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Gene Dmel\Fem-1

General Information
Symbol	Dmel\Fem-1	Species	D. melanogaster
Name	Fem-1	Annotation symbol	CG9025
Feature type	protein_coding_gene	FlyBase ID	FBgn0034542
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57A9-57A9	Sequence location	2R:16,549,979..16,554,811 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fem-1 is referred to in FlyBase by the symbol Dmel\Fem-1 (CG9025, FBgn0034542). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. Gene sequence location is 2R:16549979..16554748.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57A9-57A9   Limits computationally determined from genome sequence between P{lacW}l(2)k02206k02206 and P{lacW}l(2)k06409k06409&P{PZ}insc05475
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fem-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fem-1-RA FBtr0086245  NM_137664   2679   702 Fem-1-RB FBtr0086246  NM_166408   2486   650
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fem-1-PA   FBpp0085558   78.7   702   6.83     NP_611508   AAF57431 Fem-1-PB   FBpp0085559   73.0   650   7.65     NP_725993   AAM68397
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441021   AE013599 AAF57431   AE013599 AAM68397   AI062515   AI062675   AI257982   AI297855   AI404234   AI513149   AQ073641   AQ073642   AQ074071   AY119043 AAM50903   BF498399   BI235894   BI357767   BI375730   BI563679   BP552542   BT001702 AAN71457   BT133040   CO176934   CO190960   CO288172   CO297682   CO304585   CO304854   CO305165   CO311141   CO314251   CO326306   CZ469298   CZ480781   EC065756   EC072754   EC087625   EC200735   EC207066   EC207067   EC207582   EC208673   EC214602   EC226081   EC245749   EC248668   EC252281   EC256819
UniProtKB/Swiss-Prot	A1ZBY1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    54 carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering  (54) carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    54 carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    54 carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    54 carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering  (54) carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    54 carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    54 carcass, 1-day adult    11 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    21 ovary, mated 4-day female    18 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    58 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    36 adult male 01day    36 adult male 05day    23 adult male 30day    26 adult female 01day    38 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr  26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6  (39) larva L3 puffstage 7-9  (58) white prepupae new  (38) white prepupae 12hr  (31) white prepupae 24hr  (27) pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP  (36) adult male 01day  (36) adult male 05day    23 adult male 30day  26 adult female 01day  (38) adult female 05day  (28) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    58 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    36 adult male 01day    36 adult male 05day    23 adult male 30day    26 adult female 01day    38 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    58 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    36 adult male 01day    36 adult male 05day    23 adult male 30day    26 adult female 01day    38 adult female 05day    28 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    58 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    36 adult male 01day    36 adult male 05day    23 adult male 30day    26 adult female 01day    38 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr  26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6  (39) larva L3 puffstage 7-9  (58) white prepupae new  (38) white prepupae 12hr  31 white prepupae 24hr  27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP  (36) adult male 01day  (36) adult male 05day    23 adult male 30day  26 adult female 01day  (38) adult female 05day  28 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    58 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    36 adult male 01day    36 adult male 05day    23 adult male 30day    26 adult female 01day    38 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    26 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    16 embryo 18-20hr    21 embryo 20-22hr    24 embryo 22-24hr    25 larva L1    17 larva L2    10 larva L3 12hr old    11 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    58 white prepupae new    38 white prepupae 12hr    31 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    36 adult male 01day    36 adult male 05day    23 adult male 30day    26 adult female 01day    38 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    12 embryonic GM2    19 embryonic Kc167    10 embryonic S1    19 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    7 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    16 ovary fGS/OSS    12 ovary OSC    7 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034542 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9025-RC;CG9025-RC;CG9025-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Fem-1GD3558 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Fem-1 Class Mutagen Stocks Known lesion Fem-1c04504 piggyBac transposase 1 -- Fem-1d02039 1 -- Fem-1e03018 piggyBac transposase 1 -- Fem-1EP2065 P-element activity 1 -- Fem-1EP2504 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fem-1 Class Mutagen Stocks Known lesion Fem-1GD3558 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6070 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3558} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Fem-1EP2065 NA P{EP}Fem-1EP2504 NA P{Mae-UAS.6.11}B1368B1368 NA P{XP}Fem-1d02039 NA miscellaneous insertions PBac{PB}Fem-1c04504 NA PBac{RB}Fem-1e03018 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2008-03-14)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fem-1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62993 DroID - A comprehensive database of gene and protein interactions. • FBgn0034542 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37344
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6C88BT Dipteran inclusive ortholog search EOG683DCN Insect inclusive ortholog search EOG6FQZMM Arthropod inclusive ortholog search EOG6V15FR Metazoa inclusive ortholog search EOG6C00VH
Orthologs in Drosophila Species (EOG6C88BT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Fem-1     Drosophila simulans   Dsim\GD25257 Y   Drosophila sechellia   Dsec\GM19767 Y   Drosophila erecta   Dere\GG20838 Y   Drosophila yakuba   Dyak\GE13777 Y   Drosophila ananassae   Dana\GF12749 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24822 Y   Drosophila persimilis   Dper\GL17431 Y   Drosophila willistoni   Dwil\GK21587 Y   Drosophila virilis   Dvir\GJ18787 Y   Drosophila mojavensis   Dmoj\GI19845 Y   Drosophila grimshawi   Dgri\GH19890 Y
Orthologs in non-Drosophila Dipterans (EOG683DCN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010108   Anopheles gambiae Malaria mosquito  Agam\AGAP007382   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010734
Orthologs in non-Dipteran Insects (EOG6FQZMM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52576   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012684   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10060   Atta cephalotes Leafcutter ant  Acep\ACEP20589   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15698   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21439   Linepithema humile Argentine ant  Lhum\LH17985   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19663   Solenopsis invicta Red fire ant  Sinv\SINV13410   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003500   Bombyx mori Silkmoth  Bmor\BGIBMGA001985   Pediculus humanus Human body louse  Phum\PHUM289620   Tribolium castaneum Red flour beetle  Tcas\TC008808
Orthologs in non-Insect Arthropods (EOG6V15FR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW000644
Orthologs in non-Arthropod Metazoa (EOG6C00VH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\fem-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002225gn Y Danio rerio Zebrafish  Drer\fem1b Y Danio rerio Zebrafish  Drer\fem1a Y Danio rerio Zebrafish  Drer\fem1c Y Xenopus tropicalis Western clawed frog  Xtro\fem1b Y Xenopus tropicalis Western clawed frog  Xtro\fem1c Y Gallus gallus Domestic chicken  Ggal\FEM1A Y Gallus gallus Domestic chicken  Ggal\FEM1C Y Gallus gallus Domestic chicken  Ggal\FEM1B Y Mus musculus House mouse  Mmus\Fem1aa Y Mus musculus House mouse  Mmus\Fem1b Y Mus musculus House mouse  Mmus\ENSMUSG00000078157 Y Mus musculus House mouse  Mmus\Fem1c Y Rattus norvegicus Norway rat  Rnor\Fem1c Y Rattus norvegicus Norway rat  Rnor\Fem1b Y Homo sapiens Human  Hsap\FEM1B Y Homo sapiens Human  Hsap\FEM1C Y Homo sapiens Human  Hsap\FEM1A Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\FEM1B     Hsap\FEM1C     Hsap\FEM1A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25257 Drosophila sechellia Dsec\GM19767 Drosophila erecta Dere\GG20838 Drosophila yakuba Dyak\GE13777 Drosophila ananassae Dana\GF12749 Drosophila pseudoobscura pseudoobscura Dpse\GA24822 Drosophila persimilis Dper\GL17431 Drosophila willistoni Dwil\GK21587 Drosophila virilis Dvir\GJ18787 Drosophila mojavensis Dmoj\GI19845 Drosophila grimshawi Dgri\GH19890
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	17232 w1118; P{EP}Fem-1EP2065
Harvard	- P{XP}Fem-1d02039 - PBac{PB}Fem-1c04504 - PBac{RB}Fem-1e03018
VDRC	v44427 w1118; P{GD3558}v44427 v44428 w1118; P{GD3558}v44428
Genomic Clones ( 2 )
	BACR08P05 BACR33D17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 37 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP06502 RE63596
Other clones	FI17859
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12785 GH01738 GH01964 GH23869 LD15781 LD45340 LP12281 RE31845 RE44328 RH34356
Other clones	20141 53036 64740 100906 108887 121908 123532 125533 214373.65 214539.63 CK01.63B.F2 CK01.85D.D11 CK01.124A.E11 EK050240 EK051640 EK067914 EK170331 EK223455 EK235531 EK245220 EK246545 EK247559 EP03627 FGM219D02
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034542 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37344
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Fem-1 CG9025 (Montana and Littleton, 2006)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137664 NM_166408 RefSeq (Proteins) • NP_611508 NP_725993 DDBJ / EMBL / GenBank • AAF57431 AAM50903 AAM68397 AAN71457 AI257982 AI297855 AQ073641 AQ073642 AQ074071 AY119043 BI375730 BT001702 CZ469298 CZ480781 Entrez Gene - A searchable database of RefSeq genes. • 37344 UniProtKB/Swiss-Prot • A1ZBY1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62993 DroID - A comprehensive database of gene and protein interactions. • FBgn0034542 DRSC - Results from RNAi screens. • FBgn0034542 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034542 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9025-RC;CG9025-RC;CG9025-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034542 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37344 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37344 modMine - Data generated by the modENCODE project. • FBgn0034542
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG9025 (Holloway et al., 2008, Montana and Littleton, 2006, Grieder et al., 2007) dFEM-1 (Montana and Littleton, 2006) Fem-1 (Wasbrough et al., 2010)
Name Synonym	CG9025   Fem-1
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...