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Gene Dmel\CG4266

General Information
Symbol	Dmel\CG4266	Species	D. melanogaster
Name		Annotation symbol	CG4266
Feature type	protein_coding_gene	FlyBase ID	FBgn0034598
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57C6-57C7	Sequence location	2R:17,049,218..17,056,163 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4266 (FBgn0034598). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. Based on sequence similarity, it is predicted to be involved in the biological process: nuclear mRNA splicing, via spliceosome. 8 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Domain of unknown function DUF618; ENTH/VHS; Nucleotide-binding, alpha-beta plait; RNA polymerase II, large subunit, CTD; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632281_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG4266. Gene sequence location is 2R:17049218..17056163.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN45754 BKN20202 BKN51324 BKN50706 HFA04456 Polypeptides CG4266-PC Clones IP17766 References Zhu et al., 2005, Genetics 170(2): Transcripts CG4266-RC
FB2011_10	Unknown in situ Controlled Vocabulary Terms ventral nerve cord embryonic stage 16
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57C6-57C7   Limits computationally determined from genome sequence between P{PZ}king-tubby02821&P{lacW}Xbp1k13803 and P{EP}CG4266EP2258
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4266 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Alternative translation stop created by use of multiphasic reading frames within coding region.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4266-RA FBtr0071629  NM_137713   4388   1215 CG4266-RB FBtr0113100  NM_001103924   4661   1306 CG4266-RC FBtr0310422     4345   412
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4266-PA   FBpp0071554   130.4   1215   8.43     NP_611557   AAF46686 CG4266-PB   FBpp0112013   140.8   1306   7.47     NP_001097394   ABV53866 CG4266-PC   FBpp0302570   45.9   412   7.66
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) RNA polymerase II, large subunit, CTD (IPR006569) Nucleotide-binding, alpha-beta plait (IPR012677) Domain of unknown function DUF618 (IPR006903) ENTH/VHS (IPR008942)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539618   AA735663   AA821234   AA949740   AA950825   AA951335   AA951514   AA952151   AA979305   AE013599 AAF46686   AE013599 ABV53866   AI108752   AQ254844   AW942946   AY058599 AAL13828   BF488977   BI169637   BI173096   BI231517   BI234739   BI236131   BI238883   BI242562   BI243192   BI356320   BI364764   BI481613   BI484089   BI485009   BI485040   BI485574   BI486715   BI577613   BI577750   BI580769   BI580882   BI632233   BI633423   BP555494   BT030168   BT030996   CC060540   CO153959   CO154365   CO183995   CO264517   CO275465   CO276080   CO280667   CO286943   CO296215   CO298304   CO308616   CO310290   CO317440   CO328622   CZ469962   EC058534   EC064645   EC072325   EC072418   EC076357   EC079965   EC084818   EC087243   EC203787   EC213161   EC213729   EC215351   EC220335   EC232710   EC237723   EC247636   EL886384   EL886430   EL886605   EL886656   EL886715   EL886769
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95TR3 Q9W2K4 A8DYK5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   ventral nerve cord   (Zhu et al., 2005, Zhu et al., 2005)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034598    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034598 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034598 expression level Developmental Stage   Expression Level embryo 00-02hr    4718 embryo 02-04hr    6332 embryo 04-06hr    6008 embryo 06-08hr    6361 embryo 08-10hr    4876 embryo 10-12hr    3583 embryo 12-14hr    2819 embryo 14-16hr    3166 embryo 16-18hr    2416 embryo 18-20hr    1663 embryo 20-22hr    2905 embryo 22-24hr    2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new    1440 white prepupae 12hr    1588 white prepupae 24hr    2092 pupae 2d postWPP    1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day    1707 adult female 05day    2432 adult female 30day    2529 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4718) embryo 02-04hr  (6332) embryo 04-06hr  (6008) embryo 06-08hr  (6361) embryo 08-10hr  (4876) embryo 10-12hr  (3583) embryo 12-14hr  (2819) embryo 14-16hr  (3166) embryo 16-18hr  (2416) embryo 18-20hr  (1663) embryo 20-22hr  (2905) embryo 22-24hr  (2319) larva L1  (1242) larva L2  (975) larva L3 12hr old  (819) larva L3 puffstage 1-2  (745) larva L3 puffstage 3-6  (1301) larva L3 puffstage 7-9  (1375) white prepupae new  (1440) white prepupae 12hr  (1588) white prepupae 24hr  (2092) pupae 2d postWPP  (1477) pupae 3d postWPP  (884) pupae 4d postWPP  (991) adult male 01day  (845) adult male 05day  (1100) adult male 30day  (1082) adult female 01day  (1707) adult female 05day  (2432) adult female 30day  (2529) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4718) embryo 02-04hr  (6332) embryo 04-06hr  (6008) embryo 06-08hr  (6361) embryo 08-10hr  (4876) embryo 10-12hr  (3583) embryo 12-14hr  (2819) embryo 14-16hr  (3166) embryo 16-18hr  (2416) embryo 18-20hr  (1663) embryo 20-22hr  (2905) embryo 22-24hr  (2319) larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new  1440 white prepupae 12hr  (1588) white prepupae 24hr  (2092) pupae 2d postWPP  1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day  (1707) adult female 05day  (2432) adult female 30day  (2529) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4718 embryo 02-04hr    6332 embryo 04-06hr    6008 embryo 06-08hr    6361 embryo 08-10hr    4876 embryo 10-12hr    3583 embryo 12-14hr    2819 embryo 14-16hr    3166 embryo 16-18hr    2416 embryo 18-20hr    1663 embryo 20-22hr    2905 embryo 22-24hr    2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new    1440 white prepupae 12hr    1588 white prepupae 24hr    2092 pupae 2d postWPP    1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day    1707 adult female 05day    2432 adult female 30day    2529 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4718 embryo 02-04hr    6332 embryo 04-06hr    6008 embryo 06-08hr    6361 embryo 08-10hr    4876 embryo 10-12hr    3583 embryo 12-14hr    2819 embryo 14-16hr    3166 embryo 16-18hr    2416 embryo 18-20hr    1663 embryo 20-22hr    2905 embryo 22-24hr    2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new    1440 white prepupae 12hr    1588 white prepupae 24hr    2092 pupae 2d postWPP    1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day    1707 adult female 05day    2432 adult female 30day    2529 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034598 expression level Developmental Stage   Expression Level embryo 00-02hr    4718 embryo 02-04hr    6332 embryo 04-06hr    6008 embryo 06-08hr    6361 embryo 08-10hr    4876 embryo 10-12hr    3583 embryo 12-14hr    2819 embryo 14-16hr    3166 embryo 16-18hr    2416 embryo 18-20hr    1663 embryo 20-22hr    2905 embryo 22-24hr    2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new    1440 white prepupae 12hr    1588 white prepupae 24hr    2092 pupae 2d postWPP    1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day    1707 adult female 05day    2432 adult female 30day    2529 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4718) embryo 02-04hr  (6332) embryo 04-06hr  (6008) embryo 06-08hr  (6361) embryo 08-10hr  (4876) embryo 10-12hr  (3583) embryo 12-14hr  (2819) embryo 14-16hr  (3166) embryo 16-18hr  (2416) embryo 18-20hr  (1663) embryo 20-22hr  (2905) embryo 22-24hr  (2319) larva L1  (1242) larva L2  (975) larva L3 12hr old  (819) larva L3 puffstage 1-2  (745) larva L3 puffstage 3-6  (1301) larva L3 puffstage 7-9  (1375) white prepupae new  (1440) white prepupae 12hr  (1588) white prepupae 24hr  (2092) pupae 2d postWPP  (1477) pupae 3d postWPP  (884) pupae 4d postWPP  (991) adult male 01day  (845) adult male 05day  (1100) adult male 30day  (1082) adult female 01day  (1707) adult female 05day  (2432) adult female 30day  (2529) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4718) embryo 02-04hr  (6332) embryo 04-06hr  (6008) embryo 06-08hr  (6361) embryo 08-10hr  (4876) embryo 10-12hr  (3583) embryo 12-14hr  (2819) embryo 14-16hr  (3166) embryo 16-18hr  2416 embryo 18-20hr  1663 embryo 20-22hr  (2905) embryo 22-24hr  2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new  1440 white prepupae 12hr  1588 white prepupae 24hr  2092 pupae 2d postWPP  1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day  1707 adult female 05day  2432 adult female 30day  (2529) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4718 embryo 02-04hr    6332 embryo 04-06hr    6008 embryo 06-08hr    6361 embryo 08-10hr    4876 embryo 10-12hr    3583 embryo 12-14hr    2819 embryo 14-16hr    3166 embryo 16-18hr    2416 embryo 18-20hr    1663 embryo 20-22hr    2905 embryo 22-24hr    2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new    1440 white prepupae 12hr    1588 white prepupae 24hr    2092 pupae 2d postWPP    1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day    1707 adult female 05day    2432 adult female 30day    2529 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4718 embryo 02-04hr    6332 embryo 04-06hr    6008 embryo 06-08hr    6361 embryo 08-10hr    4876 embryo 10-12hr    3583 embryo 12-14hr    2819 embryo 14-16hr    3166 embryo 16-18hr    2416 embryo 18-20hr    1663 embryo 20-22hr    2905 embryo 22-24hr    2319 larva L1    1242 larva L2    975 larva L3 12hr old    819 larva L3 puffstage 1-2    745 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1375 white prepupae new    1440 white prepupae 12hr    1588 white prepupae 24hr    2092 pupae 2d postWPP    1477 pupae 3d postWPP    884 pupae 4d postWPP    991 adult male 01day    845 adult male 05day    1100 adult male 30day    1082 adult female 01day    1707 adult female 05day    2432 adult female 30day    2529 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034598    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034598 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034598 expression level Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034598 expression level Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    309.75 Larval Midgut    112.9 Larval Hindgut    162.5 Larval Malpighian Tubules    100 Larval Fat Body    78.7 Larval Salivary Gland    167.9 Larval Trachea    94.85 Larval Carcass    134.325 Adult Head    84.6 Adult Eye    49.225 Adult Brain    223.9 Adult Thoracic-Abdominal Ganglion    127.4 Adult Crop    94.2 Adult Midgut    73.7 Adult Hindgut    99.2 Adult Malpighian Tubules    78 Adult Fat Body    127.4 Adult Salivary Gland    105 Adult Heart    63.45 Adult VirginFemale Spermatheca    72.8 Adult InseminatedFemale Spermatheca    59.8 Adult Ovary    298.5 Adult Testis    31.9 Adult Male Accessory Gland    90 Adult Carcass    82.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    84.6   NA  Eye    49.225   NA  Brain    223.9   309.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    127.4   NA  Crop    94.2   112.9  Midgut    73.7   162.5  Hindgut    99.2   100  Malpighian Tubules    78   78.7  Fat Body    127.4   167.9  Salivary Gland    105   NA  Heart    63.45   94.85  Trachea    NA   NA  VirginFemale Spermatheca    72.8   NA  InseminatedFemale Spermatheca    59.8   NA  Ovary    298.5   NA  Testis    31.9   NA  Male Accessory Gland    90   134.325  Carcass    82.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034598 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4266-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG4266GD11266 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 CG4266GD11266 visible, with Scer\GAL4pnr-MD237 CG4266GD11266 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 CG4266GD11266 mesothoracic tergum, with Scer\GAL4pnr-MD237 CG4266GD11266
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of CG4266 Class Mutagen Stocks Known lesion CG4266c02793 1 -- CG4266c05426 piggyBac transposase 1 -- CG4266c05464a 1 -- CG4266EY04414 P-element activity 1 -- CG4266G7664 P-element activity 1 -- CG4266SH1128 1 -- CG4266EP2258 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4266 Class Mutagen Stocks Known lesion CG4266GD11266 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6072 (Ryder, 2004.4.26) Df(2R)Exel6073 (Ryder, 2004.4.26) Df(2R)Exel7167 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11266} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG4266EP2258 NA P{EP}CG4266G7664 NA P{EPgy2}CG4266EY04414 NA insertion of enhancer trap P{lacW}CG4266SH1128 No miscellaneous insertions PBac{PB}CG4266c02793 NA PBac{PB}CG4266c05426 NA PBac{PB}CG4266c05464a NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred from sequence or structural similarity with EMBL:AF023142 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4266 allele Gene References CG4266EP2258 btl (Zhu et al., 2005) Pvr (Zhu et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63045 DroID - A comprehensive database of gene and protein interactions. • FBgn0034598 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37411
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12972 Dere\GG20798 Dgri\GH21172 Dmoj\GI18767 Dper\GL10172 Dpse\GA18068 Dvir\GJ21791 Dwil\GK19487 Dyak\GE13738
Curated drosophilid orthologs	Dpse\GA18068
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002986-PA Aedes aegypti (mosquito) AGAP003369-PA Anopheles gambiae (mosquito) XP_392804.3 Apis mellifera (honey bee) XP_001951100.1 Acyrthosiphon pisum (pea aphid) BGIBMGA010991-PA Bombyx mori (silk worm) ENSBTAP00000025104 Bos taurus (bovine) CN06764 Caenorhabditis brenneri (small nematode) CBP33721 Caenorhabditis briggsae (nematode) CE26916 Caenorhabditis elegans (worm) ENSCAFP00000013024 Canis familiaris (dog) CAGL0J07810g Candida glabrata (haploid yeast) ENSCINP00000008719 Ciona intestinalis (sea squirt) cgd3_4150 Cryptosporidium parvum (protozoan parasite) CPIJ010606 Culex pipens (mosquito) ENSCPOP00000011197 Cavia porcellus (guinea pig) RP39437 Caenorhabditis remanei (nematode) ENSECAP00000012330 Equus caballus (horse) ENSGACP00000027214 Gymnopilus aculeatus (mushroom) ENSGALP00000025508 Gallus gallus (chicken) ENSP00000356146 Homo sapiens (human) 4979 Monocosta brevicollis (choanoflagellate) ENSMODP00000026309 Monodelphis domestica (gray opossum) ENSMMUP00000019884 Macaca mulatta (rhesus monkey) ENSMUSP00000076024 Mus musculus (house mouse) ENSORLP00000005492 Oryzias latipes (japanese killifish) PHUM001738-PA Pediculus humanus (human body louse) ENSPPYP00000012677 Pongo pygmaeus (orangutan) 83537 Phytophthora ramorum (sudden oak death pathogen) 135055 Phytophthora sojae (root rot pathogen) ENSPTRP00000049519 Pan troglodytes (chimpanzee) ENSRNOP00000022872 Rattus norvegicus (norway rat) Smp_148120 Schistosoma mansoni (trematode parasite) SPAC222.09 Schizosaccharomyces pombe (fission yeast) XP_784032.2 Strongylocentrotus purpuratus (purple sea urchin) XP_967119.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020002 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019358 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000028751 Xenopus tropicalis (frog) YALI0A02981g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18019 LH11130 ISCW001746 FBgn0231392 FBgn0221485 FBgn0208909 FBgn0196533 FBgn0170660 FBgn0170661 JGI_V11_14394 FBgn0078076 FBgn0147782 FBgn0141506 FBgn0128634 FBgn0112984 FBgn0090006 CPIJ010606 BGIBMGA010991 ACYPI002554 GB17650 AGAP003369 AAEL002986 PB20503 PHUM600390 GLEAN_10693
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	27967 y1 w*; P{EP}CG4266G7664 15931 y1 w67c23; P{EPgy2}CG4266EY04414 P{EPgy2}PuEY04414 29491 w*; P{FRT(whs)}G13 P{lacW}CG4266SH1128, l(2)SH1128SH1128/CyO
Harvard	- PBac{PB}CG4266c02793 - PBac{PB}CG4266c05426 - PBac{PB}CG4266c05464a, PBac{PB}c05464b
VDRC	v26472 w1118; P{GD11266}v26472 v26475 w1118; P{GD11266}v26475
Genomic Clones ( 2 )
	BACR12O13 BACR16B07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29226 LD44216
Other clones	IP17766
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT24659 GH07984 HL07935 LD17862 LD21702 LD29738 LD30965 LD31746 LD32015 LD33691 RE10875 RE15835 RE21988 RE30488 RE32140 RE39937 RE40756 RE42436 RE49942 RE64205 RE67122 RE68234 RE68293 RE68935 RE70173 RE71323 RE71481 RE75003 RE75127 SD25926 SD27504
Other clones	14765 29167 30575 41654 80729 81640 81943 98375 103432 103494 123073 156125 161682 CK01.8B.H1 CK01.81D.D6 CK01.145C.A2 EC26863 EK064336 EK117644 EK119633 EK139447 EK154564 EK172721 EK213046 EK221024 EK258858 EK268042 EK291025 EN03204 EN04006 FGM235E12 IP17666 IP17866 IP17966 RE41988
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034598 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37411
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137713 NM_001103924 RefSeq (Proteins) • NP_611557 NP_001097394 DDBJ / EMBL / GenBank • AA951335 AA952151 AAF46686 AAL13828 ABV53866 AQ254844 AW942946 AY058599 CC060540 CZ469962 Entrez Gene - A searchable database of RefSeq genes. • 37411 UniProtKB/TrEMBL • A8DYK5 Q9W2K4 Q95TR3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) RNA polymerase II, large subunit, CTD (IPR006569) Nucleotide-binding, alpha-beta plait (IPR012677) Domain of unknown function DUF618 (IPR006903) ENTH/VHS (IPR008942)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63045 DroID - A comprehensive database of gene and protein interactions. • FBgn0034598 DRSC - Results from RNAi screens. • FBgn0034598 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034598 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4266-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034598 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37411 InParanoid A subset of ortholog calls from InParanoid. • AAEL002986-PA Aedes aegypti (mosquito) AGAP003369-PA Anopheles gambiae (mosquito) XP_392804.3 Apis mellifera (honey bee) XP_001951100.1 Acyrthosiphon pisum (pea aphid) BGIBMGA010991-PA Bombyx mori (silk worm) ENSBTAP00000025104 Bos taurus (bovine) CN06764 Caenorhabditis brenneri (small nematode) CBP33721 Caenorhabditis briggsae (nematode) CE26916 Caenorhabditis elegans (worm) ENSCAFP00000013024 Canis familiaris (dog) CAGL0J07810g Candida glabrata (haploid yeast) ENSCINP00000008719 Ciona intestinalis (sea squirt) cgd3_4150 Cryptosporidium parvum (protozoan parasite) CPIJ010606 Culex pipens (mosquito) ENSCPOP00000011197 Cavia porcellus (guinea pig) RP39437 Caenorhabditis remanei (nematode) ENSECAP00000012330 Equus caballus (horse) ENSGACP00000027214 Gymnopilus aculeatus (mushroom) ENSGALP00000025508 Gallus gallus (chicken) ENSP00000356146 Homo sapiens (human) 4979 Monocosta brevicollis (choanoflagellate) ENSMODP00000026309 Monodelphis domestica (gray opossum) ENSMMUP00000019884 Macaca mulatta (rhesus monkey) ENSMUSP00000076024 Mus musculus (house mouse) ENSORLP00000005492 Oryzias latipes (japanese killifish) PHUM001738-PA Pediculus humanus (human body louse) ENSPPYP00000012677 Pongo pygmaeus (orangutan) 83537 Phytophthora ramorum (sudden oak death pathogen) 135055 Phytophthora sojae (root rot pathogen) ENSPTRP00000049519 Pan troglodytes (chimpanzee) ENSRNOP00000022872 Rattus norvegicus (norway rat) Smp_148120 Schistosoma mansoni (trematode parasite) SPAC222.09 Schizosaccharomyces pombe (fission yeast) XP_784032.2 Strongylocentrotus purpuratus (purple sea urchin) XP_967119.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020002 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019358 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000028751 Xenopus tropicalis (frog) YALI0A02981g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37411 modMine - Data generated by the modENCODE project. • FBgn0034598 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18019 LH11130 ISCW001746 FBgn0231392 FBgn0221485 FBgn0208909 FBgn0196533 FBgn0170660 FBgn0170661 JGI_V11_14394 FBgn0078076 FBgn0147782 FBgn0141506 FBgn0128634 FBgn0112984 FBgn0090006 CPIJ010606 BGIBMGA010991 ACYPI002554 GB17650 AGAP003369 AAEL002986 PB20503 PHUM600390 GLEAN_10693
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG4266 (Isogai et al., 2007, Altenhein et al., 2006, Somma et al., 2008) cg4266 (Lasko, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 3 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...