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Gene Dmel\CG13510

General Information
Symbol	Dmel\CG13510	Species	D. melanogaster
Name		Annotation symbol	CG13510
Feature type	protein_coding_gene	FlyBase ID	FBgn0034758
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58F4-58F4	Sequence location	2R:18,545,406..18,546,931 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG13510 (FBgn0034758). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: cold acclimation. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: LPS-induced tumor necrosis factor alpha factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1638487_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG13510: 3 out of 14 probes fall into this exonic region. Gene sequence location is 2R:18545410..18546718.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58F4-58F4   Limits computationally determined from genome sequence between P{PZ}l(2)rG270rG270 and P{EP}EP718EP718
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG13510 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Possible dicistronic gene pair (CG13510 and CG13511). Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG13510-RA FBtr0071862  NM_137856   586   129 CG13510-RB FBtr0309799  NM_001259536   875   129
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG13510-PA   FBpp0071773   14.1   129   7.17     NP_611700   AAF46879 CG13510-PB   FBpp0301552   14.1   129   7.17     NP_001246465   AFH08218
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • LPS-induced tumor necrosis factor alpha factor (IPR006629)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46879   AE013599 AFH08218   BI242632   BI374828   BI580512   BT022713   BT082109   CA805126   CK661528   CO182859   CO312082   EC076453   EC226077   EV583145   FD586041   FD586543   FD587231   FD587278   FD587290   GH739884   GH740215   GH740901   GH741432   GH741730   GH742625   GH742739   GH744534   GH746154   GH761960   GH762312   GH762905   GH764277   GH764302   GH764729   GH765334   GH766594   GH767515   GH768946
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W221
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.45 Larval Midgut    301.9 Larval Hindgut    35.4 Larval Malpighian Tubules    113.5 Larval Fat Body    9 Larval Salivary Gland    31.8 Larval Trachea    5.075 Larval Carcass    11.5 Adult Head    6.3 Adult Eye    9.975 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    19.3 Adult Midgut    195.3 Adult Hindgut    30.7 Adult Malpighian Tubules    70 Adult Fat Body    6.1 Adult Salivary Gland    91.4 Adult Heart    3.025 Adult VirginFemale Spermatheca    11.7 Adult InseminatedFemale Spermatheca    11.9 Adult Ovary    3.4 Adult Testis    8.3 Adult Male Accessory Gland    57.4 Adult Carcass    7.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    6.3   NA  Eye    9.975   NA  Brain    3.7   2.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.8   NA  Crop    19.3   301.9  Midgut    195.3   35.4  Hindgut    30.7   113.5  Malpighian Tubules    70   9  Fat Body    6.1   31.8  Salivary Gland    91.4   NA  Heart    3.025   5.075  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    3.4   NA  Testis    8.3   NA  Male Accessory Gland    57.4   no informative data  Carcass    7.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    596 central nervous system, larvae L3    33 central nervous system, pupae P8    30 head, virgin 1-day female    23 head, virgin 4-day female    45 head, virgin 20-day female    36 head, mated 1-day female    31 head, mated 4-day female    19 head, mated 20-day female    38 head, mated 1-day male    32 head, mated 4-day male    38 head, mated 20-day male    58 salivary gland, larvae L3 wandering    707 salivary gland, white prepupae    500 digestive system, larvae L3 wandering    6252 digestive system, 1-day adult    3432 digestive system, 4-day adult    2646 digestive system, 20-day adult    3653 fat body, larvae L3 wandering    82 fat body, white prepupae    286 fat body, pupae P8    1172 carcass, larvae L3 wandering    289 carcass, 1-day adult    106 carcass, 4-day adult    91 carcass, 20-day adult    188 ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male    159 accessory gland, mated 4-day male    1004 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (596) central nervous system, larvae L3  (33) central nervous system, pupae P8  (30) head, virgin 1-day female    23 head, virgin 4-day female  (45) head, virgin 20-day female  (36) head, mated 1-day female  (31) head, mated 4-day female    19 head, mated 20-day female  (38) head, mated 1-day male  (32) head, mated 4-day male  (38) head, mated 20-day male  (58) salivary gland, larvae L3 wandering  (707) salivary gland, white prepupae  (500) digestive system, larvae L3 wandering  (6252) digestive system, 1-day adult  (3432) digestive system, 4-day adult  (2646) digestive system, 20-day adult  (3653) fat body, larvae L3 wandering  (82) fat body, white prepupae  (286) fat body, pupae P8  (1172) carcass, larvae L3 wandering  (289) carcass, 1-day adult  (106) carcass, 4-day adult  (91) carcass, 20-day adult  (188) ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male  (159) accessory gland, mated 4-day male  (1004) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (596) central nervous system, larvae L3    33 central nervous system, pupae P8    30 head, virgin 1-day female    23 head, virgin 4-day female    45 head, virgin 20-day female    36 head, mated 1-day female    31 head, mated 4-day female    19 head, mated 20-day female    38 head, mated 1-day male    32 head, mated 4-day male    38 head, mated 20-day male    58 salivary gland, larvae L3 wandering  (707) salivary gland, white prepupae  (500) digestive system, larvae L3 wandering  (6252) digestive system, 1-day adult  (3432) digestive system, 4-day adult  (2646) digestive system, 20-day adult  (3653) fat body, larvae L3 wandering    82 fat body, white prepupae  (286) fat body, pupae P8  (1172) carcass, larvae L3 wandering  (289) carcass, 1-day adult  106 carcass, 4-day adult    91 carcass, 20-day adult  (188) ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male  (159) accessory gland, mated 4-day male  (1004) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    596 central nervous system, larvae L3    33 central nervous system, pupae P8    30 head, virgin 1-day female    23 head, virgin 4-day female    45 head, virgin 20-day female    36 head, mated 1-day female    31 head, mated 4-day female    19 head, mated 20-day female    38 head, mated 1-day male    32 head, mated 4-day male    38 head, mated 20-day male    58 salivary gland, larvae L3 wandering    707 salivary gland, white prepupae    500 digestive system, larvae L3 wandering    6252 digestive system, 1-day adult    3432 digestive system, 4-day adult    2646 digestive system, 20-day adult    3653 fat body, larvae L3 wandering    82 fat body, white prepupae    286 fat body, pupae P8    1172 carcass, larvae L3 wandering    289 carcass, 1-day adult    106 carcass, 4-day adult    91 carcass, 20-day adult    188 ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male    159 accessory gland, mated 4-day male    1004 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    596 central nervous system, larvae L3    33 central nervous system, pupae P8    30 head, virgin 1-day female    23 head, virgin 4-day female    45 head, virgin 20-day female    36 head, mated 1-day female    31 head, mated 4-day female    19 head, mated 20-day female    38 head, mated 1-day male    32 head, mated 4-day male    38 head, mated 20-day male    58 salivary gland, larvae L3 wandering    707 salivary gland, white prepupae    500 digestive system, larvae L3 wandering    6252 digestive system, 1-day adult    3432 digestive system, 4-day adult    2646 digestive system, 20-day adult    3653 fat body, larvae L3 wandering    82 fat body, white prepupae    286 fat body, pupae P8    1172 carcass, larvae L3 wandering    289 carcass, 1-day adult    106 carcass, 4-day adult    91 carcass, 20-day adult    188 ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male    159 accessory gland, mated 4-day male    1004 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (596) central nervous system, larvae L3  (33) central nervous system, pupae P8  30 head, virgin 1-day female    23 head, virgin 4-day female  (45) head, virgin 20-day female  (36) head, mated 1-day female  31 head, mated 4-day female    19 head, mated 20-day female  (38) head, mated 1-day male  32 head, mated 4-day male  (38) head, mated 20-day male  (58) salivary gland, larvae L3 wandering  (707) salivary gland, white prepupae  (500) digestive system, larvae L3 wandering  (6252) digestive system, 1-day adult  (3432) digestive system, 4-day adult  (2646) digestive system, 20-day adult  (3653) fat body, larvae L3 wandering  (82) fat body, white prepupae  (286) fat body, pupae P8  (1172) carcass, larvae L3 wandering  (289) carcass, 1-day adult  (106) carcass, 4-day adult  (91) carcass, 20-day adult  (188) ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male  (159) accessory gland, mated 4-day male  (1004) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (596) central nervous system, larvae L3    33 central nervous system, pupae P8    30 head, virgin 1-day female    23 head, virgin 4-day female    45 head, virgin 20-day female    36 head, mated 1-day female    31 head, mated 4-day female    19 head, mated 20-day female    38 head, mated 1-day male    32 head, mated 4-day male    38 head, mated 20-day male    58 salivary gland, larvae L3 wandering  (707) salivary gland, white prepupae  (500) digestive system, larvae L3 wandering  (6252) digestive system, 1-day adult  (3432) digestive system, 4-day adult  (2646) digestive system, 20-day adult  (3653) fat body, larvae L3 wandering    82 fat body, white prepupae  (286) fat body, pupae P8  (1172) carcass, larvae L3 wandering  (289) carcass, 1-day adult  106 carcass, 4-day adult    91 carcass, 20-day adult  (188) ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male  (159) accessory gland, mated 4-day male  (1004) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    596 central nervous system, larvae L3    33 central nervous system, pupae P8    30 head, virgin 1-day female    23 head, virgin 4-day female    45 head, virgin 20-day female    36 head, mated 1-day female    31 head, mated 4-day female    19 head, mated 20-day female    38 head, mated 1-day male    32 head, mated 4-day male    38 head, mated 20-day male    58 salivary gland, larvae L3 wandering    707 salivary gland, white prepupae    500 digestive system, larvae L3 wandering    6252 digestive system, 1-day adult    3432 digestive system, 4-day adult    2646 digestive system, 20-day adult    3653 fat body, larvae L3 wandering    82 fat body, white prepupae    286 fat body, pupae P8    1172 carcass, larvae L3 wandering    289 carcass, 1-day adult    106 carcass, 4-day adult    91 carcass, 20-day adult    188 ovary, virgin 4-day female    12 ovary, mated 4-day female    23 testis, mated 4-day male    159 accessory gland, mated 4-day male    1004 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr    33 embryo 12-14hr    39 embryo 14-16hr    92 embryo 16-18hr    102 embryo 18-20hr    89 embryo 20-22hr    92 embryo 22-24hr    99 larva L1    83 larva L2    99 larva L3 12hr old    78 larva L3 puffstage 1-2    133 larva L3 puffstage 3-6    160 larva L3 puffstage 7-9    165 white prepupae new    105 white prepupae 12hr    222 white prepupae 24hr    66 pupae 2d postWPP    40 pupae 3d postWPP    26 pupae 4d postWPP    36 adult male 01day    52 adult male 05day    69 adult male 30day    97 adult female 01day    62 adult female 05day    28 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr  (33) embryo 12-14hr  (39) embryo 14-16hr  (92) embryo 16-18hr  (102) embryo 18-20hr  (89) embryo 20-22hr  (92) embryo 22-24hr  (99) larva L1  (83) larva L2  (99) larva L3 12hr old  (78) larva L3 puffstage 1-2  (133) larva L3 puffstage 3-6  (160) larva L3 puffstage 7-9  (165) white prepupae new  (105) white prepupae 12hr  (222) white prepupae 24hr  (66) pupae 2d postWPP  (40) pupae 3d postWPP  26 pupae 4d postWPP  (36) adult male 01day  (52) adult male 05day  (69) adult male 30day  (97) adult female 01day  (62) adult female 05day  (28) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr    33 embryo 12-14hr    39 embryo 14-16hr    92 embryo 16-18hr  102 embryo 18-20hr    89 embryo 20-22hr    92 embryo 22-24hr    99 larva L1    83 larva L2    99 larva L3 12hr old    78 larva L3 puffstage 1-2  (133) larva L3 puffstage 3-6  (160) larva L3 puffstage 7-9  (165) white prepupae new  105 white prepupae 12hr  (222) white prepupae 24hr    66 pupae 2d postWPP    40 pupae 3d postWPP    26 pupae 4d postWPP    36 adult male 01day    52 adult male 05day    69 adult male 30day    97 adult female 01day    62 adult female 05day    28 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr    33 embryo 12-14hr    39 embryo 14-16hr    92 embryo 16-18hr    102 embryo 18-20hr    89 embryo 20-22hr    92 embryo 22-24hr    99 larva L1    83 larva L2    99 larva L3 12hr old    78 larva L3 puffstage 1-2    133 larva L3 puffstage 3-6    160 larva L3 puffstage 7-9    165 white prepupae new    105 white prepupae 12hr    222 white prepupae 24hr    66 pupae 2d postWPP    40 pupae 3d postWPP    26 pupae 4d postWPP    36 adult male 01day    52 adult male 05day    69 adult male 30day    97 adult female 01day    62 adult female 05day    28 adult female 30day    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr    33 embryo 12-14hr    39 embryo 14-16hr    92 embryo 16-18hr    102 embryo 18-20hr    89 embryo 20-22hr    92 embryo 22-24hr    99 larva L1    83 larva L2    99 larva L3 12hr old    78 larva L3 puffstage 1-2    133 larva L3 puffstage 3-6    160 larva L3 puffstage 7-9    165 white prepupae new    105 white prepupae 12hr    222 white prepupae 24hr    66 pupae 2d postWPP    40 pupae 3d postWPP    26 pupae 4d postWPP    36 adult male 01day    52 adult male 05day    69 adult male 30day    97 adult female 01day    62 adult female 05day    28 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr  (33) embryo 12-14hr  (39) embryo 14-16hr  (92) embryo 16-18hr  (102) embryo 18-20hr  (89) embryo 20-22hr  (92) embryo 22-24hr  (99) larva L1  (83) larva L2  (99) larva L3 12hr old  (78) larva L3 puffstage 1-2  (133) larva L3 puffstage 3-6  (160) larva L3 puffstage 7-9  (165) white prepupae new  (105) white prepupae 12hr  (222) white prepupae 24hr  (66) pupae 2d postWPP  (40) pupae 3d postWPP  26 pupae 4d postWPP  (36) adult male 01day  (52) adult male 05day  (69) adult male 30day  (97) adult female 01day  (62) adult female 05day  28 adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr    33 embryo 12-14hr    39 embryo 14-16hr    92 embryo 16-18hr  102 embryo 18-20hr    89 embryo 20-22hr    92 embryo 22-24hr    99 larva L1    83 larva L2    99 larva L3 12hr old    78 larva L3 puffstage 1-2  133 larva L3 puffstage 3-6  (160) larva L3 puffstage 7-9  (165) white prepupae new  105 white prepupae 12hr  (222) white prepupae 24hr    66 pupae 2d postWPP    40 pupae 3d postWPP    26 pupae 4d postWPP    36 adult male 01day    52 adult male 05day    69 adult male 30day    97 adult female 01day    62 adult female 05day    28 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    6 embryo 08-10hr    11 embryo 10-12hr    33 embryo 12-14hr    39 embryo 14-16hr    92 embryo 16-18hr    102 embryo 18-20hr    89 embryo 20-22hr    92 embryo 22-24hr    99 larva L1    83 larva L2    99 larva L3 12hr old    78 larva L3 puffstage 1-2    133 larva L3 puffstage 3-6    160 larva L3 puffstage 7-9    165 white prepupae new    105 white prepupae 12hr    222 white prepupae 24hr    66 pupae 2d postWPP    40 pupae 3d postWPP    26 pupae 4d postWPP    36 adult male 01day    52 adult male 05day    69 adult male 30day    97 adult female 01day    62 adult female 05day    28 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    145 tumorous blood cells mbn2    42 ovary fGS/OSS    1095 ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2  (145) tumorous blood cells mbn2  (42) ovary fGS/OSS  (1095) ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2  (145) tumorous blood cells mbn2    42 ovary fGS/OSS  (1095) ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    145 tumorous blood cells mbn2    42 ovary fGS/OSS    1095 ovary OSC    7 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    145 tumorous blood cells mbn2    42 ovary fGS/OSS    1095 ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2  (145) tumorous blood cells mbn2  (42) ovary fGS/OSS  (1095) ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2  (145) tumorous blood cells mbn2    42 ovary fGS/OSS  (1095) ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    145 tumorous blood cells mbn2    42 ovary fGS/OSS    1095 ovary OSC    7 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1283 cold shock, 4-day adult    1381 heat shock, 4-day adult    485 Cadmium 50 mM 6 hrs, larvae L3    684 Cadmium 50 mM 12 hrs, larvae L3    955 Cadmium 50 mM 48 hrs, 4-day adult    679 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    1304 Copper 15 mM 48 hrs, 4-day adult    1183 Zinc 5 mM 12 hrs, larvae L3    2862 Zinc 4.5 mM 48 hrs, 4-day adult    1694 Ethanol 2.5% 3 hrs, larvae L3    278 Ethanol 5% 3 hrs, larvae L3    1307 Ethanol 10% 3 hrs, larvae L3    958 Caffeine 1.5 mg/ml 4 hrs, larvae L3    674 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    511 Caffeine 25 mg/ml 48 hrs, 4-day adult    1248 Paraquat 5 mM 48 hrs, 4-day adult    446 Paraquat 10 mM 48 hrs, 4-day adult    489 Rotenone 2 μg 12 hrs, larvae L3    1093 Rotenone 8 μg 12 hrs, larvae L3    874 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (1283) cold shock, 4-day adult  (1381) heat shock, 4-day adult  (485) Cadmium 50 mM 6 hrs, larvae L3  (684) Cadmium 50 mM 12 hrs, larvae L3  (955) Cadmium 50 mM 48 hrs, 4-day adult  (679) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (1304) Copper 15 mM 48 hrs, 4-day adult  (1183) Zinc 5 mM 12 hrs, larvae L3  (2862) Zinc 4.5 mM 48 hrs, 4-day adult  (1694) Ethanol 2.5% 3 hrs, larvae L3  (278) Ethanol 5% 3 hrs, larvae L3  (1307) Ethanol 10% 3 hrs, larvae L3  (958) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (674) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (511) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1248) Paraquat 5 mM 48 hrs, 4-day adult  (446) Paraquat 10 mM 48 hrs, 4-day adult  (489) Rotenone 2 μg 12 hrs, larvae L3  (1093) Rotenone 8 μg 12 hrs, larvae L3  (874) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (1283) cold shock, 4-day adult  (1381) heat shock, 4-day adult  (485) Cadmium 50 mM 6 hrs, larvae L3  (684) Cadmium 50 mM 12 hrs, larvae L3  (955) Cadmium 50 mM 48 hrs, 4-day adult  (679) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (1304) Copper 15 mM 48 hrs, 4-day adult  (1183) Zinc 5 mM 12 hrs, larvae L3  (2862) Zinc 4.5 mM 48 hrs, 4-day adult  (1694) Ethanol 2.5% 3 hrs, larvae L3  (278) Ethanol 5% 3 hrs, larvae L3  (1307) Ethanol 10% 3 hrs, larvae L3  (958) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (674) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (511) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1248) Paraquat 5 mM 48 hrs, 4-day adult  (446) Paraquat 10 mM 48 hrs, 4-day adult  (489) Rotenone 2 μg 12 hrs, larvae L3  (1093) Rotenone 8 μg 12 hrs, larvae L3  (874) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1283 cold shock, 4-day adult    1381 heat shock, 4-day adult    485 Cadmium 50 mM 6 hrs, larvae L3    684 Cadmium 50 mM 12 hrs, larvae L3    955 Cadmium 50 mM 48 hrs, 4-day adult    679 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    1304 Copper 15 mM 48 hrs, 4-day adult    1183 Zinc 5 mM 12 hrs, larvae L3    2862 Zinc 4.5 mM 48 hrs, 4-day adult    1694 Ethanol 2.5% 3 hrs, larvae L3    278 Ethanol 5% 3 hrs, larvae L3    1307 Ethanol 10% 3 hrs, larvae L3    958 Caffeine 1.5 mg/ml 4 hrs, larvae L3    674 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    511 Caffeine 25 mg/ml 48 hrs, 4-day adult    1248 Paraquat 5 mM 48 hrs, 4-day adult    446 Paraquat 10 mM 48 hrs, 4-day adult    489 Rotenone 2 μg 12 hrs, larvae L3    1093 Rotenone 8 μg 12 hrs, larvae L3    874 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1283 cold shock, 4-day adult    1381 heat shock, 4-day adult    485 Cadmium 50 mM 6 hrs, larvae L3    684 Cadmium 50 mM 12 hrs, larvae L3    955 Cadmium 50 mM 48 hrs, 4-day adult    679 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    1304 Copper 15 mM 48 hrs, 4-day adult    1183 Zinc 5 mM 12 hrs, larvae L3    2862 Zinc 4.5 mM 48 hrs, 4-day adult    1694 Ethanol 2.5% 3 hrs, larvae L3    278 Ethanol 5% 3 hrs, larvae L3    1307 Ethanol 10% 3 hrs, larvae L3    958 Caffeine 1.5 mg/ml 4 hrs, larvae L3    674 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    511 Caffeine 25 mg/ml 48 hrs, 4-day adult    1248 Paraquat 5 mM 48 hrs, 4-day adult    446 Paraquat 10 mM 48 hrs, 4-day adult    489 Rotenone 2 μg 12 hrs, larvae L3    1093 Rotenone 8 μg 12 hrs, larvae L3    874 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (1283) cold shock, 4-day adult  (1381) heat shock, 4-day adult  (485) Cadmium 50 mM 6 hrs, larvae L3  (684) Cadmium 50 mM 12 hrs, larvae L3  (955) Cadmium 50 mM 48 hrs, 4-day adult  (679) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (1304) Copper 15 mM 48 hrs, 4-day adult  (1183) Zinc 5 mM 12 hrs, larvae L3  (2862) Zinc 4.5 mM 48 hrs, 4-day adult  (1694) Ethanol 2.5% 3 hrs, larvae L3  (278) Ethanol 5% 3 hrs, larvae L3  (1307) Ethanol 10% 3 hrs, larvae L3  (958) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (674) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (511) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1248) Paraquat 5 mM 48 hrs, 4-day adult  (446) Paraquat 10 mM 48 hrs, 4-day adult  (489) Rotenone 2 μg 12 hrs, larvae L3  (1093) Rotenone 8 μg 12 hrs, larvae L3  (874) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (1283) cold shock, 4-day adult  (1381) heat shock, 4-day adult  (485) Cadmium 50 mM 6 hrs, larvae L3  (684) Cadmium 50 mM 12 hrs, larvae L3  (955) Cadmium 50 mM 48 hrs, 4-day adult  (679) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (1304) Copper 15 mM 48 hrs, 4-day adult  (1183) Zinc 5 mM 12 hrs, larvae L3  (2862) Zinc 4.5 mM 48 hrs, 4-day adult  (1694) Ethanol 2.5% 3 hrs, larvae L3  (278) Ethanol 5% 3 hrs, larvae L3  (1307) Ethanol 10% 3 hrs, larvae L3  (958) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (674) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (511) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1248) Paraquat 5 mM 48 hrs, 4-day adult  (446) Paraquat 10 mM 48 hrs, 4-day adult  (489) Rotenone 2 μg 12 hrs, larvae L3  (1093) Rotenone 8 μg 12 hrs, larvae L3  (874) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1283 cold shock, 4-day adult    1381 heat shock, 4-day adult    485 Cadmium 50 mM 6 hrs, larvae L3    684 Cadmium 50 mM 12 hrs, larvae L3    955 Cadmium 50 mM 48 hrs, 4-day adult    679 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    1304 Copper 15 mM 48 hrs, 4-day adult    1183 Zinc 5 mM 12 hrs, larvae L3    2862 Zinc 4.5 mM 48 hrs, 4-day adult    1694 Ethanol 2.5% 3 hrs, larvae L3    278 Ethanol 5% 3 hrs, larvae L3    1307 Ethanol 10% 3 hrs, larvae L3    958 Caffeine 1.5 mg/ml 4 hrs, larvae L3    674 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    511 Caffeine 25 mg/ml 48 hrs, 4-day adult    1248 Paraquat 5 mM 48 hrs, 4-day adult    446 Paraquat 10 mM 48 hrs, 4-day adult    489 Rotenone 2 μg 12 hrs, larvae L3    1093 Rotenone 8 μg 12 hrs, larvae L3    874 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034758 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG13510 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG13510GD12829 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG13510 Class Mutagen Stocks Known lesion CG13510[EY05214] P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG13510 Class Mutagen Stocks Known lesion CG13510GD12829 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG13510KK113081 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG13510NIG.13510R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12829} NA P{KK113081} NA P{NIG.13510R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG13510EY05214 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data on: 2012-06-22)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cold acclimation inferred from expression pattern (Qin et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG13510 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63211 DroID - A comprehensive database of gene and protein interactions. • FBgn0034758 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37596
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RBR5B Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6ZKHJ2 Arthropod inclusive ortholog search EOG61VHKP Metazoa inclusive ortholog search EOG6NGVJ2
Orthologs in Drosophila Species (EOG6RBR5B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG13510     Drosophila simulans   Dsim\GD11684 Y   Drosophila sechellia   Dsec\GM15931 Y   Drosophila erecta   Dere\GG21061 Y   Drosophila yakuba   Dyak\GE14003 Y   Drosophila ananassae   Dana\GF11281 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12335 Y   Drosophila persimilis   Dper\GL11361 Y   Drosophila willistoni   Dwil\GK21440 Y   Drosophila virilis   Dvir\GJ22026 Y   Drosophila mojavensis   Dmoj\GI20298 Y   Drosophila grimshawi   Dgri\GH19761 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6ZKHJ2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC725688 Y Apis mellifera Western honey bee  Amel\LOC551998 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021007 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000550 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17121 Y Atta cephalotes Leafcutter ant  Acep\ACEP12142 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12237 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19632 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19630 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19633 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23552 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16414 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16260 Y Linepithema humile Argentine ant  Lhum\LH16749 Y Linepithema humile Argentine ant  Lhum\LH18386 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23542 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20846 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17771 Y Solenopsis invicta Red fire ant  Sinv\SINV10618 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI23122 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006651 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009512 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI46913 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000883 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000885 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000886 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000884 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000541 Y Pediculus humanus Human body louse  Phum\PHUM131500 Y Pediculus humanus Human body louse  Phum\PHUM603960 Y Pediculus humanus Human body louse  Phum\PHUM581980 Y Tribolium castaneum Red flour beetle  Tcas\TC003371 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6NGVJ2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\si:ch211-202h22.7 Y Danio rerio Zebrafish  Drer\si:ch211-202h22.9 Y Danio rerio Zebrafish  Drer\ENSDARG00000076069 Y Danio rerio Zebrafish  Drer\si:ch211-202h22.8 Y Danio rerio Zebrafish  Drer\ENSDARG00000075902 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11684 Drosophila sechellia Dsec\GM15931 Drosophila erecta Dere\GG21061 Drosophila yakuba Dyak\GE14003 Drosophila ananassae Dana\GF11281 Drosophila pseudoobscura pseudoobscura Dpse\GA12335 Drosophila persimilis Dper\GL11361 Drosophila willistoni Dwil\GK21440 Drosophila virilis Dvir\GJ22026 Drosophila mojavensis Dmoj\GI20298 Drosophila grimshawi Dgri\GH19761
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	22310 y1 w67c23; P{EPgy2}CG13510EY05214/SM6a
VDRC	v103009 P{KK113081}VIE-260B v28434 w1118; P{GD12829}v28434 v28433 w1118; P{GD12829}v28433/TM3
Genomic Clones ( 1 )
	BACR11M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE62510
Other clones	MIP04282
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP21101 RE40023 RE74718
Other clones	104635 121792 Dmel_dig_012666_0625_3135 EC24151 EK227847 ESG0116c.B21_E09 RM02791 RM02891 RM03191 RM03291 RM03391 RP001001473 RP001004436 RP001015389 RP001015391 RP001016592 RP001021923 RP001023403 RP001031264 RP001033764 RP001035191 RP001036822 RP001038603 RP001039357 RP001040875 RP001041480 RP001047451 RP001048545 RP001050657 RP001053061
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034758 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37596
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137856 NM_001259536 RefSeq (Proteins) • NP_611700 NP_001246465 DDBJ / EMBL / GenBank • AAF46879 AFH08218 BI374828 Entrez Gene - A searchable database of RefSeq genes. • 37596 UniProtKB/TrEMBL • Q9W221
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • LPS-induced tumor necrosis factor alpha factor (IPR006629)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63211 DroID - A comprehensive database of gene and protein interactions. • FBgn0034758 DRSC - Results from RNAi screens. • FBgn0034758 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034758 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034758 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37596 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37596 modMine - Data generated by the modENCODE project. • FBgn0034758
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG13510 (Ranade et al., 2008, Qin et al., 2005, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 14 )
Research paper	Ranade et al., 2008, Dev. Biol. 315(2): 521--534 Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. [FBrf0204284] Qin et al., 2005, Insect Mol. Biol. 14(6): 607--613 Cold hardening and transcriptional change in Drosophila melanogaster. [FBrf0190857]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bellen, 2006.4.12, Batch655.xml Batch655.xml [FBrf0200401] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]