Gene Dmel\eIF3-S8

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General Information

Symbol

Dmel\eIF3-S8

Species

D. melanogaster

Name

eIF3-S8

Annotation symbol

CG4954

Feature type

protein_coding_gene

FlyBase ID

FBgn0034258

Gene Model Status

Current

Stock availability

5 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

54D4-54D4

Sequence location

2R:13,553,183..13,556,780 [+]

Genomic Maps

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Summary Information

Automatically generated summary

See sections below for more information

The gene eIF3-S8 is referred to in FlyBase by the symbol Dmel\eIF3-S8 (CG4954, FBgn0034258). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: translational initiation. 22 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Eukaryotic translation initiation factor 3 subunit 8, N-terminal; Proteasome component (PCI) domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637193_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eIF3-S8. Gene sequence location is 2R:13553183..13556780.

User Contributed Data

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Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

Controlled Vocabulary Terms

translation initiation factor binding

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

54D4-54D4

Limits computationally determined from genome sequence between P{PZ}l(2)10505¹⁰⁵⁰⁵ and P{lacW}l(2)k07509^k07509&P{EP}CG10934^EP538

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\eIF3-S8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

eIF3-S8-RA

FBtr0086836

NM_137398

3143

910

eIF3-S8-RB

FBtr0340269

3275

910

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

eIF3-S8-PA

FBpp0086013

105.7

910

5.92

NP_611242

AAF57818

eIF3-S8-PB

FBpp0309235

105.7

910

5.92

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Proteasome component (PCI) domain (IPR000717)

Eukaryotic translation initiation factor 3 subunit C, N-terminal domain (IPR008905)

Winged helix-turn-helix DNA-binding domain (IPR011991)

Eukaryotic translation initiation factor 3 subunit C (IPR027516)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

A1ZAX1

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3