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Gene Dmel\CG10543

General Information
Symbol	Dmel\CG10543	Species	D. melanogaster
Name		Annotation symbol	CG10543
Feature type	protein_coding_gene	FlyBase ID	FBgn0034570
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57B5-57B5	Sequence location	2R:16,883,725..16,895,245 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10543 (FBgn0034570). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: SWR1-complex protein 5/Craniofacial development protein; Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1633894_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10543. Gene sequence location is 2R:16883725..16895245.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57B5-57B5   Limits computationally determined from genome sequence between P{PZ}l(2)0780607806 and P{EP}grauEP688&P{PZ}shg10469
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10543 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.45 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10543-RA FBtr0071524  NM_137690   7070   1634 CG10543-RD FBtr0303195  NM_176241   5618   1631 CG10543-RE FBtr0332593  NM_166416   5550   1634 CG10543-RF FBtr0332594  NM_001274183   7073   1635
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10543-PA   FBpp0071453   183.0   1634   6.51     NP_611534   AAF46652 CG10543-PD   FBpp0292294   182.6   1631   6.55     NP_788421   AAO41340 CG10543-PE   FBpp0304844   183.0   1634   6.51     NP_726015   AAM68188 CG10543-PF   FBpp0304845   183.1   1635   6.51     NP_001261112   AGB93644
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880) SWR1-complex protein 5/Craniofacial development protein (IPR027124) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46652   AE013599 AAM68188   AE013599 AAO41340   AE013599 AGB93644   AY118689 AAM50549   BF500643   BI563367   BI570092   BI570617   BI589822   BI592417   BI592622   BI605263   BI619876   BP545331   BP546575   BP547792   BT029104   BT125724   CK659767   CO153874   CO277526   CO284727   CO297522   CO297768   CO298565   CO307220   CO311043   CO314620   CO322113   CO326334   CZ474415   EC058762   EC200168   EC234334   EC234933   EC236684   EC243592   EC248727   EC253075   EC255352   EL874610   ES691057   ES691061   ES694311   EV578507   EV588280   EY198997   EY199027   FE527626   FE527660   FL502737   GH291456   GH947437   GH952627   GH963253   GH964128   GH971461   GH971869   GH972006   GH976884   GH977875   GH984212
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86BG2 Q9W2N8 Q8MLW9 Q8MSN5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    34.325 Larval Midgut    11.9 Larval Hindgut    15.9 Larval Malpighian Tubules    17.2 Larval Fat Body    16.8 Larval Salivary Gland    18.8 Larval Trachea    17.625 Larval Carcass    17.55 Adult Head    28.2 Adult Eye    27.025 Adult Brain    62.7 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    41.2 Adult Midgut    20.1 Adult Hindgut    21.1 Adult Malpighian Tubules    8.9 Adult Fat Body    24.5 Adult Salivary Gland    41.3 Adult Heart    19.2 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    52.7 Adult Testis    40.1 Adult Male Accessory Gland    19 Adult Carcass    33.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    28.2   NA  Eye    27.025   NA  Brain    62.7   34.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    36.8   NA  Crop    41.2   no informative data  Midgut    20.1   no informative data  Hindgut    21.1   no informative data  Malpighian Tubules    8.9   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    19.2   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    5.1   NA  InseminatedFemale Spermatheca    4.4   NA  Ovary    52.7   NA  Testis    40.1   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female    29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female  (29) testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female    29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female    29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female    29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female  29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female    29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    8 head, mated 1-day male    16 head, mated 4-day male    15 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    10 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    22 ovary, mated 4-day female    29 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr    30 embryo 08-10hr    27 embryo 10-12hr    23 embryo 12-14hr    32 embryo 14-16hr    42 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr  (30) embryo 08-10hr  (27) embryo 10-12hr    23 embryo 12-14hr  (32) embryo 14-16hr  (42) embryo 16-18hr  (30) embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr    30 embryo 08-10hr    27 embryo 10-12hr    23 embryo 12-14hr    32 embryo 14-16hr    42 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr    30 embryo 08-10hr    27 embryo 10-12hr    23 embryo 12-14hr    32 embryo 14-16hr    42 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr    30 embryo 08-10hr    27 embryo 10-12hr    23 embryo 12-14hr    32 embryo 14-16hr    42 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr  30 embryo 08-10hr  27 embryo 10-12hr    23 embryo 12-14hr  32 embryo 14-16hr  (42) embryo 16-18hr  30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr    30 embryo 08-10hr    27 embryo 10-12hr    23 embryo 12-14hr    32 embryo 14-16hr    42 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    19 embryo 06-08hr    30 embryo 08-10hr    27 embryo 10-12hr    23 embryo 12-14hr    32 embryo 14-16hr    42 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    8 white prepupae 24hr    12 pupae 2d postWPP    14 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    12 adult male 30day    12 adult female 01day    16 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    6 embryonic 1182-4H    19 embryonic GM2    15 embryonic Kc167    16 embryonic S1    25 embryonic S3    14 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    4 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    18 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	BDGP expression data • PC00119 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034570 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10543-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10543GD6647 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG10543 Class Mutagen Stocks Known lesion CG10543EY00916 1 -- CG10543NP1253 1 -- CG10543d05245 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10543 Class Mutagen Stocks Known lesion CG10543GD6647 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10543JF02977 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10543KK112630 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10543NIG.10543R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6071 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6647} NA P{GD14947} NA P{KK112630} NA P{NIG.10543R} NA P{TRiP.JF02977} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}CG10543NP1253 No insertion of mobile activating element P{EPgy2}CG10543EY00916 NA P{XP}CG10543d05245 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10543 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63020 DroID - A comprehensive database of gene and protein interactions. • FBgn0034570 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37379
Orthologs
OrthoDB Orthologs (19) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CNRB1 Dipteran inclusive ortholog search EOG6J3WRJ Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6CNRB1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG10543     Drosophila simulans   Dsim\GD11554 Y   Drosophila sechellia   Dsec\GM18362     Drosophila sechellia   Dsec\GM15793 Y   Drosophila erecta   Dere\GG22075 Y   Drosophila erecta   Dere\GG21849     Drosophila yakuba   Dyak\GE12156 Y   Drosophila ananassae   Dana\GF12214 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25089 Y   Drosophila persimilis   Dper\GL10140 Y   Drosophila willistoni   Dwil\GK22958 Y   Drosophila virilis   Dvir\GJ21991 Y   Drosophila mojavensis   Dmoj\GI21068 Y   Drosophila grimshawi   Dgri\GH20522 Y
Orthologs in non-Drosophila Dipterans (EOG6J3WRJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012168   Anopheles gambiae Malaria mosquito  Agam\AGAP005135   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002267   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002269   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002268
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11554 Drosophila sechellia Dsec\GM15793 Drosophila erecta Dere\GG22075 Drosophila yakuba Dyak\GE12156 Drosophila ananassae Dana\GF12214 Drosophila pseudoobscura pseudoobscura Dpse\GA25089 Drosophila persimilis Dper\GL10140 Drosophila willistoni Dwil\GK22958 Drosophila virilis Dvir\GJ21991 Drosophila mojavensis Dmoj\GI21068 Drosophila grimshawi Dgri\GH20522
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31964 y1 v1; P{TRiP.JF02977}attP2 15047 y1 w67c23; P{EPgy2}CG10543EY00916
Kyoto	103959 y* w*; P{GawB}CG10543NP1253 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v103520 P{KK112630}VIE-260B v30888 w1118; P{GD6647}v30888
Genomic Clones ( 2 )
	BACR10P11 BACR16B07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT15637 IP14602
Other clones	MIP26658
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP17761 RH02342 RH03318 RH05378 RH10093 RH10364 RH33992 RH51007 RH70840
Other clones	1287 53099 56952 61576 100606 117854 214417.68 214469.53 CK01.91B.E4 Dmel_dig_011245_0691_2905 Dmel_neb_012351_0173_2744 DMG3-chr2R.4575.pred.a DMG4-chr2R.29.007.pred.a DMG5-chr2R.29.006.pred.a EK125408 EK166635 EK170014 EK170513 EK173250 EK187242 EK223218 EK237163 EK254001 EN03009 EP03660 FGC030G01 FGH107H03 FGH120G04 IP14702 RP004141417 RP004200583 RP004209013 RP004275158 RP004307739 RP004404108 RP004406166 RP004412187 RP004507957 RP004516542
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37379
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137690 NM_166416 NM_176241 NM_001274183 RefSeq (Proteins) • NP_611534 NP_726015 NP_788421 NP_001261112 DDBJ / EMBL / GenBank • AAF46652 AAM50549 AAM68188 AAO41340 AGB93644 AY118689 BF500643 CZ474415 Entrez Gene - A searchable database of RefSeq genes. • 37379 UniProtKB/TrEMBL • Q8MLW9 Q8MSN5 Q9W2N8 Q86BG2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880) SWR1-complex protein 5/Craniofacial development protein (IPR027124) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00119
Linkouts
	BioGRID - A database of protein and genetic interactions • 63020 DroID - A comprehensive database of gene and protein interactions. • FBgn0034570 DRSC - Results from RNAi screens. • FBgn0034570 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034570 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10543-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37379 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37379 modMine - Data generated by the modENCODE project. • FBgn0034570
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10543 (Herranz et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Tokusumi et al., 2012, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Show all research papers ...