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Gene Dmel\CG5174

General Information
Symbol	Dmel\CG5174	Species	D. melanogaster
Name		Annotation symbol	CG5174
Feature type	protein_coding_gene	FlyBase ID	FBgn0034345
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55C8-55C9	Sequence location	2R:14,308,918..14,313,726 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5174 (FBgn0034345). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Tumour protein D52. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: virgin spermatheca, adult testis, adult carcass. Gene sequence location is 2R:14308918..14313726.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55C8-55C9   Limits computationally determined from genome sequence between P{PZ}sbb04525&P{EP}EP1081EP1081 and P{lacW}l(2)08770k04808
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5174 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5174-RA FBtr0086686  NM_137487   1532   208 CG5174-RB FBtr0086690  NM_166288   2195   355 CG5174-RG FBtr0086689  NM_166284   848   166 CG5174-RH FBtr0086687  NM_166286   1472   188 CG5174-RJ FBtr0086684  NM_166283   908   186 CG5174-RL FBtr0301148  NM_001169723   981   209 CG5174-RM FBtr0301149  NM_166285   1514   202 CG5174-RN FBtr0306636  NM_001259477   1574   222 CG5174-RO FBtr0306637  NM_001259478   2237   369 CG5174-RP FBtr0340359     2225   365
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5174-PA   FBpp0085865   22.6   208   4.99     NP_611331   AAM68455 CG5174-PB   FBpp0085869   39.4   355   4.62     NP_725793   AAF57690 CG5174-PG   FBpp0085868   18.3   166   7.70     NP_725789   AAM68453 CG5174-PH   FBpp0085866   20.3   188   5.14     NP_725791   AAM68456 CG5174-PJ   FBpp0085863   20.5   186   6.56     NP_725788   AAM68452 CG5174-PL   FBpp0290371   22.7   209   4.86     NP_001163194   ACZ94466 CG5174-PM   FBpp0290372   21.9   202   4.77     NP_725790   AAM68454 CG5174-PN   FBpp0297591   24.2   222   5.17     NP_001246406   AFH08159 CG5174-PO   FBpp0297592   41.0   369   4.68     NP_001246407   AFH08160 CG5174-PP   FBpp0309317   40.6   365   4.63
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tumour protein D52 (IPR007327)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263893   AA390326   AA392910   AA567481   AA735199   AA802243   AA950585   AE013599 AAF57690   AE013599 AAM68452   AE013599 AAM68453   AE013599 AAM68454   AE013599 AAM68455   AE013599 AAM68456   AE013599 ACZ94466   AE013599 AFH08159   AE013599 AFH08160   AI135497   AI135498   AI259074   AI259112   AI259848   AI293826   AI386545   AI455056   AI455735   AI456898   AI512743   AI519801   AI534597   AI542975   AI543838   AI945033   AW943738   AY061481 AAL29029   BF486527   BF494658   BF503633   BF503956   BG638954   BG640684   BI162610   BI162611   BI170193   BI213239   BI216754   BI228042   BI231389   BI231400   BI232909   BI236640   BI237562   BI242618   BI352315   BI352462   BI353962   BI354843   BI356811   BI361884   BI486263   BI580779   BI584904   BI587126   BI621840   BI624355   BI641518   BP544355   BQ103106   BT001567 AAN71322   BT001799 AAN71554   BT003773   BT050497   CK659698   CO156313   CO177998   CO188057   CO190363   CO196690   CO267233   CO270945   CO272242   CO274820   CO275899   CO276281   CO280083   CO280502   CO284187   CO285167   CO300396   CO301772   CO302147   CO302503   CO308818   CO314108   CO316388   CO324649   CO329409   CO336998   CO344739   EC059964   EC062443   EC062820   EC063372   EC073192   EC075444   EC078826   EC085483   EC198199   EC199271   EC199323   EC214134   EC218293   EC220222   EC220690   EC223315   EC226647   EC226848   EC230192   EC231862   EC232034   EC240315   EC249760   EC259688   EC262117   EC265145   EC265544   EL873411   EL873412   EV595072   GH942846   GH944576   GH945891   GH947356   GH947614   GH949391   GH958200   GH961109   GH966916   GH970459   GH975219   GH977980   GH979271   GH979355   GH980490   GH981650   GH982755
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZB83 Q7JRI6 A1ZB78 A1ZB79 A1ZB77 A1ZB80 A1ZB82 E1JGL5 Q8IGG3 Q95RC4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: virgin spermatheca, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    62 central nervous system, larvae L3    49 central nervous system, pupae P8    42 head, virgin 1-day female    32 head, virgin 4-day female    31 head, virgin 20-day female    35 head, mated 1-day female    24 head, mated 4-day female    27 head, mated 20-day female    33 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    57 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    55 digestive system, 1-day adult    39 digestive system, 4-day adult    37 digestive system, 20-day adult    36 fat body, larvae L3 wandering    15 fat body, white prepupae    28 fat body, pupae P8    87 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult    26 ovary, virgin 4-day female    53 ovary, mated 4-day female    43 testis, mated 4-day male    44 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (62) central nervous system, larvae L3  (49) central nervous system, pupae P8  (42) head, virgin 1-day female  (32) head, virgin 4-day female  (31) head, virgin 20-day female  (35) head, mated 1-day female    24 head, mated 4-day female  (27) head, mated 20-day female  (33) head, mated 1-day male  (38) head, mated 4-day male  (43) head, mated 20-day male  (57) salivary gland, larvae L3 wandering  (28) salivary gland, white prepupae  (48) digestive system, larvae L3 wandering  (55) digestive system, 1-day adult  (39) digestive system, 4-day adult  (37) digestive system, 20-day adult  (36) fat body, larvae L3 wandering    15 fat body, white prepupae  (28) fat body, pupae P8  (87) carcass, larvae L3 wandering  (43) carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult  26 ovary, virgin 4-day female  (53) ovary, mated 4-day female  (43) testis, mated 4-day male  (44) accessory gland, mated 4-day male  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    62 central nervous system, larvae L3    49 central nervous system, pupae P8    42 head, virgin 1-day female    32 head, virgin 4-day female    31 head, virgin 20-day female    35 head, mated 1-day female    24 head, mated 4-day female    27 head, mated 20-day female    33 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    57 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    55 digestive system, 1-day adult    39 digestive system, 4-day adult    37 digestive system, 20-day adult    36 fat body, larvae L3 wandering    15 fat body, white prepupae    28 fat body, pupae P8    87 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult    26 ovary, virgin 4-day female    53 ovary, mated 4-day female    43 testis, mated 4-day male    44 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    62 central nervous system, larvae L3    49 central nervous system, pupae P8    42 head, virgin 1-day female    32 head, virgin 4-day female    31 head, virgin 20-day female    35 head, mated 1-day female    24 head, mated 4-day female    27 head, mated 20-day female    33 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    57 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    55 digestive system, 1-day adult    39 digestive system, 4-day adult    37 digestive system, 20-day adult    36 fat body, larvae L3 wandering    15 fat body, white prepupae    28 fat body, pupae P8    87 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult    26 ovary, virgin 4-day female    53 ovary, mated 4-day female    43 testis, mated 4-day male    44 accessory gland, mated 4-day male    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    62 central nervous system, larvae L3    49 central nervous system, pupae P8    42 head, virgin 1-day female    32 head, virgin 4-day female    31 head, virgin 20-day female    35 head, mated 1-day female    24 head, mated 4-day female    27 head, mated 20-day female    33 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    57 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    55 digestive system, 1-day adult    39 digestive system, 4-day adult    37 digestive system, 20-day adult    36 fat body, larvae L3 wandering    15 fat body, white prepupae    28 fat body, pupae P8    87 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult    26 ovary, virgin 4-day female    53 ovary, mated 4-day female    43 testis, mated 4-day male    44 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (62) central nervous system, larvae L3  (49) central nervous system, pupae P8  (42) head, virgin 1-day female  32 head, virgin 4-day female  31 head, virgin 20-day female  (35) head, mated 1-day female    24 head, mated 4-day female  27 head, mated 20-day female  (33) head, mated 1-day male  (38) head, mated 4-day male  (43) head, mated 20-day male  (57) salivary gland, larvae L3 wandering  28 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering  (55) digestive system, 1-day adult  (39) digestive system, 4-day adult  (37) digestive system, 20-day adult  (36) fat body, larvae L3 wandering    15 fat body, white prepupae  28 fat body, pupae P8  (87) carcass, larvae L3 wandering  (43) carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult  26 ovary, virgin 4-day female  (53) ovary, mated 4-day female  (43) testis, mated 4-day male  (44) accessory gland, mated 4-day male  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    62 central nervous system, larvae L3    49 central nervous system, pupae P8    42 head, virgin 1-day female    32 head, virgin 4-day female    31 head, virgin 20-day female    35 head, mated 1-day female    24 head, mated 4-day female    27 head, mated 20-day female    33 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    57 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    55 digestive system, 1-day adult    39 digestive system, 4-day adult    37 digestive system, 20-day adult    36 fat body, larvae L3 wandering    15 fat body, white prepupae    28 fat body, pupae P8    87 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult    26 ovary, virgin 4-day female    53 ovary, mated 4-day female    43 testis, mated 4-day male    44 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    62 central nervous system, larvae L3    49 central nervous system, pupae P8    42 head, virgin 1-day female    32 head, virgin 4-day female    31 head, virgin 20-day female    35 head, mated 1-day female    24 head, mated 4-day female    27 head, mated 20-day female    33 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    57 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    55 digestive system, 1-day adult    39 digestive system, 4-day adult    37 digestive system, 20-day adult    36 fat body, larvae L3 wandering    15 fat body, white prepupae    28 fat body, pupae P8    87 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    25 carcass, 20-day adult    26 ovary, virgin 4-day female    53 ovary, mated 4-day female    43 testis, mated 4-day male    44 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    56 embryo 02-04hr    67 embryo 04-06hr    42 embryo 06-08hr    22 embryo 08-10hr    38 embryo 10-12hr    64 embryo 12-14hr    82 embryo 14-16hr    73 embryo 16-18hr    52 embryo 18-20hr    34 embryo 20-22hr    36 embryo 22-24hr    40 larva L1    33 larva L2    54 larva L3 12hr old    35 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    58 white prepupae new    55 white prepupae 12hr    64 white prepupae 24hr    86 pupae 2d postWPP    89 pupae 3d postWPP    51 pupae 4d postWPP    31 adult male 01day    44 adult male 05day    43 adult male 30day    44 adult female 01day    44 adult female 05day    55 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (56) embryo 02-04hr  (67) embryo 04-06hr  (42) embryo 06-08hr    22 embryo 08-10hr  (38) embryo 10-12hr  (64) embryo 12-14hr  (82) embryo 14-16hr  (73) embryo 16-18hr  (52) embryo 18-20hr  (34) embryo 20-22hr  (36) embryo 22-24hr  (40) larva L1  (33) larva L2  (54) larva L3 12hr old  (35) larva L3 puffstage 1-2  (41) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9  (58) white prepupae new  (55) white prepupae 12hr  (64) white prepupae 24hr  (86) pupae 2d postWPP  (89) pupae 3d postWPP  (51) pupae 4d postWPP  (31) adult male 01day  (44) adult male 05day  (43) adult male 30day  (44) adult female 01day  (44) adult female 05day  (55) adult female 30day  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    56 embryo 02-04hr    67 embryo 04-06hr    42 embryo 06-08hr    22 embryo 08-10hr    38 embryo 10-12hr    64 embryo 12-14hr    82 embryo 14-16hr    73 embryo 16-18hr    52 embryo 18-20hr    34 embryo 20-22hr    36 embryo 22-24hr    40 larva L1    33 larva L2    54 larva L3 12hr old    35 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    58 white prepupae new    55 white prepupae 12hr    64 white prepupae 24hr    86 pupae 2d postWPP    89 pupae 3d postWPP    51 pupae 4d postWPP    31 adult male 01day    44 adult male 05day    43 adult male 30day    44 adult female 01day    44 adult female 05day    55 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    56 embryo 02-04hr    67 embryo 04-06hr    42 embryo 06-08hr    22 embryo 08-10hr    38 embryo 10-12hr    64 embryo 12-14hr    82 embryo 14-16hr    73 embryo 16-18hr    52 embryo 18-20hr    34 embryo 20-22hr    36 embryo 22-24hr    40 larva L1    33 larva L2    54 larva L3 12hr old    35 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    58 white prepupae new    55 white prepupae 12hr    64 white prepupae 24hr    86 pupae 2d postWPP    89 pupae 3d postWPP    51 pupae 4d postWPP    31 adult male 01day    44 adult male 05day    43 adult male 30day    44 adult female 01day    44 adult female 05day    55 adult female 30day    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    56 embryo 02-04hr    67 embryo 04-06hr    42 embryo 06-08hr    22 embryo 08-10hr    38 embryo 10-12hr    64 embryo 12-14hr    82 embryo 14-16hr    73 embryo 16-18hr    52 embryo 18-20hr    34 embryo 20-22hr    36 embryo 22-24hr    40 larva L1    33 larva L2    54 larva L3 12hr old    35 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    58 white prepupae new    55 white prepupae 12hr    64 white prepupae 24hr    86 pupae 2d postWPP    89 pupae 3d postWPP    51 pupae 4d postWPP    31 adult male 01day    44 adult male 05day    43 adult male 30day    44 adult female 01day    44 adult female 05day    55 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (56) embryo 02-04hr  (67) embryo 04-06hr  (42) embryo 06-08hr    22 embryo 08-10hr  (38) embryo 10-12hr  (64) embryo 12-14hr  (82) embryo 14-16hr  (73) embryo 16-18hr  (52) embryo 18-20hr  (34) embryo 20-22hr  (36) embryo 22-24hr  (40) larva L1  (33) larva L2  (54) larva L3 12hr old  (35) larva L3 puffstage 1-2  (41) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9  (58) white prepupae new  (55) white prepupae 12hr  (64) white prepupae 24hr  (86) pupae 2d postWPP  (89) pupae 3d postWPP  (51) pupae 4d postWPP  31 adult male 01day  (44) adult male 05day  (43) adult male 30day  (44) adult female 01day  (44) adult female 05day  (55) adult female 30day  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    56 embryo 02-04hr    67 embryo 04-06hr    42 embryo 06-08hr    22 embryo 08-10hr    38 embryo 10-12hr    64 embryo 12-14hr    82 embryo 14-16hr    73 embryo 16-18hr    52 embryo 18-20hr    34 embryo 20-22hr    36 embryo 22-24hr    40 larva L1    33 larva L2    54 larva L3 12hr old    35 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    58 white prepupae new    55 white prepupae 12hr    64 white prepupae 24hr    86 pupae 2d postWPP    89 pupae 3d postWPP    51 pupae 4d postWPP    31 adult male 01day    44 adult male 05day    43 adult male 30day    44 adult female 01day    44 adult female 05day    55 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    56 embryo 02-04hr    67 embryo 04-06hr    42 embryo 06-08hr    22 embryo 08-10hr    38 embryo 10-12hr    64 embryo 12-14hr    82 embryo 14-16hr    73 embryo 16-18hr    52 embryo 18-20hr    34 embryo 20-22hr    36 embryo 22-24hr    40 larva L1    33 larva L2    54 larva L3 12hr old    35 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    58 white prepupae new    55 white prepupae 12hr    64 white prepupae 24hr    86 pupae 2d postWPP    89 pupae 3d postWPP    51 pupae 4d postWPP    31 adult male 01day    44 adult male 05day    43 adult male 30day    44 adult female 01day    44 adult female 05day    55 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    143 Schneider line 2 Sg4    66 embryonic 1182-4H    89 embryonic GM2    83 embryonic Kc167    53 embryonic S1    86 embryonic S3    100 leg disc CME L1    105 wing disc CME-W2    123 wing disc ML-DmD8    83 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    75 wing disc ML-DmD21    51 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    63 antennal disc ML-DmD20-c5    90 mixed discs ML-DmD4-c1    84 CNS ML-DmBG1-c1    82 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    113 ovary fGS/OSS    53 ovary OSC    60 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (143) Schneider line 2 Sg4  (66) embryonic 1182-4H  (89) embryonic GM2  (83) embryonic Kc167  (53) embryonic S1  (86) embryonic S3  (100) leg disc CME L1  (105) wing disc CME-W2  (123) wing disc ML-DmD8  (83) wing disc ML-DmD9  (67) wing disc ML-DmD16-c3  (75) wing disc ML-DmD21  (51) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (77) eye-antennal disc ML-DmD11  (63) antennal disc ML-DmD20-c5  (90) mixed discs ML-DmD4-c1  (84) CNS ML-DmBG1-c1  (82) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (113) ovary fGS/OSS  (53) ovary OSC  (60) ovary OSS  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (143) Schneider line 2 Sg4    66 embryonic 1182-4H    89 embryonic GM2    83 embryonic Kc167    53 embryonic S1    86 embryonic S3    100 leg disc CME L1  105 wing disc CME-W2  (123) wing disc ML-DmD8    83 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    75 wing disc ML-DmD21    51 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    63 antennal disc ML-DmD20-c5    90 mixed discs ML-DmD4-c1    84 CNS ML-DmBG1-c1    82 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2  (113) ovary fGS/OSS    53 ovary OSC    60 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    143 Schneider line 2 Sg4    66 embryonic 1182-4H    89 embryonic GM2    83 embryonic Kc167    53 embryonic S1    86 embryonic S3    100 leg disc CME L1    105 wing disc CME-W2    123 wing disc ML-DmD8    83 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    75 wing disc ML-DmD21    51 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    63 antennal disc ML-DmD20-c5    90 mixed discs ML-DmD4-c1    84 CNS ML-DmBG1-c1    82 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    113 ovary fGS/OSS    53 ovary OSC    60 ovary OSS    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    143 Schneider line 2 Sg4    66 embryonic 1182-4H    89 embryonic GM2    83 embryonic Kc167    53 embryonic S1    86 embryonic S3    100 leg disc CME L1    105 wing disc CME-W2    123 wing disc ML-DmD8    83 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    75 wing disc ML-DmD21    51 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    63 antennal disc ML-DmD20-c5    90 mixed discs ML-DmD4-c1    84 CNS ML-DmBG1-c1    82 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    113 ovary fGS/OSS    53 ovary OSC    60 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (143) Schneider line 2 Sg4  (66) embryonic 1182-4H  (89) embryonic GM2  (83) embryonic Kc167  (53) embryonic S1  (86) embryonic S3  (100) leg disc CME L1  (105) wing disc CME-W2  (123) wing disc ML-DmD8  (83) wing disc ML-DmD9  (67) wing disc ML-DmD16-c3  (75) wing disc ML-DmD21  (51) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (77) eye-antennal disc ML-DmD11  (63) antennal disc ML-DmD20-c5  (90) mixed discs ML-DmD4-c1  (84) CNS ML-DmBG1-c1  (82) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (113) ovary fGS/OSS  (53) ovary OSC  (60) ovary OSS  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  143 Schneider line 2 Sg4    66 embryonic 1182-4H    89 embryonic GM2    83 embryonic Kc167    53 embryonic S1    86 embryonic S3    100 leg disc CME L1  105 wing disc CME-W2  123 wing disc ML-DmD8    83 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    75 wing disc ML-DmD21    51 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    63 antennal disc ML-DmD20-c5    90 mixed discs ML-DmD4-c1    84 CNS ML-DmBG1-c1    82 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2  113 ovary fGS/OSS    53 ovary OSC    60 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    143 Schneider line 2 Sg4    66 embryonic 1182-4H    89 embryonic GM2    83 embryonic Kc167    53 embryonic S1    86 embryonic S3    100 leg disc CME L1    105 wing disc CME-W2    123 wing disc ML-DmD8    83 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    75 wing disc ML-DmD21    51 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    63 antennal disc ML-DmD20-c5    90 mixed discs ML-DmD4-c1    84 CNS ML-DmBG1-c1    82 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    113 ovary fGS/OSS    53 ovary OSC    60 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult    36 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    55 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult  (36) Cadmium 50 mM 6 hrs, larvae L3  (41) Cadmium 50 mM 12 hrs, larvae L3  (55) Cadmium 50 mM 48 hrs, 4-day adult  (42) Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3  (44) Ethanol 10% 3 hrs, larvae L3  (34) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (33) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (37) Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult    36 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    55 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult    36 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    55 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult    36 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    55 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult  (36) Cadmium 50 mM 6 hrs, larvae L3  (41) Cadmium 50 mM 12 hrs, larvae L3  (55) Cadmium 50 mM 48 hrs, 4-day adult  (42) Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3  (44) Ethanol 10% 3 hrs, larvae L3  (34) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (33) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (37) Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult    36 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    55 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    18 heat shock, 4-day adult    36 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    55 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • RE18604 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034345 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5174-RJ;CG5174-RK;CG5174-RB;CG5174-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG5174CA07176 CG5174f00017 viable, with Scer\GAL4pnr-MD237 CG5174GD15172 Sterility Allele fertile CG5174f00017 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG5174 Class Mutagen Stocks Known lesion CG5174f00017 piggyBac transposase 2 -- CG5174CA07176 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5174 Class Mutagen Stocks Known lesion CG5174GD15172 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5174HMS00669 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5174HMS00787 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5174KK109455 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15172} NA P{KK109455} NA P{TRiP.HMS00669} NA P{TRiP.HMS00787} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GA}CG5174CA07176 NA PBac{WH}CG5174f00017 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG5174 - A16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - AnxB10 experimental knowledge based (Guruharsha et al., 2011) CG5174 - CG10638 experimental knowledge based (Guruharsha et al., 2011) CG5174 - CG11191 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG12200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG12241 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG12289 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG14109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG16817 experimental knowledge based (Guruharsha et al., 2011) CG5174 - CG17260 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG2209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - CoVa experimental knowledge based (Guruharsha et al., 2011) CG5174 - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - Df31 experimental knowledge based (Guruharsha et al., 2011) CG5174 - Drep-1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG5174 - EndoGI experimental knowledge based (Guruharsha et al., 2011) CG5174 - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) CG5174 - GstE6 experimental knowledge based (Guruharsha et al., 2011) CG5174 - Inos experimental knowledge based (Guruharsha et al., 2011) CG5174 - Mdh2 experimental knowledge based (Guruharsha et al., 2011) CG5174 - Nacα experimental knowledge based (Guruharsha et al., 2011) CG5174 - Nlp experimental knowledge based (Guruharsha et al., 2011) CG5174 - RhoGDI experimental knowledge based (Guruharsha et al., 2011) CG5174 - Sdc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - TwdlQ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - Uch experimental knowledge based (Guruharsha et al., 2011) CG5174 - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5174 - capt experimental knowledge based (Guruharsha et al., 2011) CG5174 - dUTPase experimental knowledge based (Guruharsha et al., 2011) CG5174 - eEF1δ experimental knowledge based (Guruharsha et al., 2011) CG5174 - fax experimental knowledge based (Guruharsha et al., 2011) CG5174 - l(2)03709 experimental knowledge based (Guruharsha et al., 2011) CG5174 - l(2)37Cc experimental knowledge based (Guruharsha et al., 2011) CG5174 - regucalcin experimental knowledge based (Guruharsha et al., 2011) CG5174 - scu experimental knowledge based (Guruharsha et al., 2011) CG5174 - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5174 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62794 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034345 DroID - A comprehensive database of gene and protein interactions. • FBgn0034345 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37117
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZKK6F Dipteran inclusive ortholog search EOG66Q72C Insect inclusive ortholog search EOG6STR1F Arthropod inclusive ortholog search EOG6JWSW8 Metazoa inclusive ortholog search EOG68WQVZ
Orthologs in Drosophila Species (EOG6ZKK6F)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG5174     Drosophila simulans   Dsim\GD11382 Y   Drosophila sechellia   Dsec\GM21885 Y   Drosophila erecta   Dere\GG21893 Y   Drosophila yakuba   Dyak\GE11969 Y   Drosophila ananassae   Dana\GF12177 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18710 Y   Drosophila persimilis   Dper\GL17776 Y   Drosophila willistoni   Dwil\GK22994 Y   Drosophila virilis   Dvir\GJ19896 Y   Drosophila mojavensis   Dmoj\GI20126 Y   Drosophila grimshawi   Dgri\GH21673 Y
Orthologs in non-Drosophila Dipterans (EOG66Q72C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007173   Anopheles gambiae Malaria mosquito  Agam\AGAP004868   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013850
Orthologs in non-Dipteran Insects (EOG6STR1F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52520   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036992   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22067   Atta cephalotes Leafcutter ant  Acep\ACEP15167   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23571   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21261   Linepithema humile Argentine ant  Lhum\LH18011   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10785   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005467   Bombyx mori Silkmoth  Bmor\BGIBMGA003519   Pediculus humanus Human body louse  Phum\PHUM613860   Tribolium castaneum Red flour beetle  Tcas\TC013379
Orthologs in non-Insect Arthropods (EOG6JWSW8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\GBSSI   Ixodes scapularis Deer tick  Isca\ISCW006441
Orthologs in non-Arthropod Metazoa (EOG68WQVZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\tpd52l2a
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11382 Drosophila sechellia Dsec\GM21885 Drosophila erecta Dere\GG21893 Drosophila yakuba Dyak\GE11969 Drosophila ananassae Dana\GF12177 Drosophila pseudoobscura pseudoobscura Dpse\GA18710 Drosophila persimilis Dper\GL17776 Drosophila willistoni Dwil\GK22994 Drosophila virilis Dvir\GJ19896 Drosophila mojavensis Dmoj\GI20126 Drosophila grimshawi Dgri\GH21673
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18285 w1118; PBac{WH}CG5174f00017 32881 y1 sc* v1; P{TRiP.HMS00669}attP2 32987 y1 sc* v1; P{TRiP.HMS00787}attP2
Harvard	- PBac{WH}CG5174f00017
VDRC	v101767 P{KK109455}VIE-260B v29752 w1118; P{GD15172}v29752
Genomic Clones ( 1 )
	BACR48A20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 128 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44733 RE18604 RE21450 RH27395
Other clones	DPiM_RE18604 FI06482
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04803 AT05206 AT20853 GH13285 GH13286 GH16658 GM04070 GM18781 GM19378 GM25721 GM28570 HL01328 LD01576 LD03251 LD07189 LD10056 LD12053 LD30442 LD35401 LD37063 LD39916 LP02403 LP02448 LP03357 LP07060 LP17639 RE11571 RE21461 RE24005 RE25458 RE29050 RE32720 RE33810 RE40008 RE43034 RE46277 RE69671 RE75013 RH24222 RH53260 RH63902 SD07507 SD09503 SD11823 SD24877
Other clones	8404 13705 38611 39184 39891 53782 55258 59076 59933 66650 77073 108628 156713 159950 161021 190568 214287.53 523136 527719 562058 bs08c01 CK01.3A.E5 CK01.59A.F9 CK01.68C.B8 CK01.130D.F1 CK01.132C.G9 CK01.144C.G12 CK01.146B.D6 Dmel_neb_016011_0606_1375 EK007519 EK037016 EK047917 EK054940 EK101125 EK106347 EK115545 EK119060 EK120247 EK149204 EK152418 EK154221 EK165444 EK168418 EK178111 EK182132 EK183243 EK184309 EK194441 EK235119 EK259438 EK264814 EK292763 EN07826 EN13630 EP19819 FGC025D09 IP05268 LD39589 RE01883 RP004040538 RP004186246 RP004207441 RP004210031 RP004217596 RP004224470 RP004229852 RP004239809 RP004240310 RP004251488 RP004252019 RP004256922 RP004265130 RP004347607 RP004426700 RP004474437 RP004538982 UUGC0504
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034345 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37117
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG5174 BcDNA:RE18604 (FlyBase, 1996-) Source for merge of: CG5174 BcDNA:RH27395 (FlyBase, 1996-)
Additional comments	Source for merge of CG5174 BcDNA:RE18604 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of CG5174 BcDNA:RH27395 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137487 NM_166283 NM_166284 NM_166285 NM_166286 NM_166288 NM_001169723 NM_001259477 NM_001259478 RefSeq (Proteins) • NP_611331 NP_725788 NP_725789 NP_725790 NP_725791 NP_725793 NP_001163194 NP_001246406 NP_001246407 DDBJ / EMBL / GenBank • AA802243 AAF57690 AAL29029 AAM68452 AAM68453 AAM68454 AAM68455 AAM68456 AAM68457 AAN71322 AAN71554 ACZ94466 AFH08159 AFH08160 AI512743 AI945033 AW943738 AY061481 BI213239 BI231389 BI587126 BT001567 BT001799 Entrez Gene - A searchable database of RefSeq genes. • 37117 UniProtKB/TrEMBL • A1ZB77 A1ZB78 A1ZB79 A1ZB80 A1ZB82 A1ZB83 E1JGL5 Q7JRI6 Q8IGG3 Q95RC4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tumour protein D52 (IPR007327) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE18604
Linkouts
	BioGRID - A database of protein and genetic interactions • 62794 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034345 DroID - A comprehensive database of gene and protein interactions. • FBgn0034345 DRSC - Results from RNAi screens. • FBgn0034345 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034345 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5174-RJ;CG5174-RK;CG5174-RB;CG5174-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034345 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37117 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37117 modMine - Data generated by the modENCODE project. • FBgn0034345
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:RE18604   BcDNA:RH27395   CG5174 (Bowler et al., 2006, Buszczak et al., 2007, Przewloka et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011)
Name Synonym
Secondary FlyBase IDs
	FBgn0064829 FBgn0064902
References ( 19 )
Research paper	Buszczak et al., 2007, Genetics 175(3): 1505--1531 The Carnegie protein trap library: A versatile tool for Drosophila developmental studies. [FBrf0200345] Przewloka et al., 2007, PLoS ONE 2(5): e478 Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster. [FBrf0200394] Bowler et al., 2006, Dev. Biol. 299(1): 78--90 Computational identification of Ftz/Ftz-F1 downstream target genes. [FBrf0200137]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]