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Gene Dmel\CG4847

General Information
Symbol	Dmel\CG4847	Species	D. melanogaster
Name		Annotation symbol	CG4847
Feature type	protein_coding_gene	FlyBase ID	FBgn0034229
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C1-54C1	Sequence location	2R:13,399,018..13,401,360 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4847 (FBgn0034229). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cysteine-type endopeptidase activity; cysteine-type peptidase activity. There is experimental evidence that it is involved in the biological process: multicellular organism reproduction. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cysteine peptidase, asparagine active site; Cysteine peptidase, cysteine active site; Peptidase C1A, papain; Peptidase C1A, papain C-terminal; Proteinase inhibitor I29, cathepsin propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed at stages throughout the larval period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval hindgut, adult heart, adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1638321_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of CG4847. Gene sequence location is 2R:13399018..13401360.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C1-54C1   Limits computationally determined from genome sequence between P{EP}l(2)k01209EP2177&P{lacW}k11012a and P{lacW}l(2)k07433k07433
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4847 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4847-RA FBtr0086933  NM_137377   1311   390 CG4847-RC FBtr0086934  NM_166237   1313   390 CG4847-RD FBtr0086935  NM_166235   1501   420 CG4847-RE FBtr0086937  NM_206152   1308   390
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4847-PA   FBpp0086089   40.8   390   5.98     NP_611221   AAF57850 CG4847-PC   FBpp0086090   40.8   390   5.98     NP_725688   AAM70882 CG4847-PD   FBpp0086091   44.1   420   6.39     NP_725686   AAM70880 CG4847-PE   FBpp0086093   40.8   390   5.98     NP_995874   AAS64820
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cysteine peptidase, asparagine active site (IPR025661) Cysteine peptidase, cysteine active site (IPR000169) Peptidase C1A, papain C-terminal (IPR000668) Peptidase C1A, papain (IPR013128) Proteinase inhibitor I29, cathepsin propeptide (IPR013201)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57850   AE013599 AAM70880   AE013599 AAM70882   AE013599 AAS64820   AI062406   AI107760   AI109372   AI113731   AI388590   AI403377   AI403864   AI404542   AI513111   AY047507 AAK77239   BF506407   BI569867   BI574102   BI574103   BI575614   BI583637   BI585105   BI590011   BI604542   BI606570   BI608774   BI608785   BI611219   BI611671   BI612849   BI616740   BI621355   BI622124   BI622216   BI622683   BI623941   BI629956   BT099507   CO312813   CO316073   EC076519   EC088298   EC232242   EC242926
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K5N8 A1ZAU4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic ventral epidermis   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular space inferred from direct assay (Findlay et al., 2009, Walker et al., 2006, Findlay et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval hindgut, adult heart, adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body    1161.7 Adult Salivary Gland    13.1 Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut  (872) Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  (1522) Adult Eye  (674.225) Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body  (1161.7) Adult Salivary Gland    13.1 Adult Heart  (822.55) Adult VirginFemale Spermatheca  (1400.7) Adult InseminatedFemale Spermatheca  (1375.3) Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  (1522) Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body  (1161.7) Adult Salivary Gland    13.1 Adult Heart    822.55 Adult VirginFemale Spermatheca  (1400.7) Adult InseminatedFemale Spermatheca  (1375.3) Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body    1161.7 Adult Salivary Gland    13.1 Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body    1161.7 Adult Salivary Gland    13.1 Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut  (872) Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  (1522) Adult Eye  674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body  (1161.7) Adult Salivary Gland    13.1 Adult Heart  (822.55) Adult VirginFemale Spermatheca  (1400.7) Adult InseminatedFemale Spermatheca  (1375.3) Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body  1161.7 Adult Salivary Gland    13.1 Adult Heart    822.55 Adult VirginFemale Spermatheca  1400.7 Adult InseminatedFemale Spermatheca  1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut    10.5 Adult Hindgut    178.7 Adult Malpighian Tubules    25.8 Adult Fat Body    1161.7 Adult Salivary Gland    13.1 Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1522   NA  Eye    674.225   NA  Brain    27   4.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    26.5   NA  Crop    83.3   3.4  Midgut    no informative data   872  Hindgut    178.7   1.4  Malpighian Tubules    no informative data   2.1  Fat Body    1161.7   6.3  Salivary Gland    no informative data   NA  Heart    822.55   390.675  Trachea    NA   NA  VirginFemale Spermatheca    1400.7   NA  InseminatedFemale Spermatheca    1375.3   NA  Ovary    5.7   NA  Testis    31.5   NA  Male Accessory Gland    9614.8   2708.2  Carcass    1758.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    123 head, virgin 4-day female    122 head, virgin 20-day female    235 head, mated 1-day female    79 head, mated 4-day female    98 head, mated 20-day female    158 head, mated 1-day male    140 head, mated 4-day male    153 head, mated 20-day male    255 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    39 carcass, 1-day adult    210 carcass, 4-day adult    138 carcass, 20-day adult    150 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    155 accessory gland, mated 4-day male    1607 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female  (123) head, virgin 4-day female  (122) head, virgin 20-day female  (235) head, mated 1-day female  (79) head, mated 4-day female  (98) head, mated 20-day female  (158) head, mated 1-day male  (140) head, mated 4-day male  (153) head, mated 20-day male  (255) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering  (39) carcass, 1-day adult  (210) carcass, 4-day adult  (138) carcass, 20-day adult  (150) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (155) accessory gland, mated 4-day male  (1607) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female  (123) head, virgin 4-day female  (122) head, virgin 20-day female  (235) head, mated 1-day female    79 head, mated 4-day female    98 head, mated 20-day female  (158) head, mated 1-day male  (140) head, mated 4-day male  (153) head, mated 20-day male  (255) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    39 carcass, 1-day adult  (210) carcass, 4-day adult  (138) carcass, 20-day adult  (150) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (155) accessory gland, mated 4-day male  (1607) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    123 head, virgin 4-day female    122 head, virgin 20-day female    235 head, mated 1-day female    79 head, mated 4-day female    98 head, mated 20-day female    158 head, mated 1-day male    140 head, mated 4-day male    153 head, mated 20-day male    255 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    39 carcass, 1-day adult    210 carcass, 4-day adult    138 carcass, 20-day adult    150 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    155 accessory gland, mated 4-day male    1607 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    123 head, virgin 4-day female    122 head, virgin 20-day female    235 head, mated 1-day female    79 head, mated 4-day female    98 head, mated 20-day female    158 head, mated 1-day male    140 head, mated 4-day male    153 head, mated 20-day male    255 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    39 carcass, 1-day adult    210 carcass, 4-day adult    138 carcass, 20-day adult    150 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    155 accessory gland, mated 4-day male    1607 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female  (123) head, virgin 4-day female  (122) head, virgin 20-day female  (235) head, mated 1-day female  (79) head, mated 4-day female  (98) head, mated 20-day female  (158) head, mated 1-day male  (140) head, mated 4-day male  (153) head, mated 20-day male  (255) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering  (39) carcass, 1-day adult  (210) carcass, 4-day adult  (138) carcass, 20-day adult  (150) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (155) accessory gland, mated 4-day male  (1607) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female  123 head, virgin 4-day female  122 head, virgin 20-day female  (235) head, mated 1-day female    79 head, mated 4-day female    98 head, mated 20-day female  (158) head, mated 1-day male  140 head, mated 4-day male  (153) head, mated 20-day male  (255) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    39 carcass, 1-day adult  (210) carcass, 4-day adult  138 carcass, 20-day adult  (150) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (155) accessory gland, mated 4-day male  (1607) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    123 head, virgin 4-day female    122 head, virgin 20-day female    235 head, mated 1-day female    79 head, mated 4-day female    98 head, mated 20-day female    158 head, mated 1-day male    140 head, mated 4-day male    153 head, mated 20-day male    255 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    22 digestive system, 4-day adult    18 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    39 carcass, 1-day adult    210 carcass, 4-day adult    138 carcass, 20-day adult    150 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    155 accessory gland, mated 4-day male    1607 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed at stages throughout the larval period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    42 embryo 22-24hr    24 larva L1    31 larva L2    30 larva L3 12hr old    166 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP    60 adult male 01day    255 adult male 05day    301 adult male 30day    212 adult female 01day    38 adult female 05day    33 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr  (42) embryo 22-24hr    24 larva L1  (31) larva L2  (30) larva L3 12hr old  (166) larva L3 puffstage 1-2  (196) larva L3 puffstage 3-6  (55) larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP  (60) adult male 01day  (255) adult male 05day  (301) adult male 30day  (212) adult female 01day  (38) adult female 05day  (33) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    42 embryo 22-24hr    24 larva L1    31 larva L2    30 larva L3 12hr old  (166) larva L3 puffstage 1-2  (196) larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP    60 adult male 01day  (255) adult male 05day  (301) adult male 30day  (212) adult female 01day    38 adult female 05day    33 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    42 embryo 22-24hr    24 larva L1    31 larva L2    30 larva L3 12hr old    166 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP    60 adult male 01day    255 adult male 05day    301 adult male 30day    212 adult female 01day    38 adult female 05day    33 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    42 embryo 22-24hr    24 larva L1    31 larva L2    30 larva L3 12hr old    166 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP    60 adult male 01day    255 adult male 05day    301 adult male 30day    212 adult female 01day    38 adult female 05day    33 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr  (42) embryo 22-24hr    24 larva L1  31 larva L2  30 larva L3 12hr old  (166) larva L3 puffstage 1-2  (196) larva L3 puffstage 3-6  (55) larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP  (60) adult male 01day  (255) adult male 05day  (301) adult male 30day  (212) adult female 01day  (38) adult female 05day  (33) adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    42 embryo 22-24hr    24 larva L1    31 larva L2    30 larva L3 12hr old  (166) larva L3 puffstage 1-2  (196) larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP    60 adult male 01day  (255) adult male 05day  (301) adult male 30day  (212) adult female 01day    38 adult female 05day    33 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    5 embryo 16-18hr    17 embryo 18-20hr    20 embryo 20-22hr    42 embryo 22-24hr    24 larva L1    31 larva L2    30 larva L3 12hr old    166 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    12 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    2 pupae 4d postWPP    60 adult male 01day    255 adult male 05day    301 adult male 30day    212 adult female 01day    38 adult female 05day    33 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult    148 Cadmium 50 mM 6 hrs, larvae L3    324 Cadmium 50 mM 12 hrs, larvae L3    105 Cadmium 50 mM 48 hrs, 4-day adult    181 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    136 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    108 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    252 Ethanol 10% 3 hrs, larvae L3    271 Caffeine 1.5 mg/ml 4 hrs, larvae L3    191 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    62 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    210 Rotenone 8 μg 12 hrs, larvae L3    324 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult  (148) Cadmium 50 mM 6 hrs, larvae L3  (324) Cadmium 50 mM 12 hrs, larvae L3  (105) Cadmium 50 mM 48 hrs, 4-day adult  (181) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (136) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (108) Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3  (252) Ethanol 10% 3 hrs, larvae L3  (271) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (191) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (62) Paraquat 10 mM 48 hrs, 4-day adult  (64) Rotenone 2 μg 12 hrs, larvae L3  (210) Rotenone 8 μg 12 hrs, larvae L3  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult  (148) Cadmium 50 mM 6 hrs, larvae L3  (324) Cadmium 50 mM 12 hrs, larvae L3  105 Cadmium 50 mM 48 hrs, 4-day adult  (181) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (136) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (108) Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3  (252) Ethanol 10% 3 hrs, larvae L3  (271) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (191) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    62 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3  (210) Rotenone 8 μg 12 hrs, larvae L3  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult    148 Cadmium 50 mM 6 hrs, larvae L3    324 Cadmium 50 mM 12 hrs, larvae L3    105 Cadmium 50 mM 48 hrs, 4-day adult    181 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    136 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    108 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    252 Ethanol 10% 3 hrs, larvae L3    271 Caffeine 1.5 mg/ml 4 hrs, larvae L3    191 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    62 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    210 Rotenone 8 μg 12 hrs, larvae L3    324 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult    148 Cadmium 50 mM 6 hrs, larvae L3    324 Cadmium 50 mM 12 hrs, larvae L3    105 Cadmium 50 mM 48 hrs, 4-day adult    181 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    136 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    108 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    252 Ethanol 10% 3 hrs, larvae L3    271 Caffeine 1.5 mg/ml 4 hrs, larvae L3    191 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    62 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    210 Rotenone 8 μg 12 hrs, larvae L3    324 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult  (148) Cadmium 50 mM 6 hrs, larvae L3  (324) Cadmium 50 mM 12 hrs, larvae L3  (105) Cadmium 50 mM 48 hrs, 4-day adult  (181) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (136) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (108) Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3  (252) Ethanol 10% 3 hrs, larvae L3  (271) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (191) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (62) Paraquat 10 mM 48 hrs, 4-day adult  (64) Rotenone 2 μg 12 hrs, larvae L3  (210) Rotenone 8 μg 12 hrs, larvae L3  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult  (148) Cadmium 50 mM 6 hrs, larvae L3  (324) Cadmium 50 mM 12 hrs, larvae L3  105 Cadmium 50 mM 48 hrs, 4-day adult  (181) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  136 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  108 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3  (252) Ethanol 10% 3 hrs, larvae L3  (271) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (191) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    62 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3  (210) Rotenone 8 μg 12 hrs, larvae L3  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    18 heat shock, 4-day adult    148 Cadmium 50 mM 6 hrs, larvae L3    324 Cadmium 50 mM 12 hrs, larvae L3    105 Cadmium 50 mM 48 hrs, 4-day adult    181 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    136 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    108 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    252 Ethanol 10% 3 hrs, larvae L3    271 Caffeine 1.5 mg/ml 4 hrs, larvae L3    191 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    62 Paraquat 10 mM 48 hrs, 4-day adult    64 Rotenone 2 μg 12 hrs, larvae L3    210 Rotenone 8 μg 12 hrs, larvae L3    324 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_16 mE1_20_mRNA_expression_cluster_16
External Data & Images
Linkouts	BDGP expression data • GH01592 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4847-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG4847 Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG4847GD1652 viable, with Scer\GAL4αTub84B.PL CG4847Scer\UAS.cMa Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG4847 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4847 Class Mutagen Stocks Known lesion CG4847GD1652 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG4847HMS02491 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4847NIG.4847R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG4847Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1652} NA P{NIG.4847R} NA P{TRiP.HMS02491} NA P{UAS-CG4847.M} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
multicellular organism reproduction inferred from expression pattern (Findlay et al., 2009, Findlay et al., 2008, Mueller et al., 2005, Swanson et al., 2001)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Findlay et al., 2009, Walker et al., 2006, Findlay et al., 2008)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with EMBL:AJ006033 (FlyBase, 1992-) cysteine-type peptidase activity inferred from sequence or structural similarity (Mueller et al., 2004)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR000169, InterPro:IPR000668 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Mueller et al., 2004)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence model (Swanson et al., 2001) extracellular space inferred from sequence model (Mueller et al., 2005)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG4847 - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Bx42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG11563 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG32344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG5792 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG7194 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG7903 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG8728 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - CG9775 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - RpL37a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - brm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - eIF4AIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mRpL2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mRpL20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mRpL22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mRpL51 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - miple2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - mor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - pav anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - sens anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - ssx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG4847 - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4847 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62665 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034229 DroID - A comprehensive database of gene and protein interactions. • FBgn0034229 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36973
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R7VWQ Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search EOG6P8D0M Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6R7VWQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG4847     Drosophila simulans   Dsim\GD11280 Y   Drosophila sechellia   Dsec\GM21790 Y   Drosophila erecta   Dere\GG20691 Y   Drosophila yakuba   Dyak\GE11675 Y   Drosophila ananassae   Dana\GF13132 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18475 Y   Drosophila persimilis   Dper\GL11434 Y   Drosophila willistoni   Dwil\GK22909 Y   Drosophila virilis   Dvir\GJ20385 Y   Drosophila mojavensis   Dmoj\GI18587 Y   Drosophila grimshawi   Dgri\GH21411 Y   Drosophila grimshawi   Dgri\GH23906
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (EOG6P8D0M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_312326   Daphnia pulex Water flea  Dpux\V1-18   Daphnia pulex Water flea  Dpux\JGI_V11_315500   Daphnia pulex Water flea  Dpux\JGI_V11_334897   Daphnia pulex Water flea  Dpux\JGI_V11_305243   Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\JGI_V11_192539   Daphnia pulex Water flea  Dpux\JGI_V11_267532   Daphnia pulex Water flea  Dpux\JGI_V11_312322   Daphnia pulex Water flea  Dpux\rps19   Daphnia pulex Water flea  Dpux\JGI_V11_246512   Daphnia pulex Water flea  Dpux\coxL   Daphnia pulex Water flea  Dpux\JGI_V11_315189   Daphnia pulex Water flea  Dpux\JGI_V11_239327   Daphnia pulex Water flea  Dpux\JGI_V11_320635   Daphnia pulex Water flea  Dpux\JGI_V11_47691   Daphnia pulex Water flea  Dpux\cytb   Daphnia pulex Water flea  Dpux\JGI_V11_267531   Daphnia pulex Water flea  Dpux\JGI_V11_306050   Daphnia pulex Water flea  Dpux\JGI_V11_334898   Daphnia pulex Water flea  Dpux\cytb   Daphnia pulex Water flea  Dpux\Cthrc1   Daphnia pulex Water flea  Dpux\cytb   Daphnia pulex Water flea  Dpux\JGI_V11_308646   Daphnia pulex Water flea  Dpux\JGI_V11_207678   Daphnia pulex Water flea  Dpux\cytb   Daphnia pulex Water flea  Dpux\JGI_V11_227872   Daphnia pulex Water flea  Dpux\JGI_V11_207683   Daphnia pulex Water flea  Dpux\IL4   Daphnia pulex Water flea  Dpux\HA1   Daphnia pulex Water flea  Dpux\JGI_V11_239326
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11280 Drosophila sechellia Dsec\GM21790 Drosophila erecta Dere\GG20691 Drosophila yakuba Dyak\GE11675 Drosophila ananassae Dana\GF13132 Drosophila pseudoobscura pseudoobscura Dpse\GA18475 Drosophila persimilis Dper\GL11434 Drosophila willistoni Dwil\GK22909 Drosophila virilis Dvir\GJ20385 Drosophila mojavensis Dmoj\GI18587 Drosophila grimshawi Dgri\GH21411
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	42655 y1 sc* v1; P{TRiP.HMS02491}attP2
VDRC	v3230 w1118; P{GD1652}v3230/TM3 v3231 w1118; P{GD1652}v3231/TM3
Genomic Clones ( 1 )
	BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01592 RH39096
Other clones	DPiM_GH01592
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08863 GH05605 GH08537 GH10168 GH22803 GH23401 GH24290 RH02038 RH03556 RH13468 RH13480 RH17392 RH18048 RH22294 RH24574 RH31353 RH41834 RH46803 RH52683 RH53948 RH54053 RH54591 RH56308 RH58903 RH69949 RH73130
Other clones	1882 105523 109284 CK01.118A.B2 EK230044 EK263615 RH09495
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36973
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Isolated in a screen for seminal fluid proteins. (Mueller et al., 2004) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and increased expression in ClkJrk background. (Claridge-Chang et al., 2001) Identified with: GH19547.3prime <up>FlyBase curator comment: EST subsequently found to be chimeric</up>. (Oliver, 2001.8.16) EST GH19547 is chimeric; the 3' portion corresponds to part of CG4847, the 5' portion corresponds matches part of AE003464 on the opposite strand to Pof. (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137377 NM_166235 NM_166237 NM_206152 RefSeq (Proteins) • NP_611221 NP_725686 NP_725688 NP_995874 DDBJ / EMBL / GenBank • AAF57850 AAK77239 AAM70880 AAM70881 AAM70882 AAS64820 AI062406 AI388590 AI513111 AY047507 Entrez Gene - A searchable database of RefSeq genes. • 36973 UniProtKB/TrEMBL • A1ZAU4 Q7K5N8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cysteine peptidase, asparagine active site (IPR025661) Cysteine peptidase, cysteine active site (IPR000169) Peptidase C1A, papain C-terminal (IPR000668) Peptidase C1A, papain (IPR013128) Proteinase inhibitor I29, cathepsin propeptide (IPR013201) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH01592
Linkouts
	BioGRID - A database of protein and genetic interactions • 62665 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034229 DroID - A comprehensive database of gene and protein interactions. • FBgn0034229 DRSC - Results from RNAi screens. • FBgn0034229 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4847-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36973 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36973 modMine - Data generated by the modENCODE project. • FBgn0034229
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BEST:GH19547   CG4847 (Wittkopp et al., 2006, Ravi Ram and Wolfner, 2007, Giardina et al., 2011, Mueller et al., 2007, Haerty et al., 2007, Takemori and Yamamoto, 2009, Findlay et al., 2009, Wittkopp et al., 2008, Walker et al., 2006, Cammarato et al., 2011, Parisi et al., 2004, Ni et al., 2010.12.1, Takács et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wong et al., 2012)
Name Synonym	cathepsinK (Walker et al., 2006)
Secondary FlyBase IDs
	FBgn0046289
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 10 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Takács et al., 2012, Int. J. Biol. Sci. 8(7): 1055--1061 Protein interactions on telomeric retrotransposons in Drosophila. [FBrf0219367] Wong et al., 2012, Mol. Biol. Evol. 29(1): 229--238 Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. [FBrf0217443] Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Giardina et al., 2011, Mol. Ecol. 20(19): 4098--4108 Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. [FBrf0216308] Show all research papers ...