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Gene Dmel\Oatp58Dc

General Information
Symbol	Dmel\Oatp58Dc	Species	D. melanogaster
Name	Organic anion transporting polypeptide 58Dc	Annotation symbol	CG3380
Feature type	protein_coding_gene	FlyBase ID	FBgn0034716
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	OATP
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58D2-58D2	Sequence location	2R:18,111,186..18,116,073 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Organic anion transporting polypeptide 58Dc is referred to in FlyBase by the symbol Dmel\Oatp58Dc (CG3380, FBgn0034716). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sodium-independent organic anion transmembrane transporter activity; organic anion transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: response to methotrexate. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Major facilitator superfamily domain, general substrate transporter; Organic anion transporter polypeptide OATP; Protease inhibitor, Kazal-type; Proteinase inhibitor I1, Kazal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1627078_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Oatp58Dc. Gene sequence location is 2R:18111186..18116073.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA04363 BKN45699 BKN24468
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58D2-58D2   Limits computationally determined from genome sequence between P{PZ}ari-207768 and P{lacW}l(2)k09801k09801
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Oatp58Dc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Oatp58Dc-RA FBtr0071777  NM_137815   3052   789 Oatp58Dc-RB FBtr0113105  NM_001103939   3008   789 Oatp58Dc-RC FBtr0301476  NM_001169780   3770   789
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Oatp58Dc-PA   FBpp0071690   87.6   789   7.98     NP_611659   AAF46826 Oatp58Dc-PB   FBpp0112018   87.6   789   7.98     NP_001097409   ABV53877 Oatp58Dc-PC   FBpp0290691   87.6   789   7.98     NP_001163251   ACZ94523
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Organic anion transporter polypeptide OATP (IPR004156) Protease inhibitor, Kazal-type (IPR011497) Proteinase inhibitor I1, Kazal (IPR002350) Major facilitator superfamily domain, general substrate transporter (IPR016196)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46826   AE013599 ABV53877   AE013599 ACZ94523   AI062185   AI259268   AI513096   AY047504 AAK77236   BI482925   BI485124   BI485943   BT023942   CO263319   CO265062   EC196850   EC208222   EC233321   GH751328   GH751655   GH753080   GH755405   GH755532   GH758761   GH759580   GH777724   GH780256   GH783290   GH787308   GH789149   GH796252   GH797192   GH801009   GH803800   GH804933   GH806907   GH809282   GH812951   GH815951   GH826092   GH835599   GH841243   GH841437   GH844219   GH848080   GH858957   GH860854   GH862672   GH862696   GH863029   GH863153   GH865655   GH875717   GH876259   GH877158   GH883664   GH884474   GH885473   GH885484   GH890348   GH896237   GH898502   GH898952   GH903316   GH909076   GH909435   GH916167   GH916427   GH917219   GH919017   GH920732   GH924118   GH925524   GH927096   GH929309   GH932877   GH938318
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q961X2 Q9W269
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034716    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034716 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034716 expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr    2068 embryo 06-08hr    6064 embryo 08-10hr    5526 embryo 10-12hr    2787 embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1    1798 larva L2    1433 larva L3 12hr old    1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day    1546 adult male 05day    1483 adult male 30day    1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr  (377) embryo 04-06hr  (2068) embryo 06-08hr  (6064) embryo 08-10hr  (5526) embryo 10-12hr  (2787) embryo 12-14hr  (1323) embryo 14-16hr  (194) embryo 16-18hr  (197) embryo 18-20hr  (379) embryo 20-22hr  (1046) embryo 22-24hr  (1292) larva L1  (1798) larva L2  (1433) larva L3 12hr old  (1583) larva L3 puffstage 1-2  (582) larva L3 puffstage 3-6  (255) larva L3 puffstage 7-9  (687) white prepupae new  (1225) white prepupae 12hr  (654) white prepupae 24hr  (337) pupae 2d postWPP  (361) pupae 3d postWPP  (444) pupae 4d postWPP  (1000) adult male 01day  (1546) adult male 05day  (1483) adult male 30day  (1998) adult female 01day  (859) adult female 05day  (472) adult female 30day  (812) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr  (2068) embryo 06-08hr  (6064) embryo 08-10hr  (5526) embryo 10-12hr  (2787) embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1  (1798) larva L2  1433 larva L3 12hr old  (1583) larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day  (1546) adult male 05day  1483 adult male 30day  (1998) adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr    2068 embryo 06-08hr    6064 embryo 08-10hr    5526 embryo 10-12hr    2787 embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1    1798 larva L2    1433 larva L3 12hr old    1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day    1546 adult male 05day    1483 adult male 30day    1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr    2068 embryo 06-08hr    6064 embryo 08-10hr    5526 embryo 10-12hr    2787 embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1    1798 larva L2    1433 larva L3 12hr old    1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day    1546 adult male 05day    1483 adult male 30day    1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034716 expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr    2068 embryo 06-08hr    6064 embryo 08-10hr    5526 embryo 10-12hr    2787 embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1    1798 larva L2    1433 larva L3 12hr old    1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day    1546 adult male 05day    1483 adult male 30day    1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr  (377) embryo 04-06hr  (2068) embryo 06-08hr  (6064) embryo 08-10hr  (5526) embryo 10-12hr  (2787) embryo 12-14hr  (1323) embryo 14-16hr  (194) embryo 16-18hr  (197) embryo 18-20hr  (379) embryo 20-22hr  (1046) embryo 22-24hr  (1292) larva L1  (1798) larva L2  (1433) larva L3 12hr old  (1583) larva L3 puffstage 1-2  (582) larva L3 puffstage 3-6  (255) larva L3 puffstage 7-9  (687) white prepupae new  (1225) white prepupae 12hr  (654) white prepupae 24hr  (337) pupae 2d postWPP  (361) pupae 3d postWPP  (444) pupae 4d postWPP  (1000) adult male 01day  (1546) adult male 05day  (1483) adult male 30day  (1998) adult female 01day  (859) adult female 05day  (472) adult female 30day  (812) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr  2068 embryo 06-08hr  (6064) embryo 08-10hr  (5526) embryo 10-12hr  (2787) embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1  1798 larva L2  1433 larva L3 12hr old  1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day  1546 adult male 05day  1483 adult male 30day  1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr    2068 embryo 06-08hr    6064 embryo 08-10hr    5526 embryo 10-12hr    2787 embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1    1798 larva L2    1433 larva L3 12hr old    1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day    1546 adult male 05day    1483 adult male 30day    1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    377 embryo 04-06hr    2068 embryo 06-08hr    6064 embryo 08-10hr    5526 embryo 10-12hr    2787 embryo 12-14hr    1323 embryo 14-16hr    194 embryo 16-18hr    197 embryo 18-20hr    379 embryo 20-22hr    1046 embryo 22-24hr    1292 larva L1    1798 larva L2    1433 larva L3 12hr old    1583 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    255 larva L3 puffstage 7-9    687 white prepupae new    1225 white prepupae 12hr    654 white prepupae 24hr    337 pupae 2d postWPP    361 pupae 3d postWPP    444 pupae 4d postWPP    1000 adult male 01day    1546 adult male 05day    1483 adult male 30day    1998 adult female 01day    859 adult female 05day    472 adult female 30day    812 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034716    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034716 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034716 expression level Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules    2089.8 Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules    6251 Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules  (2089.8) Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion  (609.8) Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules  (6251) Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules  (2089.8) Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules  (6251) Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules    2089.8 Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules    6251 Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034716 expression level Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules    2089.8 Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules    6251 Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules  (2089.8) Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion  609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules  (6251) Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules  (2089.8) Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules  (6251) Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    133.425 Larval Midgut    9 Larval Hindgut    15.8 Larval Malpighian Tubules    2089.8 Larval Fat Body    6.9 Larval Salivary Gland    9.2 Larval Trachea    8.875 Larval Carcass    7.125 Adult Head    199.2 Adult Eye    239.35 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    609.8 Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    97.9 Adult Malpighian Tubules    6251 Adult Fat Body    7.3 Adult Salivary Gland    9.1 Adult Heart    9.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    4.8 Adult Male Accessory Gland no informative data Adult Carcass    30.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    199.2   NA  Eye    239.35   NA  Brain    449.3   133.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    609.8   NA  Crop    4.4   9  Midgut    no informative data   15.8  Hindgut    97.9   2089.8  Malpighian Tubules    6251   6.9  Fat Body    7.3   9.2  Salivary Gland    9.1   NA  Heart    9.075   8.875  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2.3   NA  Testis    4.8   NA  Male Accessory Gland    no informative data   7.125  Carcass    30.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034716 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3380-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Oatp58Dc Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Oatp58DcGD2151 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Oatp58Dc Class Mutagen Stocks Known lesion Oatp58DcMB03731 1 -- Oatp58DcMI00159 1 -- Oatp58Dc01D01W-L034 0 -- Oatp58Dc01D01W-L121 0 -- Oatp58DcMB00526 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Oatp58Dc Class Mutagen Stocks Known lesion Oatp58DcGD2151 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7171 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2151} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Oatp58DcMI00159 NA P{5'wHy}Oatp58Dc01D01W-L034 NA P{5'wHy}Oatp58Dc01D01W-L121 NA insertion of enhancer trap binary system Mi{ET1}Oatp58DcMB00526 No Mi{ET1}Oatp58DcMB03731 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to methotrexate inferred from expression pattern (Chahine and O'Donnell, 2010, Chahine and O'Donnell, 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
organic anion transmembrane transporter activity inferred from sequence or structural similarity (Torrie, 2004.1.22) sodium-independent organic anion transmembrane transporter activity inferred from sequence or structural similarity with UniProtKB:P46720 (FlyBase, 1992-)
Biological Process
CV term Evidence References
organic anion transport inferred from sequence or structural similarity (Torrie, 2004.1.22) inferred from sequence or structural similarity with UniProtKB:Q96BD0 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with UniProtKB:Q96BD0 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Oatp58Dc allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034716
Orthologs
Genome-wide drosophilid orthologs	Dmoj\GI19615 Dpse\GA17415 Dsec\GM15648 Dwil\GK20832
Curated drosophilid orthologs	Dpse\GA17415
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010921-PA Aedes aegypti (mosquito) AGAP006638-PA Anopheles gambiae (mosquito) XP_393148.3 Apis mellifera (honey bee) CPIJ005186 Culex pipens (mosquito) ISCW006481-PA Ixodes scapularis (deer tick) XP_001606202.1 Nasonia vitripennis (wasp) PHUM001226-PA Pediculus humanus (human body louse) XP_967848.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13497 LH12929 ISCW011146 ISCW006481 FBgn0229481 FBgn0222828 FBgn0202181 FBgn0170566 FBgn0077428 FBgn0154537 FBgn0142352 FBgn0127896 FBgn0112892 FBgn0089357 CPIJ005186 ACYPI008520 GB14105 AGAP006638 AAEL010921 AAEL001613 PB21143 PHUM502970 GLEAN_01718
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	24188 w1118; Mi{ET1}Oatp58DcMB03731 30642 y1 w*; Mi{MIC}Oatp58DcMI00159
VDRC	v39469 w1118; P{GD2151}v39469 v39470 w1118; P{GD2151}v39470
Genomic Clones ( 2 )
	BACR02I11 BACR02O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01304 LP09443
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP02646 RE65734 RE68407 RE69307
Other clones	31747 CK01.105C.D7 EK088216 EK141424 RP003031809 RP003040243 RP003076327 RP003076622 RP003104742 RP003119157 RP003120435 RP003124104 RP003133478 RP003142574 RP003143530 RP003155439 RP003165757 RP003166272 RP003166600 RP003170760 RP003171251 RP003202693 RP003221108 RP003222291 RP003244813 RP003246227 RP003257833 RP003266622 RP003273359 RP003278917 RP003284286 RP003298773 RP003303903 RP003311111 RP003333702 RP003335884 RP003346120 RP003349765 RP003352736 RP003364751 RP003369018 RP003401942 RP003410820 RP003437102 RP003444403 RP003468318 RP003469505 RP003469769 RP003474299 RP003488586 RP003491494 RP003491612 RP003491944 RP003548598 RP003552981 RP003578859 RP003579674 RP003582504 RP003584168 RP003584268 RP003638651 RP003641518 RP003657592
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37545
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Oatp58Dc CG3380 (Torrie, 2004.1.22)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137815 NM_001103939 NM_001169780 RefSeq (Proteins) • NP_611659 NP_001097409 NP_001163251 DDBJ / EMBL / GenBank • AAF46826 AAK77236 ABV53877 ACZ94523 AI062185 AI513096 AY047504 Entrez Gene - A searchable database of RefSeq genes. • 37545 UniProtKB/TrEMBL • Q9W269 Q961X2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Organic anion transporter polypeptide OATP (IPR004156) Protease inhibitor, Kazal-type (IPR011497) Proteinase inhibitor I1, Kazal (IPR002350) Major facilitator superfamily domain, general substrate transporter (IPR016196)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034716 DRSC - Results from RNAi screens. • FBgn0034716 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034716 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3380-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034716 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37545 InParanoid A subset of ortholog calls from InParanoid. • AAEL010921-PA Aedes aegypti (mosquito) AGAP006638-PA Anopheles gambiae (mosquito) XP_393148.3 Apis mellifera (honey bee) CPIJ005186 Culex pipens (mosquito) ISCW006481-PA Ixodes scapularis (deer tick) XP_001606202.1 Nasonia vitripennis (wasp) PHUM001226-PA Pediculus humanus (human body louse) XP_967848.2 Tribolium castaneum (red flour beetle) modMine - Data generated by the modENCODE project. • FBgn0034716 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13497 LH12929 ISCW011146 ISCW006481 FBgn0229481 FBgn0222828 FBgn0202181 FBgn0170566 FBgn0077428 FBgn0154537 FBgn0142352 FBgn0127896 FBgn0112892 FBgn0089357 CPIJ005186 ACYPI008520 GB14105 AGAP006638 AAEL010921 AAEL001613 PB21143 PHUM502970 GLEAN_01718
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG3380 (Wang et al., 2004, Chung et al., 2009, Chahine and O'Donnell, 2010, Chahine and O'Donnell, 2009) OATP (Chahine and O'Donnell, 2010, Chahine and O'Donnell, 2009) oatp 58Dc (Torrie, 2004.1.22) Oatp58Dc
Name Synonym	organic anion transporting polypeptide (Chahine and O'Donnell, 2010, Chahine and O'Donnell, 2009) Organic anion transporting polypeptide 58Dc (Torrie, 2004.1.22)
Secondary FlyBase IDs
References ( 19 )
Research paper	Chahine and O'Donnell, 2010, Arch. Insect Biochem. Physiol. 73(3): 128--147 Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules of Drosophila melanogaster larvae. [FBrf0214072] Chahine and O'Donnell, 2009, J. Insect Physiol. 55(10): 927--935 Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster. [FBrf0208694] Chung et al., 2009, Curr. Biol. 19(5): 386--390 The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. [FBrf0207520] Torrie et al., 2004, Proc. Natl. Acad. Sci. USA 101(37): 13689--13693 Resolution of the insect ouabain paradox. [FBrf0180636] Wang et al., 2004, GenomeBiol. 5(9): R69 Function-informed transcriptome analysis of Drosophila renal tubule. [FBrf0180324]
Supplementary material	Khanna et al., 2010, BMC Genomics 11(1): Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210978] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2010.3.31, BDGP_2010_0401.GDP.xml BDGP_2010_0401.GDP.xml [FBrf0210427] BDGP TI submission, 2007.8.20, GDPset753.xml GDPset753.xml [FBrf0200262] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bellen, 2006.10.10, MB687.correct.xml MB687.correct.xml [FBrf0191803] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Torrie, 2004.1.22, BDGP genome annotation. BDGP genome annotation. [FBrf0173284]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]