FlyBase Gene Report: Dmel\Toll-7

General Information

Symbol

Dmel\Toll-7

Species

D. melanogaster

Name

Toll-7

Annotation Symbol

CG8595

Feature Type

protein_coding_gene

FlyBase ID

FBgn0034476

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Snapshot

Toll-7 (Toll-7) encodes a plasma membrane Toll receptor that binds to viral glycoproteins, leading to the activation of antiviral defenses including autophagy. [Date last reviewed: 2018-10-18]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Tl-7

Key Links

Genomic Location

Cytogenetic map

56E4-56E4

Sequence location

2R:19,826,578..19,832,973 [+]

Recombination map

2-90

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

TOLL RECEPTORS

Protein Family (UniProt)

Belongs to the Toll-like receptor family. (Q7KIN0)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

neurotrophin receptor activity; virion binding

Predictions / Assertions

signaling pattern recognition receptor activity

Summaries

Gene Group (FlyBase)

TOLL RECEPTORS -: The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).

Protein Function (UniProtKB)

Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).

(UniProt, Q7KIN0)

Summary (Interactive Fly)

Toll-like receptors - Neurotrophin receptors - regulation of locomotion, motor axon targeting and neuronal survival - innate immunity

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Toll-7 or the JBrowse view of Dmel\Toll-7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Toll-7-RA

FBtr0086336

NM_079073

6396

1446

Additional Transcript Data and Comments

Reported size (kB)

6.4, 5.2 (northern blot)

(Tauszig et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Toll-7-PA

FBpp0085638

160.9

1446

6.59

NP_523797

AAF57514

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1446 (aa)

(Tauszig et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Toll-7_1

Linkouts

Gene Ontology (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

neurotrophin receptor activity

inferred from mutant phenotype

(McIlroy et al., 2013)

virion binding

inferred from direct assay

(Nakamoto et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

signaling pattern recognition receptor activity

inferred by curator from GO:0009897,GO:0010508,GO:0046790

(Nakamoto et al., 2012)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

axon guidance

inferred from mutant phenotype

(Ward et al., 2015)

defense response to virus

inferred from mutant phenotype

(Nakamoto et al., 2012)

positive regulation of autophagy

inferred from mutant phenotype

(Nakamoto et al., 2012)

regulation of defense response to virus

inferred from mutant phenotype

(Moy et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

cell surface pattern recognition receptor signaling pathway

inferred by curator from GO:0009897,GO:0010508,GO:0046790

(Nakamoto et al., 2012)

signal transduction

inferred from electronic annotation with InterPro:IPR000157

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

external side of plasma membrane

inferred from direct assay

(Nakamoto et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN001224703

(assigned by GO_Central )

(Gaudet et al., 2011)

extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN001224703

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

organism | restricted

(Kambris et al., 2002)

embryonic stage 9 -- 10

antennal primordium