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Gene Dmel\SP2637

General Information
Symbol	Dmel\SP2637	Species	D. melanogaster
Name	SP2637	Annotation symbol	CG5473
Feature type	protein_coding_gene	FlyBase ID	FBgn0034371
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55E3-55E5	Sequence location	2R:14,528,476..14,545,706 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene SP2637 is referred to in FlyBase by the symbol Dmel\SP2637 (CG5473, FBgn0034371). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: asparaginase activity; protein N-terminal asparagine amidohydrolase activity. The biological processes in which it is involved are not known. 13 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, adult ovary, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638485_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of SP2637. Gene sequence location is 2R:14528476..14545706.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA07546 BKN27726
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55E3-55E5   Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)0370903709
Experimentally Determined Cytological Location
Cytogenetic map Notes References 55E8-55E9     (Serano, 2000.2.28)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\SP2637 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) SP2637-RA FBtr0086657  NM_137511   1319   310 SP2637-RB FBtr0086658  NM_166300   1448   310 SP2637-RC FBtr0301861  NM_001169728   1636   310 SP2637-RD FBtr0301862  NM_001169729   1765   310
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein SP2637-PA   FBpp0085839   34.5   310   4.80     NP_611355   AAF57658 SP2637-PB   FBpp0085840   34.5   310   4.80     NP_725811   AAF57659 SP2637-PC   FBpp0291075   34.5   310   5.01     NP_001163199   ACZ94471 SP2637-PD   FBpp0291076   34.5   310   5.01     NP_001163200   ACZ94472
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246294   AE013599 AAF57658   AE013599 AAF57659   AE013599 ACZ94471   AE013599 ACZ94472   AF239612 AAF63504   AI238727   AI405079   AQ073540   AY118895 AAM50755   BI165953   BI168197   BI173933   BI236355   BI356835   CL525981   CO155855   CO177674   CO275565   CO278190   CO305722   CO321037   CO324220   CO333553   CO342677   CZ468794   CZ468795   CZ471402   CZ471403   CZ472967   CZ475855   CZ476443   CZ484977   EC086269   EC088421   EC088847   EC206571   EC216751   EC218462   EC243310   EC254865   EC262057   EL870221   EL870222   EV591509   GH757444   GH774585   GH788630   GH789439   GH813727   GH817880   GH857302   GH871167   GH876064   GH897003   GH910700   GH918698   GH922784   GH927233   GH931181   GH939108
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KIS4 Q8MSD1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034371    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034371 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034371 expression level Developmental Stage   Expression Level embryo 00-02hr    2615 embryo 02-04hr    1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr    1553 embryo 10-12hr    2674 embryo 12-14hr    1927 embryo 14-16hr    1781 embryo 16-18hr    1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9    1550 white prepupae new    1821 white prepupae 12hr    2177 white prepupae 24hr    2818 pupae 2d postWPP    2070 pupae 3d postWPP    1619 pupae 4d postWPP    1474 adult male 01day    2035 adult male 05day    2391 adult male 30day    2609 adult female 01day    2249 adult female 05day    1892 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2615) embryo 02-04hr  (1794) embryo 04-06hr  (564) embryo 06-08hr  (911) embryo 08-10hr  (1553) embryo 10-12hr  (2674) embryo 12-14hr  (1927) embryo 14-16hr  (1781) embryo 16-18hr  (1423) embryo 18-20hr  (1117) embryo 20-22hr  (1067) embryo 22-24hr  (1027) larva L1  (954) larva L2  (731) larva L3 12hr old  (690) larva L3 puffstage 1-2  (891) larva L3 puffstage 3-6  (1207) larva L3 puffstage 7-9  (1550) white prepupae new  (1821) white prepupae 12hr  (2177) white prepupae 24hr  (2818) pupae 2d postWPP  (2070) pupae 3d postWPP  (1619) pupae 4d postWPP  (1474) adult male 01day  (2035) adult male 05day  (2391) adult male 30day  (2609) adult female 01day  (2249) adult female 05day  (1892) adult female 30day  (2075) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2615) embryo 02-04hr  (1794) embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr  (1553) embryo 10-12hr  (2674) embryo 12-14hr  (1927) embryo 14-16hr  (1781) embryo 16-18hr  1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9  (1550) white prepupae new  (1821) white prepupae 12hr  (2177) white prepupae 24hr  (2818) pupae 2d postWPP  (2070) pupae 3d postWPP  (1619) pupae 4d postWPP  1474 adult male 01day  (2035) adult male 05day  (2391) adult male 30day  (2609) adult female 01day  (2249) adult female 05day  (1892) adult female 30day  (2075) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2615 embryo 02-04hr    1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr    1553 embryo 10-12hr    2674 embryo 12-14hr    1927 embryo 14-16hr    1781 embryo 16-18hr    1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9    1550 white prepupae new    1821 white prepupae 12hr    2177 white prepupae 24hr    2818 pupae 2d postWPP    2070 pupae 3d postWPP    1619 pupae 4d postWPP    1474 adult male 01day    2035 adult male 05day    2391 adult male 30day    2609 adult female 01day    2249 adult female 05day    1892 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2615 embryo 02-04hr    1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr    1553 embryo 10-12hr    2674 embryo 12-14hr    1927 embryo 14-16hr    1781 embryo 16-18hr    1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9    1550 white prepupae new    1821 white prepupae 12hr    2177 white prepupae 24hr    2818 pupae 2d postWPP    2070 pupae 3d postWPP    1619 pupae 4d postWPP    1474 adult male 01day    2035 adult male 05day    2391 adult male 30day    2609 adult female 01day    2249 adult female 05day    1892 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034371 expression level Developmental Stage   Expression Level embryo 00-02hr    2615 embryo 02-04hr    1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr    1553 embryo 10-12hr    2674 embryo 12-14hr    1927 embryo 14-16hr    1781 embryo 16-18hr    1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9    1550 white prepupae new    1821 white prepupae 12hr    2177 white prepupae 24hr    2818 pupae 2d postWPP    2070 pupae 3d postWPP    1619 pupae 4d postWPP    1474 adult male 01day    2035 adult male 05day    2391 adult male 30day    2609 adult female 01day    2249 adult female 05day    1892 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2615) embryo 02-04hr  (1794) embryo 04-06hr  (564) embryo 06-08hr  (911) embryo 08-10hr  (1553) embryo 10-12hr  (2674) embryo 12-14hr  (1927) embryo 14-16hr  (1781) embryo 16-18hr  (1423) embryo 18-20hr  (1117) embryo 20-22hr  (1067) embryo 22-24hr  (1027) larva L1  (954) larva L2  (731) larva L3 12hr old  (690) larva L3 puffstage 1-2  (891) larva L3 puffstage 3-6  (1207) larva L3 puffstage 7-9  (1550) white prepupae new  (1821) white prepupae 12hr  (2177) white prepupae 24hr  (2818) pupae 2d postWPP  (2070) pupae 3d postWPP  (1619) pupae 4d postWPP  (1474) adult male 01day  (2035) adult male 05day  (2391) adult male 30day  (2609) adult female 01day  (2249) adult female 05day  (1892) adult female 30day  (2075) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2615) embryo 02-04hr  1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr  1553 embryo 10-12hr  (2674) embryo 12-14hr  1927 embryo 14-16hr  1781 embryo 16-18hr  1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9  1550 white prepupae new  1821 white prepupae 12hr  2177 white prepupae 24hr  (2818) pupae 2d postWPP  2070 pupae 3d postWPP  1619 pupae 4d postWPP  1474 adult male 01day  2035 adult male 05day  2391 adult male 30day  (2609) adult female 01day  2249 adult female 05day  1892 adult female 30day  2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2615 embryo 02-04hr    1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr    1553 embryo 10-12hr    2674 embryo 12-14hr    1927 embryo 14-16hr    1781 embryo 16-18hr    1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9    1550 white prepupae new    1821 white prepupae 12hr    2177 white prepupae 24hr    2818 pupae 2d postWPP    2070 pupae 3d postWPP    1619 pupae 4d postWPP    1474 adult male 01day    2035 adult male 05day    2391 adult male 30day    2609 adult female 01day    2249 adult female 05day    1892 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2615 embryo 02-04hr    1794 embryo 04-06hr    564 embryo 06-08hr    911 embryo 08-10hr    1553 embryo 10-12hr    2674 embryo 12-14hr    1927 embryo 14-16hr    1781 embryo 16-18hr    1423 embryo 18-20hr    1117 embryo 20-22hr    1067 embryo 22-24hr    1027 larva L1    954 larva L2    731 larva L3 12hr old    690 larva L3 puffstage 1-2    891 larva L3 puffstage 3-6    1207 larva L3 puffstage 7-9    1550 white prepupae new    1821 white prepupae 12hr    2177 white prepupae 24hr    2818 pupae 2d postWPP    2070 pupae 3d postWPP    1619 pupae 4d postWPP    1474 adult male 01day    2035 adult male 05day    2391 adult male 30day    2609 adult female 01day    2249 adult female 05day    1892 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034371    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034371 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, adult ovary, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034371 expression level Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034371 expression level Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    132.475 Larval Midgut    35.3 Larval Hindgut    57.8 Larval Malpighian Tubules    64.5 Larval Fat Body    157.7 Larval Salivary Gland    86.1 Larval Trachea    55.125 Larval Carcass    57.975 Adult Head    183 Adult Eye    89.1 Adult Brain    260.2 Adult Thoracic-Abdominal Ganglion    266.1 Adult Crop    466.9 Adult Midgut no informative data Adult Hindgut    282.4 Adult Malpighian Tubules    49.1 Adult Fat Body    256.6 Adult Salivary Gland    136.2 Adult Heart    225.375 Adult VirginFemale Spermatheca    84.9 Adult InseminatedFemale Spermatheca    80 Adult Ovary    107.2 Adult Testis    71 Adult Male Accessory Gland no informative data Adult Carcass    243.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    183   NA  Eye    89.1   NA  Brain    260.2   132.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    266.1   NA  Crop    466.9   35.3  Midgut    no informative data   57.8  Hindgut    282.4   64.5  Malpighian Tubules    49.1   157.7  Fat Body    256.6   86.1  Salivary Gland    136.2   NA  Heart    225.375   55.125  Trachea    NA   NA  VirginFemale Spermatheca    84.9   NA  InseminatedFemale Spermatheca    80   NA  Ovary    107.2   NA  Testis    71   NA  Male Accessory Gland    no informative data   57.975  Carcass    243.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034371 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5473-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable SP2637EY08074 viable, with Scer\GAL4pnr-MD237 SP2637GD10550 Sterility Allele fertile SP2637EY08074 Phenotype manifest in Allele
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of SP2637 Class Mutagen Stocks Known lesion SP2637c03644 piggyBac transposase 1 -- SP2637d00136 P-element activity 1 -- SP2637d02734 P-element activity 1 -- SP2637e04646 1 -- SP2637EP2381 P-element activity 1 -- SP2637EY08074 P-element activity 1 -- SP2637f02460 piggyBac transposase 1 -- SP2637NP1111 1 -- SP2637d02085 0 -- SP2637d07653 P-element activity 0 -- SP2637d08856 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of SP2637 Class Mutagen Stocks Known lesion SP2637GD10550 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SP2637KK107726 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7157 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10550} NA P{KK107726} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}SP2637EP2381 NA P{EPgy2}SP2637EY08074 NA P{XP}SP2637d00136 NA P{XP}SP2637d02085 NA P{XP}SP2637d02734 NA P{XP}SP2637d07653 NA P{XP}SP2637d08856 NA miscellaneous insertions PBac{PB}SP2637c03644 NA PBac{RB}SP2637e04646 NA PBac{WH}SP2637f02460 NA insertion of enhancer trap binary system P{GawB}SP2637NP1111 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
asparaginase activity inferred from sequence or structural similarity (Serano, 2000.2.28) protein N-terminal asparagine amidohydrolase activity inferred from sequence or structural similarity with UniProtKB:Q28955 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions SP2637 allele Gene References unspecified rpr (Ditzel et al., 2003) W (Ditzel et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62820 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034371 DroID - A comprehensive database of gene and protein interactions. • FBgn0034371 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37147
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12800 Dere\GG20959 Dgri\GH21856 Dmoj\GI20358 Dper\GL11325 Dpse\GA18907 Dsec\GM19890 Dsim\GD25375 Dvir\GJ22083 Dwil\GK15790 Dyak\GE13898
Curated drosophilid orthologs	Dpse\GA18907
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004952-PA Aedes aegypti (mosquito) AGAP010963-PA Anopheles gambiae (mosquito) XP_396337.1 Apis mellifera (honey bee) XP_001942778.1 Acyrthosiphon pisum (pea aphid) XP_001949831.1 Acyrthosiphon pisum (pea aphid) At2g44420.1 Arabidopsis thaliana (wall cress) 200206 Branchiostoma floridae (lancelet) 227393 Branchiostoma floridae (lancelet) BGIBMGA012054-PA Bombyx mori (silk worm) ENSBTAP00000006307 Bos taurus (bovine) ENSCAFP00000027702 Canis familiaris (dog) CPIJ016351 Culex pipens (mosquito) ENSCPOP00000003342 Cavia porcellus (guinea pig) ENSCSAVP00000014820 Ciona savignyi (sedentary tunicate) 142681 Capitella spl (polychaete worm) 197112 Daphnia pulex (daphnia) ENSDARP00000061760 Danio rerio (zebra fish) ENSECAP00000002638 Equus caballus (horse) ENSGACP00000025325 Gymnopilus aculeatus (mushroom) ENSGALP00000004465 Gallus gallus (chicken) 99061 Hypsipyla robusta (cedar shoot borer) ENSP00000287706 Homo sapiens (human) ISCW013167-PA Ixodes scapularis (deer tick) 186232 Lottia gigantea (owl limpet) 5128 Monocosta brevicollis (choanoflagellate) ENSMODP00000005632 Monodelphis domestica (gray opossum) ENSMMUP00000003994 Macaca mulatta (rhesus monkey) ENSMUSP00000023362 Mus musculus (house mouse) XP_001608273.1 Nasonia vitripennis (wasp) ENSOANP00000008187 Ornithorynchus anatinus (platypus) ENSORLP00000017139 Oryzias latipes (japanese killifish) LOC_Os06g41390.1 Oryza sativa (asian rice) PHUM002853-PA Pediculus humanus (human body louse) ENSPPYP00000008058 Pongo pygmaeus (orangutan) 821582 Populus trichocarpa (black cottonwood) ENSPTRP00000013307 Pan troglodytes (chimpanzee) 5011164 Sorghum bicolor (sorghum) Smp_066830 Schistosoma mansoni (trematode parasite) XP_781525.2 Strongylocentrotus purpuratus (purple sea urchin) 52945 Trichoplax adhaerens (metazoa) XP_966317.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008999 Tetraodon nigroviridis (green spotted pufferfish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10988 LH20219 ISCW013167 FBgn0231543 FBgn0217793 FBgn0209197 FBgn0196672 FBgn0174776 JGI_V11_197112 FBgn0078907 FBgn0148934 FBgn0143094 FBgn0129317 FBgn0113143 FBgn0089834 CPIJ016351 BGIBMGA012054 ACYPI007960 ACYPI001422 GB10784 AGAP010965 AGAP010963 AAEL004952 PB21242 PHUM188470 GLEAN_03666
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	17246 w1118; P{EP}SP2637EP2381 17427 y1 w67c23; P{EPgy2}SP2637EY08074
Harvard	- P{XP}SP2637d00136 - P{XP}SP2637d02734 - PBac{PB}SP2637c03644 - PBac{RB}SP2637e04646 - PBac{WH}SP2637f02460
Kyoto	103887 y* w*; P{GawB}SP2637NP1111 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v105482 P{KK107726}VIE-260B v21567 w1118; P{GD10550}v21567
Genomic Clones ( 1 )
	BACR08F09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05256
Other clones	DPiM_LD05256
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14827 GH24992 RE05956 RE08780 RE17081 RE32396 RE43075
Other clones	65968 119311 146697 214511.66 282070 525643 CK01.36B.D5 CK01.66D.G7 CK01.141C.H7 Dmel_neb_015075_0440_2679 EK054028 EK117932 EK129304 EK193016 EK249313 EK290207 EK307246 EN06849 EP15324 IP02314 RP003098670 RP003138551 RP003145547 RP003172983 RP003196256 RP003268450 RP003280531 RP003281400 RP003332792 RP003349106 RP003413596 RP003461135 RP003468047 RP003476227 RP003597163 RP003668843
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034371 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37147
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: SP2637 CG5473 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of SP2637 CG5473 was sequence comparison (date:000414). (FlyBase, 1996-)
Other Comments
	Identified with: GH24992 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>. (Zou et al., 2000) EST GH24992 is chimeric; the 5' portion (AI405079) corresponds to part of SP2637, the 3' portion (BG633345) corresponds to part of RfC40. (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137511 NM_166300 NM_001169728 NM_001169729 RefSeq (Proteins) • NP_611355 NP_725811 NP_001163199 NP_001163200 DDBJ / EMBL / GenBank • AA246294 AAF57658 AAF57659 AAF63504 AAM50755 ACZ94471 ACZ94472 AF239612 AI405079 AQ073540 AY118895 CL525981 CZ468794 CZ468795 CZ471402 CZ471403 CZ472967 CZ475855 CZ476443 CZ484977 Entrez Gene - A searchable database of RefSeq genes. • 37147 UniProtKB/TrEMBL • Q7KIS4 Q8MSD1
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 62820 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034371 DroID - A comprehensive database of gene and protein interactions. • FBgn0034371 DRSC - Results from RNAi screens. • FBgn0034371 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034371 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5473-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034371 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37147 InParanoid A subset of ortholog calls from InParanoid. • AAEL004952-PA Aedes aegypti (mosquito) AGAP010963-PA Anopheles gambiae (mosquito) XP_396337.1 Apis mellifera (honey bee) XP_001942778.1 Acyrthosiphon pisum (pea aphid) XP_001949831.1 Acyrthosiphon pisum (pea aphid) At2g44420.1 Arabidopsis thaliana (wall cress) 200206 Branchiostoma floridae (lancelet) 227393 Branchiostoma floridae (lancelet) BGIBMGA012054-PA Bombyx mori (silk worm) ENSBTAP00000006307 Bos taurus (bovine) ENSCAFP00000027702 Canis familiaris (dog) CPIJ016351 Culex pipens (mosquito) ENSCPOP00000003342 Cavia porcellus (guinea pig) ENSCSAVP00000014820 Ciona savignyi (sedentary tunicate) 142681 Capitella spl (polychaete worm) 197112 Daphnia pulex (daphnia) ENSDARP00000061760 Danio rerio (zebra fish) ENSECAP00000002638 Equus caballus (horse) ENSGACP00000025325 Gymnopilus aculeatus (mushroom) ENSGALP00000004465 Gallus gallus (chicken) 99061 Hypsipyla robusta (cedar shoot borer) ENSP00000287706 Homo sapiens (human) ISCW013167-PA Ixodes scapularis (deer tick) 186232 Lottia gigantea (owl limpet) 5128 Monocosta brevicollis (choanoflagellate) ENSMODP00000005632 Monodelphis domestica (gray opossum) ENSMMUP00000003994 Macaca mulatta (rhesus monkey) ENSMUSP00000023362 Mus musculus (house mouse) XP_001608273.1 Nasonia vitripennis (wasp) ENSOANP00000008187 Ornithorynchus anatinus (platypus) ENSORLP00000017139 Oryzias latipes (japanese killifish) LOC_Os06g41390.1 Oryza sativa (asian rice) PHUM002853-PA Pediculus humanus (human body louse) ENSPPYP00000008058 Pongo pygmaeus (orangutan) 821582 Populus trichocarpa (black cottonwood) ENSPTRP00000013307 Pan troglodytes (chimpanzee) 5011164 Sorghum bicolor (sorghum) Smp_066830 Schistosoma mansoni (trematode parasite) XP_781525.2 Strongylocentrotus purpuratus (purple sea urchin) 52945 Trichoplax adhaerens (metazoa) XP_966317.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008999 Tetraodon nigroviridis (green spotted pufferfish) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37147 modMine - Data generated by the modENCODE project. • FBgn0034371 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10988 LH20219 ISCW013167 FBgn0231543 FBgn0217793 FBgn0209197 FBgn0196672 FBgn0174776 JGI_V11_197112 FBgn0078907 FBgn0148934 FBgn0143094 FBgn0129317 FBgn0113143 FBgn0089834 CPIJ016351 BGIBMGA012054 ACYPI007960 ACYPI001422 GB10784 AGAP010965 AGAP010963 AAEL004952 PB21242 PHUM188470 GLEAN_03666
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BEST:GH24992   CG5473 (Keleman et al., 2009.8.5) dm-ntan1 (Ditzel et al., 2003) SP2637 (Choksi et al., 2006)
Name Synonym	SP2637
Secondary FlyBase IDs
	FBgn0043808
References ( 17 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Choksi et al., 2006, Dev. Cell 11(6): 775--789 Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. [FBrf0206393] Ditzel et al., 2003, Nature Cell Biol. 5(5): 467--473 Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. [FBrf0159242] Zou et al., 2000, Proc. Natl. Acad. Sci. USA 97(25): 13726--13731 Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. [FBrf0131436]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Serano, 2000.2.28, GenBank/EMBL/DDBJ: AF239612 Drosophila melanogaster SP2637 mRNA, complete cds. [FBrf0128055]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]