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Gene Dmel\CG11257

General Information
Symbol	Dmel\CG11257	Species	D. melanogaster
Name		Annotation symbol	CG11257
Feature type	protein_coding_gene	FlyBase ID	FBgn0034442
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56D3-56D3	Sequence location	2R:15,277,633..15,279,405 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11257 (FBgn0034442). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: heme binding; oxidoreductase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome b5; Cytochrome b5, heme-binding site; Ferredoxin reductase-type FAD-binding domain; HSP20-like chaperone; NADH:cytochrome b5 reductase (CBR); Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; Riboflavin synthase-like beta-barrel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1631483_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11257. Gene sequence location is 2R:15277633..15279405.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN28720 HFA06068
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D3-56D3   Limits computationally determined from genome sequence between P{PZ}ena02029&P{lacW}corak08713 and P{lacW}htsk06121
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11257 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11257-RA FBtr0086525  NM_137575   1718   535
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11257-PA   FBpp0085713   60.2   535   8.39     NP_611419   AAF57568
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b5 (IPR001199) NADH:cytochrome b5 reductase (CBR) (IPR001834) Oxidoreductase, FAD-binding domain (IPR008333) Cytochrome b5, heme-binding site (IPR018506) HSP20-like chaperone (IPR008978) Ferredoxin reductase-type FAD-binding domain (IPR017927) Riboflavin synthase-like beta-barrel (IPR017938) Oxidoreductase FAD/NAD(P)-binding (IPR001433)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57568   BT022440   BT128874   CO274542   CO295428   CO341062   EC198146   EC224706   EC257116   EC259598   EC261068   EL881786   EV577650
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZBK6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034442    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034442 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034442 expression level Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (592) embryo 02-04hr  (418) embryo 04-06hr  (696) embryo 06-08hr  (345) embryo 08-10hr  (302) embryo 10-12hr  (265) embryo 12-14hr  (227) embryo 14-16hr  (197) embryo 16-18hr  (217) embryo 18-20hr  (132) embryo 20-22hr  (166) embryo 22-24hr  (208) larva L1  (175) larva L2  (197) larva L3 12hr old  (177) larva L3 puffstage 1-2  (155) larva L3 puffstage 3-6  (225) larva L3 puffstage 7-9  (303) white prepupae new  (240) white prepupae 12hr  (223) white prepupae 24hr  (253) pupae 2d postWPP  (333) pupae 3d postWPP  (218) pupae 4d postWPP  (125) adult male 01day  (187) adult male 05day  (192) adult male 30day  (164) adult female 01day  (244) adult female 05day  (351) adult female 30day  (389) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034442 expression level Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (592) embryo 02-04hr  (418) embryo 04-06hr  (696) embryo 06-08hr  (345) embryo 08-10hr  (302) embryo 10-12hr  (265) embryo 12-14hr  (227) embryo 14-16hr  (197) embryo 16-18hr  (217) embryo 18-20hr  132 embryo 20-22hr  (166) embryo 22-24hr  (208) larva L1  (175) larva L2  (197) larva L3 12hr old  (177) larva L3 puffstage 1-2  (155) larva L3 puffstage 3-6  (225) larva L3 puffstage 7-9  (303) white prepupae new  (240) white prepupae 12hr  (223) white prepupae 24hr  (253) pupae 2d postWPP  (333) pupae 3d postWPP  (218) pupae 4d postWPP  125 adult male 01day  (187) adult male 05day  (192) adult male 30day  (164) adult female 01day  (244) adult female 05day  (351) adult female 30day  (389) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    592 embryo 02-04hr    418 embryo 04-06hr    696 embryo 06-08hr    345 embryo 08-10hr    302 embryo 10-12hr    265 embryo 12-14hr    227 embryo 14-16hr    197 embryo 16-18hr    217 embryo 18-20hr    132 embryo 20-22hr    166 embryo 22-24hr    208 larva L1    175 larva L2    197 larva L3 12hr old    177 larva L3 puffstage 1-2    155 larva L3 puffstage 3-6    225 larva L3 puffstage 7-9    303 white prepupae new    240 white prepupae 12hr    223 white prepupae 24hr    253 pupae 2d postWPP    333 pupae 3d postWPP    218 pupae 4d postWPP    125 adult male 01day    187 adult male 05day    192 adult male 30day    164 adult female 01day    244 adult female 05day    351 adult female 30day    389 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034442    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034442 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034442 expression level Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034442 expression level Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    36.8 Larval Midgut no informative data Larval Hindgut    26.6 Larval Malpighian Tubules    34 Larval Fat Body no informative data Larval Salivary Gland    52.2 Larval Trachea    50.9 Larval Carcass    37.325 Adult Head    23.5 Adult Eye    28.675 Adult Brain    32 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    37.3 Adult Midgut    38.9 Adult Hindgut    31.8 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland    64.5 Adult Heart    26.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    86.5 Adult Testis    34.1 Adult Male Accessory Gland    33.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    23.5   NA  Eye    28.675   NA  Brain    32   36.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    37.3   no informative data  Midgut    38.9   26.6  Hindgut    31.8   34  Malpighian Tubules    no informative data   no informative data  Fat Body    27.7   52.2  Salivary Gland    64.5   NA  Heart    26.225   50.9  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    86.5   NA  Testis    34.1   NA  Male Accessory Gland    33.2   37.325  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034442 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11257-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG11257f06315 viable, with Scer\GAL4pnr-MD237 CG11257GD7255 Sterility Allele fertile CG11257f06315 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11257 Class Mutagen Stocks Known lesion CG11257f06315 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11257 Class Mutagen Stocks Known lesion CG11257GD7255 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7255} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG11257f06315 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
heme binding inferred from electronic annotation with InterPro:IPR001199, InterPro:IPR018506 (FlyBase Curators et al., 2004-) oxidoreductase activity inferred from electronic annotation with InterPro:IPR001433, InterPro:IPR001834, InterPro:IPR017927, InterPro:IPR017938 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR001433, InterPro:IPR001834, InterPro:IPR017927, InterPro:IPR017938 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11257 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034442 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37227
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12339 Dere\GG21968 Dgri\GH22815 Dmoj\GI21190 Dper\GL10825 Dpse\GA10870 Dsec\GM21957 Dsim\GD11452 Dvir\GJ20792 Dwil\GK22167 Dyak\GE12047
Curated drosophilid orthologs	Dpse\GA10870
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005478-PA Aedes aegypti (mosquito) AGAP011314-PA Anopheles gambiae (mosquito) XP_001123296.1 Apis mellifera (honey bee) XP_001948334.1 Acyrthosiphon pisum (pea aphid) 242356 Branchiostoma floridae (lancelet) XP_001896672.1 Brugia malayi (roundworm nematode) BGIBMGA009014-PA Bombyx mori (silk worm) ENSBTAP00000051953 Bos taurus (bovine) CBP33678 Caenorhabditis briggsae (nematode) CE41283 Caenorhabditis elegans (worm) ENSCAFP00000004410 Canis familiaris (dog) ENSCINP00000017586 Ciona intestinalis (sea squirt) JA09701 Caenorhabditis japonica (nematode) cn03003 Cryptococcus neoformans (yeast-like fungus) CPIJ018120 Culex pipens (mosquito) ENSCPOP00000000045 Cavia porcellus (guinea pig) RP10488 Caenorhabditis remanei (nematode) ENSCSAVP00000005428 Ciona savignyi (sedentary tunicate) 226969 Capitella spl (polychaete worm) DDB0266822 Dictyostelium discoideum (amoeba) 52230 Daphnia pulex (daphnia) ENSDARP00000003991 Danio rerio (zebra fish) ENSECAP00000017443 Equus caballus (horse) ENSGACP00000018711 Gymnopilus aculeatus (mushroom) ENSGALP00000025497 Gallus gallus (chicken) 109107 Hypsipyla robusta (cedar shoot borer) ENSP00000358695 Homo sapiens (human) ISCW022524-PA Ixodes scapularis (deer tick) KLLA0B14476g Kluyveromyces lactis (yeast) 133451 Lottia gigantea (owl limpet) LmjF30.0610 Leishmania major (virus) 33925 Monocosta brevicollis (choanoflagellate) ENSMODP00000029849 Monodelphis domestica (gray opossum) ENSMMUP00000012531 Macaca mulatta (rhesus monkey) ENSMUSP00000059660 Mus musculus (house mouse) 20757 Nematostella vectensis (starlet anemone) XP_001601916.1 Nasonia vitripennis (wasp) ENSOANP00000002013 Ornithorynchus anatinus (platypus) ENSORLP00000005236 Oryzias latipes (japanese killifish) LOC_Os08g36480.1 Oryza sativa (asian rice) LOC_Os08g36500.1 Oryza sativa (asian rice) PHUM003669-PA Pediculus humanus (human body louse) ENSPPYP00000018819 Pongo pygmaeus (orangutan) 83719 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000031416 Pan troglodytes (chimpanzee) ENSRNOP00000039062 Rattus norvegicus (norway rat) Smp_127160 Schistosoma mansoni (trematode parasite) XP_001184658.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001198870.1 Strongylocentrotus purpuratus (purple sea urchin) 56539 Trichoplax adhaerens (metazoa) XP_968228.1 Tribolium castaneum (red flour beetle) Tc00.1047053507019.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003564 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000025408 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000048892 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14624 NV15901 LH10182 ISCW022524 FBgn0229820 FBgn0224152 FBgn0207929 FBgn0183201 FBgn0176834 JGI_V11_52230 FBgn0070926 FBgn0148435 FBgn0143921 FBgn0130272 FBgn0114146 FBgn0089376 CPIJ018120 BGIBMGA009014 ACYPI002740 GB18586 AGAP011314 AAEL005478 PHUM376170 GLEAN_05424
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18962 w1118; PBac{WH}CG11257f06315
Harvard	- PBac{WH}CG11257f06315
VDRC	v31475 w1118; P{GD7255}v31475 v31474 w1118; P{GD7255}v31474/CyO
Genomic Clones ( 2 )
	BACR21D20 BACR25K02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP11715
Other clones	IP11815
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	12725 79609 214223.48 214225.57 524540 Dmel_dig_001589_0679_3637 EK114413 EK209822 EP11813 IP11615
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034442 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37227
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137575 RefSeq (Proteins) • NP_611419 DDBJ / EMBL / GenBank • AAF57568 Entrez Gene - A searchable database of RefSeq genes. • 37227 UniProtKB/TrEMBL • A1ZBK6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b5 (IPR001199) NADH:cytochrome b5 reductase (CBR) (IPR001834) Oxidoreductase, FAD-binding domain (IPR008333) Cytochrome b5, heme-binding site (IPR018506) HSP20-like chaperone (IPR008978) Ferredoxin reductase-type FAD-binding domain (IPR017927) Riboflavin synthase-like beta-barrel (IPR017938) Oxidoreductase FAD/NAD(P)-binding (IPR001433)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034442 DRSC - Results from RNAi screens. • FBgn0034442 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034442 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11257-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034442 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37227 InParanoid A subset of ortholog calls from InParanoid. • AAEL005478-PA Aedes aegypti (mosquito) AGAP011314-PA Anopheles gambiae (mosquito) XP_001123296.1 Apis mellifera (honey bee) XP_001948334.1 Acyrthosiphon pisum (pea aphid) 242356 Branchiostoma floridae (lancelet) XP_001896672.1 Brugia malayi (roundworm nematode) BGIBMGA009014-PA Bombyx mori (silk worm) ENSBTAP00000051953 Bos taurus (bovine) CBP33678 Caenorhabditis briggsae (nematode) CE41283 Caenorhabditis elegans (worm) ENSCAFP00000004410 Canis familiaris (dog) ENSCINP00000017586 Ciona intestinalis (sea squirt) JA09701 Caenorhabditis japonica (nematode) cn03003 Cryptococcus neoformans (yeast-like fungus) CPIJ018120 Culex pipens (mosquito) ENSCPOP00000000045 Cavia porcellus (guinea pig) RP10488 Caenorhabditis remanei (nematode) ENSCSAVP00000005428 Ciona savignyi (sedentary tunicate) 226969 Capitella spl (polychaete worm) DDB0266822 Dictyostelium discoideum (amoeba) 52230 Daphnia pulex (daphnia) ENSDARP00000003991 Danio rerio (zebra fish) ENSECAP00000017443 Equus caballus (horse) ENSGACP00000018711 Gymnopilus aculeatus (mushroom) ENSGALP00000025497 Gallus gallus (chicken) 109107 Hypsipyla robusta (cedar shoot borer) ENSP00000358695 Homo sapiens (human) ISCW022524-PA Ixodes scapularis (deer tick) KLLA0B14476g Kluyveromyces lactis (yeast) 133451 Lottia gigantea (owl limpet) LmjF30.0610 Leishmania major (virus) 33925 Monocosta brevicollis (choanoflagellate) ENSMODP00000029849 Monodelphis domestica (gray opossum) ENSMMUP00000012531 Macaca mulatta (rhesus monkey) ENSMUSP00000059660 Mus musculus (house mouse) 20757 Nematostella vectensis (starlet anemone) XP_001601916.1 Nasonia vitripennis (wasp) ENSOANP00000002013 Ornithorynchus anatinus (platypus) ENSORLP00000005236 Oryzias latipes (japanese killifish) LOC_Os08g36480.1 Oryza sativa (asian rice) LOC_Os08g36500.1 Oryza sativa (asian rice) PHUM003669-PA Pediculus humanus (human body louse) ENSPPYP00000018819 Pongo pygmaeus (orangutan) 83719 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000031416 Pan troglodytes (chimpanzee) ENSRNOP00000039062 Rattus norvegicus (norway rat) Smp_127160 Schistosoma mansoni (trematode parasite) XP_001184658.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001198870.1 Strongylocentrotus purpuratus (purple sea urchin) 56539 Trichoplax adhaerens (metazoa) XP_968228.1 Tribolium castaneum (red flour beetle) Tc00.1047053507019.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003564 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000025408 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000048892 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37227 modMine - Data generated by the modENCODE project. • FBgn0034442 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14624 NV15901 LH10182 ISCW022524 FBgn0229820 FBgn0224152 FBgn0207929 FBgn0183201 FBgn0176834 JGI_V11_52230 FBgn0070926 FBgn0148435 FBgn0143921 FBgn0130272 FBgn0114146 FBgn0089376 CPIJ018120 BGIBMGA009014 ACYPI002740 GB18586 AGAP011314 AAEL005478 PHUM376170 GLEAN_05424
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11257 (Chen et al., 2008)
Name Synonym
Secondary FlyBase IDs
References ( 10 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Chen et al., 2008, Genome Res. 18(1): 123--136 Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. [FBrf0202125]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]