect inclusive ortholog search EOG6N2ZHR Arthropod inclusive ortholog search EOG6VHHN8 Metazoa inclusive ortholog search EOG6MPWGT
Orthologs in Drosophila Species (EOG69S6RR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\clu     Drosophila simulans   Dsim\GD11169     Drosophila erecta   Dere\GG20578 Y   Drosophila yakuba   Dyak\GE11763 Y   Drosophila ananassae   Dana\GF12179 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21082 Y   Drosophila persimilis   Dper\GL11405 Y   Drosophila willistoni   Dwil\GK22132 Y   Drosophila virilis   Dvir\GJ21424 Y   Drosophila mojavensis   Dmoj\GI20574 Y   Drosophila grimshawi   Dgri\GH22778 Y
Orthologs in non-Drosophila Dipterans (EOG6PG67V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000794   Anopheles gambiae Malaria mosquito  Agam\AGAP011851   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001445
Orthologs in non-Dipteran Insects (EOG6N2ZHR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552519   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003957   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13593   Atta cephalotes Leafcutter ant  Acep\ACEP11699   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13733   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20238   Linepithema humile Argentine ant  Lhum\LH15693   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26108   Solenopsis invicta Red fire ant  Sinv\SINV10486   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002221   Bombyx mori Silkmoth  Bmor\BGIBMGA005468   Pediculus humanus Human body louse  Phum\PHUM438320   Tribolium castaneum Red flour beetle  Tcas\TC003310
Orthologs in non-Insect Arthropods (EOG6VHHN8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303760
Orthologs in non-Arthropod Metazoa (EOG6MPWGT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\clu-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014439gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003873gn   Danio rerio Zebrafish  Drer\si:ch211-274p24.5   Danio rerio Zebrafish  Drer\DKEY-95O3.3   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030875   Xenopus tropicalis Western clawed frog  Xtro\kiaa0664   Gallus gallus Domestic chicken  Ggal\KIAA0664   Mus musculus House mouse  Mmus\ENSMUSG00000020741   Rattus norvegicus Norway rat  Rnor\RGD1307222   Homo sapiens Human  Hsap\KIAA0664
Human Orthologs (1)
Gene OMIM HGNC Hsap\KIAA0664
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG20578 Drosophila yakuba Dyak\GE11763 Drosophila ananassae Dana\GF12179 Drosophila pseudoobscura pseudoobscura Dpse\GA21082 Drosophila persimilis Dper\GL11405 Drosophila willistoni Dwil\GK22132 Drosophila virilis Dvir\GJ21424 Drosophila mojavensis Dmoj\GI20574 Drosophila grimshawi Dgri\GH22778
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	6842 w1118; P{PTT-GA}cluG00271 13476 y1 w67c23; P{SUPor-P}cluKG02346
Harvard	- P{XP}clud00713 - P{XP}clud08713 - PBac{WH}cluf04554
Kyoto	110643 P{PTT-GA}cluG00271 123515 w1118; P{RS3}cluCB-5222-3 124030 w1118; P{RS3}cluCB-6294-3 126269 w1118; P{RS5}clu5-SZ-3983
VDRC	v100709 P{KK108024}VIE-260B v42136 w1118; P{GD13926}v42136 v42138 w1118; P{GD13926}v42138
	More stocks available...
Genomic Clones ( 1 )
	BACR29I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM10569 LD19312 RH51925
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01437 AT02306 AT04227 AT05724 AT26654 GH14653 GM05063 GM06321 GM13893 LD04629 LD09788 LP05787 LP21665 RE38381 RH53735
Other clones	15075 43489 47740 60328 66239 67650 104018 104616 148680 162575 165277 192295 193696 214245.76 214253.6 bs19h09 bs60a07 CK01.33D.G9 CK01.60D.D2 CK01.97C.C8 CK01.105D.D11 CK01.132B.E5 CK01.132B.E8 CK01.170C.F12 Dmel_dig_005089_0676_2318 Dmel_dig_006685_0604_1892 Dmel_neb_011242_0928_1377 EK005509 EK048934 EK075544 EK088316 EK095119 EK095152 EK104742 EK104955 EK133607 EK163051 EK175755 EK186562 EK194214 EK195830 EK227235 EK243318 EK255233 EK295444 EP02243 EP06907 EP08305 EP13121 GM01884
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034087 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36793
Antibody Information
	polyclonal (Cox and Spradling, 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: clu CG8443 (Cox and Spradling, 2009)
Source for database merge of	Source for merge of: CG8443 anon-WO0118547.143 (FlyBase, 1996-)
Additional comments	Source for merge of CG8443 anon-WO0118547.143 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway. (Mukherjee et al., 2006) Area matching Drosophila ESTs AA802791 and AA390699. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137251 NM_001274092 RefSeq (Proteins) • NP_611095 NP_001261021 DDBJ / EMBL / GenBank • AA390699 AA539996 AA802791 AA803322 AAF58047 AAL28813 AAM75024 AGB93553 AI946036 AQ025006 AQ072904 AW942527 AX094019 AY061265 AY128431 BH740770 BI620723 CZ471760 CZ487094 Entrez Gene - A searchable database of RefSeq genes. • 36793 UniProtKB/Swiss-Prot • A1ZAB5 UniProtKB/TrEMBL • Q8MQR3 Q95RN1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CLU domain (IPR025697) Clustered mitochondria protein (IPR027523) Protein of unknown function DUF727 (IPR007967) Tetratricopeptide-like helical (IPR011990) GSKIP/TIF31 domain (IPR023231) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM10569 LD19312
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034087 DRSC - Results from RNAi screens. • FBgn0034087 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034087 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8443-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034087 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36793 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36793 modMine - Data generated by the modENCODE project. • FBgn0034087
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	anon-WO0118547.143   CG8443 (Cox and Spradling, 2009, Mukherjee et al., 2006, Buszczak et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011, Davis et al., 2011, Japanese National Institute of Genetics, 2012.5.21) clu (Cox et al., 2008, )
Name Synonym	clueless (Cox and Spradling, 2002, Cox et al., 2008, )
Secondary FlyBase IDs
	FBgn0062217
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Show all research papers ...