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Gene Dmel\Dcr-2

General Information
Symbol	Dmel\Dcr-2	Species	D. melanogaster
Name	Dicer-2	Annotation symbol	CG6493
Feature type	protein_coding_gene	FlyBase ID	FBgn0034246
Gene Model Status	Current	Stock availability	31 publicly available
Also Known As	DCR2, Dicer
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C10-54C10	Sequence location	2R:13,462,484..13,469,011 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dicer-2 is referred to in FlyBase by the symbol Dmel\Dcr-2 (CG6493, FBgn0034246). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ATPase activity; siRNA binding. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; gene silencing; cellular component organization or biogenesis; gene expression; RNA interference; response to other organism; negative regulation of cellular biosynthetic process; cellular macromolecular complex subunit organization; immune system process; detection of biotic stimulus; localization; regulation of gene expression, epigenetic; locomotory behavior. 36 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Argonaute/Dicer protein, PAZ; DEAD-like helicase; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Dicer double-stranded RNA-binding fold; Double-stranded RNA-binding; Helicase, C-terminal; Ribonuclease III. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641449_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dcr-2. Gene sequence location is 2R:13462484..13469011.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Alleles Dcr-2[P1496L] Dcr-2[R269W] Dcr-2[P8S] Dcr-2[A1453T] Dcr-2[P365L] Dcr-2[L188F] Controlled Vocabulary Terms mRNA cleavage References Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Saito et al., 2010, Genes Dev. 24(22): 2493--2498 Chiu et al., 2011, Cell 145(3): 357--370 Clones FI15132
FB2012_01	References Handler et al., 2011, EMBO J. 30(19): 3977--3993 Khurana et al., 2010, PLoS Genet. 6(12): e1001246 Thomsen et al., 2010, Genome Biol. 11(9): R93 Johnson et al., 2010, PLoS ONE 5(9): e12799 Sequence features BKN23409 HFA06992
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C10-54C10   Limits computationally determined from genome sequence between P{EP}MESR4EP386&P{EP}POSHEP1206 and P{PZ}l(2)1050510505
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dcr-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dcr-2-RA FBtr0086904  NM_079054   5665   1722
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dcr-2-PA   FBpp0086061   197.8   1722   6.84     NP_523778   AAF57830
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease III (IPR000999) Double-stranded RNA-binding (IPR001159) Helicase, C-terminal (IPR001650) Argonaute/Dicer protein, PAZ (IPR003100) Dicer double-stranded RNA-binding fold (IPR005034) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) DEAD-like helicase (IPR014001)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141810   AA438616   AA696387   AA802516   AA803809   AE013599 AAF57830   AB073024 BAB69959   AI512684   BG637618   BG639464   BG639465   BG640151   BI635709   BP552099   BP556123   BP560070   BT011073   BT128787   CO154563   CO191637   CO282421   CO291918   CO304990   CO311653   CO312333   CO313193   CZ468331   CZ468332   CZ489251   DQ228792 ABB54745   DQ228793 ABB54746   DQ228794 ABB54747   DQ228795 ABB54748   DQ228796 ABB54749   DQ228797 ABB54750   DQ228798 ABB54751   DQ228799 ABB54752   EC056854   EC088051   EC210941   EC214569   EC248210   EC266486   EV591186
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2Q3V4 Q2Q3V5 Q2Q3V6 Q2Q3V7 Q2Q3V8 Q2Q3V9 Q2Q3W0 Q2Q3W1 Q95YG3 A1ZAW0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034246    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034246 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034246 expression level Developmental Stage   Expression Level embryo 00-02hr    1735 embryo 02-04hr    1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9    1775 white prepupae new    1806 white prepupae 12hr    2084 white prepupae 24hr    1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day    1872 adult female 30day    1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1735) embryo 02-04hr  (1474) embryo 04-06hr  (1004) embryo 06-08hr  (1226) embryo 08-10hr  (1331) embryo 10-12hr  (668) embryo 12-14hr  (1036) embryo 14-16hr  (643) embryo 16-18hr  (590) embryo 18-20hr  (340) embryo 20-22hr  (803) embryo 22-24hr  (850) larva L1  (313) larva L2  (401) larva L3 12hr old  (483) larva L3 puffstage 1-2  (790) larva L3 puffstage 3-6  (1337) larva L3 puffstage 7-9  (1775) white prepupae new  (1806) white prepupae 12hr  (2084) white prepupae 24hr  (1780) pupae 2d postWPP  (792) pupae 3d postWPP  (389) pupae 4d postWPP  (338) adult male 01day  (672) adult male 05day  (621) adult male 30day  (530) adult female 01day  (946) adult female 05day  (1872) adult female 30day  (1730) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1735) embryo 02-04hr  1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9  (1775) white prepupae new  (1806) white prepupae 12hr  (2084) white prepupae 24hr  (1780) pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day  (1872) adult female 30day  (1730) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1735 embryo 02-04hr    1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9    1775 white prepupae new    1806 white prepupae 12hr    2084 white prepupae 24hr    1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day    1872 adult female 30day    1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1735 embryo 02-04hr    1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9    1775 white prepupae new    1806 white prepupae 12hr    2084 white prepupae 24hr    1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day    1872 adult female 30day    1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034246 expression level Developmental Stage   Expression Level embryo 00-02hr    1735 embryo 02-04hr    1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9    1775 white prepupae new    1806 white prepupae 12hr    2084 white prepupae 24hr    1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day    1872 adult female 30day    1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1735) embryo 02-04hr  (1474) embryo 04-06hr  (1004) embryo 06-08hr  (1226) embryo 08-10hr  (1331) embryo 10-12hr  (668) embryo 12-14hr  (1036) embryo 14-16hr  (643) embryo 16-18hr  (590) embryo 18-20hr  (340) embryo 20-22hr  (803) embryo 22-24hr  (850) larva L1  (313) larva L2  (401) larva L3 12hr old  (483) larva L3 puffstage 1-2  (790) larva L3 puffstage 3-6  (1337) larva L3 puffstage 7-9  (1775) white prepupae new  (1806) white prepupae 12hr  (2084) white prepupae 24hr  (1780) pupae 2d postWPP  (792) pupae 3d postWPP  (389) pupae 4d postWPP  (338) adult male 01day  (672) adult male 05day  (621) adult male 30day  (530) adult female 01day  (946) adult female 05day  (1872) adult female 30day  (1730) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1735 embryo 02-04hr  1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9  1775 white prepupae new  1806 white prepupae 12hr  2084 white prepupae 24hr  1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day  1872 adult female 30day  1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1735 embryo 02-04hr    1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9    1775 white prepupae new    1806 white prepupae 12hr    2084 white prepupae 24hr    1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day    1872 adult female 30day    1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1735 embryo 02-04hr    1474 embryo 04-06hr    1004 embryo 06-08hr    1226 embryo 08-10hr    1331 embryo 10-12hr    668 embryo 12-14hr    1036 embryo 14-16hr    643 embryo 16-18hr    590 embryo 18-20hr    340 embryo 20-22hr    803 embryo 22-24hr    850 larva L1    313 larva L2    401 larva L3 12hr old    483 larva L3 puffstage 1-2    790 larva L3 puffstage 3-6    1337 larva L3 puffstage 7-9    1775 white prepupae new    1806 white prepupae 12hr    2084 white prepupae 24hr    1780 pupae 2d postWPP    792 pupae 3d postWPP    389 pupae 4d postWPP    338 adult male 01day    672 adult male 05day    621 adult male 30day    530 adult female 01day    946 adult female 05day    1872 adult female 30day    1730 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034246    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034246 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034246 expression level Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034246 expression level Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    229.75 Larval Midgut    195.9 Larval Hindgut    249.7 Larval Malpighian Tubules    381.2 Larval Fat Body    320.8 Larval Salivary Gland    233.3 Larval Trachea    216.275 Larval Carcass    161.775 Adult Head    136.3 Adult Eye    58.825 Adult Brain    96.1 Adult Thoracic-Abdominal Ganglion    100.2 Adult Crop    202.6 Adult Midgut    209 Adult Hindgut    192.2 Adult Malpighian Tubules    204.8 Adult Fat Body    309.5 Adult Salivary Gland    167.5 Adult Heart    125.825 Adult VirginFemale Spermatheca    342.5 Adult InseminatedFemale Spermatheca    333.5 Adult Ovary    279.7 Adult Testis    88.9 Adult Male Accessory Gland    186.1 Adult Carcass    151.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    136.3   NA  Eye    58.825   NA  Brain    96.1   229.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    100.2   NA  Crop    202.6   195.9  Midgut    209   249.7  Hindgut    192.2   381.2  Malpighian Tubules    204.8   320.8  Fat Body    309.5   233.3  Salivary Gland    167.5   NA  Heart    125.825   216.275  Trachea    NA   NA  VirginFemale Spermatheca    342.5   NA  InseminatedFemale Spermatheca    333.5   NA  Ovary    279.7   NA  Testis    88.9   NA  Male Accessory Gland    186.1   161.775  Carcass    151.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034246 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6493-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Dcr-2L811fsX viable Dcr-2A1453T Dcr-2L188F Dcr-2P8S Dcr-2P365L Dcr-2P1496L Dcr-2R269W viable, with Scer\GAL4pnr-MD237 Dcr-2GD11939 Other Phenotypes Allele immune response defective Dcr-2L811fsX immune response defective | conditional Dcr-2R416X locomotor behavior defective, with Scer\GAL4ple.PF Dcr-2Scer\UAS.cDa suppressor of variegation (with Dcr-2L811fsX) Dcr-2R416X suppressor of variegation (with Dcr-2R416X) Dcr-2L811fsX suppressor of variegation | dominant Dcr-2G31R Dcr-2L811fsX Dcr-2R416X suppressor of variegation | partially, with P{T1(-FRT)}T190-177 Dcr-2R416X suppressor of variegation | partially, with P{T1}T190-177 Dcr-2R416X wild-type Dcr-2A500V Dcr-2C473Y Dcr-2G31R Dcr-2L811fsX Dcr-2R416X Phenotype manifest in Allele
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of Dcr-2 Class Mutagen Stocks Known lesion Dcr-2f06544 piggyBac transposase 2 -- Dcr-2L811fsX loss of function allele ethyl methanesulfonate 2 Yes Dcr-2A500V ethyl methanesulfonate 1 Yes Dcr-2c02925 piggyBac transposase 1 -- Dcr-2MI00978 1 -- Dcr-2A1453T hypomorphic allele - molecular evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dcr-2C473Y ethyl methanesulfonate 0 Yes Dcr-2G173E ethyl methanesulfonate 0 Yes Dcr-2G31R ethyl methanesulfonate 0 Yes Dcr-2L188F hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dcr-2L812bsX 0 -- Dcr-2P1496L hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dcr-2P365L hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dcr-2P8S hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dcr-2R269W hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dcr-2R416X ethyl methanesulfonate 0 Yes Dcr-2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dcr-2 Class Mutagen Stocks Known lesion Dcr-2Scer\UAS.cDa in vitro construct - regulatory fusion 21 Yes Dcr-2+t7.2 in vitro construct - genomic fragment 1 Yes Dcr-2E1371K.t7.2 in vitro construct - site directed mutagenesis 1 Yes Dcr-2GD11939 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcr-2HMS00062 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcr-2JF02636 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcr-2dsRNA.4580-5166 in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cBa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cDa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cFa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cJa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cLa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cOa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cRa in vitro construct - RNAi 0 Yes Dcr-2dsRNA.cSa in vitro construct - RNAi 0 Yes Dcr-2E1210V.t7.2 in vitro construct - site directed mutagenesis 0 Yes Dcr-2E1237A.t7.2 in vitro construct - site directed mutagenesis 0 Yes Dcr-2E1371K.E1617K.t7.2 in vitro construct - site directed mutagenesis 0 Yes Dcr-2E1617K.t7.2 in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11939} NA P{TRiP.HMS00062} NA P{TRiP.JF02636} NA P{UAS-Dcr-2.D} NA characterization construct P{Dcr-2+t7.2} NA P{Dcr-2E1210V.t7.2} NA P{Dcr-2E1237A.t7.2} NA P{Dcr-2E1371K.E1617K.t7.2} NA P{Dcr-2E1371K.t7.2} NA P{Dcr-2E1617K.t7.2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Dcr-2MI00978 NA PBac{PB}Dcr-2c02925 NA PBac{WH}Dcr-2f06544 NA
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from direct assay (Cenik et al., 2011) siRNA binding inferred from direct assay (Gerbasi et al., 2011)
Biological Process
CV term Evidence References
chromatin silencing inferred from mutant phenotype (Grimaud et al., 2006) defense response to virus inferred from mutant phenotype (Wang et al., 2006, Galiana-Arnoux et al., 2006, Mueller et al., 2010) detection of virus inferred from mutant phenotype (Deddouche et al., 2008) dsRNA transport inferred from mutant phenotype (Saleh et al., 2006) heterochromatin organization involved in chromatin silencing inferred from mutant phenotype (Fagegaltier et al., 2009) locomotory behavior inferred from mutant phenotype (White et al., 2010) mRNA cleavage inferred from mutant phenotype (Lim et al., 2008) NOT pre-miRNA processing inferred from direct assay (Cenik et al., 2011) production of siRNA involved in RNA interference inferred from direct assay (Liu et al., 2003) inferred from mutant phenotype (Lee et al., 2004, Vagin et al., 2006, Ghildiyal et al., 2008, Okamura et al., 2008, Lim et al., 2008) RNA interference inferred from direct assay (Bernstein et al., 2001) inferred from mutant phenotype (Lee et al., 2004) siRNA loading onto RISC involved in RNA interference inferred from mutant phenotype (Lee et al., 2004) targeting of mRNA for destruction involved in RNA interference inferred from mutant phenotype (Lee et al., 2004)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Grimaud et al., 2006) nucleus inferred from direct assay (Grimaud et al., 2006) RNA-induced silencing complex inferred from direct assay (Liu et al., 2009)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent helicase activity inferred from electronic annotation with InterPro:IPR011545 (FlyBase Curators et al., 2004-) double-stranded RNA binding inferred from electronic annotation with InterPro:IPR001159 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Zenno, 2001.10.15) helicase activity inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Zenno, 2001.10.15) ribonuclease III activity inferred from electronic annotation with InterPro:IPR000999 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
production of siRNA involved in RNA interference traceable author statement (Heinrichs, 2004, He and Hannon, 2004) RNA interference non-traceable author statement (Zenno, 2001.10.15) traceable author statement (Heinrichs, 2004)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dcr-2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034246
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13246 Dere\GG21041 Dgri\GH20958 Dmoj\GI21295 Dper\GL10619 Dpse\GA19635 Dsec\GM19969 Dsim\Dcr-2 Dvir\GJ20897 Dwil\GK10670 Dyak\Dcr-2
Curated drosophilid orthologs	Dpse\GA19635   Dsim\Dcr-2 (Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3) Dtei\Dcr-2 (Obbard et al., 2005.10.3) Dyak\Dcr-2 (Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3, Obbard et al., 2005.10.3)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006794-PA Aedes aegypti (mosquito) AGAP012289-PA Anopheles gambiae (mosquito) XP_001945890.1 Acyrthosiphon pisum (pea aphid) BGIBMGA011542-PA Bombyx mori (silk worm) CPIJ010534 Culex pipens (mosquito) 173928 Chlamidomonas reinhardtii (green alga) DDB0216193 Dictyostelium discoideum (amoeba) DEHA2D16896g Debaryomyces Hansenii (yeast) XP_001602524.1 Nasonia vitripennis (wasp) SPCC188.13c Schizosaccharomyces pombe (fission yeast) NP_001107840.1 Tribolium castaneum (red flour beetle) 3687.m01153 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15253 NV16620 LH15872 ISCW000889 FBgn0084944 FBgn0212683 FBgn0208033 FBgn0084576 FBgn0174855 JGI_V11_311480 JGI_V11_309030 JGI_V11_329028 FBgn0079631 FBgn0148229 FBgn0144025 FBgn0128420 FBgn0113225 FBgn0090278 CPIJ010534 BGIBMGA011543 BGIBMGA011542 ACYPI007300 GB30289 GB19288 AGAP012289 AAEL006794 PHUM174480 GLEAN_01108
Stocks & Reagents
Stocks Listed in FlyBase ( 31 )
Bloomington	24648 P{UAS-Dcr-2.D}1 24646 P{UAS-Dcr-2.D}1, w1118 24650 w1118; P{UAS-Dcr-2.D}2 24651 w1118; P{UAS-Dcr-2.D}10 27486 y1 v1; P{TRiP.JF02636}attP2 18987 w1118; PBac{WH}Dcr-2f06544/CyO 25756 P{UAS-Dcr-2.D}1, w1118; P{GAL4-Mef2.R}R1 24644 P{UAS-Dcr-2.D}1, w1118; Pin1/CyO 25707 P{UAS-Dcr-2.D}1, w1118; P{GAL4-twi.2xPE}1
Harvard	- PBac{PB}Dcr-2c02925 - PBac{WH}Dcr-2f06544
VDRC	v25090 w1118; P{GD11939}v25090/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR12C23 BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD11113
Other clones	FI15132
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM05742 GM07586 LD12933 LD44626 SD17147
Other clones	102636 124313 CK02494 Dmel_neb_013612_0380_2025 EC31570 EK160436 EK198802 EK225660 EK228508 EK231840 EK246851 EN04356 FGM216G08 FGM301E07 FGM324E03 GM14331 LP12433
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034246 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36993
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dcr-2 CG6493 (Bernstein et al., 2001)
Source for database merge of
Additional comments
Other Comments
	The loqs-PD isoform is capable of associating with the Dcr-2 protein, but not with the Dcr-1 protein. The loqs-PB and loqs-PA isoforms can associate with the Dcr-1 protein, and also to some extent with Dcr-2 protein. (Hartig et al., 2009) The loqs-PB isoform, and to a lesser extent the loqs-PA isoform, is capable of associating with the Dcr-1 protein. The loqs-PD isoform is capable of associating with the Dcr-2 protein, but not with the Dcr-1 protein. (Zhou et al., 2009) Production of mature siRNAs from endogenous long hairpin RNA genes is a hybrid mechanism that combines canonical RNA interference factors (Dcr-2, Hen1 and AGO2) and a canonical microRNA factor loqs. (Okamura et al., 2008) The Dcr-2-r2d2 heterodimer acts as a gatekeeper for the assembly of AGO2 complexes, promoting the incorporation of siRNAs and disfavoring miRNAs as loading substrates for AGO2. A separate mechanism acts in parallel to favor miRNA/miRNA* duplexes and exclude siRNAs from assembly into AGO1 complexes. (Tomari et al., 2007) Dcr-2 is required for maintenance of long-distance chromosomal interactions between endogenous PcG target loci. (Grimaud et al., 2006) Dcr-2 is in the top 2% of fastest-evolving Drosophila genes. (Obbard et al., 2006) Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) Dcr-2 is not required for repeat-associated small interfering RNA (rasiRNA) production (Vagin et al., 2006) The orientation of the Dcr-2/r2d2 protein heterodimer on the siRNA duplex determines which siRNA strand associates with the core RISC (RNA-induced silencing complex) protein AGO2. r2d2 protein binds the siRNA end with the greatest double-stranded character, thereby orienting the Dcr-2/r2d2 heterodimer on the siRNA duplex. Strong binding by the r2d2 protein requires a 5'-phosphate on the siRNA strand that is excluded from the RISC. (Tomari et al., 2004) Dcr-2 protein alone efficiently cleaves dsRNA into siRNA. This enzymatic activity is not affected by association with r2d2 protein. Dcr-2 protein alone does not bind siRNA, but the r2d2/Dcr-2 protein complex binds siRNA and also facilitates the loading of siRNA onto the RNA-initiated silencing complex (RISC). This latter activity is dependent on the dsRNA-binding domains of the r2d2 protein. (Liu et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079054 RefSeq (Proteins) • NP_523778 DDBJ / EMBL / GenBank • AAF57830 AB073024 ABB54745 ABB54746 ABB54747 ABB54748 ABB54749 ABB54750 ABB54751 ABB54752 BAB69959 BG640151 CZ468331 CZ468332 CZ489251 DQ228792 DQ228793 DQ228794 DQ228795 DQ228796 DQ228797 DQ228798 DQ228799 Entrez Gene - A searchable database of RefSeq genes. • 36993 UniProtKB/TrEMBL • A1ZAW0 Q2Q3V4 Q2Q3V5 Q2Q3V6 Q2Q3V7 Q2Q3V8 Q2Q3V9 Q2Q3W0 Q2Q3W1 Q95YG3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease III (IPR000999) Double-stranded RNA-binding (IPR001159) Helicase, C-terminal (IPR001650) Argonaute/Dicer protein, PAZ (IPR003100) Dicer double-stranded RNA-binding fold (IPR005034) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) DEAD-like helicase (IPR014001)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034246 DRSC - Results from RNAi screens. • FBgn0034246 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034246 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6493-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034246 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36993 InParanoid A subset of ortholog calls from InParanoid. • AAEL006794-PA Aedes aegypti (mosquito) AGAP012289-PA Anopheles gambiae (mosquito) XP_001945890.1 Acyrthosiphon pisum (pea aphid) BGIBMGA011542-PA Bombyx mori (silk worm) CPIJ010534 Culex pipens (mosquito) 173928 Chlamidomonas reinhardtii (green alga) DDB0216193 Dictyostelium discoideum (amoeba) DEHA2D16896g Debaryomyces Hansenii (yeast) XP_001602524.1 Nasonia vitripennis (wasp) SPCC188.13c Schizosaccharomyces pombe (fission yeast) NP_001107840.1 Tribolium castaneum (red flour beetle) 3687.m01153 Tetrahymena thermophila (ciliate protozoa) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/dicer2-1.htm modMine - Data generated by the modENCODE project. • FBgn0034246 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15253 NV16620 LH15872 ISCW000889 FBgn0084944 FBgn0212683 FBgn0208033 FBgn0084576 FBgn0174855 JGI_V11_311480 JGI_V11_309030 JGI_V11_329028 FBgn0079631 FBgn0148229 FBgn0144025 FBgn0128420 FBgn0113225 FBgn0090278 CPIJ010534 BGIBMGA011543 BGIBMGA011542 ACYPI007300 GB30289 GB19288 AGAP012289 AAEL006794 PHUM174480 GLEAN_01108
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	CG6493 (Hammond, 2005, Bernstein et al., 2001, Saleh et al., 2006, Perkins et al., 2009, Heger and Ponting, 2007, Lee et al., 2004, Ni et al., 2010.12.1) cg6493 (Lasko, 2000) Dcr (Dalton et al., 2011) Dcr-2 (Rogowski et al., 2009, Baumgardt et al., 2007, Pham and Sontheimer, 2005, Preall et al., 2006, Obbard et al., 2006, Brodersen and Voinnet, 2006, Preall and Sontheimer, 2005, Budde, 2006, Budde, 2006, Dorner et al., 2006, Shigenobu et al., 2006, Meyer et al., 2006, Yapici et al., 2008, Okamura et al., 2009, Okamura et al., 2007, Tomari et al., 2007, van Rij et al., 2006, Dietzl et al., 2007, Haerty et al., 2007, Czech et al., 2008, Okamura et al., 2008, Bai et al., 2008, Kawamura et al., 2008, Galiana-Arnoux et al., 2006, Deddouche et al., 2008, Zhou et al., 2008, Taft et al., 2009, Habayeb et al., 2009, Sabin et al., 2009, Liu et al., 2006, Liu et al., 2007, Lipardi and Paterson, 2009, Parrish et al., 2009, Zhou et al., 2009, Heger and Ponting, 2007, Bayersdorfer et al., 2010, Nayak et al., 2010, Mukherjee and Hanley, 2010, Carthew, 2010.7.8, Raja et al., 2010, Bao et al., 2010, Moshkovich and Lei, 2010, Tsurudome et al., 2010, Mueller et al., 2010, Okamura et al., 2011, Marques et al., 2010, Gerbasi et al., 2011, Sellami et al., 2010, Kim et al., 2010, Chatterjee et al., 2011, Tao and Rolls, 2011, Cenik et al., 2011, Poulton et al., 2011, Iwasaki et al., 2010, Kawamata et al., 2009, Handler et al., 2011) DCR-2 (Grewal and Elgin, 2007) dcr-2 (Forstemann et al., 2005, Tomari et al., 2004, Heinrichs, 2004, Zenno, 2001.10.15, Vagin et al., 2006, Matranga et al., 2005, Wang et al., 2006, Wang et al., 2006, Vagin et al., 2006, Ashraf et al., 2006, Pek and Kai, 2011, Lim and Kai, 2007, Hartig et al., 2009, Haynes et al., 2006, Kavi et al., 2006, Peng and Karpen, 2007, Lim et al., 2008, Förstemann et al., 2007, Horwich et al., 2007, Bilen et al., 2006, Ghildiyal et al., 2008, Lim and Kai, 2007, Chung et al., 2008, Blumenstiel et al., 2008, Martin et al., 2009, Peng and Karpen, 2009, Flynt et al., 2009, Kalidas et al., 2008, Lee et al., 2009, Lucchetta et al., 2009, Weng et al., 2010, Liu et al., 2009, Czech et al., 2009, Lee et al., 2004, Rehwinkel et al., 2005, Ghildiyal et al., 2010, Neto-Silva et al., 2010, Pek and Kai, 2011, Jepson and Reenan, 2009, Ameres et al., 2011, Pelisson et al., 2007, Kawamata et al., 2009) DCR2 (Tang, 2005, Matzke and Birchler, 2005, Neely et al., 2010) dcr2 (Kavi and Birchler, 2007, Kavi and Birchler, 2008, Rogulja et al., 2008, Oh and Irvine, 2008, Chung et al., 2009, Yang et al., 2009, Peng and Karpen, 2009, Chambeyron et al., 2008, Fagegaltier et al., 2009, Shafer and Taghert, 2009, Coulthard et al., 2010, Yan et al., 2010, Astigarraga et al., 2010, Khurana et al., 2010, Johnson et al., 2010) Dcr2 (Zaratiegui, 2007, Kawamura et al., 2008, Saleh et al., 2009, Häsemeyer et al., 2009, Obbard et al., 2009, Rallis et al., 2010, White et al., 2010, de Navascués and Modolell, 2010) dic2 (Shen et al., 2011) Dicer (Pearson et al., 2005, Zhang and Broadie, 2005, Finnegan and Matzke, 2003, Chekulaeva and Ephrussi, 2004, Hutvagner and Zamore, 2002, Findley et al., 2003, Carmell et al., 2002, Ishizuka et al., 2002, Pasquinelli, 2002, Zamore, 2002, Hannon, 2002, Schwarz and Zamore, 2002, Matzke et al., 2001, Ruvkun, 2001, Moss, 2001, Yu et al., 2007, Jia et al., 2010) dicer (Denli and Hannon, 2003) DICER (Lakatos et al., 2004) dicer2 (Meyer et al., 2005)
Name Synonym	Dicer (Stitzel and Seydoux, 2007, Yu et al., 2007, Carthew, 2006, Celotto and Graveley, 2002, Rousset et al., 2010, Dalton et al., 2011) dicer (Kavi et al., 2006, Molnar et al., 2011, Horabin and Olcese, 2008, Benítez et al., 2009, Glavic et al., 2009, Agrawal et al., 2010) Dicer-2 (Waterhouse et al., 2007, Czech et al., 2008, Bernstein et al., 2001, Pham and Sontheimer, 2005, Glaser et al., 2007, Rand et al., 2005, Grimaud et al., 2006, Wang et al., 2006, Carmi, 2006, Vagin et al., 2006, Ulvila et al., 2006, Lin, 2007, Deddouche et al., 2008, Shcherbata et al., 2008, van Rij et al., 2006, Rehwinkel et al., 2006, Okamura et al., 2008, Bai et al., 2008, Kawamura et al., 2008, Chung et al., 2008, Berdnik et al., 2008, Leiss et al., 2009, Blumenstiel et al., 2008, Saleh et al., 2006, Eulalio et al., 2007, Deddouche et al., 2008, Taft et al., 2009, Liu et al., 2009, Liu et al., 2006, Fagegaltier et al., 2009, Berdnik et al., 2008, Tchurikov and Kretova, 2007, Zhou et al., 2009, Heger and Ponting, 2007, Kupsco et al., 2006, Mukherjee and Hanley, 2010, Blanchard et al., 2010, Gerbasi et al., 2010, White et al., 2010, Marques et al., 2010, Gangaraju et al., 2011, Welker et al., 2011, Cenik et al., 2011, Pelisson et al., 2007, Handler et al., 2011) Dicer2 (Landthaler et al., 2004, Zhang et al., 2008, Shalaby et al., 2009, Siomi et al., 2005, Wayburn and Volk, 2009, Saj et al., 2010, Rousset et al., 2010, Usha and Shashidhara, 2010, Miyoshi et al., 2010, Mattie et al., 2010, Mitchell et al., 2010, Rauskolb et al., 2011, Miyoshi et al., 2010) dicer-2 (Heinrichs, 2004, Zenno, 2001.10.15, Budde, 2007, Lei and Corces, 2006, Ruby et al., 2007, Peng and Karpen, 2007, Lim et al., 2008, Ruby et al., 2007, Bilen et al., 2006, Lee et al., 2009, Hari et al., 2008, Ghildiyal et al., 2010, Guitart et al., 2010, Marinho et al., 2011, Jepson and Reenan, 2009, Ameres et al., 2011, Thomsen et al., 2010) DICER-2 (Megosh et al., 2006, Lucchetta et al., 2009) dicer2 (Oh and Irvine, 2008, Shafer and Taghert, 2009, Johnson and Cagan, 2009, Saito et al., 2010) Dicer 2 (Saleh et al., 2009) DICER2 (Chiu et al., 2011)
Secondary FlyBase IDs
References ( 268 )
Generate a list of	All references relating to this gene ( 268 )
List References by type	Research paper  ( 172 ) Supplementary material  ( 6 ) Review  ( 45 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 11 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 19 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 58 )
	Ameres et al., 2011, RNA 17(1): 54--63 Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. [FBrf0212657] Cenik et al., 2011, Mol. Cell 42(2): 172--184 Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease. [FBrf0213543] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Chiu et al., 2011, Cell 145(3): 357--370 NEMO/NLK Phosphorylates PERIOD to Initiate a Time-Delay Phosphorylation Circuit that Sets Circadian Clock Speed. [FBrf0213577] Dalton et al., 2011, Cell Death Differ. 18(7): 1150--1160 Drosophila Ndfip is a novel regulator of Notch signaling. [FBrf0214123] Gangaraju et al., 2011, Nat. Genet. 43(2): 153--158 Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. [FBrf0212873] Gerbasi et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(8): 3204--3209 Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. [FBrf0213185] Handler et al., 2011, EMBO J. 30(19): 3977--3993 A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. [FBrf0216344] Liu et al., 2011, Dev. Growth Differ. 53(6): 822--841 Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila. [FBrf0214664] Marinho et al., 2011, Development 138(2): 349--357 The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. [FBrf0212565] Molnar et al., 2011, PLoS Genet. 7(3): e1001335 Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. [FBrf0213301] Okamura et al., 2011, Mol. Cell. Biol. 31(4): 884--896 R2D2 Organizes Small Regulatory RNA Pathways in Drosophila. [FBrf0212879] Pek and Kai, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(29): 12007--12012 DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. [FBrf0214405] Pek and Kai, 2011, Curr. Biol. 21(1): 39--44 A role for vasa in regulating mitotic chromosome condensation in Drosophila. [FBrf0212718] Poulton et al., 2011, Development 138(9): 1737--1745 The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. [FBrf0213494] Rauskolb et al., 2011, PLoS Biol. 9(6): e1000624 Zyxin links fat signaling to the hippo pathway. [FBrf0213900] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Tao and Rolls, 2011, J. Neurosci. 31(14): 5398--5405 Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. [FBrf0213404] Welker et al., 2011, Mol. Cell 41(5): 589--599 Dicer's Helicase Domain Discriminates dsRNA Termini to Promote an Altered Reaction Mode. [FBrf0213184] Agrawal et al., 2010, J. Neurosci. 30(4): 1301--1313 Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight. [FBrf0209847] Astigarraga et al., 2010, J. Neurosci. 30(46): 15358--15368 Three Drosophila liprins interact to control synapse formation. [FBrf0212351] Bao et al., 2010, Dev. Biol. 344(2): 948--956 Preferential adhesion maintains separation of ommatidia in the Drosophila eye. [FBrf0211429] Bayersdorfer et al., 2010, Neurobiol. Disease 40(1): 113--119 Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. [FBrf0211574] Blanchard et al., 2010, J. Neurosci. 30(17): 5855--5865 The transcription factor Mef2 is required for normal circadian behavior in Drosophila. [FBrf0210652] Bunt et al., 2010, Dev. Cell 19(2): 296--306 Hemocyte-Secreted Type IV Collagen Enhances BMP Signaling to Guide Renal Tubule Morphogenesis in Drosophila. [FBrf0211514] Coulthard et al., 2010, Genetics 185(2): 479--495 Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. [FBrf0211235] de Navascués and Modolell, 2010, Mech. Dev. 127(9-12): 393--406 The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. [FBrf0212072] Gerbasi et al., 2010, Mol. Cell. Proteomics 9(9): 1866--1872 Proteomics Identification of Drosophila Small Interfering RNA-associated Factors. [FBrf0211707] Ghildiyal et al., 2010, RNA 16(1): 43--56 Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. [FBrf0209572] Guitart et al., 2010, J. Biol. Chem. 285(49): 38157--38166 New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. [FBrf0212542] Iwasaki et al., 2010, Mol. Cell 39(2): 292--299 Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes. [FBrf0214214] Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. [FBrf0214177] Johnson et al., 2010, PLoS ONE 5(9): e12799 Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. [FBrf0211905] Khurana et al., 2010, PLoS Genet. 6(12): e1001246 Distinct Functions for the Drosophila piRNA Pathway in Genome Maintenance and Telomere Protection. [FBrf0212661] Kim et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(14): 6520--6525 MIPs are ancestral ligands for the sex peptide receptor. [FBrf0210504] Marques et al., 2010, Nat. Struct. Mol. Biol. 17(1): 24--30 Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. [FBrf0209625] Mattie et al., 2010, Curr. Biol. 20(24): 2169--2177 Directed Microtubule Growth, +TIPs, and Kinesin-2 Are Required for Uniform Microtubule Polarity in Dendrites. [FBrf0212550] Mitchell et al., 2010, Development 137(17): 2875--2884 Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner. [FBrf0211524] Miyoshi et al., 2010, RNA 16(3): 506--515 Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila. [FBrf0210024] Miyoshi et al., 2010, Nat. Struct. Mol. Biol. 17(8): 1024--1026 A direct role for Hsp90 in pre-RISC formation in Drosophila. [FBrf0211382] Moshkovich and Lei, 2010, PLoS Genet. 6(3): e1000880 HP1 Recruitment in the Absence of Argonaute Proteins in Drosophila. [FBrf0210291] Mueller et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(45): 19390--19395 RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila. [FBrf0212288] Mukherjee and Hanley, 2010, BMC Microbiol. 10: 127 RNA interference modulates replication of dengue virus in Drosophila melanogaster cells. [FBrf0210847] Nayak et al., 2010, Nat. Struct. Mol. Biol. 17(5): 547--554 Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila. [FBrf0210742] Neely et al., 2010, Cell 143(4): 628--638 A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene. [FBrf0212295] Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap. [FBrf0212043] Raja et al., 2010, Mol. Cell 38(6): 827--841 The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila. [FBrf0211222] Rallis et al., 2010, Dev. Biol. 339(1): 65--77 Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. [FBrf0209975] Rousset et al., 2010, Development 137(13): 2177--2186 The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative-feedback loop during epithelial morphogenesis. [FBrf0211045] Saito et al., 2010, Genes Dev. 24(22): 2493--2498 Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. [FBrf0212297] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Sellami et al., 2010, Peptides 31(7): 1383--1389 Expression of the mu opioid receptor in Drosophila and its effects on trehalose and glycogen when expressed by the AKH neuroendocrine cells. [FBrf0210869] Thomsen et al., 2010, Genome Biol. 11(9): R93 Genome-wide analysis of mRNA decay patterns during early Drosophila development. [FBrf0212195] Tsurudome et al., 2010, Neuron 68(5): 879--893 The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction. [FBrf0212495] Usha and Shashidhara, 2010, Dev. Biol. 341(2): 389--399 Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. [FBrf0210647] Weng et al., 2010, Dev. Cell 18(1): 126--135 dFezf/Earmuff Maintains the Restricted Developmental Potential of Intermediate Neural Progenitors in Drosophila. [FBrf0209927] White et al., 2010, Front. Neurosci. 4: 205 The dopaminergic system in the aging brain of Drosophila. [FBrf0212667] Yan et al., 2010, Curr. Biol. 20(15): 1378--1382 Rabex-5 Ubiquitin Ligase Activity Restricts Ras Signaling to Establish Pathway Homeostasis in Drosophila. [FBrf0211477] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...