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Gene Dmel\Gbp

General Information
Symbol	Dmel\Gbp	Species	D. melanogaster
Name	Growth-blocking peptide	Annotation symbol	CG15917
Feature type	protein_coding_gene	FlyBase ID	FBgn0034199
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54A1-54A1	Sequence location	2R:13,023,962..13,024,408 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Growth-blocking peptide is referred to in FlyBase by the symbol Dmel\Gbp (CG15917, FBgn0034199). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cytokine activity. There is experimental evidence that it is involved in the biological process: negative regulation of growth; antimicrobial peptide production; positive regulation of homotypic cell-cell adhesion; response to wounding; peptidoglycan recognition protein signaling pathway. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641623_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG15917. Gene sequence location is 2R:13023962..13024408.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54A1-54A1   Limits computationally determined from genome sequence between P{lacW}l(2)k10815k10815 and P{EP}EP710
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gbp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gbp-RA FBtr0086986  NM_137350   447   118
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gbp-PA   FBpp0086139   13.2   118   4.89     NP_611194   AAF57890
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57890   BT023635   CO266453   CO335427   EC199042   EC262218   EL875843   EL875974   EL876104
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZAQ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body    1272.5 Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head    615.9 Adult Eye    588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body    779.3 Adult Salivary Gland    570.7 Adult Heart    527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body  (1272.5) Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head  (615.9) Adult Eye  (588) Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body  (779.3) Adult Salivary Gland  (570.7) Adult Heart  527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body  (1272.5) Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head    615.9 Adult Eye    588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body    779.3 Adult Salivary Gland    570.7 Adult Heart    527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body    1272.5 Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head    615.9 Adult Eye    588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body    779.3 Adult Salivary Gland    570.7 Adult Heart    527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body    1272.5 Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head    615.9 Adult Eye    588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body    779.3 Adult Salivary Gland    570.7 Adult Heart    527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body  (1272.5) Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head  615.9 Adult Eye  588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body  779.3 Adult Salivary Gland  570.7 Adult Heart  527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body  1272.5 Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head    615.9 Adult Eye    588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body    779.3 Adult Salivary Gland    570.7 Adult Heart    527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    2.4 Larval Hindgut    35.6 Larval Malpighian Tubules    79.7 Larval Fat Body    1272.5 Larval Salivary Gland    8.1 Larval Trachea    68.525 Larval Carcass    19.325 Adult Head    615.9 Adult Eye    588 Adult Brain    18.3 Adult Thoracic-Abdominal Ganglion    24.7 Adult Crop    116 Adult Midgut    18.4 Adult Hindgut    75.8 Adult Malpighian Tubules    44.3 Adult Fat Body    779.3 Adult Salivary Gland    570.7 Adult Heart    527.725 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    368.4 Adult Ovary    5.9 Adult Testis    29.5 Adult Male Accessory Gland    326.9 Adult Carcass    371 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    615.9   NA  Eye    588   NA  Brain    18.3   2.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    24.7   NA  Crop    116   2.4  Midgut    no informative data   35.6  Hindgut    75.8   79.7  Malpighian Tubules    44.3   1272.5  Fat Body    779.3   8.1  Salivary Gland    570.7   NA  Heart    527.725   68.525  Trachea    NA   NA  VirginFemale Spermatheca    490.6   NA  InseminatedFemale Spermatheca    368.4   NA  Ovary    5.9   NA  Testis    29.5   NA  Male Accessory Gland    326.9   no informative data  Carcass    371 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    49 head, virgin 4-day female    68 head, virgin 20-day female    92 head, mated 1-day female    59 head, mated 4-day female    47 head, mated 20-day female    70 head, mated 1-day male    58 head, mated 4-day male    42 head, mated 20-day male    83 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    198 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    67 fat body, white prepupae    735 fat body, pupae P8    191 carcass, larvae L3 wandering    7 carcass, 1-day adult    42 carcass, 4-day adult    30 carcass, 20-day adult    60 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male    141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (49) head, virgin 4-day female  (68) head, virgin 20-day female  (92) head, mated 1-day female  (59) head, mated 4-day female  (47) head, mated 20-day female  (70) head, mated 1-day male  (58) head, mated 4-day male  (42) head, mated 20-day male  (83) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (198) digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (67) fat body, white prepupae  (735) fat body, pupae P8  (191) carcass, larvae L3 wandering    7 carcass, 1-day adult  (42) carcass, 4-day adult  (30) carcass, 20-day adult  (60) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male  (141) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    49 head, virgin 4-day female    68 head, virgin 20-day female    92 head, mated 1-day female    59 head, mated 4-day female    47 head, mated 20-day female    70 head, mated 1-day male    58 head, mated 4-day male    42 head, mated 20-day male    83 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (198) digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    67 fat body, white prepupae  (735) fat body, pupae P8  (191) carcass, larvae L3 wandering    7 carcass, 1-day adult    42 carcass, 4-day adult    30 carcass, 20-day adult    60 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male  (141) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    49 head, virgin 4-day female    68 head, virgin 20-day female    92 head, mated 1-day female    59 head, mated 4-day female    47 head, mated 20-day female    70 head, mated 1-day male    58 head, mated 4-day male    42 head, mated 20-day male    83 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    198 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    67 fat body, white prepupae    735 fat body, pupae P8    191 carcass, larvae L3 wandering    7 carcass, 1-day adult    42 carcass, 4-day adult    30 carcass, 20-day adult    60 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male    141 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    49 head, virgin 4-day female    68 head, virgin 20-day female    92 head, mated 1-day female    59 head, mated 4-day female    47 head, mated 20-day female    70 head, mated 1-day male    58 head, mated 4-day male    42 head, mated 20-day male    83 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    198 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    67 fat body, white prepupae    735 fat body, pupae P8    191 carcass, larvae L3 wandering    7 carcass, 1-day adult    42 carcass, 4-day adult    30 carcass, 20-day adult    60 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male    141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (49) head, virgin 4-day female  (68) head, virgin 20-day female  (92) head, mated 1-day female  (59) head, mated 4-day female  (47) head, mated 20-day female  (70) head, mated 1-day male  (58) head, mated 4-day male  (42) head, mated 20-day male  (83) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (198) digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (67) fat body, white prepupae  (735) fat body, pupae P8  (191) carcass, larvae L3 wandering    7 carcass, 1-day adult  (42) carcass, 4-day adult  30 carcass, 20-day adult  (60) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male  (141) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    49 head, virgin 4-day female    68 head, virgin 20-day female    92 head, mated 1-day female    59 head, mated 4-day female    47 head, mated 20-day female    70 head, mated 1-day male    58 head, mated 4-day male    42 head, mated 20-day male    83 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (198) digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    67 fat body, white prepupae  (735) fat body, pupae P8  (191) carcass, larvae L3 wandering    7 carcass, 1-day adult    42 carcass, 4-day adult    30 carcass, 20-day adult    60 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male  141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    49 head, virgin 4-day female    68 head, virgin 20-day female    92 head, mated 1-day female    59 head, mated 4-day female    47 head, mated 20-day female    70 head, mated 1-day male    58 head, mated 4-day male    42 head, mated 20-day male    83 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    198 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    67 fat body, white prepupae    735 fat body, pupae P8    191 carcass, larvae L3 wandering    7 carcass, 1-day adult    42 carcass, 4-day adult    30 carcass, 20-day adult    60 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    18 accessory gland, mated 4-day male    141 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    65 white prepupae new    182 white prepupae 12hr    99 white prepupae 24hr    81 pupae 2d postWPP    82 pupae 3d postWPP    31 pupae 4d postWPP    25 adult male 01day    48 adult male 05day    38 adult male 30day    31 adult female 01day    28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6  (31) larva L3 puffstage 7-9  (65) white prepupae new  (182) white prepupae 12hr  (99) white prepupae 24hr  (81) pupae 2d postWPP  (82) pupae 3d postWPP  (31) pupae 4d postWPP    25 adult male 01day  (48) adult male 05day  (38) adult male 30day  (31) adult female 01day  (28) adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    65 white prepupae new  (182) white prepupae 12hr    99 white prepupae 24hr    81 pupae 2d postWPP    82 pupae 3d postWPP    31 pupae 4d postWPP    25 adult male 01day    48 adult male 05day    38 adult male 30day    31 adult female 01day    28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    65 white prepupae new    182 white prepupae 12hr    99 white prepupae 24hr    81 pupae 2d postWPP    82 pupae 3d postWPP    31 pupae 4d postWPP    25 adult male 01day    48 adult male 05day    38 adult male 30day    31 adult female 01day    28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    65 white prepupae new    182 white prepupae 12hr    99 white prepupae 24hr    81 pupae 2d postWPP    82 pupae 3d postWPP    31 pupae 4d postWPP    25 adult male 01day    48 adult male 05day    38 adult male 30day    31 adult female 01day    28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6  31 larva L3 puffstage 7-9  (65) white prepupae new  (182) white prepupae 12hr  (99) white prepupae 24hr  (81) pupae 2d postWPP  (82) pupae 3d postWPP  31 pupae 4d postWPP    25 adult male 01day  (48) adult male 05day  (38) adult male 30day  31 adult female 01day  28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    65 white prepupae new  (182) white prepupae 12hr    99 white prepupae 24hr    81 pupae 2d postWPP    82 pupae 3d postWPP    31 pupae 4d postWPP    25 adult male 01day    48 adult male 05day    38 adult male 30day    31 adult female 01day    28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    8 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    4 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    65 white prepupae new    182 white prepupae 12hr    99 white prepupae 24hr    81 pupae 2d postWPP    82 pupae 3d postWPP    31 pupae 4d postWPP    25 adult male 01day    48 adult male 05day    38 adult male 30day    31 adult female 01day    28 adult female 05day    12 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    7 embryonic 1182-4H    169 embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3    44 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    73 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    38 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (37) Schneider line 2 Sg4    7 embryonic 1182-4H  (169) embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3  (44) leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9  (27) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (73) wing disc ML-DmD32  (31) haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5  (34) mixed discs ML-DmD4-c1  (52) CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2  (38) ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    7 embryonic 1182-4H  (169) embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3    44 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    73 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    38 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    7 embryonic 1182-4H    169 embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3    44 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    73 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    38 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    7 embryonic 1182-4H    169 embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3    44 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    73 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    38 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (37) Schneider line 2 Sg4    7 embryonic 1182-4H  (169) embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3  (44) leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9  27 wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (73) wing disc ML-DmD32  31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5  (34) mixed discs ML-DmD4-c1  (52) CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2  (38) ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    7 embryonic 1182-4H  (169) embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3    44 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    73 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    38 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    7 embryonic 1182-4H    169 embryonic GM2    2 embryonic Kc167    1 embryonic S1    3 embryonic S3    44 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    11 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    73 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    38 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    40 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (40) cold shock, 4-day adult  (40) heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (29) Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    40 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    40 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    40 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (40) cold shock, 4-day adult  (40) heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    40 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    40 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034199 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15917-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 GbpGD5288 Other Phenotypes Allele developmental rate defective | larval stage, with Scer\GAL4hs.PB GbpScer\UAS.cTa GbpScer\UAS.pro.cTa immune response defective, with Scer\GAL4hs.PB GbpdsRNA.Scer\UAS.cTa stress response defective, with Scer\GAL4hs.PB GbpdsRNA.Scer\UAS.cTa Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Gbp Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gbp Class Mutagen Stocks Known lesion GbpGD5288 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GbpKK110262 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GbpdsRNA.Scer\UAS.cTa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes GbpNIG.5519R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GbpScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes GbpScer\UAS.pro.cTa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6066 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11681} NA P{NIG.5519R} NA P{UAS-dsGbp.T} NA P{UAS-Gbp.T} NA P{UAS-proGbp.T} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
cytokine activity inferred from mutant phenotype (Tsuzuki et al., 2012)
Biological Process
CV term Evidence References
antimicrobial peptide production inferred from mutant phenotype (Tsuzuki et al., 2012) negative regulation of growth inferred from mutant phenotype (Tsuzuki et al., 2012) peptidoglycan recognition protein signaling pathway inferred from genetic interaction with imd (Tsuzuki et al., 2012) positive regulation of homotypic cell-cell adhesion inferred from direct assay (Matsumoto et al., 2012) response to wounding inferred from mutant phenotype (Tsuzuki et al., 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular space inferred by curator from GO:0005125 (Tsuzuki et al., 2012)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Gbp - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gbp - CG8578 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gbp - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gbp - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gbp - Rpd3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gbp - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gbp allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034199 DroID - A comprehensive database of gene and protein interactions. • FBgn0034199
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XD4BX Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6XD4BX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gbp     Drosophila simulans   Dsim\GD11253 Y   Drosophila sechellia   Dsec\GM21762 Y   Drosophila erecta   Dere\GG20666 Y   Drosophila yakuba   Dyak\GE11651 Y   Drosophila ananassae   Dana\GF11445 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25053 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22236     Drosophila persimilis   Dper\GL17239 Y   Drosophila willistoni   Dwil\GK18882 Y   Drosophila virilis   Dvir\GJ21625     Drosophila mojavensis   Dmoj\GI18610 Y   Drosophila grimshawi   Dgri\GH21014 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11253 Drosophila sechellia Dsec\GM21762 Drosophila erecta Dere\GG20666 Drosophila yakuba Dyak\GE11651 Drosophila ananassae Dana\GF11445 Drosophila pseudoobscura pseudoobscura Dpse\GA25053 Drosophila persimilis Dper\GL17239 Drosophila willistoni Dwil\GK18882 Drosophila mojavensis Dmoj\GI18610 Drosophila grimshawi Dgri\GH21014
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v108755 P{KK110262}VIE-260B v15512 w1118; P{GD5288}v15512
Genomic Clones ( 1 )
	BACR32P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05665
Other clones	DPiM_IP05665
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	35311 533863 EK146445 EN10317 IP05765 IP05865 IP05965
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034199 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36936
Antibody Information
	polyclonal (Tsuzuki et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gbp CG15917 (Tsuzuki et al., 2012)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137350 RefSeq (Proteins) • NP_611194 DDBJ / EMBL / GenBank • AAF57890 Entrez Gene - A searchable database of RefSeq genes. • 36936 UniProtKB/TrEMBL • A1ZAQ9
Other Crossreferences
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034199 DroID - A comprehensive database of gene and protein interactions. • FBgn0034199 DRSC - Results from RNAi screens. • FBgn0034199 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034199 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15917-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034199 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36936 modMine - Data generated by the modENCODE project. • FBgn0034199
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG15917 (Tsuzuki et al., 2012, Willis et al., 2010, Keleman et al., 2009.8.5, Fujikawa et al., 2009, Nelson et al., 2005, Matsumoto et al., 2012) Gbp (Japanese National Institute of Genetics, 2012.5.21) GBP (Tsuzuki et al., 2012, Matsumoto et al., 2012)
Name Synonym	Growth-blocking peptide   growth-blocking peptide-like factor (Tsuzuki et al., 2012)
Secondary FlyBase IDs
References ( 12 )
Research paper	Matsumoto et al., 2012, Insect Biochem. Mol. Biol. 42(6): 446--454 Characteristics common to a cytokine family spanning five orders of insects. [FBrf0218168] Tsuzuki et al., 2012, Sci. Rep. 2: 210 Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress. [FBrf0217467] Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Fujikawa et al., 2009, Gene 446(1): 11--17 Characteristics of genes up-regulated and down-regulated after 24 h starvation in the head of Drosophila. [FBrf0208557] Nelson et al., 2005, Cell Death Differ. 12(8): 1115--1123 Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. [FBrf0187248]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]