• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Rtf1

General Information
Symbol	Dmel\Rtf1	Species	D. melanogaster
Name	Rtf1	Annotation symbol	CG10955
Feature type	protein_coding_gene	FlyBase ID	FBgn0034722
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58D4-58D4	Sequence location	2R:18,262,597..18,265,352 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rtf1 is referred to in FlyBase by the symbol Dmel\Rtf1 (CG10955, FBgn0034722). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: positive regulation of Notch signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of histone H3-K4 methylation. 6 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Plus-3; Plus-3 domain, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633884_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rtf1. Gene sequence location is 2R:18262597..18265352.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN21260 HFA04085
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58D4-58D4   Limits computationally determined from genome sequence between P{PZ}ari-207768 and P{lacW}l(2)k09801k09801
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rtf1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rtf1-RA FBtr0071820  NM_137821   2522   775
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rtf1-PA   FBpp0071731   87.6   775   9.00     NP_611665   AAF46837
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Plus-3 (IPR004343) Plus-3 domain, subgroup (IPR018144)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440126   AA979679   AE013599 AAF46837   AI135236   AI520657   AY075333   BF488627   BF490734   BG635426   BI230617   BI231317   BI365180   BI369157   BI374934   BI481709   BI641669   BT031278   CO185779   CO186722   CO269469   CO271999   CO275693   CO296483   CO304884   CO310426   CO328644   CO343121   EC058811   EC068628   EC090463   EC194889   EC206066   EC209550   EC209562   EC214561   EC217148   EC240671   EC243119   EC247992   EC253682   GH740282   GH742995   GH743750   GH766638   GH769637   GO254365
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W261
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034722    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034722 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034722 expression level Developmental Stage   Expression Level embryo 00-02hr    5330 embryo 02-04hr    5601 embryo 04-06hr    5023 embryo 06-08hr    5089 embryo 08-10hr    4373 embryo 10-12hr    2998 embryo 12-14hr    2816 embryo 14-16hr    1690 embryo 16-18hr    1635 embryo 18-20hr    1371 embryo 20-22hr    1695 embryo 22-24hr    1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1530 larva L3 puffstage 7-9    1771 white prepupae new    1933 white prepupae 12hr    1901 white prepupae 24hr    2234 pupae 2d postWPP    1865 pupae 3d postWPP    1457 pupae 4d postWPP    1039 adult male 01day    1899 adult male 05day    2308 adult male 30day    1715 adult female 01day    1462 adult female 05day    3544 adult female 30day    3352 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5330) embryo 02-04hr  (5601) embryo 04-06hr  (5023) embryo 06-08hr  (5089) embryo 08-10hr  (4373) embryo 10-12hr  (2998) embryo 12-14hr  (2816) embryo 14-16hr  (1690) embryo 16-18hr  (1635) embryo 18-20hr  (1371) embryo 20-22hr  (1695) embryo 22-24hr  (1671) larva L1  (1001) larva L2  (974) larva L3 12hr old  (781) larva L3 puffstage 1-2  (907) larva L3 puffstage 3-6  (1530) larva L3 puffstage 7-9  (1771) white prepupae new  (1933) white prepupae 12hr  (1901) white prepupae 24hr  (2234) pupae 2d postWPP  (1865) pupae 3d postWPP  (1457) pupae 4d postWPP  (1039) adult male 01day  (1899) adult male 05day  (2308) adult male 30day  (1715) adult female 01day  (1462) adult female 05day  (3544) adult female 30day  (3352) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5330) embryo 02-04hr  (5601) embryo 04-06hr  (5023) embryo 06-08hr  (5089) embryo 08-10hr  (4373) embryo 10-12hr  (2998) embryo 12-14hr  (2816) embryo 14-16hr  (1690) embryo 16-18hr  (1635) embryo 18-20hr    1371 embryo 20-22hr  (1695) embryo 22-24hr  (1671) larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6  (1530) larva L3 puffstage 7-9  (1771) white prepupae new  (1933) white prepupae 12hr  (1901) white prepupae 24hr  (2234) pupae 2d postWPP  (1865) pupae 3d postWPP  1457 pupae 4d postWPP    1039 adult male 01day  (1899) adult male 05day  (2308) adult male 30day  (1715) adult female 01day  1462 adult female 05day  (3544) adult female 30day  (3352) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5330 embryo 02-04hr    5601 embryo 04-06hr    5023 embryo 06-08hr    5089 embryo 08-10hr    4373 embryo 10-12hr    2998 embryo 12-14hr    2816 embryo 14-16hr    1690 embryo 16-18hr    1635 embryo 18-20hr    1371 embryo 20-22hr    1695 embryo 22-24hr    1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1530 larva L3 puffstage 7-9    1771 white prepupae new    1933 white prepupae 12hr    1901 white prepupae 24hr    2234 pupae 2d postWPP    1865 pupae 3d postWPP    1457 pupae 4d postWPP    1039 adult male 01day    1899 adult male 05day    2308 adult male 30day    1715 adult female 01day    1462 adult female 05day    3544 adult female 30day    3352 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5330 embryo 02-04hr    5601 embryo 04-06hr    5023 embryo 06-08hr    5089 embryo 08-10hr    4373 embryo 10-12hr    2998 embryo 12-14hr    2816 embryo 14-16hr    1690 embryo 16-18hr    1635 embryo 18-20hr    1371 embryo 20-22hr    1695 embryo 22-24hr    1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1530 larva L3 puffstage 7-9    1771 white prepupae new    1933 white prepupae 12hr    1901 white prepupae 24hr    2234 pupae 2d postWPP    1865 pupae 3d postWPP    1457 pupae 4d postWPP    1039 adult male 01day    1899 adult male 05day    2308 adult male 30day    1715 adult female 01day    1462 adult female 05day    3544 adult female 30day    3352 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034722 expression level Developmental Stage   Expression Level embryo 00-02hr    5330 embryo 02-04hr    5601 embryo 04-06hr    5023 embryo 06-08hr    5089 embryo 08-10hr    4373 embryo 10-12hr    2998 embryo 12-14hr    2816 embryo 14-16hr    1690 embryo 16-18hr    1635 embryo 18-20hr    1371 embryo 20-22hr    1695 embryo 22-24hr    1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1530 larva L3 puffstage 7-9    1771 white prepupae new    1933 white prepupae 12hr    1901 white prepupae 24hr    2234 pupae 2d postWPP    1865 pupae 3d postWPP    1457 pupae 4d postWPP    1039 adult male 01day    1899 adult male 05day    2308 adult male 30day    1715 adult female 01day    1462 adult female 05day    3544 adult female 30day    3352 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5330) embryo 02-04hr  (5601) embryo 04-06hr  (5023) embryo 06-08hr  (5089) embryo 08-10hr  (4373) embryo 10-12hr  (2998) embryo 12-14hr  (2816) embryo 14-16hr  (1690) embryo 16-18hr  (1635) embryo 18-20hr  (1371) embryo 20-22hr  (1695) embryo 22-24hr  (1671) larva L1  (1001) larva L2  (974) larva L3 12hr old  (781) larva L3 puffstage 1-2  (907) larva L3 puffstage 3-6  (1530) larva L3 puffstage 7-9  (1771) white prepupae new  (1933) white prepupae 12hr  (1901) white prepupae 24hr  (2234) pupae 2d postWPP  (1865) pupae 3d postWPP  (1457) pupae 4d postWPP  (1039) adult male 01day  (1899) adult male 05day  (2308) adult male 30day  (1715) adult female 01day  (1462) adult female 05day  (3544) adult female 30day  (3352) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5330) embryo 02-04hr  (5601) embryo 04-06hr  (5023) embryo 06-08hr  (5089) embryo 08-10hr  (4373) embryo 10-12hr  (2998) embryo 12-14hr  (2816) embryo 14-16hr  1690 embryo 16-18hr  1635 embryo 18-20hr    1371 embryo 20-22hr  1695 embryo 22-24hr  1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6  1530 larva L3 puffstage 7-9  1771 white prepupae new  1933 white prepupae 12hr  1901 white prepupae 24hr  2234 pupae 2d postWPP  1865 pupae 3d postWPP  1457 pupae 4d postWPP    1039 adult male 01day  1899 adult male 05day  2308 adult male 30day  1715 adult female 01day  1462 adult female 05day  (3544) adult female 30day  (3352) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5330 embryo 02-04hr    5601 embryo 04-06hr    5023 embryo 06-08hr    5089 embryo 08-10hr    4373 embryo 10-12hr    2998 embryo 12-14hr    2816 embryo 14-16hr    1690 embryo 16-18hr    1635 embryo 18-20hr    1371 embryo 20-22hr    1695 embryo 22-24hr    1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1530 larva L3 puffstage 7-9    1771 white prepupae new    1933 white prepupae 12hr    1901 white prepupae 24hr    2234 pupae 2d postWPP    1865 pupae 3d postWPP    1457 pupae 4d postWPP    1039 adult male 01day    1899 adult male 05day    2308 adult male 30day    1715 adult female 01day    1462 adult female 05day    3544 adult female 30day    3352 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5330 embryo 02-04hr    5601 embryo 04-06hr    5023 embryo 06-08hr    5089 embryo 08-10hr    4373 embryo 10-12hr    2998 embryo 12-14hr    2816 embryo 14-16hr    1690 embryo 16-18hr    1635 embryo 18-20hr    1371 embryo 20-22hr    1695 embryo 22-24hr    1671 larva L1    1001 larva L2    974 larva L3 12hr old    781 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1530 larva L3 puffstage 7-9    1771 white prepupae new    1933 white prepupae 12hr    1901 white prepupae 24hr    2234 pupae 2d postWPP    1865 pupae 3d postWPP    1457 pupae 4d postWPP    1039 adult male 01day    1899 adult male 05day    2308 adult male 30day    1715 adult female 01day    1462 adult female 05day    3544 adult female 30day    3352 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034722    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034722 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034722 expression level Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis    597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis  (597.8) Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis    597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis    597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034722 expression level Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis    597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis  597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis    597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    225.075 Larval Midgut    88.1 Larval Hindgut    107.7 Larval Malpighian Tubules    179.4 Larval Fat Body    174.8 Larval Salivary Gland    111.8 Larval Trachea    128.6 Larval Carcass    126.9 Adult Head    143.2 Adult Eye    114.1 Adult Brain    193.6 Adult Thoracic-Abdominal Ganglion    173.7 Adult Crop    99.7 Adult Midgut    136.1 Adult Hindgut    113.4 Adult Malpighian Tubules    72 Adult Fat Body    63.6 Adult Salivary Gland    93.2 Adult Heart    53.275 Adult VirginFemale Spermatheca    40.5 Adult InseminatedFemale Spermatheca    46.7 Adult Ovary    458.9 Adult Testis    597.8 Adult Male Accessory Gland    83 Adult Carcass    103.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    143.2   NA  Eye    114.1   NA  Brain    193.6   225.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    173.7   NA  Crop    99.7   88.1  Midgut    136.1   107.7  Hindgut    113.4   179.4  Malpighian Tubules    72   174.8  Fat Body    63.6   111.8  Salivary Gland    93.2   NA  Heart    53.275   128.6  Trachea    NA   NA  VirginFemale Spermatheca    40.5   NA  InseminatedFemale Spermatheca    46.7   NA  Ovary    458.9   NA  Testis    597.8   NA  Male Accessory Gland    83   126.9  Carcass    103.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034722 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10955-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4Act5C.PU Rtf1dsRNA.Sym.Scer\UAS semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Rtf1GD7143 viable | temperature conditional, with Scer\GAL4hs.PB Rtf1dsRNA.Sym.Scer\UAS Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Rtf1GD7143 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Rtf1GD7143
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Rtf1 Class Mutagen Stocks Known lesion Rtf1G11617 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rtf1 Class Mutagen Stocks Known lesion Rtf1GD7143 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rtf1HM04026 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rtf1HMS00168 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rtf1dsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Rtf1KK101209 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7143} NA P{KK101209} NA P{Sym-UAS-Rft1} NA P{TRiP.HM04026} NA P{TRiP.HMS00168} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0566SH0566 No insertion of mobile activating element P{EP}Rtf1G11617 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of histone H3-K4 methylation inferred from mutant phenotype (Tenney et al., 2006) positive regulation of Notch signaling pathway inferred from genetic interaction with N (Tenney et al., 2006) positive regulation of transcription, DNA-dependent inferred from mutant phenotype (Adelman et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Adelman et al., 2006) transcriptionally active chromatin inferred from direct assay (Adelman et al., 2006)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR004343, InterPro:IPR018144 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
transcription initiation, DNA-dependent inferred from electronic annotation with InterPro:IPR004343, InterPro:IPR018144 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rtf1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63170 DroID - A comprehensive database of gene and protein interactions. • FBgn0034722 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37554
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11885 Dere\GG22183 Dgri\GH21360 Dmoj\GI20555 Dper\GL17538 Dpse\GA10665 Dsec\GM15903 Dsim\GD11662 Dvir\GJ22408 Dwil\GK20812 Dyak\GE14177
Curated drosophilid orthologs	Dpse\GA10665
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003976-PA Aedes aegypti (mosquito) AGAP012057-PA Anopheles gambiae (mosquito) XP_001121513.1 Apis mellifera (honey bee) XP_001943293.1 Acyrthosiphon pisum (pea aphid) At1g61040.1 Arabidopsis thaliana (wall cress) 124040 Branchiostoma floridae (lancelet) XP_001898381.1 Brugia malayi (roundworm nematode) BGIBMGA000069-PA Bombyx mori (silk worm) ENSBTAP00000002191 Bos taurus (bovine) CAL0002058 Candida albicans (a form of yeast) CN24631 Caenorhabditis brenneri (small nematode) CN26522 Caenorhabditis brenneri (small nematode) CBP11136 Caenorhabditis briggsae (nematode) CE09619 Caenorhabditis elegans (worm) ENSCAFP00000014037 Canis familiaris (dog) ENSCINP00000021817 Ciona intestinalis (sea squirt) JA06179 Caenorhabditis japonica (nematode) CPIJ006192 Culex pipens (mosquito) ENSCPOP00000008401 Cavia porcellus (guinea pig) 147410 Chlamidomonas reinhardtii (green alga) RP10183 Caenorhabditis remanei (nematode) RP26888 Caenorhabditis remanei (nematode) ENSCSAVP00000012309 Ciona savignyi (sedentary tunicate) 18025 Capitella spl (polychaete worm) DDB0218834 Dictyostelium discoideum (amoeba) DEHA2F22682g Debaryomyces Hansenii (yeast) 303485 Daphnia pulex (daphnia) ENSDARP00000006961 Danio rerio (zebra fish) ENSECAP00000018601 Equus caballus (horse) ENSGACP00000016140 Gymnopilus aculeatus (mushroom) ENSGALP00000013980 Gallus gallus (chicken) 194108 Hypsipyla robusta (cedar shoot borer) ENSP00000374280 Homo sapiens (human) ISCW018465-PA Ixodes scapularis (deer tick) KLLA0A00737g Kluyveromyces lactis (yeast) 53767 Lottia gigantea (owl limpet) 34337 Monocosta brevicollis (choanoflagellate) ENSMODP00000000154 Monodelphis domestica (gray opossum) ENSMMUP00000020308 Macaca mulatta (rhesus monkey) ENSMUSP00000028767 Mus musculus (house mouse) 96339 Nematostella vectensis (starlet anemone) XP_001601558.1 Nasonia vitripennis (wasp) ENSORLP00000012122 Oryzias latipes (japanese killifish) LOC_Os12g35030.1 Oryza sativa (asian rice) PHUM004967-PA Pediculus humanus (human body louse) PP12075 Pristionchus pacificus (nematode) 162718 Physcomitrella patens (moss) ENSPPYP00000007219 Pongo pygmaeus (orangutan) 76673 Phytophthora ramorum (sudden oak death pathogen) 140598 Phytophthora sojae (root rot pathogen) 771126 Populus trichocarpa (black cottonwood) ENSPTRP00000011849 Pan troglodytes (chimpanzee) 4766029 Sorghum bicolor (sorghum) Smp_161170 Schistosoma mansoni (trematode parasite) XP_786848.1 Strongylocentrotus purpuratus (purple sea urchin) 61226 Trichoplax adhaerens (metazoa) XP_968097.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022559 Tetraodon nigroviridis (green spotted pufferfish) 23469 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031453 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038858 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11051 LH24306 ISCW018465 FBgn0231799 FBgn0222808 FBgn0209520 FBgn0183402 FBgn0170819 JGI_V11_303485 FBgn0070721 FBgn0155141 FBgn0143291 FBgn0128822 FBgn0114357 FBgn0088925 CPIJ015837 CPIJ006192 BGIBMGA000069 ACYPI003316 GB10828 AGAP012057 AAEL003976 PB25974 PHUM164700 GLEAN_01573
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	31718 y1 v1; P{TRiP.HM04026}attP2 28083 y1 w*; P{EP}Rtf1G11617 34850 y1 sc* v1; P{TRiP.HMS00168}attP2/TM3, Sb1
VDRC	v27341 w1118; P{GD7143}v27341
Genomic Clones ( 2 )
	BACR02I11 BACR48M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 43 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12904 LP07508
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT24109 AT27294 LD14720 LD34393 RE14333 RE20768 RE50419 RE55261 RE62628 RE64308 SD25190
Other clones	14995 15253 99203 124059 211048.2 214409.75 CK01.9C.E2 CK01.15B.D7 CK01.20A.E8 CK01.25A.A10 CK01.93D.H6 CK01.117C.G6 CK01.124D.C9 EK012049 EK022433 EK094711 EK105428 EK118322 EK213807 EK221622 EK246646 EK291050 EP16138 RP01158 RP001019256 RP001033069 RP001042258 RP001049552 RP001050573 SD12835
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034722 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37554
Antibody Information
	polyclonal (Adelman et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Rtf1 CG10955 (Tenney et al., 2006)
Source for database merge of
Additional comments
Other Comments
	Rtf1 is required for proper regulation of heat shock gene expression. (Tenney et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137821 RefSeq (Proteins) • NP_611665 DDBJ / EMBL / GenBank • AAF46837 AI135236 AI520657 AY075333 Entrez Gene - A searchable database of RefSeq genes. • 37554 UniProtKB/TrEMBL • Q9W261
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Plus-3 (IPR004343) Plus-3 domain, subgroup (IPR018144)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63170 DroID - A comprehensive database of gene and protein interactions. • FBgn0034722 DRSC - Results from RNAi screens. • FBgn0034722 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034722 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10955-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034722 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37554 InParanoid A subset of ortholog calls from InParanoid. • AAEL003976-PA Aedes aegypti (mosquito) AGAP012057-PA Anopheles gambiae (mosquito) XP_001121513.1 Apis mellifera (honey bee) XP_001943293.1 Acyrthosiphon pisum (pea aphid) At1g61040.1 Arabidopsis thaliana (wall cress) 124040 Branchiostoma floridae (lancelet) XP_001898381.1 Brugia malayi (roundworm nematode) BGIBMGA000069-PA Bombyx mori (silk worm) ENSBTAP00000002191 Bos taurus (bovine) CAL0002058 Candida albicans (a form of yeast) CN24631 Caenorhabditis brenneri (small nematode) CN26522 Caenorhabditis brenneri (small nematode) CBP11136 Caenorhabditis briggsae (nematode) CE09619 Caenorhabditis elegans (worm) ENSCAFP00000014037 Canis familiaris (dog) ENSCINP00000021817 Ciona intestinalis (sea squirt) JA06179 Caenorhabditis japonica (nematode) CPIJ006192 Culex pipens (mosquito) ENSCPOP00000008401 Cavia porcellus (guinea pig) 147410 Chlamidomonas reinhardtii (green alga) RP10183 Caenorhabditis remanei (nematode) RP26888 Caenorhabditis remanei (nematode) ENSCSAVP00000012309 Ciona savignyi (sedentary tunicate) 18025 Capitella spl (polychaete worm) DDB0218834 Dictyostelium discoideum (amoeba) DEHA2F22682g Debaryomyces Hansenii (yeast) 303485 Daphnia pulex (daphnia) ENSDARP00000006961 Danio rerio (zebra fish) ENSECAP00000018601 Equus caballus (horse) ENSGACP00000016140 Gymnopilus aculeatus (mushroom) ENSGALP00000013980 Gallus gallus (chicken) 194108 Hypsipyla robusta (cedar shoot borer) ENSP00000374280 Homo sapiens (human) ISCW018465-PA Ixodes scapularis (deer tick) KLLA0A00737g Kluyveromyces lactis (yeast) 53767 Lottia gigantea (owl limpet) 34337 Monocosta brevicollis (choanoflagellate) ENSMODP00000000154 Monodelphis domestica (gray opossum) ENSMMUP00000020308 Macaca mulatta (rhesus monkey) ENSMUSP00000028767 Mus musculus (house mouse) 96339 Nematostella vectensis (starlet anemone) XP_001601558.1 Nasonia vitripennis (wasp) ENSORLP00000012122 Oryzias latipes (japanese killifish) LOC_Os12g35030.1 Oryza sativa (asian rice) PHUM004967-PA Pediculus humanus (human body louse) PP12075 Pristionchus pacificus (nematode) 162718 Physcomitrella patens (moss) ENSPPYP00000007219 Pongo pygmaeus (orangutan) 76673 Phytophthora ramorum (sudden oak death pathogen) 140598 Phytophthora sojae (root rot pathogen) 771126 Populus trichocarpa (black cottonwood) ENSPTRP00000011849 Pan troglodytes (chimpanzee) 4766029 Sorghum bicolor (sorghum) Smp_161170 Schistosoma mansoni (trematode parasite) XP_786848.1 Strongylocentrotus purpuratus (purple sea urchin) 61226 Trichoplax adhaerens (metazoa) XP_968097.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022559 Tetraodon nigroviridis (green spotted pufferfish) 23469 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031453 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038858 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/rtf1-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37554 modMine - Data generated by the modENCODE project. • FBgn0034722 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11051 LH24306 ISCW018465 FBgn0231799 FBgn0222808 FBgn0209520 FBgn0183402 FBgn0170819 JGI_V11_303485 FBgn0070721 FBgn0155141 FBgn0143291 FBgn0128822 FBgn0114357 FBgn0088925 CPIJ015837 CPIJ006192 BGIBMGA000069 ACYPI003316 GB10828 AGAP012057 AAEL003976 PB25974 PHUM164700 GLEAN_01573
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG10955 (Tenney et al., 2006, Estes et al., 2008, Baeg et al., 2007, Zhou et al., 2008, Ni et al., 2008, Adelman et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dRtf1 (Tenney et al., 2006) Rtf1 (Tenney et al., 2006, Adelman et al., 2006)
Name Synonym	CG10955   Rtf1
Secondary FlyBase IDs
References ( 16 )
Research paper	Estes et al., 2008, Genetics 178(2): 787--799 Identification of motifs that are conserved in 12 Drosophila species and regulate midline glia vs. neuron expression. [FBrf0204137] Ni et al., 2008, Nature Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Zhou et al., 2008, Mol. Cell 32(4): 592--599 Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. [FBrf0206362] Adelman et al., 2006, Molec. Cell. Biol. 26(1): 250--260 Drosophila Paf1 modulates chromatin structure at actively transcribed genes. [FBrf0191186] Tenney et al., 2006, Proc. Natl. Acad. Sci. USA 103(32): 11970--11974 Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. [FBrf0194946]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Erratum	Baeg et al., 2007, Genes Dev. 21(7): 875--877 Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. [FBrf0201371]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Bellen, 2009.6.29, BDGP_2009_0629.GenExel.xml BDGP_2009_0629.GenExel.xml [FBrf0208121] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]