Tl-7
Toll-like receptors - Neurotrophin receptors - regulation of locomotion, motor axon targeting and neuronal survival - innate immunity
Please see the JBrowse view of Dmel\Toll-7 for information on other features
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Gene model reviewed during 5.51
6.4, 5.2 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
1446 (aa)
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-7 using the Feature Mapper tool.
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as posterior spiracle specific anlage
Tollo transcript is expressed in the proximal region of the wing disc, and distal segments of the leg discs; expression is absent from the wing pouch.
Toll-7 is expressed dynamically throughout embryogenesis. At the beginning of germ band extension, a strong spot is seen in the head region and diffuse staining in the trunk. At full germ band extension, a pattern of 14 strips is seen and they are positioned posterior to the wg stripes. At germ band retraction, Toll-7 is expressed in some neurons of the CNS, in the precursors to the leg imaginal discs, in the ventral epithelium of the large intestine, and in the anterior and posterior spiracles. At stage 16 Toll-7 is reduced and is mostly restricted to the CNS.
Toll-7-protein is enriched in a cluster of glomeruli in the anterior and lateral regions of the antennal lobe, which include the DA1, VA1d and VA1v glomeruli.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Toll-7 in GBrowse 22-90
2-90
2-95.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Toll-7 CG8595
Source for identity of Toll-7 CG8595 was sequence comparison ( date:000721 ).
Toll-6 acts cell autonomously to instruct the targeting of specific classes of olfactory receptor neuron axons.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.