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Gene Dmel\Toll-7

General Information
Symbol	Dmel\Toll-7	Species	D. melanogaster
Name	Toll-7	Annotation symbol	CG8595
Feature type	protein_coding_gene	FlyBase ID	FBgn0034476
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Tl-7
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56E4-56E4	Sequence location	2R:15,714,410..15,720,473 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Toll-7 is referred to in FlyBase by the symbol Dmel\Toll-7 (CG8595, FBgn0034476). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane signaling receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: signal transduction. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine-rich flanking region, C-terminal; Leucine-rich repeat; Leucine-rich repeat, typical subtype; Leucine-rich repeat-containing N-terminal; Toll/interleukin-1 receptor homology (TIR) domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1639160_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Toll-7. Gene sequence location is 2R:15714410..15720473.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Insertions Mi{MIC}Toll-7[MI03386] Alleles Toll-7[MI03386] Sequence features HFA07563 BKN23172 References Bellen, 2011.10.25, set956.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56E4-56E4   Limits computationally determined from genome sequence between P{PZ}sm05338&P{PZ}emm1 and P{lacW}l(2)k08002k08002
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56E3-56F9     (Tauszig, 2000.3.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Toll-7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Toll-7-RA FBtr0086336  NM_079073   6064   1446
Additional Transcript Data & Comments
Reported size (kB)	6.4, 5.2 (northern blot) (Tauszig et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Toll-7-PA   FBpp0085638   160.9   1446   6.59     NP_523797   AAF57514
Additional Polypeptide Data & Comments
Reported size (kDa)	1446 (aa) (Tauszig et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat-containing N-terminal (IPR000372) Cysteine-rich flanking region, C-terminal (IPR000483) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142227   AA201652   AE013599 AAF57514   AF247765 AAF86225   AI107604   AI107969   AW942051   BF499457   BT053721   BT125656   CK660718   CO185658   CO189340   CO269571   CO270853   CO292065   CO299044   CO304830   CO306126   DQ138914 ABA86520   EC064507   EC068405   EC077278   EC198852   EC213181   EC228335   EC229787   EC231864   EC235531   EC237084   EC240462   EC240473   EC260737   ES690641   EV576035
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2XXU8 Q7KIN0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Tauszig et al., 2000) adult stage | male     (Tauszig et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034476    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034476 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034476 expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr    1847 embryo 06-08hr    2582 embryo 08-10hr    3664 embryo 10-12hr    3248 embryo 12-14hr    3680 embryo 14-16hr    2501 embryo 16-18hr    2216 embryo 18-20hr    1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr    1637 white prepupae 24hr    1890 pupae 2d postWPP    1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr  (352) embryo 04-06hr  (1847) embryo 06-08hr  (2582) embryo 08-10hr  (3664) embryo 10-12hr  (3248) embryo 12-14hr  (3680) embryo 14-16hr  (2501) embryo 16-18hr  (2216) embryo 18-20hr  (1648) embryo 20-22hr  (1040) embryo 22-24hr  (1338) larva L1  (930) larva L2  (400) larva L3 12hr old  (207) larva L3 puffstage 1-2  (305) larva L3 puffstage 3-6  (832) larva L3 puffstage 7-9  (1275) white prepupae new  (1341) white prepupae 12hr  (1637) white prepupae 24hr  (1890) pupae 2d postWPP  (1447) pupae 3d postWPP  (825) pupae 4d postWPP  (311) adult male 01day  (423) adult male 05day  (442) adult male 30day  (323) adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr  (1847) embryo 06-08hr  (2582) embryo 08-10hr  (3664) embryo 10-12hr  (3248) embryo 12-14hr  (3680) embryo 14-16hr  (2501) embryo 16-18hr  (2216) embryo 18-20hr  (1648) embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr  (1637) white prepupae 24hr  (1890) pupae 2d postWPP  1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr    1847 embryo 06-08hr    2582 embryo 08-10hr    3664 embryo 10-12hr    3248 embryo 12-14hr    3680 embryo 14-16hr    2501 embryo 16-18hr    2216 embryo 18-20hr    1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr    1637 white prepupae 24hr    1890 pupae 2d postWPP    1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr    1847 embryo 06-08hr    2582 embryo 08-10hr    3664 embryo 10-12hr    3248 embryo 12-14hr    3680 embryo 14-16hr    2501 embryo 16-18hr    2216 embryo 18-20hr    1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr    1637 white prepupae 24hr    1890 pupae 2d postWPP    1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034476 expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr    1847 embryo 06-08hr    2582 embryo 08-10hr    3664 embryo 10-12hr    3248 embryo 12-14hr    3680 embryo 14-16hr    2501 embryo 16-18hr    2216 embryo 18-20hr    1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr    1637 white prepupae 24hr    1890 pupae 2d postWPP    1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr  (352) embryo 04-06hr  (1847) embryo 06-08hr  (2582) embryo 08-10hr  (3664) embryo 10-12hr  (3248) embryo 12-14hr  (3680) embryo 14-16hr  (2501) embryo 16-18hr  (2216) embryo 18-20hr  (1648) embryo 20-22hr  (1040) embryo 22-24hr  (1338) larva L1  (930) larva L2  (400) larva L3 12hr old  (207) larva L3 puffstage 1-2  (305) larva L3 puffstage 3-6  (832) larva L3 puffstage 7-9  (1275) white prepupae new  (1341) white prepupae 12hr  (1637) white prepupae 24hr  (1890) pupae 2d postWPP  (1447) pupae 3d postWPP  (825) pupae 4d postWPP  (311) adult male 01day  (423) adult male 05day  (442) adult male 30day  (323) adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr  1847 embryo 06-08hr  (2582) embryo 08-10hr  (3664) embryo 10-12hr  (3248) embryo 12-14hr  (3680) embryo 14-16hr  (2501) embryo 16-18hr  2216 embryo 18-20hr  1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr  1637 white prepupae 24hr  1890 pupae 2d postWPP  1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr    1847 embryo 06-08hr    2582 embryo 08-10hr    3664 embryo 10-12hr    3248 embryo 12-14hr    3680 embryo 14-16hr    2501 embryo 16-18hr    2216 embryo 18-20hr    1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr    1637 white prepupae 24hr    1890 pupae 2d postWPP    1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    352 embryo 04-06hr    1847 embryo 06-08hr    2582 embryo 08-10hr    3664 embryo 10-12hr    3248 embryo 12-14hr    3680 embryo 14-16hr    2501 embryo 16-18hr    2216 embryo 18-20hr    1648 embryo 20-22hr    1040 embryo 22-24hr    1338 larva L1    930 larva L2    400 larva L3 12hr old    207 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    832 larva L3 puffstage 7-9    1275 white prepupae new    1341 white prepupae 12hr    1637 white prepupae 24hr    1890 pupae 2d postWPP    1447 pupae 3d postWPP    825 pupae 4d postWPP    311 adult male 01day    423 adult male 05day    442 adult male 30day    323 adult female 01day    85 adult female 05day    25 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034476    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034476 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034476 expression level Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034476 expression level Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7   NA  Eye    3.275   NA  Brain    no informative data   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    5   4.8  Midgut    8.6   1.7  Hindgut    5.4   2.6  Malpighian Tubules    1   6.8  Fat Body    1.2   2.7  Salivary Gland    7.9   NA  Heart    0.575   4.275  Trachea    NA   NA  VirginFemale Spermatheca    1   NA  InseminatedFemale Spermatheca    1.4   NA  Ovary    0.7   NA  Testis    29.9   NA  Male Accessory Gland    5.5   1.225  Carcass    5.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034476 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8595-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Toll-7 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Toll-7GD16 Toll-7GD14417 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Toll-7 Class Mutagen Stocks Known lesion Toll-7MI03386 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Toll-7 Class Mutagen Stocks Known lesion Toll-7GD16 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Toll-7GD14417 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-7HM05230 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-7GD2512 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16} NA P{GD2512} NA P{GD14417} NA P{TRiP.HM05230} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Toll-7MI03386 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
transmembrane signaling receptor activity inferred from sequence or structural similarity (Lemaitre, 2000.12.20) non-traceable author statement (Tauszig, 2000.3.23)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) signal transduction inferred from electronic annotation with InterPro:IPR000157 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lemaitre, 2000.12.20)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Lemaitre, 2000.12.20) intracellular inferred from electronic annotation with InterPro:IPR000157 (FlyBase Curators et al., 2004-) plasma membrane non-traceable author statement (Tauszig, 2000.3.23)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Toll-7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62928 DroID - A comprehensive database of gene and protein interactions. • FBgn0034476 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37272
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11739 Dere\GG22003 Dgri\GH23021 Dmoj\GI21088 Dper\GL10362 Dpse\GA21191 Dsec\GM21984 Dsim\GD11482 Dvir\GJ20935 Dwil\GK15893 Dyak\GE12083
Curated drosophilid orthologs	Dafs\Toll-7 (Bartolome and Charlesworth, 2006) Dere\GG22003 (Comeron and Guthrie, 2005.7.21) Dmir\Toll-7 (Bartolome and Charlesworth, 2006, Bartolome and Charlesworth, 2006) Dpse\GA21191 (Bartolome and Charlesworth, 2006) Dsim\GD11482 (Comeron and Guthrie, 2005.7.21) Dyak\GE12083 (Comeron and Guthrie, 2005.7.21)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002583-PA Aedes aegypti (mosquito) AGAP012326-PA Anopheles gambiae (mosquito) NP_001013379.1 Apis mellifera (honey bee) XP_001946943.1 Acyrthosiphon pisum (pea aphid) At1g74170.1 Arabidopsis thaliana (wall cress) At1g74180.1 Arabidopsis thaliana (wall cress) At2g34930.1 Arabidopsis thaliana (wall cress) BGIBMGA011037-PA Bombyx mori (silk worm) CPIJ016598 Culex pipens (mosquito) ENSP00000366283 Homo sapiens (human) ENSMMUP00000003819 Macaca mulatta (rhesus monkey) ENSOANP00000005876 Ornithorynchus anatinus (platypus) ENSOANP00000018831 Ornithorynchus anatinus (platypus) LOC_Os02g01800.1 Oryza sativa (asian rice) LOC_Os02g11980.1 Oryza sativa (asian rice) LOC_Os02g12030.1 Oryza sativa (asian rice) LOC_Os02g12450.1 Oryza sativa (asian rice) LOC_Os03g21730.1 Oryza sativa (asian rice) LOC_Os09g25540.1 Oryza sativa (asian rice) PHUM002657-PA Pediculus humanus (human body louse) ENSPPYP00000006195 Pongo pygmaeus (orangutan) ENSPTRP00000010126 Pan troglodytes (chimpanzee) XP_972409.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13114 NV50152 LH13356 FBgn0084731 FBgn0217896 FBgn0208071 FBgn0084945 FBgn0176861 JGI_V11_128614 FBgn0081179 FBgn0147972 FBgn0143820 FBgn0130478 FBgn0084217 FBgn0088779 CPIJ016598 BGIBMGA011038 BGIBMGA011037 ACYPI008698 GB15177 TOLL7 PHUM480550 GLEAN_04474
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	30488 y1 sc* v1; P{TRiP.HM05230}attP2
VDRC	v39176 w1118; P{GD14417}v39176 v6541 w1118; P{GD16}v6541/TM3 v24473 w1118; P{GD16}v24473/TM3
Genomic Clones ( 1 )
	BACR22J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	LD03945 RT09953
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14018 GH05368 GH05879 LP19537
Other clones	32255 71247 82166 83976 105848 144443 214311.62 281854 CK01.3A.E6 CK01.7D.A6 CK01.8A.E6 CK01.54A.G5 CK01.130D.H8 CK00091 Dmel_dig_013786_0608_0495 EK010735 EK044027 EK095032 EK100564 EK174404 EK199115 EK246453 EK250320
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034476 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37272
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Toll-7 CG8595 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Toll-7 CG8595 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079073 RefSeq (Proteins) • NP_523797 DDBJ / EMBL / GenBank • AA201652 AAF57514 AAF86225 ABA86520 AF247765 AW942051 DQ138914 Entrez Gene - A searchable database of RefSeq genes. • 37272 UniProtKB/TrEMBL • Q2XXU8 Q7KIN0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat-containing N-terminal (IPR000372) Cysteine-rich flanking region, C-terminal (IPR000483) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62928 DroID - A comprehensive database of gene and protein interactions. • FBgn0034476 DRSC - Results from RNAi screens. • FBgn0034476 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034476 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8595-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034476 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37272 InParanoid A subset of ortholog calls from InParanoid. • AAEL002583-PA Aedes aegypti (mosquito) AGAP012326-PA Anopheles gambiae (mosquito) NP_001013379.1 Apis mellifera (honey bee) XP_001946943.1 Acyrthosiphon pisum (pea aphid) At1g74170.1 Arabidopsis thaliana (wall cress) At1g74180.1 Arabidopsis thaliana (wall cress) At2g34930.1 Arabidopsis thaliana (wall cress) BGIBMGA011037-PA Bombyx mori (silk worm) CPIJ016598 Culex pipens (mosquito) ENSP00000366283 Homo sapiens (human) ENSMMUP00000003819 Macaca mulatta (rhesus monkey) ENSOANP00000005876 Ornithorynchus anatinus (platypus) ENSOANP00000018831 Ornithorynchus anatinus (platypus) LOC_Os02g01800.1 Oryza sativa (asian rice) LOC_Os02g11980.1 Oryza sativa (asian rice) LOC_Os02g12030.1 Oryza sativa (asian rice) LOC_Os02g12450.1 Oryza sativa (asian rice) LOC_Os03g21730.1 Oryza sativa (asian rice) LOC_Os09g25540.1 Oryza sativa (asian rice) PHUM002657-PA Pediculus humanus (human body louse) ENSPPYP00000006195 Pongo pygmaeus (orangutan) ENSPTRP00000010126 Pan troglodytes (chimpanzee) XP_972409.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37272 modMine - Data generated by the modENCODE project. • FBgn0034476 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13114 NV50152 LH13356 FBgn0084731 FBgn0217896 FBgn0208071 FBgn0084945 FBgn0176861 JGI_V11_128614 FBgn0081179 FBgn0147972 FBgn0143820 FBgn0130478 FBgn0084217 FBgn0088779 CPIJ016598 BGIBMGA011038 BGIBMGA011037 ACYPI008698 GB15177 TOLL7 PHUM480550 GLEAN_04474
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG8595 (Wasserman, 2000, Perkins et al., 2009) CT24947 (Hynes and Zhao, 2000) dTLR7 (Silverman and Maniatis, 2001) dToll7 (Singh et al., 2003) Tl-7 (Lemaitre, 2000.12.20, Khush and Lemaitre, 2000) toll (Janssens and Beyaert, 2002) Toll-7 (Swanson et al., 2009, Bartolome and Charlesworth, 2006, Sandoval and Eldon, 2008, Ooi et al., 2002, Tauszig-Delamasure et al., 2002, Wagner et al., 2008) TOLL 7 (Christophides et al., 2002)
Name Synonym	Toll-7 (Tauszig, 2000.3.23) Toll-like (Hynes and Zhao, 2000) toll receptor (Haesemeyer M et al., 2007)
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 5 ) Review  ( 8 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...