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Gene Dmel\CG10924

General Information
Symbol	Dmel\CG10924	Species	D. melanogaster
Name		Annotation symbol	CG10924
Feature type	protein_coding_gene	FlyBase ID	FBgn0034356
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55D1-55D2	Sequence location	2R:14,414,937..14,423,263 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10924 (FBgn0034356). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: phosphoenolpyruvate carboxykinase (GTP) activity. Based on sequence similarity, it is predicted to be involved in the biological process: gluconeogenesis. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Phosphoenolpyruvate carboxykinase, C-terminal; Phosphoenolpyruvate carboxykinase, GTP-utilising; Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site; Phosphoenolpyruvate carboxykinase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634794_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10924. Gene sequence location is 2R:14414937..14423263.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA06013 BKN23432
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55D1-55D2   Limits computationally determined from genome sequence between P{lacW}l(2)08770k04808 and P{EP}EP437
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10924 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10924-RA FBtr0086699  NM_137497   3456   638 CG10924-RB FBtr0113093  NM_001103897   3153   563
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10924-PA   FBpp0085878   70.7   638   7.61     NP_611341   AAF57677 CG10924-PB   FBpp0112006   62.2   563   7.02     NP_001097367   ABV53844
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphoenolpyruvate carboxykinase, GTP-utilising (IPR008209) Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site (IPR018091) Phosphoenolpyruvate carboxykinase, C-terminal (IPR013035) Phosphoenolpyruvate carboxykinase, N-terminal (IPR008210) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME10924
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA541198   AE013599 AAF57677   AE013599 ABV53844   AI259209   AI534775   AY094852 AAM11205   BG635908   BG638249   BG639865   BI170937   BI229887   BI232006   BI238119   BI486035   BI578555   CK658501   CK658936   CK660614   CO181207   CO191936   CO287486   CO298549   CO298568   CZ481544   CZ485840   EC065682   EC196689   EC198635   EL885410   ES692114   EV576315   GH738849   GH738967   GH739852   GH739866   GH739984   GH740076   GH740553   GH740693   GH741036   GH741751   GH745021   GH745188   GH745859   GH762424   GH762591   GH765088   GH765776   GH765901   GH766023   GH766271   GH768938   GO254530
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JXB5 A8DYI3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034356    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034356 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034356 expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr    2137 embryo 08-10hr    3012 embryo 10-12hr    3896 embryo 12-14hr    2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2    1601 larva L3 12hr old    6842 larva L3 puffstage 1-2    5031 larva L3 puffstage 3-6    8072 larva L3 puffstage 7-9    8604 white prepupae new    6525 white prepupae 12hr    5862 white prepupae 24hr    4172 pupae 2d postWPP    2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr  (208) embryo 04-06hr  (575) embryo 06-08hr  (2137) embryo 08-10hr  (3012) embryo 10-12hr  (3896) embryo 12-14hr  (2295) embryo 14-16hr  (635) embryo 16-18hr  (345) embryo 18-20hr  (370) embryo 20-22hr  (289) embryo 22-24hr  (619) larva L1  (854) larva L2  (1601) larva L3 12hr old  (6842) larva L3 puffstage 1-2  (5031) larva L3 puffstage 3-6  (8072) larva L3 puffstage 7-9  (8604) white prepupae new  (6525) white prepupae 12hr  (5862) white prepupae 24hr  (4172) pupae 2d postWPP  (2027) pupae 3d postWPP  (859) pupae 4d postWPP  (547) adult male 01day  (470) adult male 05day  (535) adult male 30day  (365) adult female 01day  (332) adult female 05day  (275) adult female 30day  (189) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr  (2137) embryo 08-10hr  (3012) embryo 10-12hr  (3896) embryo 12-14hr  (2295) embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2  (1601) larva L3 12hr old  (6842) larva L3 puffstage 1-2  (5031) larva L3 puffstage 3-6  (8072) larva L3 puffstage 7-9  (8604) white prepupae new  (6525) white prepupae 12hr  (5862) white prepupae 24hr  (4172) pupae 2d postWPP  (2027) pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr    2137 embryo 08-10hr    3012 embryo 10-12hr    3896 embryo 12-14hr    2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2    1601 larva L3 12hr old    6842 larva L3 puffstage 1-2    5031 larva L3 puffstage 3-6    8072 larva L3 puffstage 7-9    8604 white prepupae new    6525 white prepupae 12hr    5862 white prepupae 24hr    4172 pupae 2d postWPP    2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr    2137 embryo 08-10hr    3012 embryo 10-12hr    3896 embryo 12-14hr    2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2    1601 larva L3 12hr old    6842 larva L3 puffstage 1-2    5031 larva L3 puffstage 3-6    8072 larva L3 puffstage 7-9    8604 white prepupae new    6525 white prepupae 12hr    5862 white prepupae 24hr    4172 pupae 2d postWPP    2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034356 expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr    2137 embryo 08-10hr    3012 embryo 10-12hr    3896 embryo 12-14hr    2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2    1601 larva L3 12hr old    6842 larva L3 puffstage 1-2    5031 larva L3 puffstage 3-6    8072 larva L3 puffstage 7-9    8604 white prepupae new    6525 white prepupae 12hr    5862 white prepupae 24hr    4172 pupae 2d postWPP    2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr  (208) embryo 04-06hr  (575) embryo 06-08hr  (2137) embryo 08-10hr  (3012) embryo 10-12hr  (3896) embryo 12-14hr  (2295) embryo 14-16hr  (635) embryo 16-18hr  (345) embryo 18-20hr  (370) embryo 20-22hr  (289) embryo 22-24hr  (619) larva L1  (854) larva L2  (1601) larva L3 12hr old  (6842) larva L3 puffstage 1-2  (5031) larva L3 puffstage 3-6  (8072) larva L3 puffstage 7-9  (8604) white prepupae new  (6525) white prepupae 12hr  (5862) white prepupae 24hr  (4172) pupae 2d postWPP  (2027) pupae 3d postWPP  (859) pupae 4d postWPP  (547) adult male 01day  (470) adult male 05day  (535) adult male 30day  (365) adult female 01day  (332) adult female 05day  (275) adult female 30day  (189) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr  2137 embryo 08-10hr  (3012) embryo 10-12hr  (3896) embryo 12-14hr  2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2  1601 larva L3 12hr old  (6842) larva L3 puffstage 1-2  (5031) larva L3 puffstage 3-6  (8072) larva L3 puffstage 7-9  (8604) white prepupae new  (6525) white prepupae 12hr  (5862) white prepupae 24hr  (4172) pupae 2d postWPP  2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr    2137 embryo 08-10hr    3012 embryo 10-12hr    3896 embryo 12-14hr    2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2    1601 larva L3 12hr old    6842 larva L3 puffstage 1-2    5031 larva L3 puffstage 3-6    8072 larva L3 puffstage 7-9    8604 white prepupae new    6525 white prepupae 12hr    5862 white prepupae 24hr    4172 pupae 2d postWPP    2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    208 embryo 04-06hr    575 embryo 06-08hr    2137 embryo 08-10hr    3012 embryo 10-12hr    3896 embryo 12-14hr    2295 embryo 14-16hr    635 embryo 16-18hr    345 embryo 18-20hr    370 embryo 20-22hr    289 embryo 22-24hr    619 larva L1    854 larva L2    1601 larva L3 12hr old    6842 larva L3 puffstage 1-2    5031 larva L3 puffstage 3-6    8072 larva L3 puffstage 7-9    8604 white prepupae new    6525 white prepupae 12hr    5862 white prepupae 24hr    4172 pupae 2d postWPP    2027 pupae 3d postWPP    859 pupae 4d postWPP    547 adult male 01day    470 adult male 05day    535 adult male 30day    365 adult female 01day    332 adult female 05day    275 adult female 30day    189 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034356    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034356 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034356 expression level Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body    4326.9 Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body  (4326.9) Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body  (4326.9) Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body    4326.9 Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034356 expression level Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body    4326.9 Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body  (4326.9) Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body  (4326.9) Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    494.8 Larval Hindgut no informative data Larval Malpighian Tubules    194.3 Larval Fat Body    4326.9 Larval Salivary Gland no informative data Larval Trachea    22.7 Larval Carcass no informative data Adult Head    74.3 Adult Eye    26.4 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    2.2 Adult Crop    2.3 Adult Midgut    161.7 Adult Hindgut no informative data Adult Malpighian Tubules    101.1 Adult Fat Body    179.6 Adult Salivary Gland    3.6 Adult Heart    112 Adult VirginFemale Spermatheca    161.8 Adult InseminatedFemale Spermatheca    176.4 Adult Ovary    2.5 Adult Testis    0.8 Adult Male Accessory Gland    1.4 Adult Carcass    183.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    74.3   NA  Eye    26.4   NA  Brain    3.5   2.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.2   NA  Crop    2.3   494.8  Midgut    161.7   no informative data  Hindgut    no informative data   194.3  Malpighian Tubules    101.1   4326.9  Fat Body    179.6   no informative data  Salivary Gland    3.6   NA  Heart    112   22.7  Trachea    NA   NA  VirginFemale Spermatheca    161.8   NA  InseminatedFemale Spermatheca    176.4   NA  Ovary    2.5   NA  Testis    0.8   NA  Male Accessory Gland    1.4   no informative data  Carcass    183.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034356 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10924-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG10924 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG10924e03788 viable, with Scer\GAL4pnr-MD237 CG10924GD5767 Sterility Allele fertile CG10924e03788 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG10924 Class Mutagen Stocks Known lesion CG10924e03788 piggyBac transposase 2 -- CG10924f03297 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10924 Class Mutagen Stocks Known lesion CG10924GD5767 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG10924KK103240 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5767} NA P{KK103240} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG10924e03788 NA PBac{WH}CG10924f03297 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
GTP binding inferred from electronic annotation with InterPro:IPR008209 (FlyBase Curators et al., 2004-) phosphoenolpyruvate carboxykinase (GTP) activity inferred from sequence or structural similarity with EMBL:AF009605 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q16822 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
gluconeogenesis inferred from sequence or structural similarity with UniProtKB:Q16822 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity with UniProtKB:Q16822 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10924 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62805 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034356 DroID - A comprehensive database of gene and protein interactions. • FBgn0034356 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37130
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11970 Dere\GG21903 Dgri\GH22961 Dmoj\GI18449 Dpse\GA10647 Dsec\GM21894 Dsim\GD11391 Dvir\GJ21534 Dwil\GK17956 Dyak\GE11979
Curated drosophilid orthologs	Dpse\GA10647
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_396295.2 Apis mellifera (honey bee) BGIBMGA004276-PA Bombyx mori (silk worm) ENSBTAP00000015834 Bos taurus (bovine) CN10019 Caenorhabditis brenneri (small nematode) CN12395 Caenorhabditis brenneri (small nematode) CBP00083 Caenorhabditis briggsae (nematode) CE12728 Caenorhabditis elegans (worm) ENSCPOP00000005929 Cavia porcellus (guinea pig) ENSCPOP00000009803 Cavia porcellus (guinea pig) RP28879 Caenorhabditis remanei (nematode) 212175 Daphnia pulex (daphnia) GL50803_10623 Giardia lamblia (flagellated protozoan) 178121 Lottia gigantea (owl limpet) ENSMUSP00000038555 Mus musculus (house mouse) 103590 Nematostella vectensis (starlet anemone) PP04915 Pristionchus pacificus (nematode) ENSPPYP00000006459 Pongo pygmaeus (orangutan) ENSPPYP00000012471 Pongo pygmaeus (orangutan) ENSRNOP00000025260 Rattus norvegicus (norway rat) XP_001182045.1 Strongylocentrotus purpuratus (purple sea urchin) ENSXETP00000031961 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12676 PB10905 NV17655 LH13186 LH13182 ISCW001902 ISCW000524 FBgn0229758 FBgn0229757 FBgn0219956 FBgn0219955 FBgn0208655 FBgn0208654 FBgn0183141 FBgn0183140 FBgn0176772 FBgn0176771 JGI_V11_314004 JGI_V11_212175 FBgn0074655 FBgn0070703 FBgn0154687 FBgn0154686 FBgn0141188 FBgn0141189 FBgn0003067 FBgn0130420 FBgn0130418 FBgn0114082 FBgn0114081 FBgn0089010 FBgn0089009 CPIJ010518 CPIJ010515 CPIJ010516 BGIBMGA004276 BGIBMGA004277 ACYPI001978 GB16196 AGAP003350 AAEL000080 AAEL000025 AAEL000006 PHUM368600 GLEAN_09072
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18191 w1118; PBac{RB}CG10924e03788
Harvard	- PBac{RB}CG10924e03788 - PBac{WH}CG10924f03297
VDRC	v107092 P{KK103240}VIE-260B v13929 w1118; P{GD5767}v13929 v13930 w1118; P{GD5767}v13930
Genomic Clones ( 1 )
	BACR27L09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE12569
Other clones	DPiM_RE12569
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD21035 LP02569 LP15455 LP16272 LP19339 RE25196 RE27763 RE34507 RE69407 RE72436 SD13430
Other clones	17190 121672 CK01.98D.H2 Dmel_dig_015424_0639_2333 EC13788 EC32443 EK066006 EK173232 EK173253 IP16725 RP01304 RP01587 RP001000354 RP001001978 RP001002678 RP001003825 RP001004915 RP001008395 RP001009415 RP001016225 RP001020205 RP001030176 RP001033480 RP001033752 RP001040436 RP001040550 RP001044520 RP001047531 RP001051564 RP001052151 RP001052455 RP001055899 SD07785
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034356 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37130
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137497 NM_001103897 RefSeq (Proteins) • NP_611341 NP_001097367 DDBJ / EMBL / GenBank • AAF57677 AAM11205 ABV53844 AY094852 BI170937 CZ481544 CZ485840 Entrez Gene - A searchable database of RefSeq genes. • 37130 UniProtKB/TrEMBL • A8DYI3 Q7JXB5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphoenolpyruvate carboxykinase, GTP-utilising (IPR008209) Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site (IPR018091) Phosphoenolpyruvate carboxykinase, C-terminal (IPR013035) Phosphoenolpyruvate carboxykinase, N-terminal (IPR008210) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME10924
Linkouts
	BioGRID - A database of protein and genetic interactions • 62805 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034356 DroID - A comprehensive database of gene and protein interactions. • FBgn0034356 DRSC - Results from RNAi screens. • FBgn0034356 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034356 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10924-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034356 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37130 InParanoid A subset of ortholog calls from InParanoid. • XP_396295.2 Apis mellifera (honey bee) BGIBMGA004276-PA Bombyx mori (silk worm) ENSBTAP00000015834 Bos taurus (bovine) CN10019 Caenorhabditis brenneri (small nematode) CN12395 Caenorhabditis brenneri (small nematode) CBP00083 Caenorhabditis briggsae (nematode) CE12728 Caenorhabditis elegans (worm) ENSCPOP00000005929 Cavia porcellus (guinea pig) ENSCPOP00000009803 Cavia porcellus (guinea pig) RP28879 Caenorhabditis remanei (nematode) 212175 Daphnia pulex (daphnia) GL50803_10623 Giardia lamblia (flagellated protozoan) 178121 Lottia gigantea (owl limpet) ENSMUSP00000038555 Mus musculus (house mouse) 103590 Nematostella vectensis (starlet anemone) PP04915 Pristionchus pacificus (nematode) ENSPPYP00000006459 Pongo pygmaeus (orangutan) ENSPPYP00000012471 Pongo pygmaeus (orangutan) ENSRNOP00000025260 Rattus norvegicus (norway rat) XP_001182045.1 Strongylocentrotus purpuratus (purple sea urchin) ENSXETP00000031961 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37130 modMine - Data generated by the modENCODE project. • FBgn0034356 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12676 PB10905 NV17655 LH13186 LH13182 ISCW001902 ISCW000524 FBgn0229758 FBgn0229757 FBgn0219956 FBgn0219955 FBgn0208655 FBgn0208654 FBgn0183141 FBgn0183140 FBgn0176772 FBgn0176771 JGI_V11_314004 JGI_V11_212175 FBgn0074655 FBgn0070703 FBgn0154687 FBgn0154686 FBgn0141188 FBgn0141189 FBgn0003067 FBgn0130420 FBgn0130418 FBgn0114082 FBgn0114081 FBgn0089010 FBgn0089009 CPIJ010518 CPIJ010515 CPIJ010516 BGIBMGA004276 BGIBMGA004277 ACYPI001978 GB16196 AGAP003350 AAEL000080 AAEL000025 AAEL000006 PHUM368600 GLEAN_09072
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10924 (Zraly et al., 2006, Ranade et al., 2008, Hurlbut et al., 2009, O'Keefe et al., 2011, Telonis-Scott et al., 2009, Teleman et al., 2008, Keleman et al., 2009.8.5, Kent et al., 2009, Morozova et al., 2007, Fernández-Ayala et al., 2010, Cammarato et al., 2011)
Name Synonym
Secondary FlyBase IDs
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Show all research papers ...