• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\cer

General Information
Symbol	Dmel\cer	Species	D. melanogaster
Name	crammer	Annotation symbol	CG10460
Feature type	protein_coding_gene	FlyBase ID	FBgn0034443
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56D3-56D3	Sequence location	2R:15,283,720..15,284,277 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crammer is referred to in FlyBase by the symbol Dmel\cer (CG10460, FBgn0034443). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cysteine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: short-term memory; long-term memory. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Proteinase inhibitor I29, cathepsin propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult midgut, adult Malpighian tubules, adult female reproductive system, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1632390_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cer. Gene sequence location is 2R:15283720..15284279.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D3-56D3   Limits computationally determined from genome sequence between P{PZ}ena02029&P{lacW}corak08713 and P{lacW}htsk06121
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cer for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cer-RA FBtr0086551  NM_137576   497   79
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cer-PA   FBpp0085735   9.5   79   5.78     NP_611420   AAF57567
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteinase inhibitor I29, cathepsin propeptide (IPR013201)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57567   AI257748   BP546464   BT050545   BT099627   CK659630   CO155207   CO185051   CO193016   CO194334   CO195087   CO273024   CO320466   CO322339   CO330675   CO338256   EC078980   EC197965   EC204719   EC246483   EC267111   EV575303   FE862802   FE862830   FE862899   FE863041   FE863081   FE863344   FE863440   GH768372
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZBK7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult midgut, adult Malpighian tubules, adult female reproductive system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut    1138 Larval Malpighian Tubules    4656.8 Larval Fat Body    4900.9 Larval Salivary Gland    1171.7 Larval Trachea    1178.825 Larval Carcass    2313.475 Adult Head    515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop    753.1 Adult Midgut    140.5 Adult Hindgut    911.6 Adult Malpighian Tubules    248.2 Adult Fat Body    899.7 Adult Salivary Gland    595.9 Adult Heart    755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland    692.2 Adult Carcass    575.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut  (1138) Larval Malpighian Tubules  (4656.8) Larval Fat Body  (4900.9) Larval Salivary Gland  (1171.7) Larval Trachea  (1178.825) Larval Carcass  (2313.475) Adult Head  515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop  (753.1) Adult Midgut    140.5 Adult Hindgut  (911.6) Adult Malpighian Tubules    248.2 Adult Fat Body  (899.7) Adult Salivary Gland  (595.9) Adult Heart  (755.25) Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland  (692.2) Adult Carcass  (575.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut  (1138) Larval Malpighian Tubules  (4656.8) Larval Fat Body  (4900.9) Larval Salivary Gland  (1171.7) Larval Trachea  (1178.825) Larval Carcass  (2313.475) Adult Head    515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop    753.1 Adult Midgut    140.5 Adult Hindgut    911.6 Adult Malpighian Tubules    248.2 Adult Fat Body    899.7 Adult Salivary Gland    595.9 Adult Heart    755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland    692.2 Adult Carcass    575.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut    1138 Larval Malpighian Tubules    4656.8 Larval Fat Body    4900.9 Larval Salivary Gland    1171.7 Larval Trachea    1178.825 Larval Carcass    2313.475 Adult Head    515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop    753.1 Adult Midgut    140.5 Adult Hindgut    911.6 Adult Malpighian Tubules    248.2 Adult Fat Body    899.7 Adult Salivary Gland    595.9 Adult Heart    755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland    692.2 Adult Carcass    575.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut    1138 Larval Malpighian Tubules    4656.8 Larval Fat Body    4900.9 Larval Salivary Gland    1171.7 Larval Trachea    1178.825 Larval Carcass    2313.475 Adult Head    515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop    753.1 Adult Midgut    140.5 Adult Hindgut    911.6 Adult Malpighian Tubules    248.2 Adult Fat Body    899.7 Adult Salivary Gland    595.9 Adult Heart    755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland    692.2 Adult Carcass    575.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut  (1138) Larval Malpighian Tubules  (4656.8) Larval Fat Body  (4900.9) Larval Salivary Gland  (1171.7) Larval Trachea  (1178.825) Larval Carcass  (2313.475) Adult Head  515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop  753.1 Adult Midgut    140.5 Adult Hindgut  (911.6) Adult Malpighian Tubules    248.2 Adult Fat Body  (899.7) Adult Salivary Gland  595.9 Adult Heart  755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland  692.2 Adult Carcass  575.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut  1138 Larval Malpighian Tubules  (4656.8) Larval Fat Body  (4900.9) Larval Salivary Gland  1171.7 Larval Trachea  1178.825 Larval Carcass  (2313.475) Adult Head    515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop    753.1 Adult Midgut    140.5 Adult Hindgut    911.6 Adult Malpighian Tubules    248.2 Adult Fat Body    899.7 Adult Salivary Gland    595.9 Adult Heart    755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland    692.2 Adult Carcass    575.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    335.5 Larval Midgut    226.9 Larval Hindgut    1138 Larval Malpighian Tubules    4656.8 Larval Fat Body    4900.9 Larval Salivary Gland    1171.7 Larval Trachea    1178.825 Larval Carcass    2313.475 Adult Head    515.4 Adult Eye    172.55 Adult Brain    239.5 Adult Thoracic-Abdominal Ganglion    215.7 Adult Crop    753.1 Adult Midgut    140.5 Adult Hindgut    911.6 Adult Malpighian Tubules    248.2 Adult Fat Body    899.7 Adult Salivary Gland    595.9 Adult Heart    755.25 Adult VirginFemale Spermatheca    365.9 Adult InseminatedFemale Spermatheca    379.2 Adult Ovary    295.9 Adult Testis    101.2 Adult Male Accessory Gland    692.2 Adult Carcass    575.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    515.4   NA  Eye    172.55   NA  Brain    239.5   335.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    215.7   NA  Crop    753.1   226.9  Midgut    140.5   1138  Hindgut    911.6   4656.8  Malpighian Tubules    248.2   4900.9  Fat Body    899.7   1171.7  Salivary Gland    595.9   NA  Heart    755.25   1178.825  Trachea    NA   NA  VirginFemale Spermatheca    365.9   NA  InseminatedFemale Spermatheca    379.2   NA  Ovary    295.9   NA  Testis    101.2   NA  Male Accessory Gland    692.2   2313.475  Carcass    575.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    43 central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male    37 salivary gland, larvae L3 wandering    893 salivary gland, white prepupae    1421 digestive system, larvae L3 wandering    244 digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering    103 fat body, white prepupae    516 fat body, pupae P8    222 carcass, larvae L3 wandering    437 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (43) central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male  (37) salivary gland, larvae L3 wandering  (893) salivary gland, white prepupae  (1421) digestive system, larvae L3 wandering  (244) digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering  (103) fat body, white prepupae  (516) fat body, pupae P8  (222) carcass, larvae L3 wandering  (437) carcass, 1-day adult  (28) carcass, 4-day adult    24 carcass, 20-day adult  (27) ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    43 central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male    37 salivary gland, larvae L3 wandering  (893) salivary gland, white prepupae  (1421) digestive system, larvae L3 wandering  (244) digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering  103 fat body, white prepupae  (516) fat body, pupae P8  (222) carcass, larvae L3 wandering  (437) carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    43 central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male    37 salivary gland, larvae L3 wandering    893 salivary gland, white prepupae    1421 digestive system, larvae L3 wandering    244 digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering    103 fat body, white prepupae    516 fat body, pupae P8    222 carcass, larvae L3 wandering    437 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    43 central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male    37 salivary gland, larvae L3 wandering    893 salivary gland, white prepupae    1421 digestive system, larvae L3 wandering    244 digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering    103 fat body, white prepupae    516 fat body, pupae P8    222 carcass, larvae L3 wandering    437 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (43) central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male  (37) salivary gland, larvae L3 wandering  (893) salivary gland, white prepupae  (1421) digestive system, larvae L3 wandering  (244) digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering  (103) fat body, white prepupae  (516) fat body, pupae P8  (222) carcass, larvae L3 wandering  (437) carcass, 1-day adult  28 carcass, 4-day adult    24 carcass, 20-day adult  27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    43 central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male    37 salivary gland, larvae L3 wandering  (893) salivary gland, white prepupae  (1421) digestive system, larvae L3 wandering  (244) digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering  103 fat body, white prepupae  (516) fat body, pupae P8  (222) carcass, larvae L3 wandering  (437) carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    43 central nervous system, pupae P8    22 head, virgin 1-day female    21 head, virgin 4-day female    13 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    16 head, mated 4-day male    23 head, mated 20-day male    37 salivary gland, larvae L3 wandering    893 salivary gland, white prepupae    1421 digestive system, larvae L3 wandering    244 digestive system, 1-day adult    21 digestive system, 4-day adult    18 digestive system, 20-day adult    12 fat body, larvae L3 wandering    103 fat body, white prepupae    516 fat body, pupae P8    222 carcass, larvae L3 wandering    437 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    27 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    21 accessory gland, mated 4-day male    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    31 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    65 embryo 10-12hr    73 embryo 12-14hr    62 embryo 14-16hr    20 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    19 embryo 22-24hr    39 larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    975 white prepupae new    1570 white prepupae 12hr    836 white prepupae 24hr    434 pupae 2d postWPP    328 pupae 3d postWPP    113 pupae 4d postWPP    32 adult male 01day    47 adult male 05day    32 adult male 30day    25 adult female 01day    31 adult female 05day    46 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr  (31) embryo 04-06hr  (55) embryo 06-08hr  (53) embryo 08-10hr  (65) embryo 10-12hr  (73) embryo 12-14hr  (62) embryo 14-16hr    20 embryo 16-18hr  (27) embryo 18-20hr  (27) embryo 20-22hr    19 embryo 22-24hr  (39) larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (479) larva L3 puffstage 7-9  (975) white prepupae new  (1570) white prepupae 12hr  (836) white prepupae 24hr  (434) pupae 2d postWPP  (328) pupae 3d postWPP  (113) pupae 4d postWPP  (32) adult male 01day  (47) adult male 05day  (32) adult male 30day    25 adult female 01day  (31) adult female 05day  (46) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    31 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    65 embryo 10-12hr    73 embryo 12-14hr    62 embryo 14-16hr    20 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    19 embryo 22-24hr    39 larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (479) larva L3 puffstage 7-9  (975) white prepupae new  (1570) white prepupae 12hr  (836) white prepupae 24hr  (434) pupae 2d postWPP  (328) pupae 3d postWPP  (113) pupae 4d postWPP    32 adult male 01day    47 adult male 05day    32 adult male 30day    25 adult female 01day    31 adult female 05day    46 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    31 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    65 embryo 10-12hr    73 embryo 12-14hr    62 embryo 14-16hr    20 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    19 embryo 22-24hr    39 larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    975 white prepupae new    1570 white prepupae 12hr    836 white prepupae 24hr    434 pupae 2d postWPP    328 pupae 3d postWPP    113 pupae 4d postWPP    32 adult male 01day    47 adult male 05day    32 adult male 30day    25 adult female 01day    31 adult female 05day    46 adult female 30day    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    31 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    65 embryo 10-12hr    73 embryo 12-14hr    62 embryo 14-16hr    20 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    19 embryo 22-24hr    39 larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    975 white prepupae new    1570 white prepupae 12hr    836 white prepupae 24hr    434 pupae 2d postWPP    328 pupae 3d postWPP    113 pupae 4d postWPP    32 adult male 01day    47 adult male 05day    32 adult male 30day    25 adult female 01day    31 adult female 05day    46 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr  31 embryo 04-06hr  (55) embryo 06-08hr  (53) embryo 08-10hr  (65) embryo 10-12hr  (73) embryo 12-14hr  (62) embryo 14-16hr    20 embryo 16-18hr  27 embryo 18-20hr  27 embryo 20-22hr    19 embryo 22-24hr  (39) larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (479) larva L3 puffstage 7-9  (975) white prepupae new  (1570) white prepupae 12hr  (836) white prepupae 24hr  (434) pupae 2d postWPP  (328) pupae 3d postWPP  (113) pupae 4d postWPP  32 adult male 01day  (47) adult male 05day  32 adult male 30day    25 adult female 01day  31 adult female 05day  (46) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    31 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    65 embryo 10-12hr    73 embryo 12-14hr    62 embryo 14-16hr    20 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    19 embryo 22-24hr    39 larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (479) larva L3 puffstage 7-9  (975) white prepupae new  (1570) white prepupae 12hr  (836) white prepupae 24hr  (434) pupae 2d postWPP  (328) pupae 3d postWPP  113 pupae 4d postWPP    32 adult male 01day    47 adult male 05day    32 adult male 30day    25 adult female 01day    31 adult female 05day    46 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    31 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    65 embryo 10-12hr    73 embryo 12-14hr    62 embryo 14-16hr    20 embryo 16-18hr    27 embryo 18-20hr    27 embryo 20-22hr    19 embryo 22-24hr    39 larva L1    6 larva L2    11 larva L3 12hr old    21 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    975 white prepupae new    1570 white prepupae 12hr    836 white prepupae 24hr    434 pupae 2d postWPP    328 pupae 3d postWPP    113 pupae 4d postWPP    32 adult male 01day    47 adult male 05day    32 adult male 30day    25 adult female 01day    31 adult female 05day    46 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    28 embryonic GM2    40 embryonic Kc167    13 embryonic S1    56 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    77 wing disc ML-DmD8    48 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    55 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    71 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    33 ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4  (60) embryonic 1182-4H  (28) embryonic GM2  (40) embryonic Kc167    13 embryonic S1  (56) embryonic S3    15 leg disc CME L1  (27) wing disc CME-W2  (77) wing disc ML-DmD8  (48) wing disc ML-DmD9  (29) wing disc ML-DmD16-c3    20 wing disc ML-DmD21  (55) wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11  (38) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (71) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  (33) ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    28 embryonic GM2    40 embryonic Kc167    13 embryonic S1    56 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    77 wing disc ML-DmD8    48 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    55 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    71 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    33 ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    28 embryonic GM2    40 embryonic Kc167    13 embryonic S1    56 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    77 wing disc ML-DmD8    48 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    55 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    71 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    33 ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    28 embryonic GM2    40 embryonic Kc167    13 embryonic S1    56 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    77 wing disc ML-DmD8    48 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    55 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    71 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    33 ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4  (60) embryonic 1182-4H  28 embryonic GM2  (40) embryonic Kc167    13 embryonic S1  (56) embryonic S3    15 leg disc CME L1  27 wing disc CME-W2  (77) wing disc ML-DmD8  (48) wing disc ML-DmD9  29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21  (55) wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11  (38) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (71) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  (33) ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    28 embryonic GM2    40 embryonic Kc167    13 embryonic S1    56 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    77 wing disc ML-DmD8    48 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    55 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    71 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    33 ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    60 embryonic 1182-4H    28 embryonic GM2    40 embryonic Kc167    13 embryonic S1    56 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    77 wing disc ML-DmD8    48 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    55 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    71 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    33 ovary fGS/OSS    25 ovary OSC    15 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    91 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    62 Cadmium 50 mM 12 hrs, larvae L3    379 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    40 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    65 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (83) cold shock, 4-day adult  (91) heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3  (62) Cadmium 50 mM 12 hrs, larvae L3  (379) Cadmium 50 mM 48 hrs, 4-day adult  (28) Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3  (40) Zinc 4.5 mM 48 hrs, 4-day adult  (39) Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3  (47) Ethanol 10% 3 hrs, larvae L3  (33) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (65) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    91 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    62 Cadmium 50 mM 12 hrs, larvae L3  (379) Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    40 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    65 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    91 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    62 Cadmium 50 mM 12 hrs, larvae L3    379 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    40 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    65 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    91 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    62 Cadmium 50 mM 12 hrs, larvae L3    379 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    40 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    65 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (83) cold shock, 4-day adult  (91) heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3  (62) Cadmium 50 mM 12 hrs, larvae L3  (379) Cadmium 50 mM 48 hrs, 4-day adult  28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3  (40) Zinc 4.5 mM 48 hrs, 4-day adult  (39) Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3  (47) Ethanol 10% 3 hrs, larvae L3  (33) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (65) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    91 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    62 Cadmium 50 mM 12 hrs, larvae L3  (379) Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    40 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    65 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    91 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    62 Cadmium 50 mM 12 hrs, larvae L3    379 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    40 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    33 Caffeine 1.5 mg/ml 4 hrs, larvae L3    65 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034443 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10460-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 cerGD12961 Other Phenotypes Allele feeding behavior defective cerMz1180 memory defective cer+t2.2 cerE29 cerMz1180 memory defective, with Scer\GAL4cer-Mz1180 cerScer\UAS.cCa memory defective, with Scer\GAL4repo cerScer\UAS.cCa memory defective | recessive cerMz1180 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of cer Class Mutagen Stocks Known lesion cerG6085 P-element activity 1 -- cerE29 P-element activity 0 Yes cerE3 P-element activity 0 Yes cerMz1180 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cer Class Mutagen Stocks Known lesion cerGD12961 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cerJF01914 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cer+t2.2 in vitro construct - genomic fragment 0 Yes cerScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes cerT:Avic\GFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12961} NA P{TRiP.JF01914} NA P{UAS-cer.C} NA characterization construct P{cer+t2.2} NA P{cer-GFP.C} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}cerMz1180 No insertion of mobile activating element P{EP}cerG6085 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase inhibitor activity inferred from direct assay (Comas et al., 2004, Deshapriya et al., 2007)
Biological Process
CV term Evidence References
long-term memory inferred from mutant phenotype (Preat et al., 2004, Comas et al., 2004) short-term memory inferred from direct assay (Colomb et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cer allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62893 DroID - A comprehensive database of gene and protein interactions. • FBgn0034443 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37229
Orthologs
OrthoDB Orthologs (23) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67M2JQ Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG60CGF2 Arthropod inclusive ortholog search EOG6XPNZZ Metazoa inclusive ortholog search EOG6NPM07
Orthologs in Drosophila Species (EOG67M2JQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cer     Drosophila simulans   Dsim\GD25324 Y   Drosophila sechellia   Dsec\GM19834 Y   Drosophila erecta   Dere\GG20910 Y   Drosophila yakuba   Dyak\GE13849 Y   Drosophila ananassae   Dana\GF12610 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10327 Y   Drosophila persimilis   Dper\GL11253 Y   Drosophila willistoni   Dwil\GK22212 Y   Drosophila virilis   Dvir\GJ21545 Y   Drosophila mojavensis   Dmoj\GI18458 Y   Drosophila grimshawi   Dgri\GH17548     Drosophila grimshawi   Dgri\GH22972 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG60CGF2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG034880   Tribolium castaneum Red flour beetle  Tcas\TC009448   Tribolium castaneum Red flour beetle  Tcas\TC009362   Tribolium castaneum Red flour beetle  Tcas\TC009366   Tribolium castaneum Red flour beetle  Tcas\TC002843   Tribolium castaneum Red flour beetle  Tcas\TC009365   Tribolium castaneum Red flour beetle  Tcas\TC009367
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6NPM07)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Mus musculus House mouse  Mmus\Ctla2b   Mus musculus House mouse  Mmus\Ctla2a   Rattus norvegicus Norway rat  Rnor\Ctla2a
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25324 Drosophila sechellia Dsec\GM19834 Drosophila erecta Dere\GG20910 Drosophila yakuba Dyak\GE13849 Drosophila ananassae Dana\GF12610 Drosophila pseudoobscura pseudoobscura Dpse\GA10327 Drosophila persimilis Dper\GL11253 Drosophila willistoni Dwil\GK22212 Drosophila virilis Dvir\GJ21545 Drosophila mojavensis Dmoj\GI18458 Drosophila grimshawi Dgri\GH22972
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	25875 y1 v1; P{TRiP.JF01914}attP2 27956 y1 w*; P{EP}cerG6085
VDRC	v22752 w1118; P{GD12961}v22752 v22751 w1118; P{GD12961}v22751/CyO
Genomic Clones ( 2 )
	BACR21D20 BACR25K02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP06209
Other clones	RE33070
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP17524
Other clones	10007 62712 180267 192968 571201 Dmel_dig_015504_0626_3299 EC29237 EC34990 EC38113 EC39687 EK109252 EK187922 EK285458 EK295860 EN05556 EN16328 FGH106F10 RM06668 RM06768 RM06868 RM06968 RM07068 RM07168 RM07368 RP001031028
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034443 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37229
Antibody Information
	monoclonal (Tseng et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cer CG10460 (Preat, 2004.2.25)
Source for database merge of
Additional comments
Other Comments
	cer encodes an inhibitor of cathepsins (a subfamily of cysteine proteinases). (Comas et al., 2004) Mutants show long-term memory defects, with no effect on short-term memory. (Comas et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137576 RefSeq (Proteins) • NP_611420 DDBJ / EMBL / GenBank • AAF57567 AI257748 Entrez Gene - A searchable database of RefSeq genes. • 37229 UniProtKB/TrEMBL • A1ZBK7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteinase inhibitor I29, cathepsin propeptide (IPR013201)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62893 DroID - A comprehensive database of gene and protein interactions. • FBgn0034443 DRSC - Results from RNAi screens. • FBgn0034443 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034443 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10460-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034443 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37229 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37229 modMine - Data generated by the modENCODE project. • FBgn0034443
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	cer (Colomb et al., 2009) CER (Eissenberg et al., 2011) CG10460 (Stempfl et al., 2002, Deshapriya et al., 2007, Toledano-Katchalski et al., 2007, Perkins et al., 1.15.2009) D/CTLA-2 (Deshapriya et al., 2007)
Name Synonym	crammer (Comas et al., 2003, Preat et al., 2004, Krashes and Waddell, 2008, Deshapriya et al., 2007, Colomb et al., 2009) Drosophila CTLA-2like protein (Deshapriya et al., 2007)
Secondary FlyBase IDs
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Chen et al., 2012, Science 335(6069): 678--685 Visualizing long-term memory formation in two neurons of the Drosophila brain. [FBrf0217453] Tseng et al., 2012, Biochem. J. 442(3): 563--572 A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin. [FBrf0218025] Eissenberg et al., 2011, Traffic 12(12): 1821--1838 Drosophila GGA Model: An Ultimate Gateway to GGA Analysis. [FBrf0216574] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...