FB2022_02, released March 29, 2022

Gene: Dmel\Mapmodulin

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General Information
Symbol
Dmel\Mapmodulin
Species
D. melanogaster
Name
Mapmodulin
Annotation Symbol
CG5784
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034282
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. (UniProt, Q9V895)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
54F4-54F4
Sequence location
Recombination map
2-84
RefSeq locus
NT_033778 REGION:17866178..17872015
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables histone binding
inferred from biological aspect of ancestor with PANTHER:PTN000146830
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in nucleocytoplasmic transport
inferred from sequence or structural similarity with UniProtKB:P39687
(assigned by UniProt )
(UniProt Curators, 2002-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:P39687
(assigned by UniProt )
(UniProt Curators, 2002-)
located_in endoplasmic reticulum
inferred from sequence or structural similarity with UniProtKB:P39687
(assigned by UniProt )
(UniProt Curators, 2002-)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:P39687
(assigned by UniProt )
(UniProt Curators, 2002-)
located_in perinuclear region of cytoplasm
inferred from sequence or structural similarity with UniProtKB:P39687
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ANP32 family. (Q9V895)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.
(UniProt, Q9V895)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Mapmodulin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V895)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mapmodulin-RA
FBtr0086823
NM_166258
2073
261
Mapmodulin-RB
FBtr0086822
NM_079056
2145
261
Mapmodulin-RC
FBtr0113091
NM_001103891
1402
363
Mapmodulin-RD
FBtr0300410
NM_001169713
2379
363
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mapmodulin-PA
FBpp0086002
29.2
261
3.81
NP_725732
AAF57776
Mapmodulin-PB
FBpp0086001
29.2
261
3.81
NP_523780
AAF57777
Mapmodulin-PC
FBpp0112004
40.7
363
3.85
NP_001097361
ABV53838
Mapmodulin-PD
FBpp0289639
40.7
363
3.85
NP_001163184
ACZ94456
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

261 aa isoforms: Mapmodulin-PA, Mapmodulin-PB
363 aa isoforms: Mapmodulin-PC, Mapmodulin-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification

Phosphorylated on serine residues.

(UniProt, Q9V895)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mapmodulin using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{681.P.FSVS-1}MapmodulinCPTI001166
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind

Comment: adult brain cortex nuclei

(Knowles-Barley, 2011.8.24)
Reporter: PBac{754.P.FSVS-0}MapmodulinCPTI003020
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mapmodulin in GBrowse 2
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mapmodulin
Transgenic constructs containing regulatory region of Mapmodulin
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ANP32B
14 of 15
Yes
Yes
Hsap\ANP32A
13 of 15
No
Yes
Hsap\ANP32E
13 of 15
No
Yes
Hsap\ANP32C
7 of 15
No
Yes
Hsap\ANP32D
6 of 15
No
Yes
Hsap\LRRIQ3
1 of 15
No
No
Hsap\SHOC2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Anp32b
14 of 15
Yes
Yes
Mmus\Anp32a
13 of 15
No
Yes
Mmus\Anp32e
11 of 15
No
Yes
Mmus\Anp32-ps
1 of 15
No
Yes
Mmus\Lrriq3
1 of 15
No
No
Mmus\Shoc2
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Anp32a
11 of 13
Yes
Yes
Rnor\Anp32b
10 of 13
No
Yes
Rnor\Anp32e
10 of 13
No
Yes
Rnor\LOC100909983
3 of 13
No
Yes
Rnor\NEWGENE_2116
3 of 13
No
Yes
Rnor\LOC680377
2 of 13
No
Yes
Rnor\Lrriq3
1 of 13
No
No
Rnor\Shoc2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\anp32c
12 of 12
Yes
Yes
Xtro\anp32a
9 of 12
No
Yes
Xtro\anp32b
9 of 12
No
Yes
Xtro\anp32e
8 of 12
No
Yes
Danio rerio (Zebrafish) (5)
Drer\anp32b
12 of 15
Yes
Yes
Drer\anp32e
12 of 15
Yes
Yes
Drer\anp32a
11 of 15
No
Yes
Drer\nap1l4a
1 of 15
No
No
Drer\si:dkey-267j14.7
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\F33H2.3
13 of 15
Yes
Yes
Cele\T19H12.2
13 of 15
Yes
Yes
Cele\Y50D4C.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT3G50690
5 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ANP32B; acidic nuclear phosphoprotein 32 family member B
    14 of 15
        ANP32A; acidic nuclear phosphoprotein 32 family member A
        13 of 15
        600832
            ANP32E; acidic nuclear phosphoprotein 32 family member E
            13 of 15
            609611
                ANP32C; acidic nuclear phosphoprotein 32 family member C
                7 of 15
                606877
                    ANP32D; acidic nuclear phosphoprotein 32 family member D
                    6 of 15
                    606878
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        External Data
                        Linkouts
                        DroID - A comprehensive database of gene and protein interactions.
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                        External Data
                        Linkouts
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        2R
                        Recombination map
                        2-84
                        Cytogenetic map
                        54F4-54F4
                        Sequence location
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        54F4-54F4
                        Limits computationally determined from genome sequence between P{PZ}grh06850&P{lacW}olf186-Fk11505 and P{PZ}Hsf03091&P{EP}Dgp-1EP731
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        Experimentally Determined Recombination Data
                        Location

                        2-84

                        (FlyBase, 2016)

                        2-87.2

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (12)
                        Genomic Clones (21)
                        cDNA Clones (120)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        DRSC - Results frm RNAi screens
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        Antibody Information
                        Laboratory Generated Antibodies
                         
                        Commercially Available Antibodies
                         
                        Other Information
                        Relationship to Other Genes
                        Source for database identify of

                        Source for identity of: Mapmodulin CG5784

                        (Hynes and Zhao, 2000)
                        Source for database merge of
                        Additional comments
                        Other Comments

                        Expression is enriched in embryonic gonads.

                        (Shigenobu et al., 2006)

                        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                        (Kiger et al., 2003)
                        Origin and Etymology
                        Discoverer
                        Etymology
                        Identification
                        External Crossreferences and Linkouts ( 52 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        FlyBase CV Report -
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        MARRVEL_MODEL - MARRVEL (model organism gene)
                        modMine - A data warehouse for the modENCODE project
                        Linkouts
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        FlyMine - An integrated database for Drosophila genomics
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Synonyms and Secondary IDs (6)
                        Datasets (8)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (8)
                        Result
                        Result Type
                        Title
                        scRNAseq_2020_Cattenoz_NI_seq_clustering
                        Clustering analysis of hemocytes from non-infested third instar larvae
                        scRNAseq_2020_Cattenoz_WI_seq_clustering
                        Clustering analysis of hemocytes from wasp-infested third instar larvae
                        scRNAseq_2020_Cho_NI72LG_seq_clustering
                        Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
                        scRNAseq_2020_Cho_NI96LG_seq_clustering
                        Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
                        scRNAseq_2020_Cho_NI120LG_seq_clustering
                        Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
                        scRNAseq_2020_Cho_WI96LG_seq_clustering
                        Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
                        scRNAseq_2020_Cho_NI96HL_seq_clustering
                        Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
                        scRNAseq_2020_Cho_NI120HL_seq_clustering
                        Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
                        References (54)