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Gene Dmel\CG11180

General Information
Symbol	Dmel\CG11180	Species	D. melanogaster
Name		Annotation symbol	CG11180
Feature type	protein_coding_gene	FlyBase ID	FBgn0034528
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57A7-57A8	Sequence location	2R:16,508,419..16,510,808 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11180 (FBgn0034528). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: nucleic acid binding. There is experimental evidence that it is involved in the biological process: neurogenesis. 4 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: D111/G-patch. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult fat body, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640808_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11180. Gene sequence location is 2R:16508419..16510808.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA06055 BKN21888
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57A7-57A8   Limits computationally determined from genome sequence between P{EP}l(2)05510EP2587&P{lacW}rigk07917 and P{lacW}l(2)k02206k02206
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11180 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11180-RA FBtr0086254  NM_137651   2334   726
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11180-PA   FBpp0085566   82.6   726   7.29     NP_611495   AAF57445
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • D111/G-patch (IPR000467)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391516   AA695916   AE013599 AAF57445   AW941233   AY118901 AAM50761   BT125083   CO278320   CO285789   CO285896   CO287784   CO304128   CO311344   CO314861   CO316160   CZ481700   EC064857   EC069928   EC076770   EC081301   EC088388   EC213617   EC223321   EC244460   EV577265   EV581799   EV586299   EV586734   EV588932   EV597956
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSC9 A1ZBW6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034528    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034528 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034528 expression level Developmental Stage   Expression Level embryo 00-02hr    1724 embryo 02-04hr    2081 embryo 04-06hr    1790 embryo 06-08hr    1666 embryo 08-10hr    1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr    1740 embryo 22-24hr    1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day    1812 adult female 30day    1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1724) embryo 02-04hr  (2081) embryo 04-06hr  (1790) embryo 06-08hr  (1666) embryo 08-10hr  (1609) embryo 10-12hr  (745) embryo 12-14hr  (1148) embryo 14-16hr  (436) embryo 16-18hr  (655) embryo 18-20hr  (530) embryo 20-22hr  (1740) embryo 22-24hr  (1789) larva L1  (1061) larva L2  (706) larva L3 12hr old  (475) larva L3 puffstage 1-2  (260) larva L3 puffstage 3-6  (262) larva L3 puffstage 7-9  (344) white prepupae new  (301) white prepupae 12hr  (306) white prepupae 24hr  (240) pupae 2d postWPP  (265) pupae 3d postWPP  (159) pupae 4d postWPP  (111) adult male 01day  (161) adult male 05day  (135) adult male 30day  (108) adult female 01day  (538) adult female 05day  (1812) adult female 30day  (1469) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1724) embryo 02-04hr  (2081) embryo 04-06hr  (1790) embryo 06-08hr  (1666) embryo 08-10hr  (1609) embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr  (1740) embryo 22-24hr  (1789) larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day  (1812) adult female 30day  1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1724 embryo 02-04hr    2081 embryo 04-06hr    1790 embryo 06-08hr    1666 embryo 08-10hr    1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr    1740 embryo 22-24hr    1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day    1812 adult female 30day    1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1724 embryo 02-04hr    2081 embryo 04-06hr    1790 embryo 06-08hr    1666 embryo 08-10hr    1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr    1740 embryo 22-24hr    1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day    1812 adult female 30day    1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034528 expression level Developmental Stage   Expression Level embryo 00-02hr    1724 embryo 02-04hr    2081 embryo 04-06hr    1790 embryo 06-08hr    1666 embryo 08-10hr    1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr    1740 embryo 22-24hr    1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day    1812 adult female 30day    1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1724) embryo 02-04hr  (2081) embryo 04-06hr  (1790) embryo 06-08hr  (1666) embryo 08-10hr  (1609) embryo 10-12hr  (745) embryo 12-14hr  (1148) embryo 14-16hr  (436) embryo 16-18hr  (655) embryo 18-20hr  (530) embryo 20-22hr  (1740) embryo 22-24hr  (1789) larva L1  (1061) larva L2  (706) larva L3 12hr old  (475) larva L3 puffstage 1-2  (260) larva L3 puffstage 3-6  (262) larva L3 puffstage 7-9  (344) white prepupae new  (301) white prepupae 12hr  (306) white prepupae 24hr  (240) pupae 2d postWPP  (265) pupae 3d postWPP  (159) pupae 4d postWPP  111 adult male 01day  (161) adult male 05day  135 adult male 30day  108 adult female 01day  (538) adult female 05day  (1812) adult female 30day  (1469) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1724 embryo 02-04hr  2081 embryo 04-06hr  1790 embryo 06-08hr  1666 embryo 08-10hr  1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr  1740 embryo 22-24hr  1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day  1812 adult female 30day  1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1724 embryo 02-04hr    2081 embryo 04-06hr    1790 embryo 06-08hr    1666 embryo 08-10hr    1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr    1740 embryo 22-24hr    1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day    1812 adult female 30day    1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1724 embryo 02-04hr    2081 embryo 04-06hr    1790 embryo 06-08hr    1666 embryo 08-10hr    1609 embryo 10-12hr    745 embryo 12-14hr    1148 embryo 14-16hr    436 embryo 16-18hr    655 embryo 18-20hr    530 embryo 20-22hr    1740 embryo 22-24hr    1789 larva L1    1061 larva L2    706 larva L3 12hr old    475 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    344 white prepupae new    301 white prepupae 12hr    306 white prepupae 24hr    240 pupae 2d postWPP    265 pupae 3d postWPP    159 pupae 4d postWPP    111 adult male 01day    161 adult male 05day    135 adult male 30day    108 adult female 01day    538 adult female 05day    1812 adult female 30day    1469 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034528    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034528 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult fat body, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034528 expression level Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034528 expression level Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.65 Larval Midgut    52.3 Larval Hindgut    95.2 Larval Malpighian Tubules    26 Larval Fat Body    23.6 Larval Salivary Gland    81.5 Larval Trachea    138.95 Larval Carcass    112.3 Adult Head    50.3 Adult Eye    38.675 Adult Brain    30.6 Adult Thoracic-Abdominal Ganglion    37.1 Adult Crop    89.3 Adult Midgut    55.1 Adult Hindgut    56.2 Adult Malpighian Tubules    47.5 Adult Fat Body    109.2 Adult Salivary Gland    61.8 Adult Heart    73.275 Adult VirginFemale Spermatheca    77.5 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    316.6 Adult Testis    20.7 Adult Male Accessory Gland    98.2 Adult Carcass    56.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    50.3   NA  Eye    38.675   NA  Brain    30.6   159.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    37.1   NA  Crop    89.3   52.3  Midgut    55.1   95.2  Hindgut    56.2   26  Malpighian Tubules    47.5   23.6  Fat Body    109.2   81.5  Salivary Gland    61.8   NA  Heart    73.275   138.95  Trachea    NA   NA  VirginFemale Spermatheca    77.5   NA  InseminatedFemale Spermatheca    95.1   NA  Ovary    316.6   NA  Testis    20.7   NA  Male Accessory Gland    98.2   112.3  Carcass    56.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034528 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11180-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CG11180GD7225 lethal, with Scer\GAL4pnr-MD237 CG11180GD7225 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CG11180GD7225 visible, with Scer\GAL4pnr-MD237 CG11180GD7225 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CG11180GD7225 ganglion mother cell | larval stage, with Scer\GAL41407 CG11180GD7225 mesothoracic tergum, with Scer\GAL4pnr-MD237 CG11180GD7225
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11180 Class Mutagen Stocks Known lesion CG11180e03938 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11180 Class Mutagen Stocks Known lesion CG11180GD7225 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11180JF03044 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11180KK101837 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6070 (Ryder, 2004.4.26) Df(2R)Exel7164 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7225} NA P{KK101837} NA P{TRiP.JF03044} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG11180e03938 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR000467 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000467 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11180 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62980 DroID - A comprehensive database of gene and protein interactions. • FBgn0034528 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37330
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12755 Dere\GG20845 Dgri\GH19898 Dmoj\GI19854 Dper\GL17437 Dpse\GA24825 Dsec\GM19774 Dsim\GD25264 Dvir\GJ18860 Dwil\GK21829 Dyak\GE13785
Curated drosophilid orthologs	Dpse\GA10820
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003676-PA Aedes aegypti (mosquito) AGAP008951-PA Anopheles gambiae (mosquito) XP_391986.3 Apis mellifera (honey bee) 280656 Branchiostoma floridae (lancelet) BGIBMGA010278-PA Bombyx mori (silk worm) CE03704 Caenorhabditis elegans (worm) CAGL0G00264g Candida glabrata (haploid yeast) cn13120 Cryptococcus neoformans (yeast-like fungus) CPIJ017220 Culex pipens (mosquito) ENSCPOP00000008142 Cavia porcellus (guinea pig) DEHA2C11506g Debaryomyces Hansenii (yeast) ENSDARP00000031264 Danio rerio (zebra fish) ENSECAP00000015716 Equus caballus (horse) ENSP00000335486 Homo sapiens (human) ENSMMUP00000016623 Macaca mulatta (rhesus monkey) ENSMUSP00000022528 Mus musculus (house mouse) 244746 Nematostella vectensis (starlet anemone) XP_001607819.1 Nasonia vitripennis (wasp) LOC_Os03g03390.1 Oryza sativa (asian rice) PHUM009992-PA Pediculus humanus (human body louse) ENSPPYP00000009363 Pongo pygmaeus (orangutan) ENSPTRP00000034220 Pan troglodytes (chimpanzee) YGR280C Saccharomyces cerevisiae (budding yeast) XP_800653.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000019429 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015382 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000001517 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14195 LH17491 LH17490 FBgn0231437 FBgn0223814 FBgn0206006 FBgn0196576 FBgn0174673 JGI_V11_34656 FBgn0246210 FBgn0155040 FBgn0142591 FBgn0127362 FBgn0113031 FBgn0089789 CPIJ017220 BGIBMGA010278 ACYPI003419 GB19424 AGAP008951 AAEL003676 PB24672 PHUM462230
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28629 y1 v1; P{TRiP.JF03044}attP2 18212 w1118; PBac{RB}CG11180e03938/CyO
Kyoto	114512 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D PBac{RB}CG11180e03938 /CyO y+
VDRC	v104340 P{KK101837}VIE-260B v31438 w1118; P{GD7225}v31438 v31439 w1118; P{GD7225}v31439
Genomic Clones ( 2 )
	BACR08P05 BACR33D17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10524
Other clones	MIP24058
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	17453 60012 102186 108995 118770 CK01.78A.D11 CK01.78C.F3 Dmel_dig_001671_0675_0915 Dmel_dig_002044_0658_0512 Dmel_neb_002012_0858_3633 Dmel_neb_006363_0135_1733 Dmel_neb_009001_0109_0592 Dmel_neb_012304_0201_0743 EK060716 EK061122 EK066802 EK129744 EK224221 EK238111 EK243917 EK263822 GM04767
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034528 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37330
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137651 RefSeq (Proteins) • NP_611495 DDBJ / EMBL / GenBank • AA391516 AA695916 AAF57445 AAM50761 AW941233 AY118901 CZ481700 Entrez Gene - A searchable database of RefSeq genes. • 37330 UniProtKB/TrEMBL • A1ZBW6 Q8MSC9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • D111/G-patch (IPR000467)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62980 DroID - A comprehensive database of gene and protein interactions. • FBgn0034528 DRSC - Results from RNAi screens. • FBgn0034528 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034528 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11180-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034528 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37330 InParanoid A subset of ortholog calls from InParanoid. • AAEL003676-PA Aedes aegypti (mosquito) AGAP008951-PA Anopheles gambiae (mosquito) XP_391986.3 Apis mellifera (honey bee) 280656 Branchiostoma floridae (lancelet) BGIBMGA010278-PA Bombyx mori (silk worm) CE03704 Caenorhabditis elegans (worm) CAGL0G00264g Candida glabrata (haploid yeast) cn13120 Cryptococcus neoformans (yeast-like fungus) CPIJ017220 Culex pipens (mosquito) ENSCPOP00000008142 Cavia porcellus (guinea pig) DEHA2C11506g Debaryomyces Hansenii (yeast) ENSDARP00000031264 Danio rerio (zebra fish) ENSECAP00000015716 Equus caballus (horse) ENSP00000335486 Homo sapiens (human) ENSMMUP00000016623 Macaca mulatta (rhesus monkey) ENSMUSP00000022528 Mus musculus (house mouse) 244746 Nematostella vectensis (starlet anemone) XP_001607819.1 Nasonia vitripennis (wasp) LOC_Os03g03390.1 Oryza sativa (asian rice) PHUM009992-PA Pediculus humanus (human body louse) ENSPPYP00000009363 Pongo pygmaeus (orangutan) ENSPTRP00000034220 Pan troglodytes (chimpanzee) YGR280C Saccharomyces cerevisiae (budding yeast) XP_800653.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000019429 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015382 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000001517 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37330 modMine - Data generated by the modENCODE project. • FBgn0034528 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14195 LH17491 LH17490 FBgn0231437 FBgn0223814 FBgn0206006 FBgn0196576 FBgn0174673 JGI_V11_34656 FBgn0246210 FBgn0155040 FBgn0142591 FBgn0127362 FBgn0113031 FBgn0089789 CPIJ017220 BGIBMGA010278 ACYPI003419 GB19424 AGAP008951 AAEL003676 PB24672 PHUM462230
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11180 (Keleman et al., 2009.8.5, Perkins et al., 2009, Buffin and Gho, 2010, Neumüller et al., 2011)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]