FB2020_01, released Feb 12, 2020

Gene: Dmel\Atg7

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General Information
Symbol
Dmel\Atg7
Species
D. melanogaster
Name
Autophagy-related 7
Annotation Symbol
CG5489
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034366
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

atg-7, Autophagy-specific gene 7, autophagy-related protein 7, autophagy-related gene 7

Key Links
Genomic Location
Cytogenetic map
55E2-55E2
Sequence location
2R:18,620,466..18,625,044 [-]
Recombination map

2-86

RefSeq locus
NT_033778 REGION:18620466..18625044
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Atg8 activating enzyme activity
Predictions / Assertions
Atg12 activating enzyme activity; Atg8 activating enzyme activity
Summaries
Gene Group (FlyBase)
AUTOPHAGY-RELATED GENES -
The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).
ATG8/12 ACTIVATING ENZYMES -
ATG8/12 activating enzymes are 'non-canonical' E1 enzymes that form obligate homodimers and activate the ubiquitin-like proteins ATG8 and ATG12 for subsequent steps along their respective conjugation cascades. (Adapted from PMID:28234446.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Atg7 or the JBrowse view of Dmel\Atg7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atg7-RA
FBtr0086712
NM_137506
2395
684
Atg7-RB
FBtr0086711
NM_166298
1873
510
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Atg7-PA
FBpp0085891
76.8
684
6.00
NP_611350
AAF57665
Atg7-PB
FBpp0085890
56.9
510
5.79
NP_725809
AAF57666
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg7 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (24 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Atg8 activating enzyme activity
inferred from direct assay
(Chang et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Atg12 activating enzyme activity
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
Atg8 activating enzyme activity
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (20 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
autophagy
inferred from mutant phenotype
(Wen et al., 2017, Xu et al., 2015)
cellular response to starvation
inferred from mutant phenotype
(Hou et al., 2008)
determination of adult lifespan
inferred from mutant phenotype
(Juhász et al., 2007)
larval midgut cell programmed cell death
inferred from mutant phenotype
(Juhász et al., 2007)
NOT larval midgut cell programmed cell death
inferred from mutant phenotype
(Chang et al., 2013)
macroautophagy
inferred from mutant phenotype
(Juhász et al., 2007, Scott et al., 2004)
oogenesis
inferred from mutant phenotype
(Hou et al., 2008)
positive regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
protein lipidation
inferred from mutant phenotype
(Chang et al., 2013)
protein modification by small protein conjugation
inferred from direct assay
(Chang et al., 2013)
regulation of autophagy
inferred from mutant phenotype
(Pircs et al., 2012, Barth et al., 2011)
regulation of defense response to virus
inferred from mutant phenotype
(Shelly et al., 2009)
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
autophagosome assembly
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
autophagy
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
autophagy of mitochondrion
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
C-terminal protein lipidation
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
cellular response to nitrogen starvation
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
late nucleophagy
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of apoptotic process
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
negative regulation of cell death
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
piecemeal microautophagy of the nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
protein modification by small protein conjugation
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000102039
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of hemopoiesis
inferred from sequence or structural similarity with UniProtKB:Q9D906
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000102040
(assigned by GO_Central )
(Gaudet et al., 2011)
phagophore assembly site
inferred from biological aspect of ancestor with PANTHER:PTN000102341
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000001214
(FlyBase Curators, 2008--)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
salivary gland
(Lee et al., 2003)
Additional Descriptive Data

The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.

(Lee et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atg7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atg7
Transgenic constructs containing regulatory region of Atg7
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Atg7d14)
viable (with Atg7d77)
Other Phenotypes
Allele
chemical sensitive (with Atg7d14)
chemical sensitive (with Atg7d77)
decreased cell death | adult stage | nutrition conditional (with Atg7d14)
decreased cell death | adult stage | nutrition conditional (with Atg7d77)
decreased cell death | prepupal stage (with Atg7d14)
decreased cell death | prepupal stage (with Atg7d77)
decreased cell death | somatic clone
decreased cell number | dominant | larval stage
immune response defective | adult stage, with Scer\GAL4hs.PB
immune response defective | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
increased cell death | adult stage (with Atg7d14)
increased cell death | adult stage (with Atg7d77)
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
long lived, with Scer\GAL4Appl.PU
long lived, with Scer\GAL4hs.PU
memory defective | progressive (with Atg7d14)
memory defective | progressive (with Atg7d77)
neuroanatomy defective (with Atg7d14)
neuroanatomy defective (with Atg7d77)
short lived, with Scer\GAL4hs.PU
short lived (with Atg7d14)
short lived (with Atg7d77)
size defective | adult stage (with Atg7d14)
size defective | adult stage (with Atg7d77)
starvation stress response defective | larval stage, with Scer\GAL4Cg.PU
stress response defective (with Atg7d14)
stress response defective (with Atg7d77)
visible, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
adult brain (with Atg7d14)
adult brain (with Atg7d77)
adult fat body | nutrition conditional, with Scer\GAL4Tub.PU
adult gut (with Atg7d14)
adult gut (with Atg7d77)
adult midgut epithelium, with Scer\GAL4esg.PU
autophagic vacuole & larval midgut (with Atg7d14)
autophagic vacuole & larval midgut (with Atg7d77)
autophagosome, with Scer\GAL4unspecified
autophagosome | adult stage | nutrition conditional, with Scer\GAL4Tub.PU
egg
egg chamber | nutrition conditional (with Atg7d14)
egg chamber | nutrition conditional (with Atg7d77)
egg chamber | somatic clone
embryonic/larval fat body | larval stage, with Scer\GAL4Cg.PU
embryonic/larval fat body | third instar larval stage (with Atg7d14)
embryonic/larval fat body | third instar larval stage (with Atg7d77)
embryonic/larval midgut | prepupal stage (with Atg7d14)
embryonic/larval midgut | prepupal stage (with Atg7d77)
eye, with Scer\GAL4GMR.PU
female germline cyst | nutrition conditional (with Atg7d14)
female germline cyst | nutrition conditional (with Atg7d77)
gamma Kenyon cell (with Atg7d14)
gamma Kenyon cell (with Atg7d77)
germarium | somatic clone
germarium region 2 | nutrition conditional (with Atg7d14)
germarium region 2 | nutrition conditional (with Atg7d77)
intestinal stem cell | chemical conditional, with Scer\GAL4NP0001
intestinal stem cell | chemical conditional, with Scer\GAL4NP5130
lysosome | adult stage | nutrition conditional, with Scer\GAL4Tub.PU
major mitochondrial derivative, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
major mitochondrial derivative (with Atg7d14)
major mitochondrial derivative (with Atg7d77)
ommatidium, with Scer\GAL4GMR.PU
prothoracic gland | third instar larval stage, with Scer\GAL4phm.PO
rhabdomere
RP2 motor neuron | larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATG7
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atg7
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Atg7
12 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\atg7
2 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\atg7
2 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\atg-7
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\APG7
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ATG7
14 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\atg7
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903IE )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Atg7
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005706
Drosophila simulans
Dsim\GD25379
Drosophila sechellia
Dsec\GM19894
Drosophila erecta
Dere\GG20962
Drosophila yakuba
Dyak\GE13902
Drosophila ananassae
Dana\GF12940
Drosophila pseudoobscura pseudoobscura
Dpse\GA30501
Drosophila persimilis
Dper\GL17443
Drosophila willistoni
Dwil\GK21355
Drosophila virilis
Dvir\GJ21152
Drosophila mojavensis
Dmoj\GI19577
Drosophila grimshawi
Dgri\GH21606
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502T2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017598
Glossina morsitans
Tsetse fly
Gmor\GMOY010920
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11392
Mayetiola destructor
Hessian fly
Mdes\Mdes007464
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009814
Anopheles gambiae
Malaria mosquito
Agam\AGAP010303
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02KH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001467
Danaus plexippus
Monarch butterfly
Dple\DPOGS208037-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004052
Apis florea
Little honeybee
Aflo\2542875524
Apis mellifera
Western honey bee
Amel\LOC726637
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22379
Bombus terrestris
Buff-tailed bumblebee
Bter\15208053
Linepithema humile
Argentine ant
Lhum\LH11154
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002788
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000710
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00231
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10049
Tribolium castaneum
Red flour beetle
Tcas\TC010974
Pediculus humanus
Human body louse
Phum\PHUM397480
Rhodnius prolixus
Kissing bug
Rpro\RPRC012046
Rhodnius prolixus
Kissing bug
Rpro\RPRC012048
Cimex lectularius
Bed bug
Clec\CLEC000439
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008937
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17566
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04460
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02HT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007013
Ixodes scapularis
Black-legged tick
Isca\ISCW008151
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67470.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02140
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302357
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0628 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Apg7l
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004841
Gallus gallus
Domestic chicken
Ggal\ATG7
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Aos1
1 of 10
APP-BP1
1 of 10
Uba1
1 of 10
Uba2
1 of 10
Uba3
1 of 10
Uba4
1 of 10
Uba5
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATG7; autophagy related 7
    14 of 15
    608760
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Atg7 - Atg8a
        experimental knowledge based
        (Guruharsha et al., 2011)
        RNA-protein
        Physical Interaction
        Assay
        References
        Atg7 - orb
        pull down, western blot, anti tag coimmunoprecipitation, quantitative reverse transcription pcr
        (Rojas-Ríos et al., 2015)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Atg7
        enhanceable
        bchs
        (Sim et al., 2019)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Acn
        suppressible
        Atg7
        (Nandi et al., 2014)
        Atg9
        suppressible
        Atg7
        (Tang et al., 2013)
        bchs
        enhanceable
        Atg7
        (Sim et al., 2019)
        bchs
        suppressible
        Atg7
        (Sim et al., 2019)
        Dcp-1
        suppressible
        Atg7
        (Kim et al., 2010)
        dom
        enhanceable
        Atg7
        (Kwon et al., 2013)
        Hsp27
        suppressible
        Atg7
        (Chen et al., 2012)
        Lrrk
        enhanceable
        Atg7
        (Dodson et al., 2014)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-86

        Cytogenetic map
        55E2-55E2
        Sequence location
        2R:18,620,466..18,625,044 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        55E2-55E2
        Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)0370903709
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-86

        (FlyBase, 2016)

        2-91.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (46)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Atg7 CG5489

        (Scott et al., 2004)
        Source for database merge of
        Additional comments
        Other Comments

        Atg7 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.

        (Politi et al., 2014)

        Atg7 mutants are viable and no major morphological defects are seen during metamorphosis. The mutant adults are hypersensitive to stress and have a reduced life span.

        (Juhász et al., 2007)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 43 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (11)
        Reported As
        Symbol Synonym
        ATG-7
        (Yadav and Srikrishna, 2019)
        ATG7
        (Kourtis and Tavernarakis, 2009)
        Atg7
        (Lu et al., 2020, Bhattacharjee et al., 2019, Guo et al., 2019, Jacomin et al., 2019, Johnson et al., 2019, Khezri and Rusten, 2019, Meltzer et al., 2019, Sim et al., 2019, Vincow et al., 2019, Xu et al., 2019, Yan et al., 2019, Zhang et al., 2019, Billes et al., 2018, Chakraborty et al., 2018, Gene Disruption Project members, 2018-, Kuo et al., 2018, Lund et al., 2018, O'Keefe and Denton, 2018, Richardson and Portela, 2018, Swevers et al., 2018, Thomas et al., 2018, Galluzzi et al., 2017, Kim et al., 2017, Kim et al., 2017, Lei et al., 2017, Lo Piccolo et al., 2017, Manent et al., 2017, Nagy et al., 2017, Péan et al., 2017, Schopf and Huber, 2017, Transgenic RNAi Project members, 2017-, Tusco et al., 2017, Wen et al., 2017, Danielsen et al., 2016, Gupta et al., 2016, Kuleesha et al., 2016, Lee et al., 2016, Lőrincz et al., 2016, Mao et al., 2016, Varga et al., 2016, Zheng et al., 2016, Bargiela et al., 2015, Carnes et al., 2015, Denton et al., 2015, Johnson et al., 2015, Kim et al., 2015, Nagy et al., 2015, Tian et al., 2015, Xu et al., 2015, Zhang and Baehrecke, 2015, Zirin et al., 2015, Banreti et al., 2014, Burke et al., 2014, DeVorkin et al., 2014, Issman-Zecharya and Schuldiner, 2014, Liu et al., 2014, Moy et al., 2014, Mulakkal et al., 2014, Nagy et al., 2014, Nandi et al., 2014, Takáts et al., 2014, Chang et al., 2013, Denton et al., 2013, Gupta et al., 2013, Lin et al., 2013, Moy and Cherry, 2013, Shin et al., 2013, Shravage et al., 2013, Takáts et al., 2013, Tang et al., 2013, Velentzas et al., 2013, Vincow et al., 2013, Wen et al., 2013, Xiong and Bellen, 2013, Yacobi-Sharon et al., 2013, Chen et al., 2012, Eleftherianos and Castillo, 2012, Érdi et al., 2012, Garcia et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Pircs et al., 2012, Wang et al., 2012, Barth et al., 2011, Bartlett et al., 2011, Du et al., 2011, Lee et al., 2011, Tang et al., 2011, Bakhrat et al., 2010, Chang and Neufeld, 2010, Chi et al., 2010, Demontis and Perrimon, 2010, Filimonenko et al., 2010, Kadandale et al., 2010, Kim et al., 2010, LaFever et al., 2010, Wasbrough et al., 2010, Zirin and Perrimon, 2010, Ren et al., 2009, Shelly et al., 2009, Chen et al., 2008, Hou et al., 2008, Liu and Lehmann, 2008, Juhasz et al., 2007, Juhász et al., 2007, Zeitouni et al., 2007)
        CG5489
        (Tsou et al., 2015, Fukuoh et al., 2014, Érdi et al., 2012, Ni et al., 2010.12.1, Perkins et al., 2009, Lee et al., 2003)
        atg-7
        (Nezis, 2012, Midorikawa et al., 2010)
        atg7
        (Bhukel et al., 2019, Shinoda et al., 2019, Singh and Chowdhuri, 2018, Volin et al., 2018, Sato and Sato, 2017, Cai et al., 2016, Zhuang et al., 2016, Rui et al., 2015, Dodson et al., 2014, Kuang et al., 2014, Politi et al., 2014, Kwon et al., 2013, Yacobi-Sharon et al., 2013, Minois et al., 2012, Chi et al., 2010, Nezis et al., 2009, Shelly et al., 2009, Wang et al., 2009)
        dAtg7
        (Li et al., 2016)
        Name Synonyms
        Autophagy-related 7
        (Carnes et al., 2015)
        Autophagy-specific gene 7
        (Scott et al., 2004, Scott et al., 2004)
        autophagy-related gene 7
        (Chen et al., 2012, Minois et al., 2012)
        autophagy-related protein 7
        (Nezis, 2012, Midorikawa et al., 2010)
        Secondary FlyBase IDs
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (186)