• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Hsl

General Information
Symbol	Dmel\Hsl	Species	D. melanogaster
Name	Hormone-sensitive lipase ortholog	Annotation symbol	CG11055
Feature type	protein_coding_gene	FlyBase ID	FBgn0034491
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	56F11-56F11	Sequence location	2R:16,145,155..16,149,231 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Hormone-sensitive lipase ortholog is referred to in FlyBase by the symbol Dmel\Hsl (CG11055, FBgn0034491). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: triglyceride lipase activity. There is experimental evidence that it is involved in the biological process: triglyceride mobilization. 5 alleles are reported. The phenotype of these alleles is annotated with: lipid particle. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Alpha/beta hydrolase fold-3; Hormone-sensitive lipase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult midgut, larval/adult hindgut, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639384_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG11055. Gene sequence location is 2R:16145157..16149241.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms cytosol
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56F11-56F11   Limits computationally determined from genome sequence between P{lacW}Ate1k10809 and P{EP}CG10444EP951
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56E-56E     (Axton et al., 1994)
Experimentally Determined Recombination Data
Location	2- (Axton et al., 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hsl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hsl-RA FBtr0086271  NM_166381   3554   881 Hsl-RB FBtr0086270  NM_137619   3522   881 Hsl-RC FBtr0086272  NM_166382   3613   881
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hsl-PA   FBpp0085583   97.5   881   4.97     NP_725941   AAF57494 Hsl-PB   FBpp0085582   97.5   881   4.97     NP_611463   AAF57495 Hsl-PC   FBpp0085584   97.5   881   4.97     NP_725942   AAM68400
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Hormone-sensitive lipase, N-terminal (IPR010468) Alpha/beta hydrolase fold-3 (IPR013094)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201718   AA264160   AA392799   AA439993   AA440607   AA441642   AA536275   AA539205   AA539448   AA540068   AA541141   AA567530   AA816757   AA820452   AA942232   AA948825   AA952048   AA979225   AE013599 AAF57494   AE013599 AAF57495   AE013599 AAM68400   AI061804   AI064478   AI106795   AI109992   AI113453   AI293355   AI406091   AI455422   AI456110   AI456344   AI513965   AI516735   AI520308   AW943335   AY051867 AAK93291   BE977570   BF490636   BF500784   BF506300   BG634126   BG636731   BI169381   BI173742   BI213288   BI230648   BI236210   BI237043   BI237359   BI239523   BI240351   BI240701   BI357532   BI367099   BI373022   BI373880   BI374376   BI482252   BI482476   BI483925   BI580859   BI640132   BT003200 AAO24955   CA804430   CO188189   CO269830   CO286835   CO292121   CO300305   CO321657   CO339859   CO344586   EC082637   EC085886   EC234379   EC241472   EC246970   EC251961   EC256322   EL870694   GH738866   GH739621   GH740342   GH740433   GH744148   GH745715   GH745727   GH745902   GH746069   GH746182   GH746776   GH746859   GH761735   GH762763   GH763157   GH763532   GH764499   GH765227   GH765797   GH765880   GH768022   GH768605   GH769711
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JR83 Q960T4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytosol inferred from direct assay (Bi et al., 2012) lipid particle inferred from direct assay (Cermelli et al., 2006, Bi et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult midgut, larval/adult hindgut, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop    949.9 Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop  (949.9) Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop    949.9 Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop    949.9 Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop    949.9 Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop  (949.9) Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop    949.9 Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    157.925 Larval Midgut    69.9 Larval Hindgut    173.1 Larval Malpighian Tubules    63.9 Larval Fat Body    45 Larval Salivary Gland    109.7 Larval Trachea    130.025 Larval Carcass    165.35 Adult Head    166.7 Adult Eye    85.35 Adult Brain    151 Adult Thoracic-Abdominal Ganglion    168.1 Adult Crop    949.9 Adult Midgut    146.8 Adult Hindgut    492.1 Adult Malpighian Tubules    107.6 Adult Fat Body    99 Adult Salivary Gland    287.9 Adult Heart    88.15 Adult VirginFemale Spermatheca    145.1 Adult InseminatedFemale Spermatheca    140.5 Adult Ovary    289.7 Adult Testis    33.8 Adult Male Accessory Gland    99.4 Adult Carcass    144.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    166.7   NA  Eye    85.35   NA  Brain    151   157.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    168.1   NA  Crop    949.9   69.9  Midgut    146.8   173.1  Hindgut    492.1   63.9  Malpighian Tubules    107.6   45  Fat Body    99   109.7  Salivary Gland    287.9   NA  Heart    88.15   130.025  Trachea    NA   NA  VirginFemale Spermatheca    145.1   NA  InseminatedFemale Spermatheca    140.5   NA  Ovary    289.7   NA  Testis    33.8   NA  Male Accessory Gland    99.4   165.35  Carcass    144.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female  (31) ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female  31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    9 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    9 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    42 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (42) embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr  (33) embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr  (28) embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP  (42) pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day  (28) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    42 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    42 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day    28 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    42 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (42) embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr  (33) embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr  28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP  (42) pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day  28 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    42 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    42 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    19 embryo 10-12hr    16 embryo 12-14hr    23 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    28 embryo 22-24hr    25 larva L1    9 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    16 adult male 01day    19 adult male 05day    22 adult male 30day    22 adult female 01day    19 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    13 embryonic 1182-4H    27 embryonic GM2    32 embryonic Kc167    28 embryonic S1    21 embryonic S3    27 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    34 ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    13 embryonic 1182-4H  (27) embryonic GM2  (32) embryonic Kc167  (28) embryonic S1    21 embryonic S3  (27) leg disc CME L1    13 wing disc CME-W2  26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (34) ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    13 embryonic 1182-4H    27 embryonic GM2    32 embryonic Kc167    28 embryonic S1    21 embryonic S3    27 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    34 ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    13 embryonic 1182-4H    27 embryonic GM2    32 embryonic Kc167    28 embryonic S1    21 embryonic S3    27 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    34 ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    13 embryonic 1182-4H    27 embryonic GM2    32 embryonic Kc167    28 embryonic S1    21 embryonic S3    27 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    34 ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    13 embryonic 1182-4H  27 embryonic GM2  32 embryonic Kc167  28 embryonic S1    21 embryonic S3  27 leg disc CME L1    13 wing disc CME-W2  26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (34) ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    13 embryonic 1182-4H    27 embryonic GM2    32 embryonic Kc167    28 embryonic S1    21 embryonic S3    27 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    34 ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    13 embryonic 1182-4H    27 embryonic GM2    32 embryonic Kc167    28 embryonic S1    21 embryonic S3    27 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    6 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    34 ovary fGS/OSS    16 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034491 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11055-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 HslGD7180 Phenotype manifest in Allele embryonic/larval fat body | larval stage Hslb24 lipid particle Hslb24
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Hsl Class Mutagen Stocks Known lesion HslEY20067 P-element activity 1 -- Hslb24 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hsl Class Mutagen Stocks Known lesion HslGD7180 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HslKK107348 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes HslScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7162 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Hsl.EGFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}HslEY20067 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
triglyceride mobilization inferred from mutant phenotype (Bi et al., 2012)
Cellular Component
CV term Evidence References
cytosol inferred from direct assay (Bi et al., 2012) lipid particle inferred from direct assay (Cermelli et al., 2006, Bi et al., 2012)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
triglyceride lipase activity inferred from sequence or structural similarity with UniProtKB:P15304 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cholesterol metabolic process inferred from electronic annotation with InterPro:IPR010468 (FlyBase Curators et al., 2004-) lipid catabolic process inferred from electronic annotation with InterPro:IPR010468 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hsl - AnxB10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Bacc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - CG16817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - CG8578 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - awd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - chic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsl - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hsl allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62945 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034491 DroID - A comprehensive database of gene and protein interactions. • FBgn0034491 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37289
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6B2TGP Dipteran inclusive ortholog search EOG69PB6J Insect inclusive ortholog search EOG631ZT3 Arthropod inclusive ortholog search EOG6WPZHN Metazoa inclusive ortholog search EOG63C0FW
Orthologs in Drosophila Species (EOG6B2TGP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hsl     Drosophila simulans   Dsim\GD11499 Y   Drosophila sechellia   Dsec\GM22000 Y   Drosophila sechellia   Dsec\GM23248     Drosophila erecta   Dere\GG22019 Y   Drosophila yakuba   Dyak\GE12096 Y   Drosophila ananassae   Dana\GF11751 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10731 Y   Drosophila persimilis   Dper\GL16902 Y   Drosophila willistoni   Dwil\GK15908 Y   Drosophila virilis   Dvir\GJ20953 Y   Drosophila mojavensis   Dmoj\GI21105 Y   Drosophila grimshawi   Dgri\GH23035 Y
Orthologs in non-Drosophila Dipterans (EOG69PB6J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005706   Anopheles gambiae Malaria mosquito  Agam\AGAP002567   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015981
Orthologs in non-Dipteran Insects (EOG631ZT3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413702   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006427   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10803   Atta cephalotes Leafcutter ant  Acep\ACEP13503   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20392   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21941   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12861   Linepithema humile Argentine ant  Lhum\LH22474   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20540   Solenopsis invicta Red fire ant  Sinv\SINV10712   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001266   Bombyx mori Silkmoth  Bmor\BGIBMGA008324   Pediculus humanus Human body louse  Phum\PHUM288260   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08216
Orthologs in non-Insect Arthropods (EOG6WPZHN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\PTP4A2   Ixodes scapularis Deer tick  Isca\ISCW018728   Ixodes scapularis Deer tick  Isca\ISCW018730
Orthologs in non-Arthropod Metazoa (EOG63C0FW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C46C11.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015823gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006603gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023225gn   Danio rerio Zebrafish  Drer\ENSDARG00000063037   Danio rerio Zebrafish  Drer\OTTDARG00000033303   Xenopus tropicalis Western clawed frog  Xtro\lipe   Mus musculus House mouse  Mmus\Lipe   Rattus norvegicus Norway rat  Rnor\Lipe   Homo sapiens Human  Hsap\LIPE
Human Orthologs (1)
Gene OMIM HGNC Hsap\LIPE
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11499 Drosophila sechellia Dsec\GM22000 Drosophila erecta Dere\GG22019 Drosophila yakuba Dyak\GE12096 Drosophila ananassae Dana\GF11751 Drosophila pseudoobscura pseudoobscura Dpse\GA10731 Drosophila persimilis Dper\GL16902 Drosophila willistoni Dwil\GK15908 Drosophila virilis Dvir\GJ20953 Drosophila mojavensis Dmoj\GI21105 Drosophila grimshawi Dgri\GH23035
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	22358 y1 w67c23; P{EPgy2}HslEY20067
VDRC	v18686 w1118; P{GD7180}v18686
Genomic Clones ( 2 )
	BACR23F24 BACR48L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 97 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD36294 RE52776
Other clones	DPiM_RE52776
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08741 AT15816 AT27171 AT30201 GH04918 GH06017 GH09414 GH09734 GH16586 GH26269 GH26993 HL01406 LD04925 LD07710 LD08415 LD11922 LD15057 LD15441 LD16641 LD16787 LD17576 LD18868 LD19418 LD20964 LD26325 LD27483 LD29077 LD33558 LD34936 LD35959 LD40429 LD42758 RE10539 RE14366 RE16834 RE18658 RE32240 RE33191 RE33577 RE36026 RE37178 RE37613 RE44046 RE60234 RE61309 RE61946 RE64915 RE65172 RE66889 RE75101 SD14508 SD22930
Other clones	53736 61090 71257 214223.49 214409.69 bs66b03 CK01.63D.F7 CK01.125B.C4 EK038324 EK064024 EK096032 EK177911 EK186121 EK199246 EP09528 EP19542 ESG0113c.B21.1_D02 IP02751 LD24088 RP01382 RP001003134 RP001008357 RP001008384 RP001012455 RP001012655 RP001022496 RP001025547 RP001025557 RP001026056 RP001026607 RP001026771 RP001030448 RP001030718 RP001035743 RP001039944 RP001042876 RP001045113 RP001046543 RP001047263 RP001050247 RP001050496 RP001052768
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034491 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37289
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hsl CG11055 (Bi et al., 2012)
Source for database merge of	Source for merge of: CG11055 anon-56Ea (FlyBase, 1996-)
Additional comments	Source for merge of CG11055 anon-56Ea was comparison of Figure 2. in FBrf0068407 with the corresponding region of the release 4.2 genome (date:060307). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137619 NM_166381 NM_166382 RefSeq (Proteins) • NP_611463 NP_725941 NP_725942 DDBJ / EMBL / GenBank • AAF57494 AAF57495 AAK93291 AAM68400 AAO24955 AI456344 AW943335 AY051867 BI367099 BT003200 Entrez Gene - A searchable database of RefSeq genes. • 37289 UniProtKB/TrEMBL • Q7JR83 Q960T4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Hormone-sensitive lipase, N-terminal (IPR010468) Alpha/beta hydrolase fold-3 (IPR013094)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62945 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034491 DroID - A comprehensive database of gene and protein interactions. • FBgn0034491 DRSC - Results from RNAi screens. • FBgn0034491 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034491 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11055-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034491 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37289 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37289 modMine - Data generated by the modENCODE project. • FBgn0034491
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	A (Axton et al., 1994) anon-56Ea   CG11055 (Bi et al., 2012, Cermelli et al., 2006, Gronke et al., 2005, Liu and Lehmann, 2008, Lee et al., 2010, Keleman et al., 2009.8.5) dHSL (Bi et al., 2012) Hsl
Name Synonym	Hormone-sensitive lipase ortholog   transcription unit A (Axton et al., 1994)
Secondary FlyBase IDs
	FBgn0014915
References ( 19 )
Research paper	Bi et al., 2012, J. Cell Sci. 125(15): 3568--3577 Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization. [FBrf0219622] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Liu and Lehmann, 2008, Insect Mol. Biol. 17(2): 91--101 Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. [FBrf0204414] Cermelli et al., 2006, Curr. Biol. 16(18): 1783--1795 The lipid-droplet proteome reveals that droplets are a protein-storage depot. [FBrf0192764] Gronke et al., 2005, Cell Metab. 1(5): 323--330 Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. [FBrf0187251] Axton et al., 1994, EMBO J. 13(2): 462--470 The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. [FBrf0068407]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bellen, 2006.8.3, MBBatch686_2.xml MBBatch686_2.xml [FBrf0191805] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]