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Gene: Dmel\Atg7

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General Information
Symbol
Dmel\Atg7
Species
D. melanogaster
Name
Autophagy-related 7
Annotation Symbol
CG5489
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034366
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
E1 ubiquitin-activating enzyme (6.2.1.45)
Gene Snapshot
Autophagy-related 7 is an E1-type ligase for the autophagic ubiquitin-like proteins Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. [Date last reviewed: 2016-06-30]
Other Summaries
Also Known As
atg-7
Key Links
Genomic Location
Cytogenetic map
55E2-55E2
Sequence location
2R:18,620,466..18,625,044 [-]
Recombination map
2-86
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
THIF-type NAD/FAD binding fold; Ubiquitin-like modifier-activating enzyme Atg7; Ubiquitin-like modifier-activating enzyme Atg7, N-terminal; Ubiquitin-activating enzyme
Molecular Function (see GO section for details)
Experimental Evidence
Atg8 activating enzyme activity; NOT ubiquitin activating enzyme activity
Predictions / Assertions
Atg12 activating enzyme activity; Atg8 activating enzyme activity
Catalytic Activity (EC)
Experimental Evidence
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine (6.2.1.45)
Predictions / Assertions
-
Summaries
Gene Group Membership
UBIQUITIN ACTIVATING ENZYMES -
E1 enzymes use ATP to activate the carboxyl terminus of ubiquitin or ubiquitin-like proteins forming a high-energy AMP conjugate, which is then subsequently transferred to the E1 active site cysteine to form a thioester intermediate. In many cases, the ubiquitin/ubiquitin-like molecule is then transferred to an E2 active site cysteine via trans-thioesterification. (Adapted from PMID:23800009).
AUTOPHAGY-RELATED GENES -
The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Atg7 or the JBrowse view of Dmel\Atg7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atg7-RA
FBtr0086712
NM_137506
2395
684
Atg7-RB
FBtr0086711
NM_166298
1873
510
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Atg7-PA
FBpp0085891
76.8
684
6.00
NP_611350
AAF57665
Atg7-PB
FBpp0085890
56.9
510
5.79
NP_725809
AAF57666
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg7 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (25 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Atg8 activating enzyme activity
inferred from direct assay
(Chang et al., 2013)
NOT ubiquitin activating enzyme activity
inferred from direct assay
(Chang et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Atg12 activating enzyme activity
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
Atg8 activating enzyme activity
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (20 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
autophagy
inferred from mutant phenotype
(Wen et al., 2017, Xu et al., 2015)
cellular response to starvation
inferred from mutant phenotype
(Hou et al., 2008)
determination of adult lifespan
inferred from mutant phenotype
(Juhász et al., 2007)
larval midgut cell programmed cell death
inferred from mutant phenotype
(Juhász et al., 2007)
NOT larval midgut cell programmed cell death
inferred from mutant phenotype
(Chang et al., 2013)
macroautophagy
inferred from mutant phenotype
(Juhász et al., 2007, Scott et al., 2004)
oogenesis
inferred from mutant phenotype
(Hou et al., 2008)
positive regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
protein lipidation
inferred from mutant phenotype
(Chang et al., 2013)
protein modification by small protein conjugation
inferred from direct assay
(Chang et al., 2013)
regulation of autophagy
inferred from mutant phenotype
(Pircs et al., 2012, Barth et al., 2011)
regulation of defense response to virus
inferred from mutant phenotype
(Shelly et al., 2009)
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
autophagosome assembly
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
autophagy
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
autophagy of mitochondrion
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
C-terminal protein lipidation
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
cellular response to nitrogen starvation
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
late nucleophagy
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of apoptotic process
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
negative regulation of cell death
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
piecemeal microautophagy of the nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
protein modification by small protein conjugation
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
regulation of hemopoiesis
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000102039
(assigned by GO_Central )
(Gaudet et al., 2011)
phagophore assembly site
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
salivary gland
(Lee et al., 2003)
Additional Descriptive Data
The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.
(Lee et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atg7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Allele of Atg7
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Atg7d77
0
Yes
Atg7d14
0
Yes
Atg7d4
0
Yes
Atg7d06996
3
Yes
Atg7d30
0
Yes
Atg7CR00724-TG4.0
1
Yes
Atg7d05866
1
Yes
Atg7d7
    0
    --
    Atg7G8010
    0
    --
    Atg7unspecified
      0
      --
      Other relevant insertions
      insertion of mobile activating element
      Name
      Expression Data
      P{EPgy2}Sec6EY10058
      NA
      Transgenic Constructs ( 6 )
      Deletions and Duplications ( 3 )
      Summary of Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      viable
      viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
      viable, with Scer\GAL4Mef2.PR
      viable, with Scer\GAL4pnr-MD237
      viable, with Scer\GAL4tin.CΔ4
      viable (with Atg7d14)
      viable (with Atg7d77)
      Other Phenotypes
      Allele
      chemical sensitive (with Atg7d14)
      chemical sensitive (with Atg7d77)
      decreased cell death | adult stage | nutrition conditional (with Atg7d14)
      decreased cell death | adult stage | nutrition conditional (with Atg7d77)
      decreased cell death | prepupal stage (with Atg7d14)
      decreased cell death | prepupal stage (with Atg7d77)
      decreased cell death | somatic clone
      immune response defective | adult stage, with Scer\GAL4hs.PB
      immune response defective | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
      increased cell death | adult stage (with Atg7d14)
      increased cell death | adult stage (with Atg7d77)
      long lived, with Scer\GAL4Appl.PU
      long lived, with Scer\GAL4hs.PU
      memory defective | progressive (with Atg7d14)
      memory defective | progressive (with Atg7d77)
      neuroanatomy defective (with Atg7d14)
      neuroanatomy defective (with Atg7d77)
      short lived, with Scer\GAL4hs.PU
      short lived (with Atg7d14)
      short lived (with Atg7d77)
      size defective | adult stage (with Atg7d14)
      size defective | adult stage (with Atg7d77)
      starvation stress response defective | larval stage, with Scer\GAL4Cg.PU
      stress response defective (with Atg7d14)
      stress response defective (with Atg7d77)
      visible, with Scer\GAL4GMR.PU
      Phenotype manifest in
      Allele
      adult brain (with Atg7d14)
      adult brain (with Atg7d77)
      adult fat body | nutrition conditional, with Scer\GAL4Tub.PU
      adult gut (with Atg7d14)
      adult gut (with Atg7d77)
      autophagic vacuole & larval midgut (with Atg7d14)
      autophagic vacuole & larval midgut (with Atg7d77)
      autophagosome, with Scer\GAL4unspecified
      autophagosome | adult stage | nutrition conditional, with Scer\GAL4Tub.PU
      egg
      egg chamber | nutrition conditional (with Atg7d14)
      egg chamber | nutrition conditional (with Atg7d77)
      egg chamber | somatic clone
      embryonic/larval fat body | larval stage, with Scer\GAL4Cg.PU
      embryonic/larval fat body | third instar larval stage (with Atg7d14)
      embryonic/larval fat body | third instar larval stage (with Atg7d77)
      embryonic/larval midgut | prepupal stage (with Atg7d14)
      embryonic/larval midgut | prepupal stage (with Atg7d77)
      eye, with Scer\GAL4GMR.PU
      female germline cyst | nutrition conditional (with Atg7d14)
      female germline cyst | nutrition conditional (with Atg7d77)
      gamma Kenyon cell (with Atg7d14)
      gamma Kenyon cell (with Atg7d77)
      germarium | somatic clone
      germarium region 2 | nutrition conditional (with Atg7d14)
      germarium region 2 | nutrition conditional (with Atg7d77)
      intestinal stem cell | chemical conditional, with Scer\GAL4NP0001
      intestinal stem cell | chemical conditional, with Scer\GAL4NP5130
      lysosome | adult stage | nutrition conditional, with Scer\GAL4Tub.PU
      major mitochondrial derivative, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
      major mitochondrial derivative (with Atg7d14)
      major mitochondrial derivative (with Atg7d77)
      ommatidium, with Scer\GAL4GMR.PU
      prothoracic gland | third instar larval stage, with Scer\GAL4phm.PO
      rhabdomere
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Download All OrthoDB Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      Isobase
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      RoundUp
      TreeFam
      ZFIN
      Alignment
      Complementation?
      Transgene?
      Hsap\ATG7
      14 of 15
      Yes
      Yes
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      Isobase
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      RoundUp
      TreeFam
      ZFIN
      Alignment
      Complementation?
      Transgene?
      Mmus\Atg7
      13 of 15
      Yes
      Yes
      Rattus norvegicus (Norway rat) (1)
      Rnor\Atg7
      12 of 13
      Yes
      Yes
      Xenopus tropicalis (Western clawed frog) (1)
      Xtro\atg7
      2 of 12
      Yes
      Yes
      Danio rerio (Zebrafish) (1)
      Drer\atg7
      2 of 15
      Yes
      Yes
      Caenorhabditis elegans (Nematode, roundworm) (1)
      Cele\atg-7
      12 of 15
      Yes
      Yes
      Arabidopsis thaliana (thale-cress) (1)
      Atha\APG7
      9 of 9
      Yes
      Yes
      Saccharomyces cerevisiae (Brewer's yeast) (1)
      Scer\ATG7
      14 of 15
      Yes
      Yes
      Schizosaccharomyces pombe (Fission yeast) (1)
      Spom\atg7
      12 of 12
      Yes
      Yes
      Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903IE )
      Organism
      Common Name
      Gene
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila melanogaster
      fruit fly
      Dmel\Atg7
      Drosophila suzukii
      Spotted wing Drosophila
      Dsuz\DS10_00005706
      Drosophila simulans
      Dsim\GD25379
      Drosophila sechellia
      Dsec\GM19894
      Drosophila erecta
      Dere\GG20962
      Drosophila yakuba
      Dyak\GE13902
      Drosophila ananassae
      Dana\GF12940
      Drosophila pseudoobscura pseudoobscura
      Dpse\GA30501
      Drosophila persimilis
      Dper\GL17443
      Drosophila willistoni
      Dwil\GK21355
      Drosophila virilis
      Dvir\GJ21152
      Drosophila mojavensis
      Dmoj\GI19577
      Drosophila grimshawi
      Dgri\GH21606
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502T2 )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Musca domestica
      House fly
      Mdoa\17017598
      Glossina morsitans
      Tsetse fly
      Gmor\GMOY010920
      Lucilia cuprina
      Australian sheep blowfly
      Lcup\FF38_11392
      Mayetiola destructor
      Hessian fly
      Mdes\Mdes007464
      Aedes aegypti
      Yellow fever mosquito
      Aaeg\AAEL009814
      Anopheles gambiae
      Malaria mosquito
      Agam\AGAP010303
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02KH )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Bombyx mori
      Silkmoth
      Bmor\BGIBMGA001467
      Danaus plexippus
      Monarch butterfly
      Dple\DPOGS208037-PA
      Heliconius melpomene
      Postman butterfly
      Hmel\HMEL004052
      Apis florea
      Little honeybee
      Aflo\2542875524
      Apis mellifera
      Western honey bee
      Amel\LOC726637
      Bombus impatiens
      Common eastern bumble bee
      Bimp\BIMP22379
      Bombus terrestris
      Buff-tailed bumblebee
      Bter\15208053
      Linepithema humile
      Argentine ant
      Lhum\LH11154
      Megachile rotundata
      Alfalfa leafcutting bee
      Mrot\MROTU:002788
      Nasonia vitripennis
      Parasitic wasp
      Nvit\Nasvi2EG000710
      Dendroctonus ponderosae
      Mountain pine beetle
      Dpod\YQE_00231
      Dendroctonus ponderosae
      Mountain pine beetle
      Dpod\YQE_10049
      Tribolium castaneum
      Red flour beetle
      Tcas\TC010974
      Pediculus humanus
      Human body louse
      Phum\PHUM397480
      Rhodnius prolixus
      Kissing bug
      Rpro\RPRC012046
      Rhodnius prolixus
      Kissing bug
      Rpro\RPRC012048
      Cimex lectularius
      Bed bug
      Clec\CLEC000439
      Acyrthosiphon pisum
      Pea aphid
      Apim\ACYPI008937
      Zootermopsis nevadensis
      Nevada dampwood termite
      Znev\Znev_17566
      Zootermopsis nevadensis
      Nevada dampwood termite
      Znev\Znev_04460
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02HT )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strigamia maritima
      European centipede
      Smar\SMAR007013
      Ixodes scapularis
      Black-legged tick
      Isca\ISCW008151
      Stegodyphus mimosarum
      African social velvet spider
      Smim\KFM67470.1
      Tetranychus urticae
      Two-spotted spider mite
      Turt\tetur04g02140
      Daphnia pulex
      Water flea
      Dpux\DAPPUDRAFT_302357
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0628 )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strongylocentrotus purpuratus
      Purple sea urchin
      Spur\Sp-Apg7l
      Ciona intestinalis
      Vase tunicate
      Cint\ENSCING00000004841
      Gallus gallus
      Domestic chicken
      Ggal\ATG7
      Human Disease Model Data
      FlyBase Human Disease Model Reports
        Alleles Reported to Model Human Disease (Disease Ontology)
        Download
        Models ( 0 )
        Allele
        Disease
        Evidence
        References
        Interactions ( 2 )
        Comments ( 0 )
         
        Human Orthologs (via DIOPT v7.1)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        Complementation?
        Transgene?
        ATG7; autophagy related 7
        14 of 15
        608760
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please look at the Interaction Group reports for full details of the physical interactions
          protein-protein
          Interacting group
          Assay
          References
          Atg7 - Atg8a
          experimental knowledge based
          (Guruharsha et al., 2011)
          RNA-protein
          Interacting group
          Assay
          References
          Atg7 - orb
          anti tag coimmunoprecipitation, quantitative reverse transcription pcr, pull down, western blot
          (Rojas-Ríos et al., 2015)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Acn
          suppressible
          Atg7
          (Nandi et al., 2014)
          Atg9
          suppressible
          Atg7
          (Tang et al., 2013)
          Dcp-1
          suppressible
          Atg7
          (Kim et al., 2010)
          dom
          enhanceable
          Atg7
          (Kwon et al., 2013)
          Hsp27
          suppressible
          Atg7
          (Chen et al., 2012)
          Lrrk
          enhanceable
          Atg7
          (Dodson et al., 2014)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Pathways
          Gene Group - Pathway Membership (FlyBase)
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-86
          Cytogenetic map
          55E2-55E2
          Sequence location
          2R:18,620,466..18,625,044 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          55E2-55E2
          Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)0370903709
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location
          2-86
          (FlyBase, 2016)
          2-91.0
          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (11)
          Genomic Clones (17)
          cDNA Clones (46)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: Atg7 CG5489
          (Scott et al., 2004)
          Source for database merge of
          Additional comments
          Other Comments
          Atg7 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.
          (Politi et al., 2014)
          Atg7 mutants are viable and no major morphological defects are seen during metamorphosis. The mutant adults are hypersensitive to stress and have a reduced life span.
          (Juhász et al., 2007)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 38 )
          Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          InterPro - A database of protein families, domains and functional sites
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DPiM - Drosophila Protein interaction map
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Synonyms and Secondary IDs (10)
          Reported As
          Symbol Synonym
          ATG7
          (Kourtis and Tavernarakis, 2009)
          Atg7
          (Chakraborty et al., 2018, Gene Disruption Project members, 2018-, Kuo et al., 2018, O'Keefe and Denton, 2018, Richardson and Portela, 2018, Swevers et al., 2018, Galluzzi et al., 2017, Kim et al., 2017, Kim et al., 2017, Lei et al., 2017, Lo Piccolo et al., 2017, Manent et al., 2017, Nagy et al., 2017, Péan et al., 2017, Schopf and Huber, 2017, Tusco et al., 2017, Wen et al., 2017, Danielsen et al., 2016, Lee et al., 2016, Lőrincz et al., 2016, Mao et al., 2016, Varga et al., 2016, Zheng et al., 2016, Bargiela et al., 2015, Carnes et al., 2015, Denton et al., 2015, Johnson et al., 2015, Kim et al., 2015, Nagy et al., 2015, Tian et al., 2015, Xu et al., 2015, Zhang and Baehrecke, 2015, Zirin et al., 2015, Banreti et al., 2014, Burke et al., 2014, DeVorkin et al., 2014, Issman-Zecharya and Schuldiner, 2014, Liu et al., 2014, Moy et al., 2014, Mulakkal et al., 2014, Nagy et al., 2014, Nandi et al., 2014, Takáts et al., 2014, Chang et al., 2013, Denton et al., 2013, Gupta et al., 2013, Lin et al., 2013, Moy and Cherry, 2013, Shin et al., 2013, Shravage et al., 2013, Takáts et al., 2013, Tang et al., 2013, Velentzas et al., 2013, Vincow et al., 2013, Wen et al., 2013, Xiong and Bellen, 2013, Yacobi-Sharon et al., 2013, Chen et al., 2012, Eleftherianos and Castillo, 2012, Érdi et al., 2012, Garcia et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Pircs et al., 2012, Wang et al., 2012, Barth et al., 2011, Bartlett et al., 2011, Du et al., 2011, Lee et al., 2011, Tang et al., 2011, Bakhrat et al., 2010, Chi et al., 2010, Demontis and Perrimon, 2010, Filimonenko et al., 2010, Kadandale et al., 2010, Kim et al., 2010, LaFever et al., 2010, Wasbrough et al., 2010, Zirin and Perrimon, 2010, Ren et al., 2009, Shelly et al., 2009, Chen et al., 2008, Hou et al., 2008, Liu and Lehmann, 2008, Juhasz et al., 2007, Juhász et al., 2007, Zeitouni et al., 2007)
          CG5489
          (Tsou et al., 2015, Fukuoh et al., 2014, Érdi et al., 2012, Ni et al., 2010.12.1, Perkins et al., 2009, Lee et al., 2003)
          atg-7
          (Nezis, 2012, Midorikawa et al., 2010)
          atg7
          (Singh and Chowdhuri, 2018, Sato and Sato, 2017, Cai et al., 2016, Zhuang et al., 2016, Rui et al., 2015, Dodson et al., 2014, Kuang et al., 2014, Politi et al., 2014, Kwon et al., 2013, Yacobi-Sharon et al., 2013, Minois et al., 2012, Chi et al., 2010, Nezis et al., 2009, Shelly et al., 2009, Wang et al., 2009)
          dAtg7
          (Li et al., 2016)
          Name Synonyms
          Autophagy-related 7
          (Carnes et al., 2015)
          Autophagy-specific gene 7
          (Scott et al., 2004, Scott et al., 2004)
          autophagy-related gene 7
          (Chen et al., 2012, Minois et al., 2012)
          autophagy-related protein 7
          (Nezis, 2012, Midorikawa et al., 2010)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (159)