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Gene Dmel\Nup75

General Information
Symbol	Dmel\Nup75	Species	D. melanogaster
Name	Nucleoporin 75	Annotation symbol	CG5733
Feature type	protein_coding_gene	FlyBase ID	FBgn0034310
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55B10-55B11	Sequence location	2R:14,052,193..14,054,634 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleoporin 75 is referred to in FlyBase by the symbol Dmel\Nup75 (CG5733, FBgn0034310). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: SMAD protein import into nucleus. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Nuclear pore complex protein, Nucleoporin Nup85-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult Malpighian tubules, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1636645_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nup75. Gene sequence location is 2R:14052193..14054634.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN22034 HFA06947
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55B10-55B11   Limits computationally determined from genome sequence between P{PZ}Hsf03091&P{EP}Dgp-1EP731 and P{PZ}sbb04525&P{EP}EP1081EP1081
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nup75 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nup75-RA FBtr0086775  NM_137456   2141   668
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nup75-PA   FBpp0085954   76.9   668   5.93     NP_611300   AAF57735
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nuclear pore complex protein, Nucleoporin Nup85-like (IPR011502)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695058   AA816817   AA949731   AA951560   AE013599 AAF57735   AI533602   AI542386   AW942983   AY070887 AAL48509   BF498365   BI354184   BI355886   BI635178   CO177040   CO177963   CO287144   CO339085   EC081066   EC237734   EC241633   EC244852   EC259986   EF057923 ABL84858   EF057924 ABL84859   EF057925 ABL84860   EF057926 ABL84861   EF057927 ABL84862   EF057928 ABL84863   EF057929 ABL84864   EF057930 ABL84865   EF057931 ABL84866   EF057932 ABL84867   EF057933 ABL84868   EF057934 ABL84869   EV594889
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SZH5 A1YK02 A1YK03 A1YK07 A1YK00 A1YK11 A1YK01
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034310    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034310 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034310 expression level Developmental Stage   Expression Level embryo 00-02hr    3599 embryo 02-04hr    2658 embryo 04-06hr    5507 embryo 06-08hr    3107 embryo 08-10hr    2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day    1458 adult female 05day    2559 adult female 30day    2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3599) embryo 02-04hr  (2658) embryo 04-06hr  (5507) embryo 06-08hr  (3107) embryo 08-10hr  (2181) embryo 10-12hr  (1328) embryo 12-14hr  (854) embryo 14-16hr  (568) embryo 16-18hr  (386) embryo 18-20hr  (245) embryo 20-22hr  (233) embryo 22-24hr  (278) larva L1  (1243) larva L2  (1170) larva L3 12hr old  (815) larva L3 puffstage 1-2  (839) larva L3 puffstage 3-6  (1083) larva L3 puffstage 7-9  (1184) white prepupae new  (1242) white prepupae 12hr  (1398) white prepupae 24hr  (1330) pupae 2d postWPP  (801) pupae 3d postWPP  (416) pupae 4d postWPP  (444) adult male 01day  (566) adult male 05day  (725) adult male 30day  (683) adult female 01day  (1458) adult female 05day  (2559) adult female 30day  (2438) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3599) embryo 02-04hr  (2658) embryo 04-06hr  (5507) embryo 06-08hr  (3107) embryo 08-10hr  (2181) embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day  1458 adult female 05day  (2559) adult female 30day  (2438) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3599 embryo 02-04hr    2658 embryo 04-06hr    5507 embryo 06-08hr    3107 embryo 08-10hr    2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day    1458 adult female 05day    2559 adult female 30day    2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3599 embryo 02-04hr    2658 embryo 04-06hr    5507 embryo 06-08hr    3107 embryo 08-10hr    2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day    1458 adult female 05day    2559 adult female 30day    2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034310 expression level Developmental Stage   Expression Level embryo 00-02hr    3599 embryo 02-04hr    2658 embryo 04-06hr    5507 embryo 06-08hr    3107 embryo 08-10hr    2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day    1458 adult female 05day    2559 adult female 30day    2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3599) embryo 02-04hr  (2658) embryo 04-06hr  (5507) embryo 06-08hr  (3107) embryo 08-10hr  (2181) embryo 10-12hr  (1328) embryo 12-14hr  (854) embryo 14-16hr  (568) embryo 16-18hr  (386) embryo 18-20hr  (245) embryo 20-22hr  (233) embryo 22-24hr  (278) larva L1  (1243) larva L2  (1170) larva L3 12hr old  (815) larva L3 puffstage 1-2  (839) larva L3 puffstage 3-6  (1083) larva L3 puffstage 7-9  (1184) white prepupae new  (1242) white prepupae 12hr  (1398) white prepupae 24hr  (1330) pupae 2d postWPP  (801) pupae 3d postWPP  (416) pupae 4d postWPP  (444) adult male 01day  (566) adult male 05day  (725) adult male 30day  (683) adult female 01day  (1458) adult female 05day  (2559) adult female 30day  (2438) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3599) embryo 02-04hr  (2658) embryo 04-06hr  (5507) embryo 06-08hr  (3107) embryo 08-10hr  2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day  1458 adult female 05day  (2559) adult female 30day  2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3599 embryo 02-04hr    2658 embryo 04-06hr    5507 embryo 06-08hr    3107 embryo 08-10hr    2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day    1458 adult female 05day    2559 adult female 30day    2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3599 embryo 02-04hr    2658 embryo 04-06hr    5507 embryo 06-08hr    3107 embryo 08-10hr    2181 embryo 10-12hr    1328 embryo 12-14hr    854 embryo 14-16hr    568 embryo 16-18hr    386 embryo 18-20hr    245 embryo 20-22hr    233 embryo 22-24hr    278 larva L1    1243 larva L2    1170 larva L3 12hr old    815 larva L3 puffstage 1-2    839 larva L3 puffstage 3-6    1083 larva L3 puffstage 7-9    1184 white prepupae new    1242 white prepupae 12hr    1398 white prepupae 24hr    1330 pupae 2d postWPP    801 pupae 3d postWPP    416 pupae 4d postWPP    444 adult male 01day    566 adult male 05day    725 adult male 30day    683 adult female 01day    1458 adult female 05day    2559 adult female 30day    2438 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034310    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034310 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult Malpighian tubules, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034310 expression level Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034310 expression level Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    474.75 Larval Midgut    81.6 Larval Hindgut    139 Larval Malpighian Tubules    99.8 Larval Fat Body    113.3 Larval Salivary Gland    327.2 Larval Trachea    160.975 Larval Carcass    161.775 Adult Head    50.4 Adult Eye    30.45 Adult Brain    41.9 Adult Thoracic-Abdominal Ganglion    46.9 Adult Crop    81.4 Adult Midgut    76.3 Adult Hindgut    62.1 Adult Malpighian Tubules    111.4 Adult Fat Body    131.9 Adult Salivary Gland    87.8 Adult Heart    75.825 Adult VirginFemale Spermatheca    110.2 Adult InseminatedFemale Spermatheca    116.1 Adult Ovary    382.8 Adult Testis    157.2 Adult Male Accessory Gland    113 Adult Carcass    57.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    50.4   NA  Eye    30.45   NA  Brain    41.9   474.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    46.9   NA  Crop    81.4   81.6  Midgut    76.3   139  Hindgut    62.1   99.8  Malpighian Tubules    111.4   113.3  Fat Body    131.9   327.2  Salivary Gland    87.8   NA  Heart    75.825   160.975  Trachea    NA   NA  VirginFemale Spermatheca    110.2   NA  InseminatedFemale Spermatheca    116.1   NA  Ovary    382.8   NA  Testis    157.2   NA  Male Accessory Gland    113   161.775  Carcass    57.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034310 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5733-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 Nup75GD11751 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Nup75 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nup75 Class Mutagen Stocks Known lesion Nup75GD11751 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nup75JF02946 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7152 (Ryder, 2004.4.26) Df(2R)Exel7153 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11751} NA P{TRiP.JF02946} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0499SH0499 No miscellaneous insertions P{SUPor-P}KG09695 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
NOT NLS-bearing substrate import into nucleus inferred from mutant phenotype (Chen and Xu, 2010) SMAD protein import into nucleus inferred from mutant phenotype (Chen and Xu, 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nup75 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62759 DroID - A comprehensive database of gene and protein interactions. • FBgn0034310 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37078
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12278 Dere\GG20987 Dgri\GH20846 Dmoj\GI20950 Dper\GL10512 Dpse\GA19092 Dsec\GM19922 Dsim\Nup75 Dvir\GJ20672 Dwil\GK20632 Dyak\GE13930
Curated drosophilid orthologs	Dpse\GA19092   Dsim\Nup75 (Presgraves and Stephan, 2006.10.11)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012989-PA Aedes aegypti (mosquito) AGAP012362-PA Anopheles gambiae (mosquito) XP_001946109.1 Acyrthosiphon pisum (pea aphid) At4g32910.1 Arabidopsis thaliana (wall cress) 123194 Branchiostoma floridae (lancelet) XP_001895678.1 Brugia malayi (roundworm nematode) BGIBMGA005702-PA Bombyx mori (silk worm) ENSBTAP00000034574 Bos taurus (bovine) CN08411 Caenorhabditis brenneri (small nematode) CBP34870 Caenorhabditis briggsae (nematode) CE06341 Caenorhabditis elegans (worm) ENSCAFP00000007050 Canis familiaris (dog) ENSCINP00000019434 Ciona intestinalis (sea squirt) JA05236 Caenorhabditis japonica (nematode) cn02170 Cryptococcus neoformans (yeast-like fungus) CPIJ006488 Culex pipens (mosquito) ENSCPOP00000001069 Cavia porcellus (guinea pig) RP31122 Caenorhabditis remanei (nematode) ENSCSAVP00000008215 Ciona savignyi (sedentary tunicate) 228245 Capitella spl (polychaete worm) DDB0235247 Dictyostelium discoideum (amoeba) 306879 Daphnia pulex (daphnia) ENSDARP00000067719 Danio rerio (zebra fish) ENSECAP00000017117 Equus caballus (horse) ENSGACP00000016245 Gymnopilus aculeatus (mushroom) ENSGALP00000012932 Gallus gallus (chicken) 185380 Hypsipyla robusta (cedar shoot borer) ENSP00000245544 Homo sapiens (human) 221230 Lottia gigantea (owl limpet) 33392 Monocosta brevicollis (choanoflagellate) ENSMODP00000008983 Monodelphis domestica (gray opossum) ENSMMUP00000023675 Macaca mulatta (rhesus monkey) ENSMUSP00000021085 Mus musculus (house mouse) 30774 Nematostella vectensis (starlet anemone) XP_001603995.1 Nasonia vitripennis (wasp) ENSOANP00000013229 Ornithorynchus anatinus (platypus) ENSORLP00000012240 Oryzias latipes (japanese killifish) LOC_Os01g54240.1 Oryza sativa (asian rice) PHUM001536-PA Pediculus humanus (human body louse) 136271 Physcomitrella patens (moss) ENSPPYP00000009681 Pongo pygmaeus (orangutan) 76373 Phytophthora ramorum (sudden oak death pathogen) 128961 Phytophthora sojae (root rot pathogen) 825675 Populus trichocarpa (black cottonwood) ENSPTRP00000016374 Pan troglodytes (chimpanzee) ENSRNOP00000005035 Rattus norvegicus (norway rat) 4879973 Sorghum bicolor (sorghum) Smp_159690 Schistosoma mansoni (trematode parasite) SPBC17G9.04c Schizosaccharomyces pombe (fission yeast) XP_794718.2 Strongylocentrotus purpuratus (purple sea urchin) 53012 Trichoplax adhaerens (metazoa) XP_972141.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014897 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028297 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000056747 Xenopus tropicalis (frog) YALI0F24563g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14397 LH24731 ISCW009772 ISCW009773 FBgn0231572 FBgn0222628 FBgn0207810 FBgn0085969 FBgn0174808 JGI_V11_306879 FBgn0079090 FBgn0148122 FBgn0143684 FBgn0128308 FBgn0113171 FBgn0089315 CPIJ006488 BGIBMGA005702 ACYPI000254 GB18180 AGAP012362 AAEL012989 PB24435 PHUM082930 GLEAN_05392
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	28315 y1 v1; P{TRiP.JF02946}attP2
VDRC	v27495 w1118 P{GD11751}v27495
Genomic Clones ( 2 )
	BACR15G20 BACR33K09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29726
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12750 GM02036 GM26743 GM32791 LD13568 LD32143 SD05492 SD08681 SD16445
Other clones	35115 123559 214571.60 CK01.64B.A2 CK01.68C.G11 Dmel_neb_016040_0583_1098 EK052225 EK054828 EK065033 EP00760
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034310 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37078
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137456 RefSeq (Proteins) • NP_611300 DDBJ / EMBL / GenBank • AA949731 AAF57735 AAL48509 ABL84858 ABL84859 ABL84860 ABL84861 ABL84862 ABL84863 ABL84864 ABL84865 ABL84866 ABL84867 ABL84868 ABL84869 AW942983 AY070887 EF057923 EF057924 EF057925 EF057926 EF057927 EF057928 EF057929 EF057930 EF057931 EF057932 EF057933 EF057934 Entrez Gene - A searchable database of RefSeq genes. • 37078 UniProtKB/TrEMBL • A1YK00 A1YK01 A1YK02 A1YK03 A1YK07 A1YK11 Q8SZH5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nuclear pore complex protein, Nucleoporin Nup85-like (IPR011502)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62759 DroID - A comprehensive database of gene and protein interactions. • FBgn0034310 DRSC - Results from RNAi screens. • FBgn0034310 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034310 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5733-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034310 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37078 InParanoid A subset of ortholog calls from InParanoid. • AAEL012989-PA Aedes aegypti (mosquito) AGAP012362-PA Anopheles gambiae (mosquito) XP_001946109.1 Acyrthosiphon pisum (pea aphid) At4g32910.1 Arabidopsis thaliana (wall cress) 123194 Branchiostoma floridae (lancelet) XP_001895678.1 Brugia malayi (roundworm nematode) BGIBMGA005702-PA Bombyx mori (silk worm) ENSBTAP00000034574 Bos taurus (bovine) CN08411 Caenorhabditis brenneri (small nematode) CBP34870 Caenorhabditis briggsae (nematode) CE06341 Caenorhabditis elegans (worm) ENSCAFP00000007050 Canis familiaris (dog) ENSCINP00000019434 Ciona intestinalis (sea squirt) JA05236 Caenorhabditis japonica (nematode) cn02170 Cryptococcus neoformans (yeast-like fungus) CPIJ006488 Culex pipens (mosquito) ENSCPOP00000001069 Cavia porcellus (guinea pig) RP31122 Caenorhabditis remanei (nematode) ENSCSAVP00000008215 Ciona savignyi (sedentary tunicate) 228245 Capitella spl (polychaete worm) DDB0235247 Dictyostelium discoideum (amoeba) 306879 Daphnia pulex (daphnia) ENSDARP00000067719 Danio rerio (zebra fish) ENSECAP00000017117 Equus caballus (horse) ENSGACP00000016245 Gymnopilus aculeatus (mushroom) ENSGALP00000012932 Gallus gallus (chicken) 185380 Hypsipyla robusta (cedar shoot borer) ENSP00000245544 Homo sapiens (human) 221230 Lottia gigantea (owl limpet) 33392 Monocosta brevicollis (choanoflagellate) ENSMODP00000008983 Monodelphis domestica (gray opossum) ENSMMUP00000023675 Macaca mulatta (rhesus monkey) ENSMUSP00000021085 Mus musculus (house mouse) 30774 Nematostella vectensis (starlet anemone) XP_001603995.1 Nasonia vitripennis (wasp) ENSOANP00000013229 Ornithorynchus anatinus (platypus) ENSORLP00000012240 Oryzias latipes (japanese killifish) LOC_Os01g54240.1 Oryza sativa (asian rice) PHUM001536-PA Pediculus humanus (human body louse) 136271 Physcomitrella patens (moss) ENSPPYP00000009681 Pongo pygmaeus (orangutan) 76373 Phytophthora ramorum (sudden oak death pathogen) 128961 Phytophthora sojae (root rot pathogen) 825675 Populus trichocarpa (black cottonwood) ENSPTRP00000016374 Pan troglodytes (chimpanzee) ENSRNOP00000005035 Rattus norvegicus (norway rat) 4879973 Sorghum bicolor (sorghum) Smp_159690 Schistosoma mansoni (trematode parasite) SPBC17G9.04c Schizosaccharomyces pombe (fission yeast) XP_794718.2 Strongylocentrotus purpuratus (purple sea urchin) 53012 Trichoplax adhaerens (metazoa) XP_972141.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014897 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028297 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000056747 Xenopus tropicalis (frog) YALI0F24563g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37078 modMine - Data generated by the modENCODE project. • FBgn0034310 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14397 LH24731 ISCW009772 ISCW009773 FBgn0231572 FBgn0222628 FBgn0207810 FBgn0085969 FBgn0174808 JGI_V11_306879 FBgn0079090 FBgn0148122 FBgn0143684 FBgn0128308 FBgn0113171 FBgn0089315 CPIJ006488 BGIBMGA005702 ACYPI000254 GB18180 AGAP012362 AAEL012989 PB24435 PHUM082930 GLEAN_05392
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG5733 (Perkins et al., 2009) Nup75 (Presgraves and Stephan, 2007, Finan et al., 2011, Chen and Xu, 2010) nup75 (Chen and Xu, 2010) Nup 75 (Clark and Aquadro, 2010)
Name Synonym	Nucleoporin 75
Secondary FlyBase IDs
References ( 16 )
Research paper	Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Chen and Xu, 2010, Mol. Cell. Biol. 30(16): 4022--4034 Specific nucleoporin requirement for smad nuclear translocation. [FBrf0211334] Clark and Aquadro, 2010, Mol. Biol. Evol. 27(5): 1152--1161 A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. [FBrf0210693] Presgraves and Stephan, 2007, Molec. Biol. Evol. 24(1): 306--314 Pervasive adaptive evolution among interactors of the Drosophila hybrid inviability gene, Nup96. [FBrf0193654]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Personal communication to FlyBase	Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
DNA/RNA sequence record	Presgraves and Stephan, 2006.10.11, GenBank/EMBL/DDBJ: EF057935 Drosophila simulans strain s006 Nup75 (CG5733) gene, complete cds. [FBrf0199500] Presgraves and Stephan, 2006.10.11, GenBank/EMBL/DDBJ: EF057923 Drosophila melanogaster strain m095 Nup75 (CG5733) gene, complete cds. [FBrf0199499]