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Gene Dmel\CG4847

General Information
Symbol	Dmel\CG4847	Species	D. melanogaster
Name		Annotation symbol	CG4847
Feature type	protein_coding_gene	FlyBase ID	FBgn0034229
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C1-54C1	Sequence location	2R:13,399,028..13,401,364 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4847 (FBgn0034229). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cysteine-type endopeptidase activity; cysteine-type peptidase activity. There is experimental evidence that it is involved in the biological process: multicellular organism reproduction. 2 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Peptidase C1A, papain; Peptidase C1A, papain C-terminal; Peptidase, cysteine peptidase active site; Proteinase inhibitor I29, cathepsin propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed at stages throughout the larval period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval hindgut, adult heart, adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1638321_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of CG4847. Gene sequence location is 2R:13399028..13401364.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Giardina et al., 2011, Mol. Ecol. 20(19): 4098--4108 Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA06897 BKN25480
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C1-54C1   Limits computationally determined from genome sequence between P{EP}l(2)k01209EP2177&P{lacW}k11012a and P{lacW}l(2)k07433k07433
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4847 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4847-RA FBtr0086933  NM_137377   1305   390 CG4847-RB FBtr0086936  NM_166236   1309   390 CG4847-RC FBtr0086934  NM_166237   1317   390 CG4847-RD FBtr0086935  NM_166235   1500   420 CG4847-RE FBtr0086937  NM_206152   1312   390
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4847-PA   FBpp0086089   40.8   390   5.98     NP_611221   AAF57850 CG4847-PB   FBpp0086092   40.8   390   5.98     NP_725687   AAM70881 CG4847-PC   FBpp0086090   40.8   390   5.98     NP_725688   AAM70882 CG4847-PD   FBpp0086091   44.1   420   6.39     NP_725686   AAM70880 CG4847-PE   FBpp0086093   40.8   390   5.98     NP_995874   AAS64820
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase, cysteine peptidase active site (IPR000169) Peptidase C1A, papain C-terminal (IPR000668) Peptidase C1A, papain (IPR013128) Proteinase inhibitor I29, cathepsin propeptide (IPR013201)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57850   AE013599 AAM70880   AE013599 AAM70881   AE013599 AAM70882   AE013599 AAS64820   AI062406   AI107760   AI109372   AI113731   AI388590   AI403377   AI403864   AI404542   AI513111   AY047507 AAK77239   BF506407   BI569867   BI574102   BI574103   BI575614   BI583637   BI585105   BI590011   BI604542   BI606570   BI608774   BI608785   BI611219   BI611671   BI612849   BI616740   BI621355   BI622124   BI622216   BI622683   BI623941   BI629956   BT099507   CO312813   CO316073   EC076519   EC088298   EC232242   EC242926
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K5N8 A1ZAU4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034229    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034229 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed at stages throughout the larval period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034229 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr    1516 embryo 20-22hr    3167 embryo 22-24hr    1844 larva L1    2355 larva L2    2269 larva L3 12hr old    12644 larva L3 puffstage 1-2    14950 larva L3 puffstage 3-6    4175 larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP    4563 adult male 01day    19440 adult male 05day    22957 adult male 30day    16158 adult female 01day    2890 adult female 05day    2519 adult female 30day    2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr  (157) embryo 14-16hr  (416) embryo 16-18hr  (1289) embryo 18-20hr  (1516) embryo 20-22hr  (3167) embryo 22-24hr  (1844) larva L1  (2355) larva L2  (2269) larva L3 12hr old  (12644) larva L3 puffstage 1-2  (14950) larva L3 puffstage 3-6  (4175) larva L3 puffstage 7-9  (908) white prepupae new  (256) white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP  (141) pupae 4d postWPP  (4563) adult male 01day  (19440) adult male 05day  (22957) adult male 30day  (16158) adult female 01day  (2890) adult female 05day  (2519) adult female 30day  (2082) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr  (1516) embryo 20-22hr  (3167) embryo 22-24hr  (1844) larva L1  (2355) larva L2  (2269) larva L3 12hr old  (12644) larva L3 puffstage 1-2  (14950) larva L3 puffstage 3-6  (4175) larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP  (4563) adult male 01day  (19440) adult male 05day  (22957) adult male 30day  (16158) adult female 01day  (2890) adult female 05day  (2519) adult female 30day  (2082) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr    1516 embryo 20-22hr    3167 embryo 22-24hr    1844 larva L1    2355 larva L2    2269 larva L3 12hr old  (12644) larva L3 puffstage 1-2  (14950) larva L3 puffstage 3-6    4175 larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP    4563 adult male 01day  (19440) adult male 05day  (22957) adult male 30day  (16158) adult female 01day    2890 adult female 05day    2519 adult female 30day    2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr    1516 embryo 20-22hr    3167 embryo 22-24hr    1844 larva L1    2355 larva L2    2269 larva L3 12hr old    12644 larva L3 puffstage 1-2    14950 larva L3 puffstage 3-6    4175 larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP    4563 adult male 01day    19440 adult male 05day    22957 adult male 30day    16158 adult female 01day    2890 adult female 05day    2519 adult female 30day    2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034229 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr    1516 embryo 20-22hr    3167 embryo 22-24hr    1844 larva L1    2355 larva L2    2269 larva L3 12hr old    12644 larva L3 puffstage 1-2    14950 larva L3 puffstage 3-6    4175 larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP    4563 adult male 01day    19440 adult male 05day    22957 adult male 30day    16158 adult female 01day    2890 adult female 05day    2519 adult female 30day    2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr  (157) embryo 14-16hr  (416) embryo 16-18hr  (1289) embryo 18-20hr  (1516) embryo 20-22hr  (3167) embryo 22-24hr  (1844) larva L1  (2355) larva L2  (2269) larva L3 12hr old  (12644) larva L3 puffstage 1-2  (14950) larva L3 puffstage 3-6  (4175) larva L3 puffstage 7-9  (908) white prepupae new  (256) white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP  141 pupae 4d postWPP  (4563) adult male 01day  (19440) adult male 05day  (22957) adult male 30day  (16158) adult female 01day  (2890) adult female 05day  (2519) adult female 30day  (2082) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr  1516 embryo 20-22hr  (3167) embryo 22-24hr  1844 larva L1  2355 larva L2  2269 larva L3 12hr old  (12644) larva L3 puffstage 1-2  (14950) larva L3 puffstage 3-6  (4175) larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP  (4563) adult male 01day  (19440) adult male 05day  (22957) adult male 30day  (16158) adult female 01day  (2890) adult female 05day  (2519) adult female 30day  2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr    1516 embryo 20-22hr    3167 embryo 22-24hr    1844 larva L1    2355 larva L2    2269 larva L3 12hr old  12644 larva L3 puffstage 1-2  14950 larva L3 puffstage 3-6    4175 larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP    4563 adult male 01day  19440 adult male 05day  (22957) adult male 30day  16158 adult female 01day    2890 adult female 05day    2519 adult female 30day    2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    17 embryo 08-10hr    24 embryo 10-12hr    78 embryo 12-14hr    157 embryo 14-16hr    416 embryo 16-18hr    1289 embryo 18-20hr    1516 embryo 20-22hr    3167 embryo 22-24hr    1844 larva L1    2355 larva L2    2269 larva L3 12hr old    12644 larva L3 puffstage 1-2    14950 larva L3 puffstage 3-6    4175 larva L3 puffstage 7-9    908 white prepupae new    256 white prepupae 12hr    10 white prepupae 24hr    28 pupae 2d postWPP    44 pupae 3d postWPP    141 pupae 4d postWPP    4563 adult male 01day    19440 adult male 05day    22957 adult male 30day    16158 adult female 01day    2890 adult female 05day    2519 adult female 30day    2082 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034229    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034229 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval hindgut, adult heart, adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034229 expression level Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body    1161.7 Adult Salivary Gland no informative data Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut  (872) Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  (1522) Adult Eye  (674.225) Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body  (1161.7) Adult Salivary Gland no informative data Adult Heart  (822.55) Adult VirginFemale Spermatheca  (1400.7) Adult InseminatedFemale Spermatheca  (1375.3) Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  (1522) Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body  (1161.7) Adult Salivary Gland no informative data Adult Heart    822.55 Adult VirginFemale Spermatheca  (1400.7) Adult InseminatedFemale Spermatheca  (1375.3) Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body    1161.7 Adult Salivary Gland no informative data Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034229 expression level Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body    1161.7 Adult Salivary Gland no informative data Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut  (872) Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  (1522) Adult Eye  674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body  (1161.7) Adult Salivary Gland no informative data Adult Heart  (822.55) Adult VirginFemale Spermatheca  (1400.7) Adult InseminatedFemale Spermatheca  (1375.3) Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass  (2708.2) Adult Head  1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body  1161.7 Adult Salivary Gland no informative data Adult Heart    822.55 Adult VirginFemale Spermatheca  1400.7 Adult InseminatedFemale Spermatheca  1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland  (9614.8) Adult Carcass  (1758.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    3.4 Larval Hindgut    872 Larval Malpighian Tubules    1.4 Larval Fat Body    2.1 Larval Salivary Gland    6.3 Larval Trachea    390.675 Larval Carcass    2708.2 Adult Head    1522 Adult Eye    674.225 Adult Brain    27 Adult Thoracic-Abdominal Ganglion    26.5 Adult Crop    83.3 Adult Midgut no informative data Adult Hindgut    178.7 Adult Malpighian Tubules no informative data Adult Fat Body    1161.7 Adult Salivary Gland no informative data Adult Heart    822.55 Adult VirginFemale Spermatheca    1400.7 Adult InseminatedFemale Spermatheca    1375.3 Adult Ovary    5.7 Adult Testis    31.5 Adult Male Accessory Gland    9614.8 Adult Carcass    1758.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1522   NA  Eye    674.225   NA  Brain    27   4.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    26.5   NA  Crop    83.3   3.4  Midgut    no informative data   872  Hindgut    178.7   1.4  Malpighian Tubules    no informative data   2.1  Fat Body    1161.7   6.3  Salivary Gland    no informative data   NA  Heart    822.55   390.675  Trachea    NA   NA  VirginFemale Spermatheca    1400.7   NA  InseminatedFemale Spermatheca    1375.3   NA  Ovary    5.7   NA  Testis    31.5   NA  Male Accessory Gland    9614.8   2708.2  Carcass    1758.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_16
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4847-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG4847 Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG4847GD1652 viable, with Scer\GAL4αTub84B.PL CG4847Scer\UAS.cMa Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG4847 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4847 Class Mutagen Stocks Known lesion CG4847GD1652 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG4847Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1652} NA P{UAS-CG4847.M} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
multicellular organism reproduction inferred from expression pattern (Findlay et al., 2009)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Findlay et al., 2009, Walker et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with EMBL:AJ006033 (FlyBase, 1992-) cysteine-type peptidase activity inferred from sequence or structural similarity (Mueller et al., 2004)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR000169, InterPro:IPR000668 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Mueller et al., 2004)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4847 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62665 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034229 DroID - A comprehensive database of gene and protein interactions. • FBgn0034229 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36973
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13132 Dere\GG20691 Dgri\GH21411 Dmoj\GI18587 Dper\GL11434 Dpse\GA18475 Dsec\GM21790 Dsim\GD11280 Dvir\GJ20385 Dwil\GK22909 Dyak\GE11675
Curated drosophilid orthologs	Dpse\GA18475 (Walker et al., 2006) Dsim\GD11280 (Swanson et al., 2001, Findlay et al., 2009)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0229470 FBgn0224871 FBgn0207525 FBgn0045613 FBgn0176668 FBgn0078477 FBgn0149043 FBgn0141326 FBgn0131363 FBgn0128873 FBgn0112878 FBgn0090165
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v3230 w1118; P{GD1652}v3230/TM3 v3231 w1118; P{GD1652}v3231/TM3
Genomic Clones ( 1 )
	BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01592 RH39096
Other clones	DPiM_GH01592
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08863 GH05605 GH08537 GH10168 GH22803 GH23401 GH24290 RH02038 RH03556 RH13468 RH13480 RH17392 RH18048 RH22294 RH24574 RH31353 RH41834 RH46803 RH52683 RH53948 RH54053 RH54591 RH56308 RH58903 RH69949 RH73130
Other clones	1882 105523 109284 CK01.118A.B2 EK230044 EK263615 RH09495
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36973
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Isolated in a screen for seminal fluid proteins. (Mueller et al., 2004) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and increased expression in ClkJrk background. (Claridge-Chang et al., 2001) Identified with: GH19547.3prime <up>FlyBase curator comment: EST subsequently found to be chimeric</up>. (Oliver, 2001.8.16) EST GH19547 is chimeric; the 3' portion corresponds to part of CG4847, the 5' portion corresponds matches part of AE003464 on the opposite strand to Pof. (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137377 NM_166235 NM_166236 NM_166237 NM_206152 RefSeq (Proteins) • NP_611221 NP_725686 NP_725687 NP_725688 NP_995874 DDBJ / EMBL / GenBank • AAF57850 AAK77239 AAM70880 AAM70881 AAM70882 AAS64820 AI062406 AI388590 AI513111 AY047507 Entrez Gene - A searchable database of RefSeq genes. • 36973 UniProtKB/TrEMBL • A1ZAU4 Q7K5N8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase, cysteine peptidase active site (IPR000169) Peptidase C1A, papain C-terminal (IPR000668) Peptidase C1A, papain (IPR013128) Proteinase inhibitor I29, cathepsin propeptide (IPR013201)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62665 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034229 DroID - A comprehensive database of gene and protein interactions. • FBgn0034229 DRSC - Results from RNAi screens. • FBgn0034229 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4847-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36973 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36973 modMine - Data generated by the modENCODE project. • FBgn0034229 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0229470 FBgn0224871 FBgn0207525 FBgn0045613 FBgn0176668 FBgn0078477 FBgn0149043 FBgn0141326 FBgn0131363 FBgn0128873 FBgn0112878 FBgn0090165
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BEST:GH19547   CG4847 (Wittkopp et al., 2006, Giardina et al., 2011, Mueller et al., 2007, Haerty et al., 2007, Takemori and Yamamoto, 2009, Findlay et al., 2009, Wittkopp et al., 2008, Walker et al., 2006, Cammarato et al., 2011, Parisi et al., 2004)
Name Synonym	cathepsinK (Walker et al., 2006)
Secondary FlyBase IDs
	FBgn0046289
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 3 ) FlyBase analysis  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Giardina et al., 2011, Mol. Ecol. 20(19): 4098--4108 Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. [FBrf0216308] Show all research papers ...