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Gene Dmel\CG15097

General Information
Symbol	Dmel\CG15097	Species	D. melanogaster
Name		Annotation symbol	CG15097
Feature type	protein_coding_gene	FlyBase ID	FBgn0034396
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55F6-55F6	Sequence location	2R:14,709,693..14,717,180 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG15097 (FBgn0034396). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: BTB/Kelch-associated; BTB/POZ; BTB/POZ fold; BTB/POZ-like; Galactose oxidase, beta-propeller; Kelch repeat type 1; Kelch-like protein, gigaxonin; Kelch-type beta propeller. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1636208_a_at partially aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG15097: 13 out of 14 probes fall into this exonic region. Gene sequence location is 2R:14709693..14717180.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA06526 BKN28287
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55F6-55F6   Limits computationally determined from genome sequence between P{PZ}l(2)0370903709 and P{lacW}prodk08810
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG15097 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	3' UTR contains an ORF that is conserved among close Drosophila species (potential peptide 116 aa in length; possible stop-codon suppression).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG15097-RA FBtr0086630  NM_137533   2792   513 CG15097-RB FBtr0086631  NM_176232   2637   617 CG15097-RC FBtr0303237  NM_001202044   3005   617
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG15097-PA   FBpp0085812   57.6   513   7.44     NP_611377   AAF57630 CG15097-PB   FBpp0085813   68.7   617   6.75     NP_788412   AAO41354 CG15097-PC   FBpp0292329   68.7   617   6.75     NP_001188973   ADV37219
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Kelch repeat type 1 (IPR006652) BTB/Kelch-associated (IPR011705) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Kelch-type beta propeller (IPR015915) Kelch-like protein, gigaxonin (IPR017096) Galactose oxidase, beta-propeller (IPR015916)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57630   AE013599 AAO41354   AE013599 ADV37219   AI109767   AI387687   AW940695   AY060733 AAL28281   BF488820   BP549668   BT001347 AAN71102   BT044263   CA804878   CO320778   CO332013   EC067274   EC090606
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IH99 Q7K2Q6 A1ZBE3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034396    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034396 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034396 expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr    1780 embryo 16-18hr    1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9    2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP    1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr  (253) embryo 12-14hr  (441) embryo 14-16hr  (1780) embryo 16-18hr  (1569) embryo 18-20hr  (1281) embryo 20-22hr  (727) embryo 22-24hr  (676) larva L1  (1179) larva L2  (437) larva L3 12hr old  (211) larva L3 puffstage 1-2  (114) larva L3 puffstage 3-6  (642) larva L3 puffstage 7-9  (2159) white prepupae new  (1145) white prepupae 12hr  (1289) white prepupae 24hr  (1102) pupae 2d postWPP  (1994) pupae 3d postWPP  (1292) pupae 4d postWPP  (1315) adult male 01day  (677) adult male 05day  (848) adult male 30day  (991) adult female 01day  (273) adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr  (1780) embryo 16-18hr  (1569) embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9  (2159) white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP  (1994) pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr    1780 embryo 16-18hr    1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9    2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP    1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr    1780 embryo 16-18hr    1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9    2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP    1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034396 expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr    1780 embryo 16-18hr    1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9    2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP    1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr  (253) embryo 12-14hr  (441) embryo 14-16hr  (1780) embryo 16-18hr  (1569) embryo 18-20hr  (1281) embryo 20-22hr  (727) embryo 22-24hr  (676) larva L1  (1179) larva L2  (437) larva L3 12hr old  (211) larva L3 puffstage 1-2  114 larva L3 puffstage 3-6  (642) larva L3 puffstage 7-9  (2159) white prepupae new  (1145) white prepupae 12hr  (1289) white prepupae 24hr  (1102) pupae 2d postWPP  (1994) pupae 3d postWPP  (1292) pupae 4d postWPP  (1315) adult male 01day  (677) adult male 05day  (848) adult male 30day  (991) adult female 01day  (273) adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr  1780 embryo 16-18hr  1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9  2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP  1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr    1780 embryo 16-18hr    1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9    2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP    1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    19 embryo 08-10hr    40 embryo 10-12hr    253 embryo 12-14hr    441 embryo 14-16hr    1780 embryo 16-18hr    1569 embryo 18-20hr    1281 embryo 20-22hr    727 embryo 22-24hr    676 larva L1    1179 larva L2    437 larva L3 12hr old    211 larva L3 puffstage 1-2    114 larva L3 puffstage 3-6    642 larva L3 puffstage 7-9    2159 white prepupae new    1145 white prepupae 12hr    1289 white prepupae 24hr    1102 pupae 2d postWPP    1994 pupae 3d postWPP    1292 pupae 4d postWPP    1315 adult male 01day    677 adult male 05day    848 adult male 30day    991 adult female 01day    273 adult female 05day    67 adult female 30day    73 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034396    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034396 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034396 expression level Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034396 expression level Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    78.75 Larval Midgut no informative data Larval Hindgut    44.4 Larval Malpighian Tubules    281.3 Larval Fat Body no informative data Larval Salivary Gland    53.3 Larval Trachea    46.15 Larval Carcass    75.05 Adult Head    68.4 Adult Eye    123.675 Adult Brain    102.1 Adult Thoracic-Abdominal Ganglion    70.9 Adult Crop    50.5 Adult Midgut    4.1 Adult Hindgut no informative data Adult Malpighian Tubules    8.5 Adult Fat Body    5.4 Adult Salivary Gland no informative data Adult Heart    52.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    8.2 Adult Testis    31.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    68.4   NA  Eye    123.675   NA  Brain    102.1   78.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    70.9   NA  Crop    50.5   no informative data  Midgut    4.1   44.4  Hindgut    no informative data   281.3  Malpighian Tubules    8.5   no informative data  Fat Body    5.4   53.3  Salivary Gland    no informative data   NA  Heart    52.8   46.15  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    6.9   NA  Ovary    8.2   NA  Testis    31.1   NA  Male Accessory Gland    no informative data   75.05  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034396 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15097-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG15097 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG15097GD8905 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG15097 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG15097 Class Mutagen Stocks Known lesion CG15097GD8905 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG15097JF01652 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG15097KK108287 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7158 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8905} NA P{KK108287} NA P{TRiP.JF01652} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AL035424 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG15097 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034396 DroID - A comprehensive database of gene and protein interactions. • FBgn0034396 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37172
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13750 Dere\GG20941 Dgri\GH19736 Dmoj\GI20160 Dper\GL10848 Dpse\GA13488 Dsec\GM19869 Dvir\GJ21999 Dwil\GK20700 Dyak\GE13880
Curated drosophilid orthologs	Dpse\GA13488
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013953-PA Aedes aegypti (mosquito) AGAP009641-PA Anopheles gambiae (mosquito) XP_001952806.1 Acyrthosiphon pisum (pea aphid) At4g11750.1 Arabidopsis thaliana (wall cress) ENSBTAP00000018351 Bos taurus (bovine) ENSCAFP00000028608 Canis familiaris (dog) CPIJ000983 Culex pipens (mosquito) ENSCPOP00000007174 Cavia porcellus (guinea pig) 187991 Chlamidomonas reinhardtii (green alga) DDB0232244 Dictyostelium discoideum (amoeba) ENSDARP00000083483 Danio rerio (zebra fish) ENSECAP00000020762 Equus caballus (horse) ENSGACP00000009760 Gymnopilus aculeatus (mushroom) ENSGALP00000003437 Gallus gallus (chicken) ENSP00000343930 Homo sapiens (human) ENSMMUP00000020763 Macaca mulatta (rhesus monkey) ENSMUSP00000101194 Mus musculus (house mouse) 165358 Nematostella vectensis (starlet anemone) ENSORLP00000006955 Oryzias latipes (japanese killifish) PHUM005712-PA Pediculus humanus (human body louse) ENSPTRP00000052977 Pan troglodytes (chimpanzee) ENSRNOP00000027547 Rattus norvegicus (norway rat) XP_794711.2 Strongylocentrotus purpuratus (purple sea urchin) 50396 Trichoplax adhaerens (metazoa) XP_974127.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018214 Tetraodon nigroviridis (green spotted pufferfish) 24961 Thalassiosira pseudonana (marine diatom) ENSTRUP00000024294 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231526 FBgn0222696 FBgn0209113 FBgn0174755 FBgn0073524 FBgn0148458 FBgn0142896 FBgn0127200 FBgn0113125 FBgn0090777 CPIJ000983 ACYPI008584 AGAP009641 AAEL013953 AAEL012285 PHUM390860 GLEAN_15037
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	31159 y1 v1; P{TRiP.JF01652}attP2
VDRC	v25188 w1118; P{GD8905}v25188
Genomic Clones ( 1 )
	BACR27C21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT24465 GH18278
Other clones	DPiM_GH18278 FI06141
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09093
Other clones	183202 274799 EK288060 EK302316 ESG0115c.B21_E01 FGM102G09
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034396 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37172
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137533 NM_176232 NM_001202044 RefSeq (Proteins) • NP_611377 NP_788412 NP_001188973 DDBJ / EMBL / GenBank • AAF57630 AAL28281 AAN71102 AAO41354 ADV37219 AI387687 AW940695 AY060733 BF488820 BT001347 Entrez Gene - A searchable database of RefSeq genes. • 37172 UniProtKB/TrEMBL • A1ZBE3 Q7K2Q6 Q8IH99
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Kelch repeat type 1 (IPR006652) BTB/Kelch-associated (IPR011705) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Kelch-type beta propeller (IPR015915) Kelch-like protein, gigaxonin (IPR017096) Galactose oxidase, beta-propeller (IPR015916)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034396 DroID - A comprehensive database of gene and protein interactions. • FBgn0034396 DRSC - Results from RNAi screens. • FBgn0034396 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034396 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15097-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034396 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37172 InParanoid A subset of ortholog calls from InParanoid. • AAEL013953-PA Aedes aegypti (mosquito) AGAP009641-PA Anopheles gambiae (mosquito) XP_001952806.1 Acyrthosiphon pisum (pea aphid) At4g11750.1 Arabidopsis thaliana (wall cress) ENSBTAP00000018351 Bos taurus (bovine) ENSCAFP00000028608 Canis familiaris (dog) CPIJ000983 Culex pipens (mosquito) ENSCPOP00000007174 Cavia porcellus (guinea pig) 187991 Chlamidomonas reinhardtii (green alga) DDB0232244 Dictyostelium discoideum (amoeba) ENSDARP00000083483 Danio rerio (zebra fish) ENSECAP00000020762 Equus caballus (horse) ENSGACP00000009760 Gymnopilus aculeatus (mushroom) ENSGALP00000003437 Gallus gallus (chicken) ENSP00000343930 Homo sapiens (human) ENSMMUP00000020763 Macaca mulatta (rhesus monkey) ENSMUSP00000101194 Mus musculus (house mouse) 165358 Nematostella vectensis (starlet anemone) ENSORLP00000006955 Oryzias latipes (japanese killifish) PHUM005712-PA Pediculus humanus (human body louse) ENSPTRP00000052977 Pan troglodytes (chimpanzee) ENSRNOP00000027547 Rattus norvegicus (norway rat) XP_794711.2 Strongylocentrotus purpuratus (purple sea urchin) 50396 Trichoplax adhaerens (metazoa) XP_974127.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018214 Tetraodon nigroviridis (green spotted pufferfish) 24961 Thalassiosira pseudonana (marine diatom) ENSTRUP00000024294 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37172 modMine - Data generated by the modENCODE project. • FBgn0034396 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231526 FBgn0222696 FBgn0209113 FBgn0174755 FBgn0073524 FBgn0148458 FBgn0142896 FBgn0127200 FBgn0113125 FBgn0090777 CPIJ000983 ACYPI008584 AGAP009641 AAEL013953 AAEL012285 PHUM390860 GLEAN_15037
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG15097 (Hoopfer et al., 2008, Bakal et al., 2007, Nelson et al., 2005, Cao et al., 2007, Kim et al., 2007, Kim et al., 2005, Ni et al., 2008, Keleman et al., 2009.8.5) Dm.CG15097 (Stogios and Prive, 2004)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Hoopfer et al., 2008, J. Neurosci. 28(24): 6092--6103 Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. [FBrf0205201] Ni et al., 2008, Nature Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Cao et al., 2007, J. Cell Biol. 176(6): 843--852 Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. [FBrf0193919] Kim et al., 2007, PLoS Biol. 5(9): e238 Down-regulation of NF-kappa B target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. [FBrf0201134] Kim et al., 2005, Nature Immunology 6(2): 211--218 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. [FBrf0184193] Nelson et al., 2005, Cell Death Diffn 12(8): 1115--1123 Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. [FBrf0187248] Arbeitman et al., 2004, Development 131(9): 2007--2021 A genomic analysis of Drosophila somatic sexual differentiation and its regulation. [FBrf0174573]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Bakal et al., 2007, Science 316(5832): Supporting online material. [FBrf0204776] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Goldstein and Gunawardena, 2000, J. Cell Biol. 150(2): Table S2. Identified cytoskeletal protein coding genes in Drosophila. [FBrf0132100]
Review	Stogios and Prive, 2004, Trends Biochem. Sci. 29(12): 634--637 The BACK domain in BTB-kelch proteins. [FBrf0183513]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Goldstein, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126668]