• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Toll-7

General Information
Symbol	Dmel\Toll-7	Species	D. melanogaster
Name	Toll-7	Annotation symbol	CG8595
Feature type	protein_coding_gene	FlyBase ID	FBgn0034476
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Tl-7
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56E4-56E4	Sequence location	2R:15,714,083..15,720,478 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Toll-7 is referred to in FlyBase by the symbol Dmel\Toll-7 (CG8595, FBgn0034476). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: virion binding. There is experimental evidence that it is involved in the biological process: positive regulation of autophagy; defense response to virus. 9 alleles are reported. The phenotypes of these alleles are annotated with: leg; eye; wing disc; adult abdomen; wing; ventral thoracic disc; wing vein. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine-rich flanking region, C-terminal; Leucine-rich repeat; Leucine-rich repeat, typical subtype; Leucine-rich repeat-containing N-terminal; Toll/interleukin-1 receptor homology (TIR) domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1639160_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Toll-7. Gene sequence location is 2R:15714410..15720473.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56E4-56E4   Limits computationally determined from genome sequence between P{PZ}sm05338&P{PZ}emm1 and P{lacW}l(2)k08002k08002
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56E3-56F9     (Tauszig, 2000.3.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Toll-7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Toll-7-RA FBtr0086336  NM_079073   6396   1446
Additional Transcript Data & Comments
Reported size (kB)	6.4, 5.2 (northern blot) (Tauszig et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Toll-7-PA   FBpp0085638   160.9   1446   6.59     NP_523797   AAF57514
Additional Polypeptide Data & Comments
Reported size (kDa)	1446 (aa) (Tauszig et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat-containing N-terminal (IPR000372) Cysteine-rich flanking region, C-terminal (IPR000483) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142227   AA201652   AE013599 AAF57514   AF247765 AAF86225   AI107604   AI107969   AW942051   BF499457   BT053721   BT125656   CK660718   CO185658   CO189340   CO269571   CO270853   CO292065   CO299044   CO304830   CO306126   DQ138914 ABA86520   EC064507   EC068405   EC077278   EC198852   EC213181   EC228335   EC229787   EC231864   EC235531   EC237084   EC240462   EC240473   EC260737   ES690641   EV576035
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KIN0 Q2XXU8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium organism | faint & ubiquitous   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Tauszig et al., 2000) adult stage | male     (Tauszig et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
external side of plasma membrane inferred from direct assay (Nakamoto et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    23.375 Larval Midgut    4.8 Larval Hindgut    1.7 Larval Malpighian Tubules    2.6 Larval Fat Body    6.8 Larval Salivary Gland    2.7 Larval Trachea    4.275 Larval Carcass    1.225 Adult Head    7 Adult Eye    3.275 Adult Brain    17.3 Adult Thoracic-Abdominal Ganglion    15.5 Adult Crop    5 Adult Midgut    8.6 Adult Hindgut    5.4 Adult Malpighian Tubules    1 Adult Fat Body    1.2 Adult Salivary Gland    7.9 Adult Heart    0.575 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    0.7 Adult Testis    29.9 Adult Male Accessory Gland    5.5 Adult Carcass    5.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7   NA  Eye    3.275   NA  Brain    no informative data   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    5   4.8  Midgut    8.6   1.7  Hindgut    5.4   2.6  Malpighian Tubules    1   6.8  Fat Body    1.2   2.7  Salivary Gland    7.9   NA  Heart    0.575   4.275  Trachea    NA   NA  VirginFemale Spermatheca    1   NA  InseminatedFemale Spermatheca    1.4   NA  Ovary    0.7   NA  Testis    29.9   NA  Male Accessory Gland    5.5   1.225  Carcass    5.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3  26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3  26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    26 central nervous system, pupae P8    22 head, virgin 1-day female    4 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    13 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr    33 embryo 08-10hr    47 embryo 10-12hr    42 embryo 12-14hr    48 embryo 14-16hr    32 embryo 16-18hr    28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr  (33) embryo 08-10hr  (47) embryo 10-12hr  (42) embryo 12-14hr  (48) embryo 14-16hr  (32) embryo 16-18hr  (28) embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr    33 embryo 08-10hr    47 embryo 10-12hr    42 embryo 12-14hr    48 embryo 14-16hr    32 embryo 16-18hr    28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr    33 embryo 08-10hr    47 embryo 10-12hr    42 embryo 12-14hr    48 embryo 14-16hr    32 embryo 16-18hr    28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr    33 embryo 08-10hr    47 embryo 10-12hr    42 embryo 12-14hr    48 embryo 14-16hr    32 embryo 16-18hr    28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr  (33) embryo 08-10hr  (47) embryo 10-12hr  (42) embryo 12-14hr  (48) embryo 14-16hr  32 embryo 16-18hr  28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr    33 embryo 08-10hr    47 embryo 10-12hr    42 embryo 12-14hr    48 embryo 14-16hr    32 embryo 16-18hr    28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    24 embryo 06-08hr    33 embryo 08-10hr    47 embryo 10-12hr    42 embryo 12-14hr    48 embryo 14-16hr    32 embryo 16-18hr    28 embryo 18-20hr    21 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    12 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    24 pupae 2d postWPP    19 pupae 3d postWPP    11 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    4 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD03945 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034476 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8595-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Toll-7 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Toll-7g1-1 lethal, with Scer\GAL4e22c Toll-7Scer\UAS.cYa lethal, with Scer\GAL4ptc-559.1 Toll-7Scer\UAS.cYa partially lethal - majority die (with Df(2R)BSC22) Toll-7g1-1 viable, with Scer\GAL4pnr-MD237 Toll-7GD16 Toll-7GD14417 Other Phenotypes Allele immune response defective, with Scer\GAL4Act.PU Toll-7GD14417 immune response defective (with Df(2R)BSC22) Toll-7g1-5 Phenotype manifest in Allele adult abdomen, with Scer\GAL432B Toll-7Scer\UAS.cYa adult abdomen, with Scer\GAL4da.G32 Toll-7Scer\UAS.cYa eye, with Scer\GAL4da.G32 Toll-7Scer\UAS.cYa eye, with Scer\GAL4GMR.PF Toll-7Scer\UAS.cYa eye, with Scer\GAL4lz-gal4 Toll-7Scer\UAS.cYa leg, with Scer\GAL4dpp.PS Toll-7Scer\UAS.cYa macrochaeta | ectopic, with Scer\GAL471B Toll-7Scer\UAS.cYa macrochaeta | ectopic, with Scer\GAL4da.G32 Toll-7Scer\UAS.cYa ventral thoracic disc, with Scer\GAL4dpp.PS Toll-7Scer\UAS.cYa wing, with Scer\GAL4dpp.PS Toll-7Scer\UAS.cYa wing disc, with Scer\GAL4dpp.PS Toll-7Scer\UAS.cYa wing vein, with Scer\GAL4da.G32 Toll-7Scer\UAS.cYa
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Toll-7 Class Mutagen Stocks Known lesion Toll-7MI03386 1 -- Toll-7g1-1 ends-in gene targeting 0 Yes Toll-7g1-5 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Toll-7 Class Mutagen Stocks Known lesion Toll-7GD16 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Toll-7GD14417 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-7HM05230 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-7GD2512 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Toll-7NIG.8595R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Toll-7Scer\UAS.cYa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16} NA P{GD2512} NA P{GD14417} NA P{NIG.8595R} NA P{TRiP.HM05230} NA P{UAS-Toll-7.Y} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Toll-7MI03386 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
virion binding inferred from direct assay (Nakamoto et al., 2012)
Biological Process
CV term Evidence References
defense response to virus inferred from mutant phenotype (Nakamoto et al., 2012) positive regulation of autophagy inferred from mutant phenotype (Nakamoto et al., 2012)
Cellular Component
CV term Evidence References
external side of plasma membrane inferred from direct assay (Nakamoto et al., 2012)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
pattern recognition receptor activity inferred by curator from GO:0009897|GO:0046790|GO:0010508 (Nakamoto et al., 2012) transmembrane signaling receptor activity inferred from sequence or structural similarity (Lemaitre, 2000.12.20) non-traceable author statement (Tauszig, 2000.3.23)
Biological Process
CV term Evidence References
cell surface pattern recognition receptor signaling pathway inferred by curator from GO:0009897|GO:0046790|GO:0010508 (Nakamoto et al., 2012) defense response non-traceable author statement (Lemaitre, 2000.12.20) signal transduction inferred from electronic annotation with InterPro:IPR000157 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lemaitre, 2000.12.20)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Lemaitre, 2000.12.20) plasma membrane non-traceable author statement (Tauszig, 2000.3.23)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Toll-7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62928 DroID - A comprehensive database of gene and protein interactions. • FBgn0034476 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37272
Orthologs
OrthoDB Orthologs (96) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63FHG5 Dipteran inclusive ortholog search EOG6CC488 Insect inclusive ortholog search EOG63JB0N Arthropod inclusive ortholog search EOG6931ZS Metazoa inclusive ortholog search EOG676XS2
Orthologs in Drosophila Species (EOG63FHG5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Toll-7     Drosophila simulans   Dsim\GD11482 Y   Drosophila sechellia   Dsec\GM21984 Y   Drosophila erecta   Dere\GG22003 Y   Drosophila yakuba   Dyak\GE12083 Y   Drosophila ananassae   Dana\GF11739 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21191 Y   Drosophila persimilis   Dper\GL10362 Y   Drosophila willistoni   Dwil\GK15893 Y   Drosophila virilis   Dvir\GJ20935 Y   Drosophila mojavensis   Dmoj\GI21088 Y   Drosophila grimshawi   Dgri\GH23021 Y
Orthologs in non-Drosophila Dipterans (EOG6CC488)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002583   Anopheles gambiae Malaria mosquito  Agam\TOLL7   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016598
Orthologs in non-Dipteran Insects (EOG63JB0N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\18w Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007768 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007767 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14297 Y Atta cephalotes Leafcutter ant  Acep\ACEP18848 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17241 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11271 Y Linepithema humile Argentine ant  Lhum\LH13356 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13114 Y Solenopsis invicta Red fire ant  Sinv\SINV17709 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008698 Y Bombyx mori Silkmoth  Bmor\Bm18w Y Bombyx mori Silkmoth  Bmor\BGIBMGA011038 Y Pediculus humanus Human body louse  Phum\PHUM480550 Y Tribolium castaneum Red flour beetle  Tcas\TC004474 Y
Orthologs in non-Insect Arthropods (EOG6931ZS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_65779 Y Daphnia pulex Water flea  Dpux\Slc6a9 Y Ixodes scapularis Deer tick  Isca\ISCW022740 Y Ixodes scapularis Deer tick  Isca\ISCW020989 Y
Orthologs in non-Arthropod Metazoa (EOG676XS2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\tol-1 Y Caenorhabditis elegans Nematode  Cele\lron-1 Y Caenorhabditis elegans Nematode  Cele\lron-11 Y Caenorhabditis elegans Nematode  Cele\egg-6 Y Caenorhabditis elegans Nematode  Cele\lron-5 Y Caenorhabditis elegans Nematode  Cele\lron-6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000428gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001676gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006951gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004360gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025731gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014928gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012666gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028380gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008227gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018608gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007859gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017640gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020527gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005148gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006952gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024731gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020257gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_030131gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013824gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020428gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025966gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000871gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024156gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000425gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012819gn Y Danio rerio Zebrafish  Drer\si:ch211-117l17.7 Y Danio rerio Zebrafish  Drer\ENSDARG00000089040 Y Danio rerio Zebrafish  Drer\ENSDARG00000063518 Y Danio rerio Zebrafish  Drer\lrrc15 Y Danio rerio Zebrafish  Drer\tlr21 Y Danio rerio Zebrafish  Drer\si:dkey-90m5.4 Y Danio rerio Zebrafish  Drer\si:ch211-66h3.1 Y Xenopus tropicalis Western clawed frog  Xtro\igfals Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000004577 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032848 Y Xenopus tropicalis Western clawed frog  Xtro\lrrc15 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030284 Y Xenopus tropicalis Western clawed frog  Xtro\gp5 Y Gallus gallus Domestic chicken  Ggal\TLR21 Y Gallus gallus Domestic chicken  Ggal\IGFALS Y Gallus gallus Domestic chicken  Ggal\LRRC15 Y Mus musculus House mouse  Mmus\Gp5 Y Mus musculus House mouse  Mmus\Lrg1 Y Mus musculus House mouse  Mmus\Lrrc15 Y Mus musculus House mouse  Mmus\Tlr13 Y Mus musculus House mouse  Mmus\Igfals Y Mus musculus House mouse  Mmus\Cpn2 Y Rattus norvegicus Norway rat  Rnor\Gp5 Y Rattus norvegicus Norway rat  Rnor\Cpn2 Y Rattus norvegicus Norway rat  Rnor\Igfals Y Rattus norvegicus Norway rat  Rnor\RGD1562655 Y Homo sapiens Human  Hsap\IGFALS Y Homo sapiens Human  Hsap\LRRC15 Y Homo sapiens Human  Hsap\CPN2 Y Homo sapiens Human  Hsap\GP5 Y Homo sapiens Human  Hsap\LRG1 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\IGFALS     Hsap\LRRC15     Hsap\CPN2     Hsap\GP5     Hsap\LRG1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11482 Drosophila sechellia Dsec\GM21984 Drosophila erecta Dere\GG22003 Drosophila yakuba Dyak\GE12083 Drosophila ananassae Dana\GF11739 Drosophila pseudoobscura pseudoobscura Dpse\GA21191 Drosophila persimilis Dper\GL10362 Drosophila willistoni Dwil\GK15893 Drosophila virilis Dvir\GJ20935 Drosophila mojavensis Dmoj\GI21088 Drosophila grimshawi Dgri\GH23021
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	37050 y1 w*; Mi{MIC}Toll-7MI03386 30488 y1 sc* v1; P{TRiP.HM05230}attP2
VDRC	v39176 w1118; P{GD14417}v39176 v6541 w1118; P{GD16}v6541/TM3 v24473 w1118; P{GD16}v24473/TM3
Genomic Clones ( 1 )
	BACR22J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	LD03945 RT09953
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14018 GH05368 GH05879 LP19537
Other clones	32255 71247 82166 83976 105848 144443 214311.62 281854 CK01.3A.E6 CK01.7D.A6 CK01.8A.E6 CK01.54A.G5 CK01.130D.H8 CK00091 Dmel_dig_013786_0608_0495 EK010735 EK044027 EK095032 EK100564 EK174404 EK199115 EK246453 EK250320
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034476 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37272
Antibody Information
	polyclonal (Nakamoto et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Toll-7 CG8595 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Toll-7 CG8595 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079073 RefSeq (Proteins) • NP_523797 DDBJ / EMBL / GenBank • AA201652 AAF57514 AAF86225 ABA86520 AF247765 AW942051 DQ138914 Entrez Gene - A searchable database of RefSeq genes. • 37272 UniProtKB/TrEMBL • Q2XXU8 Q7KIN0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat-containing N-terminal (IPR000372) Cysteine-rich flanking region, C-terminal (IPR000483) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD03945
Linkouts
	BioGRID - A database of protein and genetic interactions • 62928 DroID - A comprehensive database of gene and protein interactions. • FBgn0034476 DRSC - Results from RNAi screens. • FBgn0034476 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034476 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8595-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034476 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37272 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37272 modMine - Data generated by the modENCODE project. • FBgn0034476
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG8595 (Wasserman, 2000, Perkins et al., 2009) CT24947 (Hynes and Zhao, 2000) dTLR7 (Silverman and Maniatis, 2001) dToll7 (Singh et al., 2003) Tl-7 (Lemaitre, 2000.12.20, Khush and Lemaitre, 2000) toll (Janssens and Beyaert, 2002) Toll-7 (Swanson et al., 2009, Bartolome and Charlesworth, 2006, Díaz-Castillo et al., 2012, Nakamoto et al., 2012, Sandoval and Eldon, 2008, Yagi et al., 2010, Ooi et al., 2002, Tauszig-Delamasure et al., 2002, Wagner et al., 2008, Japanese National Institute of Genetics, 2012.5.21) TOLL 7 (Christophides et al., 2002)
Name Synonym	Toll-7 (Tauszig, 2000.3.23) Toll-like (Hynes and Zhao, 2000) toll receptor (Haesemeyer M et al., 2007)
Secondary FlyBase IDs
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 6 ) Review  ( 8 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Díaz-Castillo et al., 2012, PLoS Genet. 8(2): e1002475 Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila. [FBrf0217446] Nakamoto et al., 2012, Immunity 36(4): 658--667 Virus recognition by toll-7 activates antiviral autophagy in Drosophila. [FBrf0218107] Xu et al., 2012, Cell Host Microbe 12(4): 531--543 Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila. [FBrf0219695] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...