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Gene Dmel\Vps35

General Information
Symbol	Dmel\Vps35	Species	D. melanogaster
Name	Vacuolar protein sorting 35	Annotation symbol	CG5625
Feature type	protein_coding_gene	FlyBase ID	FBgn0034708
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	dvps35
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58C7-58C7	Sequence location	2R:18,073,477..18,077,391 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Vacuolar protein sorting 35 is referred to in FlyBase by the symbol Dmel\Vps35 (CG5625, FBgn0034708). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: endocytosis. 11 alleles are reported. The phenotypes of these alleles are annotated with: NMJ bouton; lamellocyte. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Vacuolar protein sorting-associated protein 35. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625656_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Vps35. Gene sequence location is 2R:18073483..18077392.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms late endosome
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58C7-58C7   Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Vps35 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Vps35-RA FBtr0071772  NM_137807   3015   803 Vps35-RB FBtr0071771  NM_166518   3369   822
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Vps35-PA   FBpp0071686   91.1   803   5.09     NP_611651   AAF46816 Vps35-PB   FBpp0071685   93.1   822   5.14     NP_726175   AAF46817
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Vacuolar protein sorting-associated protein 35 (IPR005378)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391009   AA391150   AA539459   AA950018   AE013599 AAF46816   AE013599 AAF46817   AI110053   AI402179   AI517517   AW942454   AY061234 AAL28782   BF506518   BI164048   BI230580   BI237580   BI238554   BI356582   BI361492   BI363496   BI366552   BI367017   BI367322   BI367397   BI370154   BI375736   BI482349   BI570751   BI570896   BI571154   BI571264   BI571955   BI580456   BI591760   BI640812   BP552580   BT015203   BT100312   CL943614   CO191990   CO264385   CO271516   CO276180   CO281850   CO283176   CO287703   CO293996   CO296447   CO307080   CO314010   CO316161   CO317357   CO317425   CO318830   CO341399   CO342865   DN154301   EC055137   EC066614   EC066615   EC075533   EC076790   EC197606   EC202857   EC204527   EC205091   EC209764   EC212725   EC213048   EC214872   EC218894   EC222747   EC234278   EC250173   EC250397   EC252350   EC258276   EV588186   EV600550   GH757923   GH758280   GH758342   GH758383   GH759785   GH773217   GH773580   GH777190   GH777447   GH777570   GH778175   GH786981   GH788398   GH789406   GH791324   GH791705   GH792079   GH793274   GH795934   GH799598   GH800631   GH801382   GH805060   GH807995   GH810557   GH811082   GH812144   GH814359   GH822566   GH823064   GH828351   GH829173   GH836860   GH838406   GH843755   GH847080   GH847132   GH849466   GH852591   GH857038   GH861907   GH864020   GH868264   GH877454   GH878863   GH878987   GH880150   GH880366   GH889630   GH894191   GH894958   GH897943   GH898827   GH904065   GH904095   GH904928   GH904945   GH909245   GH914326   GH918762   GH920154   GH922000   GH922134   GH922533   GH923846   GH923863   GH925467   GH926233   GH928144   GH928428   GH928580   GH930356   GH931194   GH933885   GH934266   GH934347   GH939772   GH940704
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KVL7 Q9W277 Q95RP4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | intense & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) organism | intense & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) garland cell primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
endosome inferred from direct assay (Korolchuk et al., 2007) late endosome inferred from direct assay (Dong et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    444.5 Larval Midgut    276.6 Larval Hindgut    382.4 Larval Malpighian Tubules    455.8 Larval Fat Body    288.1 Larval Salivary Gland    492.5 Larval Trachea    342.575 Larval Carcass    305.875 Adult Head    288.5 Adult Eye    393.625 Adult Brain    304.7 Adult Thoracic-Abdominal Ganglion    312.9 Adult Crop    349.3 Adult Midgut    330.7 Adult Hindgut    311.7 Adult Malpighian Tubules    430.8 Adult Fat Body    272 Adult Salivary Gland    433.3 Adult Heart    342.55 Adult VirginFemale Spermatheca    300.3 Adult InseminatedFemale Spermatheca    331.5 Adult Ovary    362.7 Adult Testis    97.1 Adult Male Accessory Gland    364.8 Adult Carcass    236.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    288.5   NA  Eye    393.625   NA  Brain    304.7   444.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    312.9   NA  Crop    349.3   276.6  Midgut    330.7   382.4  Hindgut    311.7   455.8  Malpighian Tubules    430.8   288.1  Fat Body    272   492.5  Salivary Gland    433.3   NA  Heart    342.55   342.575  Trachea    NA   NA  VirginFemale Spermatheca    300.3   NA  InseminatedFemale Spermatheca    331.5   NA  Ovary    362.7   NA  Testis    97.1   NA  Male Accessory Gland    364.8   305.875  Carcass    236.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    45 central nervous system, pupae P8    32 head, virgin 1-day female    26 head, virgin 4-day female    27 head, virgin 20-day female    28 head, mated 1-day female    20 head, mated 4-day female    27 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    48 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae    35 fat body, pupae P8    24 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female    65 ovary, mated 4-day female    55 testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (45) central nervous system, pupae P8  (32) head, virgin 1-day female  26 head, virgin 4-day female  (27) head, virgin 20-day female  (28) head, mated 1-day female    20 head, mated 4-day female  (27) head, mated 20-day female    22 head, mated 1-day male  (35) head, mated 4-day male  (41) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering  (30) digestive system, 1-day adult    23 digestive system, 4-day adult  26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae  (35) fat body, pupae P8    24 carcass, larvae L3 wandering  (43) carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female  (65) ovary, mated 4-day female  (55) testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    45 central nervous system, pupae P8    32 head, virgin 1-day female    26 head, virgin 4-day female    27 head, virgin 20-day female    28 head, mated 1-day female    20 head, mated 4-day female    27 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    48 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae    35 fat body, pupae P8    24 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female    65 ovary, mated 4-day female    55 testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    45 central nervous system, pupae P8    32 head, virgin 1-day female    26 head, virgin 4-day female    27 head, virgin 20-day female    28 head, mated 1-day female    20 head, mated 4-day female    27 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    48 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae    35 fat body, pupae P8    24 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female    65 ovary, mated 4-day female    55 testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    45 central nervous system, pupae P8    32 head, virgin 1-day female    26 head, virgin 4-day female    27 head, virgin 20-day female    28 head, mated 1-day female    20 head, mated 4-day female    27 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    48 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae    35 fat body, pupae P8    24 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female    65 ovary, mated 4-day female    55 testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (45) central nervous system, pupae P8  32 head, virgin 1-day female  26 head, virgin 4-day female  27 head, virgin 20-day female  28 head, mated 1-day female    20 head, mated 4-day female  27 head, mated 20-day female    22 head, mated 1-day male  (35) head, mated 4-day male  (41) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering  30 digestive system, 1-day adult    23 digestive system, 4-day adult  26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae  (35) fat body, pupae P8    24 carcass, larvae L3 wandering  (43) carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female  (65) ovary, mated 4-day female  (55) testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    45 central nervous system, pupae P8    32 head, virgin 1-day female    26 head, virgin 4-day female    27 head, virgin 20-day female    28 head, mated 1-day female    20 head, mated 4-day female    27 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    48 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae    35 fat body, pupae P8    24 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female    65 ovary, mated 4-day female    55 testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    45 central nervous system, pupae P8    32 head, virgin 1-day female    26 head, virgin 4-day female    27 head, virgin 20-day female    28 head, mated 1-day female    20 head, mated 4-day female    27 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    48 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    23 digestive system, 4-day adult    26 digestive system, 20-day adult    25 fat body, larvae L3 wandering    13 fat body, white prepupae    35 fat body, pupae P8    24 carcass, larvae L3 wandering    43 carcass, 1-day adult    21 carcass, 4-day adult    23 carcass, 20-day adult    21 ovary, virgin 4-day female    65 ovary, mated 4-day female    55 testis, mated 4-day male    15 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    59 embryo 04-06hr    44 embryo 06-08hr    40 embryo 08-10hr    47 embryo 10-12hr    40 embryo 12-14hr    39 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    33 white prepupae new    35 white prepupae 12hr    30 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day    27 adult male 30day    25 adult female 01day    29 adult female 05day    41 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (59) embryo 04-06hr  (44) embryo 06-08hr  (40) embryo 08-10hr  (47) embryo 10-12hr  (40) embryo 12-14hr  (39) embryo 14-16hr  (33) embryo 16-18hr  (27) embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr  (27) larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (33) white prepupae new  (35) white prepupae 12hr  (30) white prepupae 24hr  (34) pupae 2d postWPP  (30) pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day  (27) adult male 30day    25 adult female 01day  (29) adult female 05day  (41) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    59 embryo 04-06hr    44 embryo 06-08hr    40 embryo 08-10hr    47 embryo 10-12hr    40 embryo 12-14hr    39 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    33 white prepupae new    35 white prepupae 12hr    30 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day    27 adult male 30day    25 adult female 01day    29 adult female 05day    41 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    59 embryo 04-06hr    44 embryo 06-08hr    40 embryo 08-10hr    47 embryo 10-12hr    40 embryo 12-14hr    39 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    33 white prepupae new    35 white prepupae 12hr    30 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day    27 adult male 30day    25 adult female 01day    29 adult female 05day    41 adult female 30day    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    59 embryo 04-06hr    44 embryo 06-08hr    40 embryo 08-10hr    47 embryo 10-12hr    40 embryo 12-14hr    39 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    33 white prepupae new    35 white prepupae 12hr    30 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day    27 adult male 30day    25 adult female 01day    29 adult female 05day    41 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (59) embryo 04-06hr  (44) embryo 06-08hr  (40) embryo 08-10hr  (47) embryo 10-12hr  (40) embryo 12-14hr  (39) embryo 14-16hr  (33) embryo 16-18hr  27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr  27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (33) white prepupae new  (35) white prepupae 12hr  30 white prepupae 24hr  (34) pupae 2d postWPP  30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day  27 adult male 30day    25 adult female 01day  29 adult female 05day  (41) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    59 embryo 04-06hr    44 embryo 06-08hr    40 embryo 08-10hr    47 embryo 10-12hr    40 embryo 12-14hr    39 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    33 white prepupae new    35 white prepupae 12hr    30 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day    27 adult male 30day    25 adult female 01day    29 adult female 05day    41 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    59 embryo 04-06hr    44 embryo 06-08hr    40 embryo 08-10hr    47 embryo 10-12hr    40 embryo 12-14hr    39 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    24 larva L2    25 larva L3 12hr old    19 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    33 white prepupae new    35 white prepupae 12hr    30 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    23 pupae 4d postWPP    18 adult male 01day    25 adult male 05day    27 adult male 30day    25 adult female 01day    29 adult female 05day    41 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    135 Schneider line 2 Sg4    47 embryonic 1182-4H    81 embryonic GM2    70 embryonic Kc167    64 embryonic S1    160 embryonic S3    105 leg disc CME L1    54 wing disc CME-W2    66 wing disc ML-DmD8    66 wing disc ML-DmD9    77 wing disc ML-DmD16-c3    87 wing disc ML-DmD21    55 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    85 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    94 CNS ML-DmBG2-c2    83 tumorous blood cells mbn2    89 ovary fGS/OSS    50 ovary OSC    61 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (135) Schneider line 2 Sg4  (47) embryonic 1182-4H  (81) embryonic GM2  (70) embryonic Kc167  (64) embryonic S1  (160) embryonic S3  (105) leg disc CME L1  (54) wing disc CME-W2  (66) wing disc ML-DmD8  (66) wing disc ML-DmD9  (77) wing disc ML-DmD16-c3  (87) wing disc ML-DmD21  (55) wing disc ML-DmD32  (62) haltere disc ML-DmD17-c3  (120) eye-antennal disc ML-DmD11  (83) antennal disc ML-DmD20-c5  (85) mixed discs ML-DmD4-c1  (80) CNS ML-DmBG1-c1  (94) CNS ML-DmBG2-c2  (83) tumorous blood cells mbn2  (89) ovary fGS/OSS  (50) ovary OSC  (61) ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (135) Schneider line 2 Sg4    47 embryonic 1182-4H    81 embryonic GM2    70 embryonic Kc167    64 embryonic S1  (160) embryonic S3  105 leg disc CME L1    54 wing disc CME-W2    66 wing disc ML-DmD8    66 wing disc ML-DmD9    77 wing disc ML-DmD16-c3    87 wing disc ML-DmD21    55 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3  (120) eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    85 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    94 CNS ML-DmBG2-c2    83 tumorous blood cells mbn2    89 ovary fGS/OSS    50 ovary OSC    61 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    135 Schneider line 2 Sg4    47 embryonic 1182-4H    81 embryonic GM2    70 embryonic Kc167    64 embryonic S1    160 embryonic S3    105 leg disc CME L1    54 wing disc CME-W2    66 wing disc ML-DmD8    66 wing disc ML-DmD9    77 wing disc ML-DmD16-c3    87 wing disc ML-DmD21    55 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    85 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    94 CNS ML-DmBG2-c2    83 tumorous blood cells mbn2    89 ovary fGS/OSS    50 ovary OSC    61 ovary OSS    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    135 Schneider line 2 Sg4    47 embryonic 1182-4H    81 embryonic GM2    70 embryonic Kc167    64 embryonic S1    160 embryonic S3    105 leg disc CME L1    54 wing disc CME-W2    66 wing disc ML-DmD8    66 wing disc ML-DmD9    77 wing disc ML-DmD16-c3    87 wing disc ML-DmD21    55 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    85 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    94 CNS ML-DmBG2-c2    83 tumorous blood cells mbn2    89 ovary fGS/OSS    50 ovary OSC    61 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (135) Schneider line 2 Sg4  (47) embryonic 1182-4H  (81) embryonic GM2  (70) embryonic Kc167  (64) embryonic S1  (160) embryonic S3  (105) leg disc CME L1  (54) wing disc CME-W2  (66) wing disc ML-DmD8  (66) wing disc ML-DmD9  (77) wing disc ML-DmD16-c3  (87) wing disc ML-DmD21  (55) wing disc ML-DmD32  (62) haltere disc ML-DmD17-c3  (120) eye-antennal disc ML-DmD11  (83) antennal disc ML-DmD20-c5  (85) mixed discs ML-DmD4-c1  (80) CNS ML-DmBG1-c1  (94) CNS ML-DmBG2-c2  (83) tumorous blood cells mbn2  (89) ovary fGS/OSS  (50) ovary OSC  (61) ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  135 Schneider line 2 Sg4    47 embryonic 1182-4H    81 embryonic GM2    70 embryonic Kc167    64 embryonic S1  (160) embryonic S3  105 leg disc CME L1    54 wing disc CME-W2    66 wing disc ML-DmD8    66 wing disc ML-DmD9    77 wing disc ML-DmD16-c3    87 wing disc ML-DmD21    55 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3  120 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    85 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    94 CNS ML-DmBG2-c2    83 tumorous blood cells mbn2    89 ovary fGS/OSS    50 ovary OSC    61 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    135 Schneider line 2 Sg4    47 embryonic 1182-4H    81 embryonic GM2    70 embryonic Kc167    64 embryonic S1    160 embryonic S3    105 leg disc CME L1    54 wing disc CME-W2    66 wing disc ML-DmD8    66 wing disc ML-DmD9    77 wing disc ML-DmD16-c3    87 wing disc ML-DmD21    55 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    85 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    94 CNS ML-DmBG2-c2    83 tumorous blood cells mbn2    89 ovary fGS/OSS    50 ovary OSC    61 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (28) Cadmium 100 mM 48 hrs, 4-day adult  (42) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (27) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (39) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  28 Cadmium 100 mM 48 hrs, 4-day adult  (42) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (39) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    27 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD17594 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034708 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5625-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)Exel6078) Vps35MH20 lethal | embryonic stage | maternal effect | recessive Vps35MH20 lethal | larval stage (with Df(2R)ED3952) Vps35EY14200 lethal | larval stage | recessive Vps35EY14200 lethal | prepupal stage | recessive Vps35MH20 lethal | pupal stage (with Df(2R)ED3952) Vps35EY14200 lethal | pupal stage | recessive Vps35EY14200 lethal | recessive Vps35EY14200 lethal | second instar larval stage Vps35E42 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Vps35GD11710 Other Phenotypes Allele melanotic mass phenotype | larval stage Vps35EY14200 Vps35MH20 melanotic mass phenotype | larval stage (with Df(2R)Exel6078) Vps35MH20 neuroanatomy defective | larval stage Vps35EY14200 neuroanatomy defective | larval stage (with Df(2R)ED3952) Vps35EY14200 visible | somatic clone Vps35MH20 Phenotype manifest in Allele embryonic/larval dorsal trunk Vps351 embryonic/larval hemocyte | supernumerary (with Df(2R)ED3952) Vps35EY14200 follicle cell | somatic clone Vps35MH20 lamellocyte Vps35EY14200 melanotic mass | larval stage Vps35EY14200 Vps35MH20 NMJ bouton Vps35EY14200 NMJ bouton (with Df(2R)ED3952) Vps35EY14200 plasmatocyte | supernumerary Vps35EY14200 wing margin | somatic clone Vps35MH20
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Vps35 Class Mutagen Stocks Known lesion Vps35EY14200 P-element activity 2 Yes Vps35EY16641 P-element activity 1 -- Vps351 P-element activity 0 Yes Vps35DG08107 0 -- Vps35E42 P-element activity 0 Yes Vps35MH20 loss of function allele P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Vps35 Class Mutagen Stocks Known lesion Vps35GD11710 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Vps35HMS01858 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Vps35dsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Vps35NIG.5625R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Vps35Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6078 (Ryder, 2004.4.26, Franch-Marro et al., 2008) Df(2R)Exel7171 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.5625R} NA P{TRiP.HMS01858} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Vps35EY14200 NA P{EPgy2}Vps35EY16641 NA miscellaneous insertions P{wHy}Vps35DG08107 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
endocytosis inferred from mutant phenotype (Korolchuk et al., 2007)
Cellular Component
CV term Evidence References
endosome inferred from direct assay (Korolchuk et al., 2007) late endosome inferred from direct assay (Dong et al., 2013)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
vesicle-mediated transport inferred from sequence or structural similarity with Saccharomyces VPS35 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Vps35 - CG4764 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Vps35 - Snx3 anti tag coimmunoprecipitation, anti tag western blot (Zhang et al., 2011) Vps35 - Vps26 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Vps35 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63153 DroID - A comprehensive database of gene and protein interactions. • FBgn0034708 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37536
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JQ4H0 Dipteran inclusive ortholog search EOG6H72KN Insect inclusive ortholog search EOG6MPGK1 Arthropod inclusive ortholog search EOG6D51CM Metazoa inclusive ortholog search EOG6SNDFD
Orthologs in Drosophila Species (EOG6JQ4H0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Vps35     Drosophila simulans   Dsim\GD11652 Y   Drosophila sechellia   Dsec\GM15895 Y   Drosophila erecta   Dere\GG22173 Y   Drosophila yakuba   Dyak\GE14166 Y   Drosophila ananassae   Dana\GF12616 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24193 Y   Drosophila persimilis   Dper\GL17528 Y   Drosophila willistoni   Dwil\GK20803 Y   Drosophila virilis   Dvir\GJ22344 Y   Drosophila mojavensis   Dmoj\GI20494 Y   Drosophila grimshawi   Dgri\GH21205 Y
Orthologs in non-Drosophila Dipterans (EOG6H72KN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013386   Anopheles gambiae Malaria mosquito  Agam\AGAP007683   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018730
Orthologs in non-Dipteran Insects (EOG6MPGK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Vps35   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005289   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14460   Atta cephalotes Leafcutter ant  Acep\ACEP26334   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22979   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15313   Linepithema humile Argentine ant  Lhum\LH13587   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25200   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25194   Solenopsis invicta Red fire ant  Sinv\SINV16024   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008757   Bombyx mori Silkmoth  Bmor\BGIBMGA014194   Pediculus humanus Human body louse  Phum\PHUM550160   Tribolium castaneum Red flour beetle  Tcas\TC008602
Orthologs in non-Insect Arthropods (EOG6D51CM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_315698   Ixodes scapularis Deer tick  Isca\ISCW014873
Orthologs in non-Arthropod Metazoa (EOG6SNDFD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\vps-35   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007036gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013012gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018885gn   Danio rerio Zebrafish  Drer\vps35   Xenopus tropicalis Western clawed frog  Xtro\vps35   Gallus gallus Domestic chicken  Ggal\VPS35   Mus musculus House mouse  Mmus\Vps35   Rattus norvegicus Norway rat  Rnor\Vps35   Homo sapiens Human  Hsap\VPS35
Human Orthologs (1)
Gene OMIM HGNC Hsap\VPS35
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11652 Drosophila sechellia Dsec\GM15895 Drosophila erecta Dere\GG22173 Drosophila yakuba Dyak\GE14166 Drosophila ananassae Dana\GF12616 Drosophila pseudoobscura pseudoobscura Dpse\GA24193 Drosophila persimilis Dper\GL17528 Drosophila willistoni Dwil\GK20803 Drosophila virilis Dvir\GJ22344 Drosophila mojavensis Dmoj\GI20494 Drosophila grimshawi Dgri\GH21205
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	38944 y1 sc* v1; P{TRiP.HMS01858}attP40 20913 y1 w67c23; P{EPgy2}Vps35EY14200/CyO 22327 y1 w67c23; P{EPgy2}Vps35EY16641/SM6a
Kyoto	114684 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{EPgy2}Vps35EY14200 /CyO y+
VDRC	v22180 w1118 P{GD11710}v22180 v45570 w1118; P{GD11710}v45570
Genomic Clones ( 1 )
	BACR02O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 148 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD17594 RE65032 SD03023
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09011 GH28513 LD09234 LD09906 LD29957 RE03618 RE14284 RE33829 RE35043 RE42761 RE45724 RE48319 RE52117 RE52682 RE53064 RE53158 RE56568 RE63606 RE74652 RH05528 RH05682 RH05977 RH06106 RH06738 RH07277 SD23815
Other clones	30019 51474 75563 78116 80413 109055 109321 148129 163304 163318 172804 175143 175757 211074.1 214445.63 214447.64 CK01.83C.A12 CK01.168D.H11 Dmel_neb_012033_0822_2195 Dmel_neb_012594_0162_0291 EC32540 EC055137 EK066536 EK103730 EK119902 EK138923 EK158929 EK162430 EK205341 EK211419 EK213657 EK234709 EK253460 EK263824 EK267763 EK267962 EK274334 EP12363 EP15639 FGM219E12 GH09501 RP003033526 RP003055165 RP003080343 RP003080705 RP003084994 RP003086011 RP003093025 RP003095611 RP003097994 RP003098456 RP003111330 RP003114937 RP003148624 RP003150533 RP003157735 RP003178279 RP003206113 RP003207993 RP003211956 RP003221222 RP003234374 RP003235115 RP003252413 RP003267625 RP003277382 RP003288586 RP003290419 RP003299076 RP003299678 RP003301865 RP003320650 RP003322221 RP003327893 RP003333714 RP003336670 RP003337678 RP003347435 RP003353946 RP003368384 RP003372296 RP003385708 RP003390982 RP003391371 RP003400788 RP003402020 RP003402309 RP003415824 RP003422594 RP003426017 RP003426312 RP003450803 RP003454216 RP003462847 RP003468890 RP003489086 RP003500176 RP003500770 RP003505287 RP003513168 RP003517757 RP003519390 RP003524214 RP003524633 RP003555054 RP003555400 RP003568504 RP003587609 RP003618205 RP003627482 RP003628871 RP003629948 RP003631287 RP003640848 RP003640989 RP003647639 RP003652573 RP003663581 RP003670983
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034708 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37536
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Vps35 CG5625 (Korolchuk et al., 2007)
Source for database merge of
Additional comments	FlyBase curator comment: Correspondence with author Lin revealed that 'Vps35' = 'CG5625'. (Lin et al., 2008)
Other Comments
	Vps35 is required for efficient progress of wg protein through the secretory pathway. (Franch-Marro et al., 2008) Vps35 is required for secretion of wg protein. (Port et al., 2008)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137807 NM_166518 RefSeq (Proteins) • NP_611651 NP_726175 DDBJ / EMBL / GenBank • AA539459 AAF46816 AAF46817 AAL28782 AW942454 AY061234 BI482349 CL943614 Entrez Gene - A searchable database of RefSeq genes. • 37536 UniProtKB/TrEMBL • Q7KVL7 Q9W277 Q95RP4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Vacuolar protein sorting-associated protein 35 (IPR005378) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD17594
Linkouts
	BioGRID - A database of protein and genetic interactions • 63153 DroID - A comprehensive database of gene and protein interactions. • FBgn0034708 DRSC - Results from RNAi screens. • FBgn0034708 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034708 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5625-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034708 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37536 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37536 modMine - Data generated by the modENCODE project. • FBgn0034708
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG5625 (FlyBase Curators, 2008, Port et al., 2008, Korolchuk et al., 2007, Belenkaya et al., 2008, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Shirasaki et al., 2012, Ni et al., 2010.12.1) dvps35 (Zhou et al., 2011) Dvps35 (Belenkaya et al., 2008, Port et al., 2008) DVps35 (Zhang et al., 2011) Vps35 (Pocha et al., 2011, Lin et al., 2008, Zhou et al., 2011, Franch-Marro et al., 2008, ) vps35 (Dong et al., 2013, Korolchuk et al., 2007, Belenkaya et al., 2008, Dong et al., 2013, Lee and Fischer, 2012, Burgess et al., 2012)
Name Synonym	CG5625   Vacuolar protein sorting 35
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 7 )
	Dong et al., 2013, Nat. Commun. 4: 1358 Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. [FBrf0220559] Burgess et al., 2012, Development 139(16): 3040--3050 Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. [FBrf0219013] Lee and Fischer, 2012, PLoS ONE 7(9): e46357 Drosophila Tel2 Is Expressed as a Translational Fusion with EpsinR and Is a Regulator of Wingless Signaling. [FBrf0219532] Shirasaki et al., 2012, Neuron 75(1): 41--57 Network organization of the huntingtin proteomic interactome in Mammalian brain. [FBrf0218881] Pocha et al., 2011, Curr. Biol. 21(13): 1111--1117 Retromer controls epithelial cell polarity by trafficking the apical determinant crumbs. [FBrf0214250] Zhang et al., 2011, Cell Res. 21(12): 1677--1690 SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. [FBrf0216871] Zhou et al., 2011, Dev. Biol. 360(1): 87--95 Retromer regulates apical-basal polarity through recycling crumbs. [FBrf0216617] Show all research papers ...