FB2019_05, released Oct 15, 2019

Gene: Dmel\DptB

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General Information
Symbol
Dmel\DptB
Species
D. melanogaster
Name
Diptericin B
Annotation Symbol
CG10794
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034407
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
Diptericin, DiptB, Dpt, dptlp, diptericin-like protein
Key Links
Genomic Location
Cytogenetic map
55F8-55F8
Sequence location
2R:18,867,391..18,867,895 [+]
Recombination map
2-86
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\DptB or the JBrowse view of Dmel\DptB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
DptB-RA
FBtr0086621
NM_079063
449
120
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
DptB-PA
FBpp0085803
13.1
120
9.48
NP_523787
AAF57618
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
Small DptB-derived peptides identified by nano LC-MS/MS: APNFDVPLH, EIVNLQPEPLAYAPNFDVPLHRV.
(Liu et al., 2006)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DptB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (6 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
defense response to Gram-positive bacterium
inferred from expression pattern
(Gordon et al., 2008)
humoral immune response
inferred from expression pattern
(Verleyen et al., 2006)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
antibacterial humoral response
inferred from biological aspect of ancestor with PANTHER:PTN002212156
(assigned by GO_Central )
(Gaudet et al., 2011)
defense response to Gram-negative bacterium
inferred from biological aspect of ancestor with PANTHER:PTN002212156
(assigned by GO_Central )
(Gaudet et al., 2011)
defense response to Gram-positive bacterium
inferred from biological aspect of ancestor with PANTHER:PTN002212156
(assigned by GO_Central )
(Gaudet et al., 2011)
response to hyperoxia
inferred from biological aspect of ancestor with PANTHER:PTN002212156
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
extracellular space
inferred from direct assay
(Liu et al., 2006, Verleyen et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN002212156
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval hemolymph

Comment: infected with M. luteus and E. coli

(Liu et al., 2006, Verleyen et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
extracellular space
inferred from direct assay
(Liu et al., 2006, Verleyen et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\DptB in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of DptB
Transgenic constructs containing regulatory region of DptB
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190IGA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\DptB
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005807
Drosophila simulans
Dsim\GD11419
Drosophila sechellia
Dsec\GM21924
Drosophila erecta
Dere\GG21935
Drosophila yakuba
Dyak\DptB
Drosophila ananassae
Dana\GF11125
Drosophila pseudoobscura pseudoobscura
Dpse\GA10563
Drosophila persimilis
Dper\GL11495
Drosophila willistoni
Dwil\GK20689
Drosophila willistoni
Dwil\GK20932
Drosophila virilis
Dvir\GJ19917
Drosophila mojavensis
Dmoj\GI19362
Drosophila grimshawi
Dgri\GH22132
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150IDI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012316
Musca domestica
House fly
Mdoa\17012317
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07220
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07224
Mayetiola destructor
Hessian fly
Mdes\Mdes010388
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BZ9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002739
Bombyx mori
Silkmoth
Bmor\BGIBMGA002747
Danaus plexippus
Monarch butterfly
Dple\DPOGS213996-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215451-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205720-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213997-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017162
Heliconius melpomene
Postman butterfly
Hmel\HMEL017161
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG023478
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017853
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03210
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00112
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07139
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07737
Tribolium castaneum
Red flour beetle
Tcas\TC007738
Rhodnius prolixus
Kissing bug
Rpro\RPRC012379
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02297
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
AttA
1 of 10
AttB
1 of 10
AttC
1 of 10
AttD
1 of 10
CG33493
1 of 10
DptA
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-86
    Cytogenetic map
    55F8-55F8
    Sequence location
    2R:18,867,391..18,867,895 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    55F8-55F8
    Limits computationally determined from genome sequence between P{PZ}l(2)0370903709 and P{lacW}prodk08810
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    55F-55F
    (Borge, 2000.11.20)
    Experimentally Determined Recombination Data
    Location
    2-86
    (FlyBase, 2016)
    2-92.2
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (20)
    cDNA Clones (52)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: DptB CG10794
      (FlyBase, 1996-)
      Source for database merge of
      Source for merge of: DptB BcDNA:RH29451
      (FlyBase, 1996-)
      Additional comments
      Source for identity of DptB CG10794 was sequence comparison ( date:010102 ).
      (FlyBase, 1996-)
      Source for merge of DptB BcDNA:RH29451 was a shared cDNA ( date:030728 ).
      (FlyBase, 1996-)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 35 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Synonyms and Secondary IDs (20)
      Reported As
      Symbol Synonym
      147473_at
      (Kristensen et al., 2005)
      BcDNA:RH29451
      CG10794
      (Sun et al., 2014, Petersen et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Hernandez-Romano et al., 2008, Valanne et al., 2007, Liu et al., 2006, Verleyen et al., 2006, De Gregorio et al., 2001, Hultmark, 2001.1.10, Irving et al., 2001, Lee et al., 2001, Lemaitre, 2000.12.20)
      Dipt
      (Min and Tatar, 2018)
      DiptB
      (Liu and Jin, 2017, Katzenberger et al., 2016, Cao et al., 2013, Katzenberger et al., 2013, Petersen et al., 2013, Petersen et al., 2012, Sampson et al., 2012, Ye and McGraw, 2011, Gordon et al., 2008)
      Diptericin
      (Bonnay et al., 2014, Kimbrell and Beutler, 2001)
      Diptericin B
      (Zhan et al., 2015, Felix et al., 2012)
      Dpt
      (Kopp and Park, 2019, Troha et al., 2018, Daisley et al., 2017, Dostálová et al., 2017, Costechareyre et al., 2016, Guillou et al., 2016, Piegholdt et al., 2016, Merkling et al., 2015)
      DptB
      (Hanson et al., 2019, Moskalev et al., 2019, Sanuki et al., 2019, Štětina et al., 2019, Barajas-Azpeleta et al., 2018, Grobler et al., 2018, Hemphill et al., 2018, Lin et al., 2018, Moskalev et al., 2018, Ueda et al., 2018, Yuan et al., 2018, Bozler et al., 2017, Christesen et al., 2017, Early et al., 2017, Mussabekova et al., 2017, Barekat et al., 2016, Kiss et al., 2016, Buchon and Osman, 2015, Hamilton et al., 2015, Kopp et al., 2015, Bonnay et al., 2014, Chen et al., 2014, Guo et al., 2014, Kuuluvainen et al., 2014, Taylor et al., 2014, Durdevic et al., 2013, Gendrin et al., 2013, Huang et al., 2013, Jennings, 2013, Short and Lazzaro, 2013, Stefanatos et al., 2013, Telonis-Scott et al., 2013, Doroszuk et al., 2012, Immonen and Ritchie, 2012, Kalajdzic et al., 2012, Vanha-Aho et al., 2012, Cheng et al., 2011, Gerbasi et al., 2011, Chen et al., 2010, Chen et al., 2010, Kim et al., 2010, Buchon et al., 2009, Feng et al., 2009, Sackton and Clark, 2009, Kleino et al., 2008, McGraw et al., 2008, Domanitskaya et al., 2007, Tsichritzis et al., 2007, Behm-Ansmant et al., 2006, King-Jones et al., 2006, Lazzaro et al., 2004, Domazet-Loso and Tautz, 2003)
      diptB
      (Orme et al., 2016)
      dpt B
      (Zsindely et al., 2009)
      dptB
      (Wei et al., 2018, Xu and Cherry, 2014, Huang et al., 2013, Kingsolver et al., 2013)
      dptlp
      (Cha et al., 2003, Lee et al., 2001)
      Name Synonyms
      Diptercin B
      (Xi et al., 2008)
      Diptericin
      (Merkling et al., 2019, Garschall and Flatt, 2018, Castillo et al., 2015, Merkling et al., 2015, Ferrandon, 2013, Vandersmissen et al., 2013, Moule et al., 2010, Lai et al., 2007, Tsichritzis et al., 2007, Kimbrell and Beutler, 2001)
      Diptericin B
      (Katzenberger et al., 2016, Arefin et al., 2014, Lee et al., 2014, Taylor et al., 2014, Longworth et al., 2012, Paré et al., 2012, Petersen et al., 2012, Cheng et al., 2011, Ragab et al., 2011, Wong et al., 2011, Kim et al., 2010, Ertürk-Hasdemir et al., 2009, Ye et al., 2009, Gordon et al., 2008, Hernandez-Romano et al., 2008, Kleino et al., 2008, Lazzaro et al., 2006, Verleyen et al., 2006, Lazzaro et al., 2004, Borge, 2000.11.20)
      Diptericin-B
      (Bost et al., 2018, Bonnay et al., 2014, Kemp et al., 2013, Lemos et al., 2010)
      DiptericinB
      (Cao et al., 2013, Zhao et al., 2010)
      Diptericine
      (Espaillat et al., 2016)
      diptericin
      (Lee et al., 2017)
      diptericin B
      (Chambers et al., 2012, Feng et al., 2009, Xi et al., 2008, Domanitskaya et al., 2007)
      diptericin-like protein
      (Cha et al., 2003, Lee et al., 2001)
      Secondary FlyBase IDs
      • FBgn0064827
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (160)