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Gene Dmel\ns2

General Information
Symbol	Dmel\ns2	Species	D. melanogaster
Name	nucleostemin 2	Annotation symbol	CG6501
Feature type	protein_coding_gene	FlyBase ID	FBgn0034243
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Ngp
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C8-54C9	Sequence location	2R:13,453,284..13,455,950 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nucleostemin 2 is referred to in FlyBase by the symbol Dmel\ns2 (CG6501, FBgn0034243). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activity. There is experimental evidence that it is involved in the biological process: compound eye morphogenesis; phagocytosis, engulfment. 13 alleles are reported. The phenotype of these alleles is annotated with: eye. It has one annotated transcript and one annotated polypeptide. Protein features are: GTP-binding domain, HSR1-related; GTP-binding protein, orthogonal bundle domain; GTP1/OBG; Nucleolar GTPase, NGP1-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1638495_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ns2. Gene sequence location is 2R:13453284..13455950.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms nucleoplasm GTPase activity References Matsuo et al., 2011, Biosci. Biotechnol. Biochem. 75(8): 1511--1515
FB2012_01	Sequence features HFA06993 BKN20478
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C8-54C9   Limits computationally determined from genome sequence between P{EP}MESR4EP386&P{EP}POSHEP1206 and P{PZ}l(2)1050510505
Experimentally Determined Cytological Location
Cytogenetic map Notes References 54D1-54D2     (Maroofi, 2000.10.24)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ns2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ns2-RA FBtr0086906  NM_137388   2222   674
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ns2-PA   FBpp0086063   76.6   674   10.23     NP_611232   AAF57834
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GTP-binding domain, HSR1-related (IPR002917) GTP1/OBG (IPR006073) Nucleolar GTPase, NGP1-type (IPR012971) GTP-binding protein, orthogonal bundle domain (IPR023179)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57834   AF315579 AAL26879   AI107337   AI543457   AI546620   AI945055   AW944621   AY089700 AAL90438   BG633274   BI235629   BI369701   BI565169   BI571188   BI572840   BI573017   BI587827   BI590080   BI590211   BI590803   BI605590   BI617551   BI635704   BI640498   BI641268   BI641286   BP547683   CK132077   CK657934   CK660088   CO280499   CO294125   CO305314   CO339324   CO340464   EC076851   EC199321   EC235845   EC252075   EC252977   GH751911   GH754238   GH756430   GH772084   GH772283   GH774469   GH777805   GH780051   GH783278   GH793041   GH799258   GH801835   GH804390   GH805598   GH809234   GH809313   GH810161   GH813384   GH815433   GH821838   GH825310   GH829162   GH833917   GH837345   GH841122   GH849493   GH854907   GH854947   GH859845   GH861504   GH865116   GH865341   GH866958   GH867932   GH868651   GH869274   GH871803   GH872016   GH872664   GH874550   GH874743   GH880618   GH881548   GH882337   GH888172   GH890830   GH892075   GH892079   GH896294   GH897747   GH900083   GH901703   GH902147   GH906149   GH907056   GH909340   GH910416   GH918466   GH919043   GH919317   GH922087   GH925943   GH929025   GH929053   GH936960   GH942282
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JXU4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034243    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034243 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034243 expression level Developmental Stage   Expression Level embryo 00-02hr    2569 embryo 02-04hr    3329 embryo 04-06hr    5423 embryo 06-08hr    6160 embryo 08-10hr    6024 embryo 10-12hr    4689 embryo 12-14hr    4028 embryo 14-16hr    2087 embryo 16-18hr    2239 embryo 18-20hr    2303 embryo 20-22hr    3994 embryo 22-24hr    4115 larva L1    4540 larva L2    2706 larva L3 12hr old    1851 larva L3 puffstage 1-2    1474 larva L3 puffstage 3-6    1788 larva L3 puffstage 7-9    2020 white prepupae new    1784 white prepupae 12hr    2126 white prepupae 24hr    2103 pupae 2d postWPP    1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day    1449 adult male 05day    1462 adult male 30day    1183 adult female 01day    2356 adult female 05day    3137 adult female 30day    3112 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2569) embryo 02-04hr  (3329) embryo 04-06hr  (5423) embryo 06-08hr  (6160) embryo 08-10hr  (6024) embryo 10-12hr  (4689) embryo 12-14hr  (4028) embryo 14-16hr  (2087) embryo 16-18hr  (2239) embryo 18-20hr  (2303) embryo 20-22hr  (3994) embryo 22-24hr  (4115) larva L1  (4540) larva L2  (2706) larva L3 12hr old  (1851) larva L3 puffstage 1-2  (1474) larva L3 puffstage 3-6  (1788) larva L3 puffstage 7-9  (2020) white prepupae new  (1784) white prepupae 12hr  (2126) white prepupae 24hr  (2103) pupae 2d postWPP  (1595) pupae 3d postWPP  (1039) pupae 4d postWPP  (1065) adult male 01day  (1449) adult male 05day  (1462) adult male 30day  (1183) adult female 01day  (2356) adult female 05day  (3137) adult female 30day  (3112) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2569) embryo 02-04hr  (3329) embryo 04-06hr  (5423) embryo 06-08hr  (6160) embryo 08-10hr  (6024) embryo 10-12hr  (4689) embryo 12-14hr  (4028) embryo 14-16hr  (2087) embryo 16-18hr  (2239) embryo 18-20hr  (2303) embryo 20-22hr  (3994) embryo 22-24hr  (4115) larva L1  (4540) larva L2  (2706) larva L3 12hr old  (1851) larva L3 puffstage 1-2  1474 larva L3 puffstage 3-6  (1788) larva L3 puffstage 7-9  (2020) white prepupae new  (1784) white prepupae 12hr  (2126) white prepupae 24hr  (2103) pupae 2d postWPP  (1595) pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day  1449 adult male 05day  1462 adult male 30day    1183 adult female 01day  (2356) adult female 05day  (3137) adult female 30day  (3112) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2569 embryo 02-04hr    3329 embryo 04-06hr    5423 embryo 06-08hr    6160 embryo 08-10hr    6024 embryo 10-12hr    4689 embryo 12-14hr    4028 embryo 14-16hr    2087 embryo 16-18hr    2239 embryo 18-20hr    2303 embryo 20-22hr    3994 embryo 22-24hr    4115 larva L1    4540 larva L2    2706 larva L3 12hr old    1851 larva L3 puffstage 1-2    1474 larva L3 puffstage 3-6    1788 larva L3 puffstage 7-9    2020 white prepupae new    1784 white prepupae 12hr    2126 white prepupae 24hr    2103 pupae 2d postWPP    1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day    1449 adult male 05day    1462 adult male 30day    1183 adult female 01day    2356 adult female 05day    3137 adult female 30day    3112 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2569 embryo 02-04hr    3329 embryo 04-06hr    5423 embryo 06-08hr    6160 embryo 08-10hr    6024 embryo 10-12hr    4689 embryo 12-14hr    4028 embryo 14-16hr    2087 embryo 16-18hr    2239 embryo 18-20hr    2303 embryo 20-22hr    3994 embryo 22-24hr    4115 larva L1    4540 larva L2    2706 larva L3 12hr old    1851 larva L3 puffstage 1-2    1474 larva L3 puffstage 3-6    1788 larva L3 puffstage 7-9    2020 white prepupae new    1784 white prepupae 12hr    2126 white prepupae 24hr    2103 pupae 2d postWPP    1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day    1449 adult male 05day    1462 adult male 30day    1183 adult female 01day    2356 adult female 05day    3137 adult female 30day    3112 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034243 expression level Developmental Stage   Expression Level embryo 00-02hr    2569 embryo 02-04hr    3329 embryo 04-06hr    5423 embryo 06-08hr    6160 embryo 08-10hr    6024 embryo 10-12hr    4689 embryo 12-14hr    4028 embryo 14-16hr    2087 embryo 16-18hr    2239 embryo 18-20hr    2303 embryo 20-22hr    3994 embryo 22-24hr    4115 larva L1    4540 larva L2    2706 larva L3 12hr old    1851 larva L3 puffstage 1-2    1474 larva L3 puffstage 3-6    1788 larva L3 puffstage 7-9    2020 white prepupae new    1784 white prepupae 12hr    2126 white prepupae 24hr    2103 pupae 2d postWPP    1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day    1449 adult male 05day    1462 adult male 30day    1183 adult female 01day    2356 adult female 05day    3137 adult female 30day    3112 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2569) embryo 02-04hr  (3329) embryo 04-06hr  (5423) embryo 06-08hr  (6160) embryo 08-10hr  (6024) embryo 10-12hr  (4689) embryo 12-14hr  (4028) embryo 14-16hr  (2087) embryo 16-18hr  (2239) embryo 18-20hr  (2303) embryo 20-22hr  (3994) embryo 22-24hr  (4115) larva L1  (4540) larva L2  (2706) larva L3 12hr old  (1851) larva L3 puffstage 1-2  (1474) larva L3 puffstage 3-6  (1788) larva L3 puffstage 7-9  (2020) white prepupae new  (1784) white prepupae 12hr  (2126) white prepupae 24hr  (2103) pupae 2d postWPP  (1595) pupae 3d postWPP  (1039) pupae 4d postWPP  (1065) adult male 01day  (1449) adult male 05day  (1462) adult male 30day  (1183) adult female 01day  (2356) adult female 05day  (3137) adult female 30day  (3112) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2569) embryo 02-04hr  (3329) embryo 04-06hr  (5423) embryo 06-08hr  (6160) embryo 08-10hr  (6024) embryo 10-12hr  (4689) embryo 12-14hr  (4028) embryo 14-16hr  2087 embryo 16-18hr  2239 embryo 18-20hr  2303 embryo 20-22hr  (3994) embryo 22-24hr  (4115) larva L1  (4540) larva L2  (2706) larva L3 12hr old  1851 larva L3 puffstage 1-2  1474 larva L3 puffstage 3-6  1788 larva L3 puffstage 7-9  2020 white prepupae new  1784 white prepupae 12hr  2126 white prepupae 24hr  2103 pupae 2d postWPP  1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day  1449 adult male 05day  1462 adult male 30day    1183 adult female 01day  2356 adult female 05day  (3137) adult female 30day  (3112) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2569 embryo 02-04hr    3329 embryo 04-06hr    5423 embryo 06-08hr    6160 embryo 08-10hr    6024 embryo 10-12hr    4689 embryo 12-14hr    4028 embryo 14-16hr    2087 embryo 16-18hr    2239 embryo 18-20hr    2303 embryo 20-22hr    3994 embryo 22-24hr    4115 larva L1    4540 larva L2    2706 larva L3 12hr old    1851 larva L3 puffstage 1-2    1474 larva L3 puffstage 3-6    1788 larva L3 puffstage 7-9    2020 white prepupae new    1784 white prepupae 12hr    2126 white prepupae 24hr    2103 pupae 2d postWPP    1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day    1449 adult male 05day    1462 adult male 30day    1183 adult female 01day    2356 adult female 05day    3137 adult female 30day    3112 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2569 embryo 02-04hr    3329 embryo 04-06hr    5423 embryo 06-08hr    6160 embryo 08-10hr    6024 embryo 10-12hr    4689 embryo 12-14hr    4028 embryo 14-16hr    2087 embryo 16-18hr    2239 embryo 18-20hr    2303 embryo 20-22hr    3994 embryo 22-24hr    4115 larva L1    4540 larva L2    2706 larva L3 12hr old    1851 larva L3 puffstage 1-2    1474 larva L3 puffstage 3-6    1788 larva L3 puffstage 7-9    2020 white prepupae new    1784 white prepupae 12hr    2126 white prepupae 24hr    2103 pupae 2d postWPP    1595 pupae 3d postWPP    1039 pupae 4d postWPP    1065 adult male 01day    1449 adult male 05day    1462 adult male 30day    1183 adult female 01day    2356 adult female 05day    3137 adult female 30day    3112 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034243    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034243 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034243 expression level Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034243 expression level Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.775 Larval Midgut    18.6 Larval Hindgut    17.9 Larval Malpighian Tubules    21.2 Larval Fat Body    38.3 Larval Salivary Gland    25.8 Larval Trachea    20.15 Larval Carcass    16.675 Adult Head    20.1 Adult Eye    20.75 Adult Brain    16.6 Adult Thoracic-Abdominal Ganglion    22.1 Adult Crop    26.9 Adult Midgut    29.7 Adult Hindgut    25.1 Adult Malpighian Tubules    23.3 Adult Fat Body    30 Adult Salivary Gland    48.2 Adult Heart    20.8 Adult VirginFemale Spermatheca    19.2 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    28.3 Adult Testis    42.9 Adult Male Accessory Gland    30.6 Adult Carcass    30.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    20.1   NA  Eye    20.75   NA  Brain    16.6   22.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    22.1   NA  Crop    26.9   18.6  Midgut    29.7   17.9  Hindgut    25.1   21.2  Malpighian Tubules    23.3   38.3  Fat Body    30   25.8  Salivary Gland    48.2   NA  Heart    20.8   20.15  Trachea    NA   NA  VirginFemale Spermatheca    19.2   NA  InseminatedFemale Spermatheca    21.5   NA  Ovary    28.3   NA  Testis    42.9   NA  Male Accessory Gland    30.6   16.675  Carcass    30.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034243 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6501-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ns2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | recessive | somatic clone ns251 ns2108 lethal (with ns211) ns251 ns254 ns257 ns275 ns278 ns2108 lethal (with ns251) ns211 lethal (with ns254) ns211 lethal (with ns257) ns211 lethal (with ns275) ns211 lethal (with ns278) ns211 lethal (with ns2108) ns211 lethal | first instar larval stage | recessive ns251 ns2108 Other Phenotypes Allele long lived, with Scer\GAL4hs.PB ns2GS2207 visible, with Scer\GAL4ey.PH ns2NIG.6501R visible, with Scer\GAL4ey.PH, ns251 ns2NIG.6501R visible, with Scer\GAL4ey.PH, ns2NIG.6501R ns251 Phenotype manifest in Allele eye, with Scer\GAL4ey.PH ns2NIG.6501R eye, with Scer\GAL4ey.PH, ns251 ns2NIG.6501R eye, with Scer\GAL4ey.PH, ns2NIG.6501R ns251 wing disc | somatic clone ns251 ns2108
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of ns2 Class Mutagen Stocks Known lesion ns2G6217 P-element activity 1 -- ns2GS2207 P-element activity 1 Yes ns2108 ethyl methanesulfonate 0 Yes ns211 P-element activity 0 Yes ns251 ethyl methanesulfonate 0 Yes ns254 ethyl methanesulfonate 0 Yes ns257 ethyl methanesulfonate 0 Yes ns275 ethyl methanesulfonate 0 Yes ns278 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ns2 Class Mutagen Stocks Known lesion ns2KK100382 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ns2GD11941 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ns2NIG.6501R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ns2Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)ns211 (Matsuo et al., 2010)
Partially disrupted in	Df(2R)ns211 (Matsuo et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK100382} NA P{UAS-ns2.M} NA characterization construct P{NIG.6501R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ns2G6217 NA P{GSV1}POSHGS2207 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from direct assay (Matsuo et al., 2011)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Matsuo et al., 2010) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
nucleolus inferred from direct assay (Kaplan et al., 2008) colocalizes_with nucleolus inferred from direct assay (Matsuo et al., 2011) colocalizes_with nucleoplasm inferred from direct assay (Matsuo et al., 2011)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
GTP binding inferred from electronic annotation with InterPro:IPR006073 (FlyBase Curators et al., 2004-) non-traceable author statement (Maroofi, 2000.10.24)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Maroofi, 2000.10.24)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ns2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034243 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36989
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13248 Dere\GG21043 Dgri\GH20960 Dmoj\GI21297 Dper\GL10621 Dpse\GA19643 Dsec\GM19971 Dsim\GD25465 Dvir\GJ20899 Dwil\GK21401 Dyak\GE13986
Curated drosophilid orthologs	Dpse\GA19643   Dsan\Ngp (Llopart et al., 2005) Dyak\Ngp (Llopart et al., 2005)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003293-PA Aedes aegypti (mosquito) AGAP011309-PA Anopheles gambiae (mosquito) At1g52980.1 Arabidopsis thaliana (wall cress) 19365 Batrachochytrium dendrobatidis (chytrid fungus) XP_001895432.1 Brugia malayi (roundworm nematode) BGIBMGA011822-PA Bombyx mori (silk worm) ENSBTAP00000005018 Bos taurus (bovine) CAL0001419 Candida albicans (a form of yeast) CN28884 Caenorhabditis brenneri (small nematode) CBP33123 Caenorhabditis briggsae (nematode) CE32493 Caenorhabditis elegans (worm) ENSCAFP00000004881 Canis familiaris (dog) CAGL0C03369g Candida glabrata (haploid yeast) Chro.20234 Cryptosporidium hominis (obligate parasite) ENSCINP00000000039 Ciona intestinalis (sea squirt) JA08440 Caenorhabditis japonica (nematode) CMT130C Cyanidioschyzon merolae (red alga) cn04073 Cryptococcus neoformans (yeast-like fungus) cgd2_2170 Cryptosporidium parvum (protozoan parasite) CPIJ001254 Culex pipens (mosquito) ENSCPOP00000019529 Cavia porcellus (guinea pig) 128793 Chlamidomonas reinhardtii (green alga) RP11763 Caenorhabditis remanei (nematode) ENSCSAVP00000002678 Ciona savignyi (sedentary tunicate) 185256 Capitella spl (polychaete worm) DDB0206493 Dictyostelium discoideum (amoeba) DEHA2E01474g Debaryomyces Hansenii (yeast) 332475 Daphnia pulex (daphnia) ENSDARP00000069707 Danio rerio (zebra fish) ENSDARP00000069882 Danio rerio (zebra fish) ENSECAP00000006451 Equus caballus (horse) XP_648675 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018106 Gymnopilus aculeatus (mushroom) ENSGALP00000003063 Gallus gallus (chicken) GL50803_89887 Giardia lamblia (flagellated protozoan) 192836 Hypsipyla robusta (cedar shoot borer) ENSP00000362153 Homo sapiens (human) ISCW011628-PA Ixodes scapularis (deer tick) KLLA0C18843g Kluyveromyces lactis (yeast) 208405 Lottia gigantea (owl limpet) LmjF05.0460 Leishmania major (virus) 19938 Monocosta brevicollis (choanoflagellate) ENSMODP00000022160 Monodelphis domestica (gray opossum) ENSMMUP00000011036 Macaca mulatta (rhesus monkey) ENSMUSP00000030684 Mus musculus (house mouse) 104439 Nematostella vectensis (starlet anemone) XP_001601194.1 Nasonia vitripennis (wasp) ENSOANP00000003260 Ornithorynchus anatinus (platypus) ENSORLP00000018355 Oryzias latipes (japanese killifish) LOC_Os03g22890.1 Oryza sativa (asian rice) 34327 Ostreococcus tauri (green alga) PF14_0221 Plasmodium falciparum (protozoal parasite) PHUM004273-PA Pediculus humanus (human body louse) PP14287 Pristionchus pacificus (nematode) 31650 Physcomitrella patens (moss) ENSPPYP00000001765 Pongo pygmaeus (orangutan) 52177 Phytophthora ramorum (sudden oak death pathogen) 155554 Phytophthora sojae (root rot pathogen) 836908 Populus trichocarpa (black cottonwood) ENSPTRP00000000969 Pan troglodytes (chimpanzee) PVX_085330 Plasmodium vivax (protozoal parasite) ENSRNOP00000012702 Rattus norvegicus (norway rat) 5049415 Sorghum bicolor (sorghum) YNR053C Saccharomyces cerevisiae (budding yeast) Smp_087810 Schistosoma mansoni (trematode parasite) SPAC6F6.03c Schizosaccharomyces pombe (fission yeast) XP_001192782.1 Strongylocentrotus purpuratus (purple sea urchin) 27600 Trichoplax adhaerens (metazoa) TA14695 Theileria annulata (apicomplexan parasite) XP_967515.1 Tribolium castaneum (red flour beetle) Tc00.1047053510609.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006333 Tetraodon nigroviridis (green spotted pufferfish) TP02_0708 Theileria parva (parasitic protozoan) 34729 Thalassiosira pseudonana (marine diatom) ENSTRUP00000024600 Takifugu rubripes (pufferfish Takifugu) 204.m00035 Tetrahymena thermophila (ciliate protozoa) 97354.m00228 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000004622 Xenopus tropicalis (frog) YALI0F28083g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16103 NV15815 LH22001 ISCW011628 FBgn0231619 FBgn0223393 FBgn0208035 FBgn0196758 FBgn0174857 JGI_V11_332475 FBgn0079639 FBgn0148231 FBgn0144027 FBgn0128422 FBgn0113227 FBgn0090280 CPIJ001254 BGIBMGA011822 GB14943 AGAP011309 AAEL003293 PHUM046990 GLEAN_14758
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27201 y1 w*; P{EP}ns2G6217
Kyoto	200330 y1 w67c23; P{GSV1}POSHGS2207/SM1
VDRC	v105605 P{KK100382}VIE-260B
Genomic Clones ( 2 )
	BACR12C23 BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10213
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04143 GH23523 LP13318 LP18343 RE29172 RE31529 RE55967 RH03646 RH03803 RH04478 RH06017 RH08484 RH08706 RH28715 RH47922 RH62864 RH71403 SD08095 SD17133 SD23380 SD24491 SD24513
Other clones	39889 75202 118256 214211.74 214275.85 bs08d11 EK154217 EK206046 EK248210 EP01623 EP10712 FGH119F03 RP003017980 RP003022826 RP003039605 RP003043500 RP003045963 RP003061031 RP003067870 RP003072958 RP003080630 RP003091397 RP003107394 RP003121986 RP003125263 RP003127403 RP003128619 RP003131166 RP003135347 RP003137710 RP003153962 RP003155267 RP003163144 RP003173341 RP003192485 RP003204227 RP003218545 RP003234843 RP003239085 RP003246982 RP003247663 RP003249793 RP003250281 RP003251034 RP003255923 RP003275679 RP003279240 RP003284284 RP003286469 RP003287496 RP003300715 RP003300722 RP003321745 RP003327596 RP003331021 RP003338958 RP003339186 RP003382150 RP003402910 RP003424736 RP003428060 RP003429369 RP003431977 RP003433087 RP003435975 RP003481440 RP003523786 RP003530137 RP003539489 RP003556521 RP003574475 RP003591970 RP003592034 RP003614357 RP003654005 RP003663668 RP003664400 RP003674858
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034243 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36989
Antibody Information
	polyclonal (Matsuo et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ngp CG6501 (FlyBase, 1996-) Source for identity of: ns2 Ngp (Kaplan et al., 2008)
Source for database merge of
Additional comments	Source for identity of Ngp CG6501 was sequence comparison (date:011104). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137388 RefSeq (Proteins) • NP_611232 DDBJ / EMBL / GenBank • AAF57834 AAL26879 AAL90438 AF315579 AI543457 AI945055 AW944621 AY089700 Entrez Gene - A searchable database of RefSeq genes. • 36989 UniProtKB/TrEMBL • Q7JXU4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GTP-binding domain, HSR1-related (IPR002917) GTP1/OBG (IPR006073) Nucleolar GTPase, NGP1-type (IPR012971) GTP-binding protein, orthogonal bundle domain (IPR023179)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034243 DRSC - Results from RNAi screens. • FBgn0034243 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034243 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6501-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034243 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36989 InParanoid A subset of ortholog calls from InParanoid. • AAEL003293-PA Aedes aegypti (mosquito) AGAP011309-PA Anopheles gambiae (mosquito) At1g52980.1 Arabidopsis thaliana (wall cress) 19365 Batrachochytrium dendrobatidis (chytrid fungus) XP_001895432.1 Brugia malayi (roundworm nematode) BGIBMGA011822-PA Bombyx mori (silk worm) ENSBTAP00000005018 Bos taurus (bovine) CAL0001419 Candida albicans (a form of yeast) CN28884 Caenorhabditis brenneri (small nematode) CBP33123 Caenorhabditis briggsae (nematode) CE32493 Caenorhabditis elegans (worm) ENSCAFP00000004881 Canis familiaris (dog) CAGL0C03369g Candida glabrata (haploid yeast) Chro.20234 Cryptosporidium hominis (obligate parasite) ENSCINP00000000039 Ciona intestinalis (sea squirt) JA08440 Caenorhabditis japonica (nematode) CMT130C Cyanidioschyzon merolae (red alga) cn04073 Cryptococcus neoformans (yeast-like fungus) cgd2_2170 Cryptosporidium parvum (protozoan parasite) CPIJ001254 Culex pipens (mosquito) ENSCPOP00000019529 Cavia porcellus (guinea pig) 128793 Chlamidomonas reinhardtii (green alga) RP11763 Caenorhabditis remanei (nematode) ENSCSAVP00000002678 Ciona savignyi (sedentary tunicate) 185256 Capitella spl (polychaete worm) DDB0206493 Dictyostelium discoideum (amoeba) DEHA2E01474g Debaryomyces Hansenii (yeast) 332475 Daphnia pulex (daphnia) ENSDARP00000069707 Danio rerio (zebra fish) ENSDARP00000069882 Danio rerio (zebra fish) ENSECAP00000006451 Equus caballus (horse) XP_648675 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018106 Gymnopilus aculeatus (mushroom) ENSGALP00000003063 Gallus gallus (chicken) GL50803_89887 Giardia lamblia (flagellated protozoan) 192836 Hypsipyla robusta (cedar shoot borer) ENSP00000362153 Homo sapiens (human) ISCW011628-PA Ixodes scapularis (deer tick) KLLA0C18843g Kluyveromyces lactis (yeast) 208405 Lottia gigantea (owl limpet) LmjF05.0460 Leishmania major (virus) 19938 Monocosta brevicollis (choanoflagellate) ENSMODP00000022160 Monodelphis domestica (gray opossum) ENSMMUP00000011036 Macaca mulatta (rhesus monkey) ENSMUSP00000030684 Mus musculus (house mouse) 104439 Nematostella vectensis (starlet anemone) XP_001601194.1 Nasonia vitripennis (wasp) ENSOANP00000003260 Ornithorynchus anatinus (platypus) ENSORLP00000018355 Oryzias latipes (japanese killifish) LOC_Os03g22890.1 Oryza sativa (asian rice) 34327 Ostreococcus tauri (green alga) PF14_0221 Plasmodium falciparum (protozoal parasite) PHUM004273-PA Pediculus humanus (human body louse) PP14287 Pristionchus pacificus (nematode) 31650 Physcomitrella patens (moss) ENSPPYP00000001765 Pongo pygmaeus (orangutan) 52177 Phytophthora ramorum (sudden oak death pathogen) 155554 Phytophthora sojae (root rot pathogen) 836908 Populus trichocarpa (black cottonwood) ENSPTRP00000000969 Pan troglodytes (chimpanzee) PVX_085330 Plasmodium vivax (protozoal parasite) ENSRNOP00000012702 Rattus norvegicus (norway rat) 5049415 Sorghum bicolor (sorghum) YNR053C Saccharomyces cerevisiae (budding yeast) Smp_087810 Schistosoma mansoni (trematode parasite) SPAC6F6.03c Schizosaccharomyces pombe (fission yeast) XP_001192782.1 Strongylocentrotus purpuratus (purple sea urchin) 27600 Trichoplax adhaerens (metazoa) TA14695 Theileria annulata (apicomplexan parasite) XP_967515.1 Tribolium castaneum (red flour beetle) Tc00.1047053510609.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006333 Tetraodon nigroviridis (green spotted pufferfish) TP02_0708 Theileria parva (parasitic protozoan) 34729 Thalassiosira pseudonana (marine diatom) ENSTRUP00000024600 Takifugu rubripes (pufferfish Takifugu) 204.m00035 Tetrahymena thermophila (ciliate protozoa) 97354.m00228 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000004622 Xenopus tropicalis (frog) YALI0F28083g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36989 modMine - Data generated by the modENCODE project. • FBgn0034243 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16103 NV15815 LH22001 ISCW011628 FBgn0231619 FBgn0223393 FBgn0208035 FBgn0196758 FBgn0174857 JGI_V11_332475 FBgn0079639 FBgn0148231 FBgn0144027 FBgn0128422 FBgn0113227 FBgn0090280 CPIJ001254 BGIBMGA011822 GB14943 AGAP011309 AAEL003293 PHUM046990 GLEAN_14758
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG6501 (Seong et al., 2001, Kaplan et al., 2008, Kaplan et al., 2008, Keleman et al., 2009.8.5, Rosby et al., 2009, Matsuo et al., 2010) dmNS2 (Kaplan et al., 2008) Ngp (Stroschein-Stevenson et al., 2006, Peng et al., 2007) Ngp1 (Rosby et al., 2009) ns2 (Kaplan et al., 2008, Matsuo et al., 2010, Matsuo et al., 2011) NS2 (Rosby et al., 2009)
Name Synonym	Ngp   nucleostemin 2 (Matsuo et al., 2010) Nucleostemin 2 (Matsuo et al., 2011)
Secondary FlyBase IDs
References ( 18 )
Research paper	Matsuo et al., 2011, Biosci. Biotechnol. Biochem. 75(8): 1511--1515 Drosophila GTPase Nucleostemin 2 Changes Cellular Distribution during Larval Development and the GTP-Binding Motif Is Essential to Nucleoplasmic Localization. [FBrf0214769] Matsuo et al., 2010, Biosci. Biotechnol. Biochem. 74(10): 2120--2123 Drosophila nucleostemin 2 proved essential for early eye development and cell survival. [FBrf0212172] Rosby et al., 2009, Mol. Biol. Cell 20(20): 4424--4434 Knockdown of the Drosophila GTPase nucleostemin 1 impairs large ribosomal subunit biogenesis, cell growth, and midgut precursor cell maintenance. [FBrf0209157] Kaplan et al., 2008, Genes Dev. 22(14): 1877--1893 A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. [FBrf0205884] Peng et al., 2007, BMC Cell Biol. 8(Suppl. 1): S7 Automatic image analysis for gene expression patterns of fly embryos. [FBrf0204631] Stroschein-Stevenson et al., 2006, PLoS Biol. 4(1): 87--99 Identification of Drosophila gene products required for phagocytosis of Candida albicans. [FBrf0191376] Llopart et al., 2005, Genetics 171(1): 197--210 Multilocus analysis of introgression between two sympatric sister species of Drosophila: Drosophila yakuba and D. santomea. [FBrf0187647] Seong et al., 2001, Biogerontology 2(3): 209--217 Application of the gene search system to screen for longevity genes in Drosophila. [FBrf0141397]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Kaplan et al., 2008, Genes Dev. 22(14): Supplemental Research Data. [FBrf0207883] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579]
Personal communication to FlyBase	Bellen, 2009.4.8, BDGP_2009_0408.GenExel.xml BDGP_2009_0408.GenExel.xml [FBrf0207636] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Maroofi, 2000.10.24, GenBank/EMBL/DDBJ: AF315579 Drosophila melanogaster nuclear GTP binding protein mRNA, complete cds. [FBrf0140039]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]