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Gene Dmel\CG11395

General Information
Symbol	Dmel\CG11395	Species	D. melanogaster
Name		Annotation symbol	CG11395
Feature type	protein_coding_gene	FlyBase ID	FBgn0034200
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54A1-54A1	Sequence location	2R:13,024,745..13,026,336 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11395 (FBgn0034200). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cytokine activity. Based on sequence similarity, it is predicted to be involved in the biological process: signal transduction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1638669_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11395. Gene sequence location is 2R:13024745..13026336.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54A1-54A1   Limits computationally determined from genome sequence between P{lacW}l(2)k10815k10815 and P{EP}EP710
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11395 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11395-RA FBtr0086987  NM_137351   1515   456
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11395-PA   FBpp0086140   48.8   456   6.72     NP_611195   AAF57889
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57889   AI062923   AI063252   AI238516   AI292726   AI293003   AI293093   AI513311   AI513514   AY051489 AAK92913   BF496117   BG632173   BI168636   BI373967   BI624550   CK604787   CK604788   CO180612   CO189457   CO193949   CO298931   CO324625   EC195350   EV597410   FD586229   FD586723   FD586768   GH744874   GH744939   GH763861   GH765865
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K533
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) embryonic stage 11 -- 12   yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval fat body   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body    4361.9 Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head    1428.4 Adult Eye    756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body    3619.8 Adult Salivary Gland    15.3 Adult Heart    2232.825 Adult VirginFemale Spermatheca    3226.2 Adult InseminatedFemale Spermatheca    2999.3 Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass    1889.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body  (4361.9) Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head  (1428.4) Adult Eye  (756.125) Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body  (3619.8) Adult Salivary Gland    15.3 Adult Heart  (2232.825) Adult VirginFemale Spermatheca  (3226.2) Adult InseminatedFemale Spermatheca  (2999.3) Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass  (1889.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body  (4361.9) Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head  (1428.4) Adult Eye    756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body  (3619.8) Adult Salivary Gland    15.3 Adult Heart  (2232.825) Adult VirginFemale Spermatheca  (3226.2) Adult InseminatedFemale Spermatheca  (2999.3) Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass  (1889.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body    4361.9 Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head    1428.4 Adult Eye    756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body    3619.8 Adult Salivary Gland    15.3 Adult Heart    2232.825 Adult VirginFemale Spermatheca    3226.2 Adult InseminatedFemale Spermatheca    2999.3 Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass    1889.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body    4361.9 Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head    1428.4 Adult Eye    756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body    3619.8 Adult Salivary Gland    15.3 Adult Heart    2232.825 Adult VirginFemale Spermatheca    3226.2 Adult InseminatedFemale Spermatheca    2999.3 Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass    1889.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body  (4361.9) Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head  (1428.4) Adult Eye  756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body  (3619.8) Adult Salivary Gland    15.3 Adult Heart  (2232.825) Adult VirginFemale Spermatheca  (3226.2) Adult InseminatedFemale Spermatheca  (2999.3) Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass  (1889.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body  (4361.9) Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head  1428.4 Adult Eye    756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body  (3619.8) Adult Salivary Gland    15.3 Adult Heart  (2232.825) Adult VirginFemale Spermatheca  (3226.2) Adult InseminatedFemale Spermatheca  (2999.3) Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass  (1889.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.65 Larval Midgut    1.8 Larval Hindgut    65.5 Larval Malpighian Tubules    14.2 Larval Fat Body    4361.9 Larval Salivary Gland    60.9 Larval Trachea    29.7 Larval Carcass    22.65 Adult Head    1428.4 Adult Eye    756.125 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    43.6 Adult Crop    34 Adult Midgut    2.4 Adult Hindgut    122.4 Adult Malpighian Tubules    31.7 Adult Fat Body    3619.8 Adult Salivary Gland    15.3 Adult Heart    2232.825 Adult VirginFemale Spermatheca    3226.2 Adult InseminatedFemale Spermatheca    2999.3 Adult Ovary    1.6 Adult Testis    51.4 Adult Male Accessory Gland    5.1 Adult Carcass    1889.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1428.4   NA  Eye    756.125   NA  Brain    45.1   0.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    43.6   NA  Crop    34   1.8  Midgut    2.4   65.5  Hindgut    122.4   no informative data  Malpighian Tubules    no informative data   4361.9  Fat Body    3619.8   60.9  Salivary Gland    no informative data   NA  Heart    2232.825   29.7  Trachea    NA   NA  VirginFemale Spermatheca    3226.2   NA  InseminatedFemale Spermatheca    2999.3   NA  Ovary    1.6   NA  Testis    51.4   NA  Male Accessory Gland    5.1   22.65  Carcass    1889.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    139 head, virgin 4-day female    214 head, virgin 20-day female    389 head, mated 1-day female    123 head, mated 4-day female    181 head, mated 20-day female    315 head, mated 1-day male    129 head, mated 4-day male    160 head, mated 20-day male    273 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    380 fat body, white prepupae    285 fat body, pupae P8    31 carcass, larvae L3 wandering    12 carcass, 1-day adult    145 carcass, 4-day adult    158 carcass, 20-day adult    313 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    36 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female  (139) head, virgin 4-day female  (214) head, virgin 20-day female  (389) head, mated 1-day female  (123) head, mated 4-day female  (181) head, mated 20-day female  (315) head, mated 1-day male  (129) head, mated 4-day male  (160) head, mated 20-day male  (273) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering  (380) fat body, white prepupae  (285) fat body, pupae P8  (31) carcass, larvae L3 wandering    12 carcass, 1-day adult  (145) carcass, 4-day adult  (158) carcass, 20-day adult  (313) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (36) accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female  (139) head, virgin 4-day female  (214) head, virgin 20-day female  (389) head, mated 1-day female  (123) head, mated 4-day female  (181) head, mated 20-day female  (315) head, mated 1-day male  (129) head, mated 4-day male  (160) head, mated 20-day male  (273) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering  (380) fat body, white prepupae  (285) fat body, pupae P8    31 carcass, larvae L3 wandering    12 carcass, 1-day adult  (145) carcass, 4-day adult  (158) carcass, 20-day adult  (313) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    36 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    139 head, virgin 4-day female    214 head, virgin 20-day female    389 head, mated 1-day female    123 head, mated 4-day female    181 head, mated 20-day female    315 head, mated 1-day male    129 head, mated 4-day male    160 head, mated 20-day male    273 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    380 fat body, white prepupae    285 fat body, pupae P8    31 carcass, larvae L3 wandering    12 carcass, 1-day adult    145 carcass, 4-day adult    158 carcass, 20-day adult    313 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    36 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    139 head, virgin 4-day female    214 head, virgin 20-day female    389 head, mated 1-day female    123 head, mated 4-day female    181 head, mated 20-day female    315 head, mated 1-day male    129 head, mated 4-day male    160 head, mated 20-day male    273 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    380 fat body, white prepupae    285 fat body, pupae P8    31 carcass, larvae L3 wandering    12 carcass, 1-day adult    145 carcass, 4-day adult    158 carcass, 20-day adult    313 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    36 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female  (139) head, virgin 4-day female  (214) head, virgin 20-day female  (389) head, mated 1-day female  (123) head, mated 4-day female  (181) head, mated 20-day female  (315) head, mated 1-day male  (129) head, mated 4-day male  (160) head, mated 20-day male  (273) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering  (380) fat body, white prepupae  (285) fat body, pupae P8  31 carcass, larvae L3 wandering    12 carcass, 1-day adult  (145) carcass, 4-day adult  (158) carcass, 20-day adult  (313) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (36) accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female  139 head, virgin 4-day female  (214) head, virgin 20-day female  (389) head, mated 1-day female  123 head, mated 4-day female  (181) head, mated 20-day female  (315) head, mated 1-day male  129 head, mated 4-day male  (160) head, mated 20-day male  (273) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering  (380) fat body, white prepupae  (285) fat body, pupae P8    31 carcass, larvae L3 wandering    12 carcass, 1-day adult  (145) carcass, 4-day adult  (158) carcass, 20-day adult  (313) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    36 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    139 head, virgin 4-day female    214 head, virgin 20-day female    389 head, mated 1-day female    123 head, mated 4-day female    181 head, mated 20-day female    315 head, mated 1-day male    129 head, mated 4-day male    160 head, mated 20-day male    273 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    11 digestive system, 20-day adult    11 fat body, larvae L3 wandering    380 fat body, white prepupae    285 fat body, pupae P8    31 carcass, larvae L3 wandering    12 carcass, 1-day adult    145 carcass, 4-day adult    158 carcass, 20-day adult    313 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    36 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    27 embryo 16-18hr    41 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2    30 larva L3 12hr old    55 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    68 larva L3 puffstage 7-9    52 white prepupae new    52 white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    49 adult male 05day    37 adult male 30day    28 adult female 01day    21 adult female 05day    26 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr  (27) embryo 16-18hr  (41) embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2  (30) larva L3 12hr old  (55) larva L3 puffstage 1-2  (79) larva L3 puffstage 3-6  (68) larva L3 puffstage 7-9  (52) white prepupae new  (52) white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day  (49) adult male 05day  (37) adult male 30day  (28) adult female 01day    21 adult female 05day  26 adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    27 embryo 16-18hr    41 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2    30 larva L3 12hr old    55 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    68 larva L3 puffstage 7-9    52 white prepupae new    52 white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    49 adult male 05day    37 adult male 30day    28 adult female 01day    21 adult female 05day    26 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    27 embryo 16-18hr    41 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2    30 larva L3 12hr old    55 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    68 larva L3 puffstage 7-9    52 white prepupae new    52 white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    49 adult male 05day    37 adult male 30day    28 adult female 01day    21 adult female 05day    26 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    27 embryo 16-18hr    41 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2    30 larva L3 12hr old    55 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    68 larva L3 puffstage 7-9    52 white prepupae new    52 white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    49 adult male 05day    37 adult male 30day    28 adult female 01day    21 adult female 05day    26 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr  27 embryo 16-18hr  (41) embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2  30 larva L3 12hr old  (55) larva L3 puffstage 1-2  (79) larva L3 puffstage 3-6  (68) larva L3 puffstage 7-9  (52) white prepupae new  (52) white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day  (49) adult male 05day  (37) adult male 30day  28 adult female 01day    21 adult female 05day  26 adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    27 embryo 16-18hr    41 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2    30 larva L3 12hr old    55 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    68 larva L3 puffstage 7-9    52 white prepupae new    52 white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    49 adult male 05day    37 adult male 30day    28 adult female 01day    21 adult female 05day    26 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    27 embryo 16-18hr    41 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    16 larva L1    17 larva L2    30 larva L3 12hr old    55 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    68 larva L3 puffstage 7-9    52 white prepupae new    52 white prepupae 12hr    8 white prepupae 24hr    15 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    49 adult male 05day    37 adult male 30day    28 adult female 01day    21 adult female 05day    26 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  (30) ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    3 embryonic 1182-4H    24 embryonic GM2    1 embryonic Kc167    2 embryonic S1    3 embryonic S3    21 leg disc CME L1    5 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    12 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    30 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    74 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    64 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    67 Rotenone 8 μg 12 hrs, larvae L3    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3  (74) Cadmium 50 mM 12 hrs, larvae L3  (84) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (41) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (47) Zinc 5 mM 12 hrs, larvae L3  (29) Zinc 4.5 mM 48 hrs, 4-day adult  (92) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (64) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (103) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (99) Caffeine 25 mg/ml 48 hrs, 4-day adult  (28) Paraquat 5 mM 48 hrs, 4-day adult  (73) Paraquat 10 mM 48 hrs, 4-day adult  (30) Rotenone 2 μg 12 hrs, larvae L3  (67) Rotenone 8 μg 12 hrs, larvae L3  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    74 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3    64 Caffeine 1.5 mg/ml 4 hrs, larvae L3  103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    67 Rotenone 8 μg 12 hrs, larvae L3    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    74 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    64 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    67 Rotenone 8 μg 12 hrs, larvae L3    60 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    74 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    64 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    67 Rotenone 8 μg 12 hrs, larvae L3    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3  (74) Cadmium 50 mM 12 hrs, larvae L3  (84) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (41) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (47) Zinc 5 mM 12 hrs, larvae L3  29 Zinc 4.5 mM 48 hrs, 4-day adult  (92) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (64) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (103) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (99) Caffeine 25 mg/ml 48 hrs, 4-day adult  28 Paraquat 5 mM 48 hrs, 4-day adult  (73) Paraquat 10 mM 48 hrs, 4-day adult  30 Rotenone 2 μg 12 hrs, larvae L3  (67) Rotenone 8 μg 12 hrs, larvae L3  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    74 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3  109 Ethanol 10% 3 hrs, larvae L3    64 Caffeine 1.5 mg/ml 4 hrs, larvae L3  103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    67 Rotenone 8 μg 12 hrs, larvae L3    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    74 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    64 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    67 Rotenone 8 μg 12 hrs, larvae L3    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	BDGP expression data • GH14572 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034200 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11395-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG11395 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 CG11395GD4931 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG11395 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11395 Class Mutagen Stocks Known lesion CG11395GD4931 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11395NIG.11395R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6066 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4931} NA P{NIG.11395R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP710 NA P{EP}EP1032 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
cytokine activity inferred from sequence or structural similarity with Gbp (Tsuzuki et al., 2012)
Biological Process
CV term Evidence References
signal transduction inferred from sequence or structural similarity with Gbp (Tsuzuki et al., 2012)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG11395 - CG9581 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG11395 - Cg25C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11395 - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11395 - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11395 - abs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11395 - vkg experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11395 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034200 DroID - A comprehensive database of gene and protein interactions. • FBgn0034200 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36937
Orthologs
OrthoDB Orthologs (24) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W6PGT Dipteran inclusive ortholog search EOG6JM80D Insect inclusive ortholog search EOG6C5BGJ Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG64FK3P
Orthologs in Drosophila Species (EOG6W6PGT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11395     Drosophila simulans   Dsim\GD11254 Y   Drosophila sechellia   Dsec\GM21763 Y   Drosophila erecta   Dere\GG20667 Y   Drosophila yakuba   Dyak\GE11652 Y   Drosophila ananassae   Dana\GF11446 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22237     Drosophila pseudoobscura pseudoobscura   Dpse\GA25054 Y   Drosophila persimilis   Dper\GL17240 Y   Drosophila willistoni   Dwil\GK17873 Y   Drosophila virilis   Dvir\GJ21627 Y   Drosophila mojavensis   Dmoj\GI18608 Y   Drosophila grimshawi   Dgri\GH21015 Y   Drosophila grimshawi   Dgri\GH21016
Orthologs in non-Drosophila Dipterans (EOG6JM80D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002987
Orthologs in non-Dipteran Insects (EOG6C5BGJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG035573   Pediculus humanus Human body louse  Phum\PHUM365710
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG64FK3P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012788gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018919gn   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031375   Gallus gallus Domestic chicken  Ggal\QRICH2   Mus musculus House mouse  Mmus\Qrich2   Rattus norvegicus Norway rat  Rnor\Qrich2   Homo sapiens Human  Hsap\QRICH2
Human Orthologs (1)
Gene OMIM HGNC Hsap\QRICH2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11254 Drosophila sechellia Dsec\GM21763 Drosophila erecta Dere\GG20667 Drosophila yakuba Dyak\GE11652 Drosophila ananassae Dana\GF11446 Drosophila pseudoobscura pseudoobscura Dpse\GA25054 Drosophila persimilis Dper\GL17240 Drosophila willistoni Dwil\GK17873 Drosophila virilis Dvir\GJ21627 Drosophila mojavensis Dmoj\GI18608 Drosophila grimshawi Dgri\GH21015
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v16696 w1118; P{GD4931}v16696
Genomic Clones ( 1 )
	BACR32P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14572
Other clones	DPiM_GH14572
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09832 GH02302 GH02825 GH04605 GH15692 GH16064 GH16183 GH26636 RE09464 RE61454 RH64129
Other clones	CK01.54D.H9 Dmel_neb_012756_0856_2141 EC02910 EC37142 EK044331 EK174135 EK194408 RM04207 RM04607 RM04707 RP001007563 RP001013103 RP001035802 RP001040115 UT01446
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034200 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36937
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137351 RefSeq (Proteins) • NP_611195 DDBJ / EMBL / GenBank • AAF57889 AAK92913 AI238516 AI513311 AY051489 Entrez Gene - A searchable database of RefSeq genes. • 36937 UniProtKB/TrEMBL • Q7K533
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH14572
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034200 DroID - A comprehensive database of gene and protein interactions. • FBgn0034200 DRSC - Results from RNAi screens. • FBgn0034200 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034200 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11395-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034200 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36937 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36937 modMine - Data generated by the modENCODE project. • FBgn0034200
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11395 (Tsuzuki et al., 2012, Müller et al., 2011, Vorobyeva et al., 2009, Tomancak et al., 2007, Vorobyeva et al., 2011, Soshnikova et al., 2008, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Tsuzuki et al., 2012, Sci. Rep. 2: 210 Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress. [FBrf0217467] Müller et al., 2011, BMC Genomics 12(1): 81 Population transcriptomics of Drosophila melanogaster females. [FBrf0213050] Vorobyeva et al., 2011, Cell Cycle 10(11): 1821--1827 SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. [FBrf0213948] Vorobyeva et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(27): 11049--11054 Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex. [FBrf0215303] Soshnikova et al., 2008, Dokl. Biochem. Biophys. 423: 346--348 Interaction of coactivators with promoter. [FBrf0215500] Tomancak et al., 2007, Genome Biol. 8(7): R145 Global analysis of patterns of gene expression during Drosophila embryogenesis. [FBrf0205271] Karlsson et al., 2004, J. Biol. Chem. 279(50): 52033--52041 Proteomic analysis of the Drosophila larval hemolymph clot. [FBrf0180365]
Supplementary material	Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]