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Gene Dmel\ppk12

General Information
Symbol	Dmel\ppk12	Species	D. melanogaster
Name	pickpocket 12	Annotation symbol	CG10972
Feature type	protein_coding_gene	FlyBase ID	FBgn0034730
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58E1-58E1	Sequence location	2R:18,314,984..18,317,089 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pickpocket 12 is referred to in FlyBase by the symbol Dmel\ppk12 (CG10972, FBgn0034730). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: sodium channel activity. It is reported to be involved in the biological process: sodium ion transport. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Na+ channel, amiloride-sensitive. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of extremely low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1628454_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ppk12. Gene sequence location is 2R:18314984..18317089.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms integral to membrane
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58E1-58E1   Limits computationally determined from genome sequence between P{lacW}l(2)k13211k13211&P{EP}EP827 and P{PZ}l(2)rG270rG270
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58D8-58E1     (Welsh, 2003.1.16)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ppk12 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ppk12-RA FBtr0071830  NM_137828   1710   569
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ppk12-PA   FBpp0071741   63.8   569   6.68     NP_611672   AAF46849
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Na+ channel, amiloride-sensitive (IPR001873)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46849   AY226543 AAO47369
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W250
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 17   embryonic/larval dorsal trunk   (Liu et al., 2003) tracheal tip cell   (Liu et al., 2003)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    5 Larval Hindgut    71.7 Larval Malpighian Tubules    12.8 Larval Fat Body    3.4 Larval Salivary Gland    2 Larval Trachea    2.475 Larval Carcass    3.125 Adult Head    0.9 Adult Eye    0.975 Adult Brain    2.5 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    2.5 Adult Midgut    5.4 Adult Hindgut    34.1 Adult Malpighian Tubules    5.8 Adult Fat Body    4.5 Adult Salivary Gland    8.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    5.7 Adult InseminatedFemale Spermatheca    4.6 Adult Ovary    1.5 Adult Testis    3.2 Adult Male Accessory Gland    3.5 Adult Carcass    4.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    0.9   NA  Eye    0.975   NA  Brain    2.5   0.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.9   NA  Crop    2.5   5  Midgut    5.4   71.7  Hindgut    34.1   no informative data  Malpighian Tubules    5.8   3.4  Fat Body    4.5   2  Salivary Gland    8.8   NA  Heart    2.425   2.475  Trachea    NA   NA  VirginFemale Spermatheca    5.7   NA  InseminatedFemale Spermatheca    4.6   NA  Ovary    1.5   NA  Testis    3.2   NA  Male Accessory Gland    3.5   3.125  Carcass    4.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of extremely low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_09 mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034730 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10972-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW ppk12KK101805 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of ppk12 Class Mutagen Stocks Known lesion ppk12MB11059 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ppk12 Class Mutagen Stocks Known lesion ppk12JF02027 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ppk12KK101805 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ppk12a.RNAi.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ppk12GD2153 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ppk12RNAi.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7173 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2153} NA P{KK101805} NA P{Sym-UAS-ppk12.RNAi} NA P{TRiP.JF02027} NA characterization construct P{ppk12-GAL4.L} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}ppk12MB11059 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
sodium channel activity inferred from sequence or structural similarity with mouse Scnn1a (Curators, 2008--) non-traceable author statement (Welsh, 2003.1.16)
Biological Process
CV term Evidence References
sodium ion transport inferred by curator from GO:0005272 (Welsh, 2003.1.16) inferred from sequence or structural similarity with mouse Scnn1a (Curators, 2008--)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with mouse Scnn1a (Curators, 2008--)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ppk12 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034730
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZS9NQ Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG61G20V Arthropod inclusive ortholog search EOG6V9S68 Metazoa inclusive ortholog search EOG6QP0Q0
Orthologs in Drosophila Species (EOG6ZS9NQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ppk12     Drosophila simulans   Dsim\GD11671 Y   Drosophila sechellia   Dsec\GM15912 Y   Drosophila erecta   Dere\GG22192 Y   Drosophila yakuba   Dyak\GE14185 Y   Drosophila ananassae   Dana\GF11893 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10679 Y   Drosophila persimilis   Dper\GL17548 Y   Drosophila willistoni   Dwil\GK20821 Y   Drosophila virilis   Dvir\GJ22416 Y   Drosophila mojavensis   Dmoj\GI20562 Y   Drosophila grimshawi   Dgri\GH21367 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG61G20V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46186 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001917 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16586 Y Atta cephalotes Leafcutter ant  Acep\ACEP22748 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13148 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14121 Y Linepithema humile Argentine ant  Lhum\LH18129 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25290 Y Solenopsis invicta Red fire ant  Sinv\SINV23004 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI50440 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012849 Y Tribolium castaneum Red flour beetle  Tcas\TC002095 Y
Orthologs in non-Insect Arthropods (EOG6V9S68)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\NADH1 Y Daphnia pulex Water flea  Dpux\Palmd Y Daphnia pulex Water flea  Dpux\Rcan3 Y Daphnia pulex Water flea  Dpux\JGI_V11_95407 Y Daphnia pulex Water flea  Dpux\JGI_V11_98455 Y Daphnia pulex Water flea  Dpux\UBQ Y Ixodes scapularis Deer tick  Isca\ISCW017829 Y Ixodes scapularis Deer tick  Isca\ISCW023720 Y Ixodes scapularis Deer tick  Isca\ISCW020661 Y Ixodes scapularis Deer tick  Isca\ISCW006559 Y Ixodes scapularis Deer tick  Isca\ISCW017563 Y Ixodes scapularis Deer tick  Isca\ISCW022840 Y
Orthologs in non-Arthropod Metazoa (EOG6QP0Q0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\del-1 Y Caenorhabditis elegans Nematode  Cele\F28A12.1 Y Caenorhabditis elegans Nematode  Cele\acd-1 Y Caenorhabditis elegans Nematode  Cele\C24G7.1 Y Caenorhabditis elegans Nematode  Cele\asic-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010265gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015892gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010858gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018814gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015895gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027071gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025391gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015718gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015310gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028125gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015893gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025390gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009765gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014519gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010559gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006217gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016076gn Y Danio rerio Zebrafish  Drer\accn4b Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11671 Drosophila sechellia Dsec\GM15912 Drosophila erecta Dere\GG22192 Drosophila yakuba Dyak\GE14185 Drosophila ananassae Dana\GF11893 Drosophila pseudoobscura pseudoobscura Dpse\GA10679 Drosophila persimilis Dper\GL17548 Drosophila willistoni Dwil\GK20821 Drosophila virilis Dvir\GJ22416 Drosophila mojavensis Dmoj\GI20562 Drosophila grimshawi Dgri\GH21367
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	29179 w1118; Mi{ET1}ppk12MB11059 27092 y1 v1; P{TRiP.JF02027}attP2
VDRC	v105131 P{KK101805}VIE-260B
Genomic Clones ( 1 )
	BACR48M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034730 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37566
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ppk12 CG10972 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of ppk12 CG10972 was sequence comparison (date:030311). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137828 RefSeq (Proteins) • NP_611672 DDBJ / EMBL / GenBank • AAF46849 AAO47369 AY226543 Entrez Gene - A searchable database of RefSeq genes. • 37566 UniProtKB/TrEMBL • Q9W250
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Na+ channel, amiloride-sensitive (IPR001873)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034730 DRSC - Results from RNAi screens. • FBgn0034730 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034730 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10972-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034730 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37566 modMine - Data generated by the modENCODE project. • FBgn0034730
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG10972 (Vogel et al., 2003, Giannakou and Dow, 2001, Huet et al., 2002, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Tsubouchi et al., 2012) PPK12 (Liu et al., 2003, Welsh, 2003.1.16, Colomb et al., 2007) ppk12 (Liu et al., 2007, Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012, Ben-Shahar, 2011, Liu et al., 2012)
Name Synonym	pickpocket 12 (Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012)
Secondary FlyBase IDs
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Liu et al., 2012, J. Neurosci. 32(34): 11879--11889 Two Drosophila DEG/ENaC Channel Subunits Have Distinct Functions in Gustatory Neurons That Activate Male Courtship. [FBrf0219294] Show all research papers ...
Recent reviews ( 1 )
	Ben-Shahar, 2011, Adv. Genet. 76: 1--26 Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). [FBrf0218999] Show all reviews ...