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Gene Dmel\Swim

General Information
Symbol	Dmel\Swim	Species	D. melanogaster
Name	Secreted Wg-interacting molecule	Annotation symbol	CG3074
Feature type	protein_coding_gene	FlyBase ID	FBgn0034709
Gene Model Status	Current	Stock availability	14 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58C7-58D1	Sequence location	2R:18,077,322..18,090,176 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Secreted Wg-interacting molecule is referred to in FlyBase by the symbol Dmel\Swim (CG3074, FBgn0034709). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-protein binding. There is experimental evidence that it is involved in the biological process: positive regulation of Wnt receptor signaling pathway; positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region. 43 alleles are reported. The phenotype of these alleles is annotated with: wing margin. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cysteine peptidase, asparagine active site; Cysteine peptidase, histidine active site; Peptidase C1A, papain; Peptidase C1A, papain C-terminal; Somatomedin B domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval hindgut, larval Malpighian tubules, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult hindgut, adult Malpighian tubules, adult heart, adult ovary, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641413_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG3074. Gene sequence location is 2R:18077326..18090178.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58C7-58D1   Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Swim for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Swim-RA FBtr0071785  NM_166519   1989   431 Swim-RB FBtr0071784  NM_137808   2049   431
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Swim-PA   FBpp0071698   48.8   431   7.08     NP_726176   AAF46818 Swim-PB   FBpp0071697   48.8   431   7.08     NP_611652   AAM68213
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cysteine peptidase, asparagine active site (IPR025661) Cysteine peptidase, histidine active site (IPR025660) Peptidase C1A, papain C-terminal (IPR000668) Somatomedin B domain (IPR001212) Peptidase C1A, papain (IPR013128)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697757   AA697983   AA802878   AE013599 AAF46818   AE013599 AAM68213   AI062180   AI062692   AI106936   AI238061   AI238399   AI257476   AI259147   AI261073   AI296193   AI387685   AI402629   AI514062   AI542302   AI543135   AW941268   AY060922 AAL28470   AY113377 AAM29382   BF493638   BF497113   BF502468   BF502995   BG632046   BG639966   BG640631   BI162398   BI162399   BI165232   BI167466   BI168264   BI171714   BI171989   BI212869   BI229162   BI229624   BI229945   BI354698   BI364091   BI369908   BI370501   BI371696   BI373866   BI374039   BI376025   BI483373   BI483458   BI484637   BI484662   BI485214   BI485569   BI567362   BI567944   BI574827   BI581380   BI581958   BI582145   BI587579   BI588154   BI588708   BI590882   BI592214   BI604775   BI609737   BI610525   BI610588   BI612572   BI615692   BI619404   BI625424   BI627443   BI640100   BI640552   BP540946   BP541209   BP541225   BP541851   BP544296   BP548503   BP548837   BP549167   BP549398   BP551359   BP551360   BP552581   BP554889   BP556750   BP557334   CK604298   CK604299   CK660552   CL526165   CO285277   CO291690   CO300327   CZ476725   CZ476932   CZ476933   EC062365   EC085391   EC246915   ES689089
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JWQ7 Q95S79
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   fat body/gonad primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic salivary gland duct   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval salivary gland common duct   (Fisher et al., 2012) gonad   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
chorion inferred from direct assay (Fakhouri et al., 2006) extracellular space inferred from direct assay (Mulligan et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval hindgut, larval Malpighian tubules, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult hindgut, adult Malpighian tubules, adult heart, adult ovary, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    734.825 Larval Midgut    1433.2 Larval Hindgut    1168 Larval Malpighian Tubules    697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea    748.5 Larval Carcass    811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    1234 Adult Midgut    507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland    758.9 Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (734.825) Larval Midgut  (1433.2) Larval Hindgut  (1168) Larval Malpighian Tubules  (697.8) Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea  (748.5) Larval Carcass  (811.375) Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop  (1234) Adult Midgut  507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland  (758.9) Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    734.825 Larval Midgut  (1433.2) Larval Hindgut  (1168) Larval Malpighian Tubules    697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea    748.5 Larval Carcass    811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop  (1234) Adult Midgut    507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland    758.9 Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    734.825 Larval Midgut    1433.2 Larval Hindgut    1168 Larval Malpighian Tubules    697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea    748.5 Larval Carcass    811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    1234 Adult Midgut    507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland    758.9 Adult Carcass    156.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    734.825 Larval Midgut    1433.2 Larval Hindgut    1168 Larval Malpighian Tubules    697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea    748.5 Larval Carcass    811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    1234 Adult Midgut    507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland    758.9 Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  734.825 Larval Midgut  (1433.2) Larval Hindgut  (1168) Larval Malpighian Tubules  697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea  748.5 Larval Carcass  811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop  (1234) Adult Midgut  507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland  758.9 Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    734.825 Larval Midgut  1433.2 Larval Hindgut  1168 Larval Malpighian Tubules    697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea    748.5 Larval Carcass    811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop  1234 Adult Midgut    507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland    758.9 Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    734.825 Larval Midgut    1433.2 Larval Hindgut    1168 Larval Malpighian Tubules    697.8 Larval Fat Body    49.5 Larval Salivary Gland    53.9 Larval Trachea    748.5 Larval Carcass    811.375 Adult Head    188.8 Adult Eye    459.2 Adult Brain    10 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    1234 Adult Midgut    507.4 Adult Hindgut    320.8 Adult Malpighian Tubules    272.7 Adult Fat Body    40.8 Adult Salivary Gland    57.6 Adult Heart    427.925 Adult VirginFemale Spermatheca    33.1 Adult InseminatedFemale Spermatheca    83.3 Adult Ovary    105.5 Adult Testis    133.7 Adult Male Accessory Gland    758.9 Adult Carcass    156.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    188.8   NA  Eye    459.2   NA  Brain    no informative data   734.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.4   NA  Crop    1234   1433.2  Midgut    507.4   1168  Hindgut    320.8   697.8  Malpighian Tubules    272.7   49.5  Fat Body    40.8   53.9  Salivary Gland    57.6   NA  Heart    427.925   748.5  Trachea    NA   NA  VirginFemale Spermatheca    33.1   NA  InseminatedFemale Spermatheca    83.3   NA  Ovary    105.5   NA  Testis    133.7   NA  Male Accessory Gland    758.9   811.375  Carcass    156.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    71 central nervous system, pupae P8    5 head, virgin 1-day female    120 head, virgin 4-day female    56 head, virgin 20-day female    12 head, mated 1-day female    113 head, mated 4-day female    34 head, mated 20-day female    10 head, mated 1-day male    150 head, mated 4-day male    50 head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    143 digestive system, 1-day adult    52 digestive system, 4-day adult    31 digestive system, 20-day adult    45 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    168 carcass, 1-day adult    108 carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3  (71) central nervous system, pupae P8    5 head, virgin 1-day female  (120) head, virgin 4-day female  (56) head, virgin 20-day female    12 head, mated 1-day female  (113) head, mated 4-day female  (34) head, mated 20-day female    10 head, mated 1-day male  (150) head, mated 4-day male  (50) head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (143) digestive system, 1-day adult  (52) digestive system, 4-day adult  (31) digestive system, 20-day adult  (45) fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering  (168) carcass, 1-day adult  (108) carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    71 central nervous system, pupae P8    5 head, virgin 1-day female  (120) head, virgin 4-day female    56 head, virgin 20-day female    12 head, mated 1-day female  (113) head, mated 4-day female    34 head, mated 20-day female    10 head, mated 1-day male  (150) head, mated 4-day male    50 head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (143) digestive system, 1-day adult    52 digestive system, 4-day adult    31 digestive system, 20-day adult    45 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering  (168) carcass, 1-day adult  (108) carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    71 central nervous system, pupae P8    5 head, virgin 1-day female    120 head, virgin 4-day female    56 head, virgin 20-day female    12 head, mated 1-day female    113 head, mated 4-day female    34 head, mated 20-day female    10 head, mated 1-day male    150 head, mated 4-day male    50 head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    143 digestive system, 1-day adult    52 digestive system, 4-day adult    31 digestive system, 20-day adult    45 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    168 carcass, 1-day adult    108 carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    71 central nervous system, pupae P8    5 head, virgin 1-day female    120 head, virgin 4-day female    56 head, virgin 20-day female    12 head, mated 1-day female    113 head, mated 4-day female    34 head, mated 20-day female    10 head, mated 1-day male    150 head, mated 4-day male    50 head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    143 digestive system, 1-day adult    52 digestive system, 4-day adult    31 digestive system, 20-day adult    45 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    168 carcass, 1-day adult    108 carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3  (71) central nervous system, pupae P8    5 head, virgin 1-day female  (120) head, virgin 4-day female  (56) head, virgin 20-day female    12 head, mated 1-day female  (113) head, mated 4-day female  (34) head, mated 20-day female    10 head, mated 1-day male  (150) head, mated 4-day male  (50) head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (143) digestive system, 1-day adult  (52) digestive system, 4-day adult  31 digestive system, 20-day adult  (45) fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering  (168) carcass, 1-day adult  (108) carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    71 central nervous system, pupae P8    5 head, virgin 1-day female  120 head, virgin 4-day female    56 head, virgin 20-day female    12 head, mated 1-day female  113 head, mated 4-day female    34 head, mated 20-day female    10 head, mated 1-day male  (150) head, mated 4-day male    50 head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  143 digestive system, 1-day adult    52 digestive system, 4-day adult    31 digestive system, 20-day adult    45 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering  (168) carcass, 1-day adult  108 carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    71 central nervous system, pupae P8    5 head, virgin 1-day female    120 head, virgin 4-day female    56 head, virgin 20-day female    12 head, mated 1-day female    113 head, mated 4-day female    34 head, mated 20-day female    10 head, mated 1-day male    150 head, mated 4-day male    50 head, mated 20-day male    18 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    143 digestive system, 1-day adult    52 digestive system, 4-day adult    31 digestive system, 20-day adult    45 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    168 carcass, 1-day adult    108 carcass, 4-day adult    25 carcass, 20-day adult    19 ovary, virgin 4-day female    9 ovary, mated 4-day female    13 testis, mated 4-day male    13 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr    56 embryo 18-20hr    183 embryo 20-22hr    263 embryo 22-24hr    222 larva L1    65 larva L2    45 larva L3 12hr old    75 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    145 white prepupae new    100 white prepupae 12hr    216 white prepupae 24hr    15 pupae 2d postWPP    33 pupae 3d postWPP    11 pupae 4d postWPP    142 adult male 01day    113 adult male 05day    48 adult male 30day    34 adult female 01day    115 adult female 05day    34 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr  (56) embryo 18-20hr  (183) embryo 20-22hr  (263) embryo 22-24hr  (222) larva L1  (65) larva L2  (45) larva L3 12hr old  (75) larva L3 puffstage 1-2  (88) larva L3 puffstage 3-6  (135) larva L3 puffstage 7-9  (145) white prepupae new  (100) white prepupae 12hr  (216) white prepupae 24hr    15 pupae 2d postWPP  (33) pupae 3d postWPP    11 pupae 4d postWPP  (142) adult male 01day  (113) adult male 05day  (48) adult male 30day  (34) adult female 01day  (115) adult female 05day  (34) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr    56 embryo 18-20hr  (183) embryo 20-22hr  (263) embryo 22-24hr  (222) larva L1    65 larva L2    45 larva L3 12hr old    75 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6  (135) larva L3 puffstage 7-9  (145) white prepupae new    100 white prepupae 12hr  (216) white prepupae 24hr    15 pupae 2d postWPP    33 pupae 3d postWPP    11 pupae 4d postWPP  (142) adult male 01day  (113) adult male 05day    48 adult male 30day    34 adult female 01day  (115) adult female 05day    34 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr    56 embryo 18-20hr    183 embryo 20-22hr    263 embryo 22-24hr    222 larva L1    65 larva L2    45 larva L3 12hr old    75 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    145 white prepupae new    100 white prepupae 12hr    216 white prepupae 24hr    15 pupae 2d postWPP    33 pupae 3d postWPP    11 pupae 4d postWPP    142 adult male 01day    113 adult male 05day    48 adult male 30day    34 adult female 01day    115 adult female 05day    34 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr    56 embryo 18-20hr    183 embryo 20-22hr    263 embryo 22-24hr    222 larva L1    65 larva L2    45 larva L3 12hr old    75 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    145 white prepupae new    100 white prepupae 12hr    216 white prepupae 24hr    15 pupae 2d postWPP    33 pupae 3d postWPP    11 pupae 4d postWPP    142 adult male 01day    113 adult male 05day    48 adult male 30day    34 adult female 01day    115 adult female 05day    34 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr  (56) embryo 18-20hr  (183) embryo 20-22hr  (263) embryo 22-24hr  (222) larva L1  (65) larva L2  (45) larva L3 12hr old  (75) larva L3 puffstage 1-2  (88) larva L3 puffstage 3-6  (135) larva L3 puffstage 7-9  (145) white prepupae new  (100) white prepupae 12hr  (216) white prepupae 24hr    15 pupae 2d postWPP  (33) pupae 3d postWPP    11 pupae 4d postWPP  (142) adult male 01day  (113) adult male 05day  (48) adult male 30day  (34) adult female 01day  (115) adult female 05day  (34) adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr    56 embryo 18-20hr  (183) embryo 20-22hr  (263) embryo 22-24hr  (222) larva L1    65 larva L2    45 larva L3 12hr old    75 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6  135 larva L3 puffstage 7-9  (145) white prepupae new    100 white prepupae 12hr  (216) white prepupae 24hr    15 pupae 2d postWPP    33 pupae 3d postWPP    11 pupae 4d postWPP  142 adult male 01day  113 adult male 05day    48 adult male 30day    34 adult female 01day  115 adult female 05day    34 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    19 embryo 16-18hr    56 embryo 18-20hr    183 embryo 20-22hr    263 embryo 22-24hr    222 larva L1    65 larva L2    45 larva L3 12hr old    75 larva L3 puffstage 1-2    88 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    145 white prepupae new    100 white prepupae 12hr    216 white prepupae 24hr    15 pupae 2d postWPP    33 pupae 3d postWPP    11 pupae 4d postWPP    142 adult male 01day    113 adult male 05day    48 adult male 30day    34 adult female 01day    115 adult female 05day    34 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1    62 embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    17 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    141 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    253 CNS ML-DmBG2-c2    65 tumorous blood cells mbn2    40 ovary fGS/OSS    193 ovary OSC    430 ovary OSS    256 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1  (62) embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3  (30) wing disc ML-DmD21    17 wing disc ML-DmD32  (27) haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5  (141) mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1  (253) CNS ML-DmBG2-c2  (65) tumorous blood cells mbn2  (40) ovary fGS/OSS  (193) ovary OSC  (430) ovary OSS  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1    62 embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    17 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5  (141) mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1  (253) CNS ML-DmBG2-c2    65 tumorous blood cells mbn2    40 ovary fGS/OSS  (193) ovary OSC  (430) ovary OSS  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1    62 embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    17 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    141 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    253 CNS ML-DmBG2-c2    65 tumorous blood cells mbn2    40 ovary fGS/OSS    193 ovary OSC    430 ovary OSS    256 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1    62 embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    17 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    141 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    253 CNS ML-DmBG2-c2    65 tumorous blood cells mbn2    40 ovary fGS/OSS    193 ovary OSC    430 ovary OSS    256 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1  (62) embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3  30 wing disc ML-DmD21    17 wing disc ML-DmD32  27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5  (141) mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1  (253) CNS ML-DmBG2-c2  (65) tumorous blood cells mbn2  (40) ovary fGS/OSS  (193) ovary OSC  (430) ovary OSS  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1    62 embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    17 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5  141 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1  (253) CNS ML-DmBG2-c2    65 tumorous blood cells mbn2    40 ovary fGS/OSS  (193) ovary OSC  (430) ovary OSS  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    3 embryonic Kc167    24 embryonic S1    62 embryonic S3    3 leg disc CME L1    5 wing disc CME-W2    16 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    17 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    141 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    253 CNS ML-DmBG2-c2    65 tumorous blood cells mbn2    40 ovary fGS/OSS    193 ovary OSC    430 ovary OSS    256 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    38 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    50 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    78 Copper 0.5 mM 12 hrs, larvae L3    60 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    89 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (59) cold shock, 4-day adult  (38) heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3  (50) Cadmium 50 mM 12 hrs, larvae L3  (84) Cadmium 50 mM 48 hrs, 4-day adult  (54) Cadmium 100 mM 48 hrs, 4-day adult  (78) Copper 0.5 mM 12 hrs, larvae L3  (60) Copper 15 mM 48 hrs, 4-day adult  (48) Zinc 5 mM 12 hrs, larvae L3  (52) Zinc 4.5 mM 48 hrs, 4-day adult  (73) Ethanol 2.5% 3 hrs, larvae L3  (42) Ethanol 5% 3 hrs, larvae L3  (89) Ethanol 10% 3 hrs, larvae L3  (59) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (78) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (54) Caffeine 25 mg/ml 48 hrs, 4-day adult  (45) Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3  (63) Rotenone 8 μg 12 hrs, larvae L3  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    38 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    50 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    78 Copper 0.5 mM 12 hrs, larvae L3    60 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    89 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    38 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    50 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    78 Copper 0.5 mM 12 hrs, larvae L3    60 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    89 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    38 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    50 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    78 Copper 0.5 mM 12 hrs, larvae L3    60 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    89 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (59) cold shock, 4-day adult  (38) heat shock, 4-day adult  (38) Cadmium 50 mM 6 hrs, larvae L3  (50) Cadmium 50 mM 12 hrs, larvae L3  (84) Cadmium 50 mM 48 hrs, 4-day adult  (54) Cadmium 100 mM 48 hrs, 4-day adult  (78) Copper 0.5 mM 12 hrs, larvae L3  (60) Copper 15 mM 48 hrs, 4-day adult  (48) Zinc 5 mM 12 hrs, larvae L3  (52) Zinc 4.5 mM 48 hrs, 4-day adult  (73) Ethanol 2.5% 3 hrs, larvae L3  (42) Ethanol 5% 3 hrs, larvae L3  (89) Ethanol 10% 3 hrs, larvae L3  (59) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (78) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (54) Caffeine 25 mg/ml 48 hrs, 4-day adult  (45) Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3  (63) Rotenone 8 μg 12 hrs, larvae L3  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    38 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    50 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    78 Copper 0.5 mM 12 hrs, larvae L3    60 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    89 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    38 heat shock, 4-day adult    38 Cadmium 50 mM 6 hrs, larvae L3    50 Cadmium 50 mM 12 hrs, larvae L3    84 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    78 Copper 0.5 mM 12 hrs, larvae L3    60 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    73 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    89 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GM06507 RE01730 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3074-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Swim Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die, with Scer\GAL4Act.PU SwimdsRNA.1.Scer\UAS viable SwimEY09931 viable, with Scer\GAL4pnr-MD237 SwimGD2147 Sterility Allele fertile SwimEY09931 Other Phenotypes Allele visible, with Scer\GAL4Act.PU SwimdsRNA.1.Scer\UAS Phenotype manifest in Allele wing margin, with Scer\GAL4Act.PU SwimdsRNA.1.Scer\UAS
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of Swim Class Mutagen Stocks Known lesion Swimd09402 P-element activity 1 -- Swimd09601 1 -- SwimEP2059 P-element activity 1 -- SwimEY09931 P-element activity 1 -- SwimG8117 P-element activity 1 -- SwimMI05127 1 -- SwimNP7371 1 -- Swim01D01W-L001 0 -- Swim01D01W-L008 0 -- Swim01D01W-L013 0 -- Swim01D01W-L023 0 -- Swim01D01W-L030 0 -- Swim01D01W-L039 0 -- Swim01D01W-L041 0 -- Swim01D01W-L046 0 -- Swim01D01W-L049 0 -- Swim01D01W-L050 0 -- Swim01D01W-L051 0 -- Swim01D01W-L072 0 -- Swim01D01W-L085 0 -- Swim01D01W-L109 0 -- Swim01D01W-L110 0 -- Swim01D01W-L113 0 -- Swim01D01W-L124 0 -- Swim01D01W-L141 0 -- Swim01D01W-L148 0 -- Swim01D01W-L150 0 -- Swim01D01W-L151 0 -- Swim01D01W-L159 0 -- Swim01D01W-L184 0 -- Swim01D01W-L200 0 -- Swim01D01W-L202 0 -- Swim01D01W-L203 0 -- Swimd09769 P-element activity 0 -- SwimDG01401 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Swim Class Mutagen Stocks Known lesion SwimGD2147 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SwimdsRNA.1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes SwimdsRNA.2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes SwimGL00551 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SwimKK108093 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SwimScer\UAS.cMa in vitro construct - regulatory fusion 1 Yes SwimTRiP.GL00551 in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes SwimNIG.3074R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7171 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.3074R} NA P{UAS-Swim.M} NA P{UAS-Swim.RNAi-1} NA P{UAS-Swim.RNAi-2} NA characterization construct P{TRiP.GL00551} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}snoRNA:Or-CD1G8117 NA P{EP}SwimEP2059 NA P{EPgy2}SwimEY09931 NA P{XP}Swimd09402 NA P{XP}Swimd09601 NA P{XP}Swimd09769 NA miscellaneous insertions Mi{MIC}SwimMI05127 NA P{5'wHy}Swim01D01W-L001 NA P{5'wHy}Swim01D01W-L008 NA P{5'wHy}Swim01D01W-L013 NA P{5'wHy}Swim01D01W-L023 NA P{5'wHy}Swim01D01W-L030 NA P{5'wHy}Swim01D01W-L039 NA P{5'wHy}Swim01D01W-L041 NA P{5'wHy}Swim01D01W-L046 NA P{5'wHy}Swim01D01W-L049 NA P{5'wHy}Swim01D01W-L050 NA P{5'wHy}Swim01D01W-L051 NA P{5'wHy}Swim01D01W-L072 NA P{5'wHy}Swim01D01W-L085 NA P{5'wHy}Swim01D01W-L109 NA P{5'wHy}Swim01D01W-L110 NA P{5'wHy}Swim01D01W-L113 NA P{5'wHy}Swim01D01W-L124 NA P{5'wHy}Swim01D01W-L141 NA P{5'wHy}Swim01D01W-L148 NA P{5'wHy}Swim01D01W-L150 NA P{5'wHy}Swim01D01W-L151 NA P{5'wHy}Swim01D01W-L159 NA P{5'wHy}Swim01D01W-L184 NA P{5'wHy}Swim01D01W-L200 NA P{5'wHy}Swim01D01W-L202 NA P{5'wHy}Swim01D01W-L203 NA P{wHy}SwimDG01401 NA insertion of enhancer trap binary system P{GawB}SwimNP7371 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
Wnt-protein binding inferred from direct assay (Mulligan et al., 2012)
Biological Process
CV term Evidence References
positive regulation of Wnt receptor signaling pathway inferred from direct assay (Mulligan et al., 2012) positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region inferred from mutant phenotype (Mulligan et al., 2012)
Cellular Component
CV term Evidence References
chorion inferred from direct assay (Fakhouri et al., 2006) extracellular space inferred from direct assay (Mulligan et al., 2012)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with EMBL:X66012 (FlyBase, 1992-) polysaccharide binding inferred from electronic annotation with InterPro:IPR001212 (FlyBase Curators et al., 2004-) scavenger receptor activity inferred from electronic annotation with InterPro:IPR001212 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
immune response inferred from electronic annotation with InterPro:IPR001212 (FlyBase Curators et al., 2004-) proteolysis inferred from electronic annotation with InterPro:IPR000169, InterPro:IPR000668 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Swim - wg inferred by author, affinity technology, fluorescence microscopy, affinity chromatography technology, molecular sieving, peptide massfingerprinting, enzyme linked immunosorbent assay (Mulligan et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Swim allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63154 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034709 DroID - A comprehensive database of gene and protein interactions. • FBgn0034709 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37537
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NS3XB Dipteran inclusive ortholog search EOG6Z36P6 Insect inclusive ortholog search EOG6BRVG2 Arthropod inclusive ortholog search EOG6M37QX Metazoa inclusive ortholog search EOG6X3VTG
Orthologs in Drosophila Species (EOG6NS3XB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Swim     Drosophila simulans   Dsim\GD25141 Y   Drosophila sechellia   Dsec\GM15657 Y   Drosophila erecta   Dere\GG20712 Y   Drosophila yakuba   Dyak\GE11695 Y   Drosophila ananassae   Dana\GF12327 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15908 Y   Drosophila persimilis   Dper\GL16940 Y   Drosophila willistoni   Dwil\GK20838 Y   Drosophila virilis   Dvir\GJ20006 Y   Drosophila mojavensis   Dmoj\GI19039 Y   Drosophila grimshawi   Dgri\GH20676 Y
Orthologs in non-Drosophila Dipterans (EOG6Z36P6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001232   Anopheles gambiae Malaria mosquito  Agam\AGAP007684   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008716
Orthologs in non-Dipteran Insects (EOG6BRVG2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409789   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009993   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16861   Atta cephalotes Leafcutter ant  Acep\ACEP11311   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14349   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22545   Linepithema humile Argentine ant  Lhum\LH14643   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19344   Solenopsis invicta Red fire ant  Sinv\SINV12302   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001407   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000485   Bombyx mori Silkmoth  Bmor\BGIBMGA004421   Pediculus humanus Human body louse  Phum\PHUM354260   Tribolium castaneum Red flour beetle  Tcas\TC009217
Orthologs in non-Insect Arthropods (EOG6M37QX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303204   Ixodes scapularis Deer tick  Isca\ISCW005779
Orthologs in non-Arthropod Metazoa (EOG6X3VTG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cpr-3   Caenorhabditis elegans Nematode  Cele\F26E4.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007225gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007151gn   Danio rerio Zebrafish  Drer\si:dkey-158b13.1   Xenopus tropicalis Western clawed frog  Xtro\tinagl1   Gallus gallus Domestic chicken  Ggal\TINAGL1   Gallus gallus Domestic chicken  Ggal\TINAG   Mus musculus House mouse  Mmus\Tinag   Mus musculus House mouse  Mmus\Tinagl1   Rattus norvegicus Norway rat  Rnor\Tinagl1   Rattus norvegicus Norway rat  Rnor\Tinag   Homo sapiens Human  Hsap\TINAG   Homo sapiens Human  Hsap\TINAGL1
Human Orthologs (2)
Gene OMIM HGNC Hsap\TINAG     Hsap\TINAGL1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25141 Drosophila sechellia Dsec\GM15657 Drosophila erecta Dere\GG20712 Drosophila yakuba Dyak\GE11695 Drosophila ananassae Dana\GF12327 Drosophila pseudoobscura pseudoobscura Dpse\GA15908 Drosophila persimilis Dper\GL16940 Drosophila willistoni Dwil\GK20838 Drosophila virilis Dvir\GJ20006 Drosophila mojavensis Dmoj\GI19039 Drosophila grimshawi Dgri\GH20676
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	38414 w*; P{UAS-Swim.RNAi-1}3 17018 w1118; P{EP}SwimEP2059 38415 w*; P{UAS-Swim.M}3/TM3, Sb1 40951 w*; L1/CyO; P{UAS-Swim.RNAi-2}3 37894 y1 w*; Mi{MIC}SwimMI05127 17622 y1 w67c23; P{EPgy2}SwimEY09931 36591 y1 sc* v1; P{TRiP.GL00551}attP2
Harvard	- P{XP}Swimd09402 - P{XP}Swimd09601
VDRC	v107301 P{KK108093}VIE-260B v6617 w1118 P{GD2147}v6617 v6618 w1118; P{GD2147}v6618/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR02O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 93 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM06507 RE01730
Other clones	DPiM_RE01730
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01954 AT11187 AT18289 AT18878 GH01294 GH01982 GH06205 GH14047 GH14437 GH18275 GH21883 GH27116 GM27942 HL03112 HL03569 LP02491 LP05148 LP05858 LP10028 LP19194 RE05076 RE07856 RE08864 RE13544 RE13904 RE18142 RE26885 RE27444 RE27846 RE49136 RE56246 RE57143 RE58640 RE61288 RE61549 RE63945 RE66255 RE66360 RE67769 RE67803 RE68507 RE68929 RH04568 RH09853 RH14558 RH16022 RH16096 RH18765 RH19812 RH20083 RH27068 RH28288 RH29250 RH30113 RH37717 RH39258 RH41492 RH45410 RH50435 RH65840 RH68764 RH70245 SD08573 SD09549 SD09749 SD11758 SD22886 SD23458
Other clones	52731 53834 70275 EK168650 EK177944 EK197964 FGA009C03 FGA011E11 FGA011F10 FGC006B03 FGC025B03 FGH128E02 FGM002A12 FGM004A08 FGM101C09 FGM212D11 FGM219E12 FGM232C06 FGM305C12 FGM308G02 GH01891 UT01072
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37537
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Swim CG3074 (Mulligan et al., 2012)
Source for database merge of
Additional comments
Other Comments
	Swim protein binds to wg protein with nanomolecular affinity and maintains wg protein solubility and signaling activity. (Mulligan et al., 2012) Expression is enriched in embryonic gonads. (Shigenobu et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137808 NM_166519 RefSeq (Proteins) • NP_611652 NP_726176 DDBJ / EMBL / GenBank • AA802878 AAF46818 AAL28470 AAM29382 AAM68213 AW941268 AY060922 AY113377 BI162398 BI162399 CL526165 CZ476725 CZ476932 CZ476933 Entrez Gene - A searchable database of RefSeq genes. • 37537 UniProtKB/TrEMBL • Q7JWQ7 Q95S79
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cysteine peptidase, asparagine active site (IPR025661) Cysteine peptidase, histidine active site (IPR025660) Peptidase C1A, papain C-terminal (IPR000668) Somatomedin B domain (IPR001212) Peptidase C1A, papain (IPR013128) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM06507 RE01730
Linkouts
	BioGRID - A database of protein and genetic interactions • 63154 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034709 DroID - A comprehensive database of gene and protein interactions. • FBgn0034709 DRSC - Results from RNAi screens. • FBgn0034709 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3074-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37537 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37537 modMine - Data generated by the modENCODE project. • FBgn0034709
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG3074 (Shigenobu et al., 2006, Huang et al., 2005, Gan et al., 2010, Haerty et al., 2007, Yakoby et al., 2008, Mulligan et al., 2012, Ni et al., 2011.7.19, Fakhouri et al., 2006, Keleman et al., 2009.8.5, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Wong et al., 2012, Nfonsam et al., 2012) dmw (LeMosy and Dinkins, 2008) Swim (Nfonsam et al., 2012) swim (Mulligan et al., 2012)
Name Synonym	dead man walking (LeMosy and Dinkins, 2008) Secreted Wg-interacting molecule (Mulligan et al., 2012)
Secondary FlyBase IDs
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Mulligan et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(2): 370--377 Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. [FBrf0217131] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Wong et al., 2012, Mol. Biol. Evol. 29(1): 229--238 Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. [FBrf0217443] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Show all research papers ...