FB2020_06, released Dec 22, 2020

Gene: Dmel\CG10433

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General Information
Symbol
Dmel\CG10433
Species
D. melanogaster
Name
Annotation Symbol
CG10433
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034638
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
57F3-57F3
Sequence location
2R:21,605,676..21,608,125 [-]
Recombination map

2-96

RefSeq locus
NT_033778 REGION:21605676..21608125
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2012-11-15 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in multicellular organism reproduction
inferred from high throughput expression pattern
(Findlay et al., 2008, Mueller et al., 2005)
involved_in regulation of female receptivity
inferred from mutant phenotype
(Liu et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in defense response
inferred from sequence or structural similarity
(Mueller et al., 2004)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from high throughput direct assay
(Findlay et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from sequence model
(Mueller et al., 2005)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    2

    Please see the JBrowse view of Dmel\CG10433 for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Gene model reviewed during 5.51

    Gene model reviewed during 5.55

    Sequence Ontology: Class of Gene
    nuclear_gene
    protein_coding_gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    CG10433-RA
    FBtr0071690
    NM_137746
    945
    127
    CG10433-RB
    FBtr0071691
    NM_166463
    1112
    98
    CG10433-RC
    FBtr0344882
    NM_001299754
    1945
    127
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    CG10433-PA
    FBpp0071607
    13.9
    127
    5.59
    NP_611590
    AAF46736
    CG10433-PB
    FBpp0071608
    10.7
    98
    4.97
    NP_726088
    AAM70922
    CG10433-PC
    FBpp0311195
    13.9
    127
    5.59
    NP_001286683
    AHN56478
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    127 aa isoforms: CG10433-PA, CG10433-PC
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG10433 using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    located_in extracellular space
    inferred from high throughput direct assay
    (Findlay et al., 2008)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\CG10433 in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 3 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 5 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of CG10433
    Transgenic constructs containing regulatory region of CG10433
    Deletions and Duplications ( 1 )
    Phenotypes
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190I3C )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Dsuz\DS10_00002247
    Drosophila simulans
    Dsim\GD25186
    Drosophila sechellia
    Dsec\GM15708
    Drosophila erecta
    Dere\GG20765
    Drosophila yakuba
    Dyak\GE13697
    Drosophila ananassae
    Dana\GF12088
    Drosophila pseudoobscura pseudoobscura
    Dpse\GA10315
    Drosophila persimilis
    Dper\GL17485
    Drosophila willistoni
    Dwil\GK22257
    Drosophila virilis
    Dvir\GJ22309
    Drosophila mojavensis
    Dmoj\GI20459
    Drosophila grimshawi
    Dgri\GH20050
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150HK3 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Mdoa\17021045
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY006993
    Lucilia cuprina
    Australian sheep blowfly
    Lcup\FF38_03859
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes013832
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL009861
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC001002
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP007049
    Culex quinquefasciatus
    Southern house mosquito
    Cqui\CPIJ004961
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MRJ )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS200019-PA
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS214905-PA
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL004524
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL004525
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_03739
    Tribolium castaneum
    Red flour beetle
    Tcas\TC001282
    Pediculus humanus
    Human body louse
    Phum\PHUM564690
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0N03 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Smar\SMAR000888
    Ixodes scapularis
    Black-legged tick
    Isca\ISCW003836
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM79539.1
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_316483
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      btl|stumps
      enhanceable
      CG10433
      (Zhu et al., 2005)
      Pvr
      suppressible
      CG10433
      (Zhu et al., 2005)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map

      2-96

      Cytogenetic map
      57F3-57F3
      Sequence location
      2R:21,605,676..21,608,125 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      57F3-57F3
      Limits computationally determined from genome sequence between P{PZ}Egfr05351 and P{EP}CG10082EP436&P{EP}EP712EP712
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-96

      (FlyBase, 2016)

      2-102.1

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (3)
      Genomic Clones (15)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (119)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        Wolbachia is likely to induce paternal defects through interaction with the JH pathway via CG10433.

        (Liu et al., 2014)

        Isolated in a screen for seminal fluid proteins.

        (Mueller et al., 2004)

        Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

        (Claridge-Chang et al., 2001)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 33 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Synonyms and Secondary IDs (1)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (44)